News on open-access publishing and its reach. Covers journal launches, open-access agreements, and research made freely available.
A new type of sensor leverages exceptional points to achieve high sensitivity and reconfigurability. The novel design addresses limitations of traditional EP-based sensors by incorporating spoof localized surface plasmon resonators, allowing for dynamic reconfiguration of EP states across a wide frequency range.
Researchers explore AI's role in addressing challenges in immunotherapy, developing new biomarkers for precise disease characterization and predicting treatment response. A comprehensive review applied AI/radiomics to cross-sectional imaging, showcasing the current landscape in IO treatment.
Researchers validate increase of specific t-Cys sites associated with aging in human proteome, suggesting potential role in age-related diseases. The study expands beyond classical proteinopathic paradigms, highlighting trioxidized cysteine as a key molecular mechanism underlying aging.
Researchers found that CHEK2 variants do not increase colorectal cancer risk compared to controls. Three low-risk missense variants were identified as potential drivers of breast cancer risk variability.
Researchers have discovered that dialyl-sulfide and trans-chalcone can prevent breast cancer by targeting SULT1E1 and HIF1a-MMPs. These compounds neutralize oxidative stress and induce the expression of SULT1E1, leading to decreased HIF1a and MMP production.
Researchers have identified HLA-E as a critical negative regulator of NK cell interactions with cancer cells. Disrupting NKG2A:HLA-E interactions may stimulate both NK cell and cytotoxic T cell effector functions against cancer, offering a promising anti-cancer strategy.
A recent study found that approximately two-thirds of inhalers used by patients hospitalized with COPD were misused, leading to inadequate medication delivery and increased exacerbations. Regular therapeutic education and proper inhaler technique can improve health outcomes.
Researchers explore the effect of exercise on age-related biomarkers in human skeletal muscle, revealing its potential to foster healthier aging. The study represents the first quantitative and qualitative analysis of this impact, highlighting the benefits of exercise for age-related diseases.
Researchers found associations between cardiorespiratory fitness and DNA methylation-based aging clocks in older men, suggesting that active lifestyles may delay biological aging. The study aims to establish fitness reference values to help prevent the onset of diseases associated with aging.
Researchers discuss the role of gut microbiota in regulating basal inflammation levels and promoting healing of the bowel after surgery. Weakened gut barrier function may lead to persistent low-grade inflammation and increased risk of cancer recurrence.
Researchers have proposed a framework encompassing all discovered host immunological pathways, including TH1, TH2a, TH2b, TH3, TH9, TH17, TH22, TH1-like, and THαβ immune reactions. These relationships can help understand host defense mechanisms against invading pathogens and provide insights for developing better therapeutic strategies.
Researchers developed a nanobody that targets V-ATPase c subunit and inhibits tumor cell invasion and metastasis. The nanobody was tested on 4T1-12B mouse breast cancer cells implanted in mice, where it showed effectiveness in preventing lung metastasis.
Rice University professor Ashutosh Sabharwal leads a project to design and develop an open-access software-defined radio system for 6G wireless networking, imaging, and sensing. The system will support diverse bands and enable research communities to explore new directions in wireless technology.
Researchers studied the association of 12 immune cell types with epigenetic age acceleration in healthy and diseased populations. Their work sheds light on the complex interplay between immune cell composition and epigenetic aging.
Researchers report a case of undifferentiated spindle cell sarcoma with primary insensitivity to standard chemotherapy, but a pronounced response to BRAF/MEK inhibitors at recurrence. The tumor was found to be BRAF exon 15 double-mutated: c.1799T>A p.V600E and c.1819T>A p.S607T.
A recent study by Harvard University researchers compares the effectiveness of one-photon (1P) versus two-photon (2P) voltage imaging in neural circuits. The study found that 2P excitation requires approximately 10,000 times more illumination power per cell compared to 1P excitation, posing significant challenges for 2P voltage imaging.
Researchers found that artificial induction of GluCer leads to cellular senescence in DA neurons, highlighting the role of lipid aggregation in PD. The study proposes that lysosomal impairment and lipid accumulation trigger expression of a cellular senescence phenotype in vulnerable DA neurons.
Researchers discuss diverse BRAF alterations found in human cancers and strategies to inhibit them. Class I BRAF inhibitors represent a landmark achievement in precision oncology, with FDA-approved dabrafenib/trametinib for metastatic BRAF p.V600E-mutant solid tumors.
A global network will be created to protect Indigenous data collection and use, leveraging worldwide policies and practices to ensure control over data related to Indigenous communities. The project aims to establish an alliance among 12 Indigenous data sovereignty networks spanning the globe.
Researchers unveil retrotransposon-derived DNA zip codes that enable myeloma cell internalization, shedding light on cancer evolution and treatment response. The findings highlight the potential of zip-code technology in improving patient outcomes and advancing human health.
Researchers identified a potential antigen for TCR recognition in melanoma, suggesting that RNLS protein could be recognized by T cells leading to local immune responses against the cancer. The study found that chemical complementarity between melanoma-resident TCR CDR3s and renalase-1 protein correlates with increased melanoma survival.
Researchers discuss how PROM2 is a predictive biomarker of distant metastases and shorter survival among patients with stage III melanomas. They also demonstrate that runaway metastasis is closely linked to PROM2 overexpression, through increased epithelial-to-mesenchymal transition marker expression and ferroptosis resistance.
A new study found that mTORC1 activity correlates with classical biometrics, such as height and macrocephaly, as well as specific neuropsychiatric diseases like anxiety and autism. The research suggests that human variability of mTORC1 gain of function may predict medication response.
A new study found that meeting partners online is positively linked to relationship success among those who have social media presence on their relationships. However, the link was absent among individuals without this social media presence, particularly in marital relationships.
A collaborative effort between The Academy of Breastfeeding Medicine and Reaching our Sisters Everywhere identified key components of a successful breastfeeding journey as defined by parents and families. The findings aim to inform research priorities and promote patient-centered outcomes in infant and young-child feeding.
Empa researchers have developed a system to investigate up to ten different reaction conditions for producing synthetic fuels from CO2. The system accelerates the discovery process by generating a large number of high-quality datasets, enabling scientists to make accelerated discoveries.
A study by Virginia Tech researchers found that shelter dogs paired with suitable companions exhibited reduced stress levels and were adopted more quickly. The findings suggest that matching dogs with compatible roommates could alleviate stress and improve their adoptability, leading to better outcomes for animal shelters.
Researchers identify UBE2J1's role in degrading the androgen receptor, a key player in prostate cancer progression. The study suggests targeting this ubiquitination machinery may help overcome antiandrogen resistance in cancer therapy.
Researchers have developed a groundbreaking solution to overcome DAC challenges, achieving record-breaking data transmission performance. The innovative approach enables the transmission of signals at rates exceeding 124 GBd PAM-4/6 and 112 GBd PAM-8 over long distances using low-cost digital-to-analog converters.
A recent study discovered a critical brain signal mediated by dopamine and its 'D2' receptors that plays a crucial role in timing actions. The research team used novel imaging techniques to observe this activity before self-timed presses, finding a gradual increase in brain signals about half a second prior.
The American College of Chest Physicians' CHEST Critical Care and CHEST Pulmonary journals have been indexed with the Directory of Open Access Journals (DOAJ), enhancing their open access content's accessibility and usage. The indexation is attributed to strong editorial boards led by Hayley Gershengorn and Matthew Miles.
Researchers in Portugal have developed an innovative open-source platform called DL4MicEverywhere, providing life scientists with easy access to advanced artificial intelligence for the analysis of microscopy images. The platform enables researchers to easily train and use deep learning models on their own data, regardless of their com...
Residents in the UK have complex views on the introduced ring-necked parakeet, with acceptance of urban presence but resistance in rural areas. Concerns include competition with native birds and unknown impacts on local ecosystems. The study suggests a possible generational divide in perceptions.
A new study found extensive alternative splicing of messenger RNA in untreated multiple sclerosis patients compared to healthy controls. Interferon-ß therapy corrected dysregulated alternative splicing, linking it to future clinical exacerbations.
A unique collaboration between archaeologists and MeatEater highlights the prevalence of equifinality, where distinct processes can lead to the same outcome. The experiment tested Clovis stone tools' efficiency in processing a bison, offering insights into early human technologies.
This special issue highlights photonics developments in Latin America, the Middle East, Eastern Europe, India, and China, showcasing regional growth and progress. The papers emphasize the importance of global cooperation and collaboration to address challenges and seize opportunities in the field.
The TIER2 project is seeking consortia to establish a new Reproducibility Network (RN) in Widening participation countries. The selected consortia will receive 5,000 Euros each as seed money to support the kick-off meeting and promote reproducible research practices.
Researchers propose combining osimertinib with gefitinib to increase progression-free survival rates in EGFR-mutant lung cancer patients. A comprehensive PC approach could dramatically boost PFS for 80% of patients, eliminating harm and improving treatment outcomes.
Researchers developed a custom-built, low-cost mesoscope that can adapt to different neuroimaging experiments in live mice and rats. The system offers excellent spatial and temporal resolutions, achieved through its reversible tandem lens configuration, which enables flexible experimentation.
A new study published in the Journal of Medical Internet Research found that sexual minority adults are more willing to use digital health tools for screening and tracking compared to heterosexual adults. The study, which analyzed data from a COVID-19 survey, highlights the need for diverse populations to be considered in the developme...
Researchers have created a computer using an array of VCSELs that leverages optical feedback to efficiently solve complex optimization problems. The system encodes information in linear polarization states, minimizing interactions between variables and overcoming the von Neumann bottleneck.
Researchers developed a high-speed modulation system combining digital display with super-resolution imaging, significantly improving lateral and axial resolution. This enables detailed study of subcellular structures in animal cells and plant ultrastructures, paving the way for future biological discoveries.
The MIT Press is accepting applications for its shift+OPEN initiative, which provides funding and support to convert subscription-based journals to diamond open access. Selected journals will receive three-year funding, professional publishing services, and sustainable funding model development support.
Researchers propose a novel augmentation regimen, IPIAD, combining five generic non-oncology drugs with standard chemotherapy for pancreatic ductal adenocarcinoma. The IPIAD regimen uses repurposed drugs like irbesartan and azithromycin to potentially slow disease growth and improve outcomes.
Researchers developed a compact microscope using a single photon avalanche diode array detector, enabling super-resolution imaging with improved signal-to-noise ratio and spatial resolution. The system also combines fluorescence lifetime measurements for enhanced structural specificity.
Dr. Mikhail V. Blagosklonny, a renowned oncologist, shares his personal journey with metastatic brain cancer and challenges conventional treatment approaches. He argues that targeted drugs alone cannot cure lung cancer, but preemptive combinations may offer hope.
A new technique using optical orbital angular momentum lattice (OAML) multiplexed holography boosts information storage capacity and offers novel approaches for implementing high-capacity holographic systems. The research unlocks supplementary encrypted dimensions, enhancing storage capacity and overcoming limitations of traditional me...
Researchers use water as a nonlinear medium to create a supercontinuum white laser covering an impressive spectral range from UV to far infrared. The resulting ultrabroadband source has potential in ultrafast spectroscopy, hyperspectral imaging, and scientific research.
Researchers from MD Anderson Cancer Center reported a case of a patient with an exceptional response to pazopanib treatment for over 5 years. The study shows that pazopanib prevents or delays the progression of additional metastasis in EWSR1-NFATC2 positive sarcomas. Further studies are warranted.
The report highlights key applications and pathways to commercialization for emerging PV technologies, including new materials and device concepts. It also discusses strategies to exceed current limits in solar PV energy conversion and challenges facing efforts to scale up globally.
A team of scientists used functional near-infrared spectroscopy (fNIRS) to measure brain activity in two key visual regions, the lateral occipital complex (LOC) and fusiform face area (FFA). The study found that fNIRS successfully measured LOC activity but had limitations in detecting FFA activity due to its depth. This research has th...
A study found that 64% of students did not engage in problematic behaviors, while 26% let participants take part despite knowing the hypothesis. Supervisors underestimated the prevalence of certain behaviors, highlighting the need for improved communication and Open Science education.
The European Societies and European Journal of Cultural and Political Sociology journals will transition to diamond open access with the MIT Press, starting in 2025. The move is driven by the growing acceptance of open access in academic fields and the European Union's new requirements.
A research team developed an innovative optical technique, 'spectrum shuttle,' to produce and shape GHz burst pulses. The method facilitates ultrafast imaging within subnanosecond timescales, enabling analysis of rapid phenomena.
A team of researchers at Ghent University and imec developed a silicon photonic temperature sensor that measures up to 180°C. The sensor was realized in the framework of the European SEER project, where partners focus on integrating optical sensors in manufacturing routines for composite parts.
A new study using Raman spectroscopy has identified Pseudomonas bacteria from turtle skin in just 5-30 minutes, offering a faster alternative to traditional methods. The technique provides detailed information about bacterial chemical structure and holds great potential for future research on other microorganisms.
Researchers found that BCMA-positive extracellular vesicles (EVs) in plasma levels correlated with myeloma patient responses to belantamab-mafodotin therapy. High EV levels preceded FLC progression and were associated with mafodotin-induced eryptosis.
Researchers found that Eurasian jays settle for less preferred food options when rivals are present, while New Caledonian crows consistently choose the better, delayed reward. The study suggests that species' social tolerance and competition levels influence self-control in animals.
The portal brings together genomic data from different biodiversity projects to aid conservation and biodiversity efforts. It allows researchers to understand genetic factors that make a species unique, including its vulnerabilities and strengths in adapting to changing environmental conditions.
Researchers developed three diffractive deep neural networks using orbital angular momentum to recognize objects in images, achieving accuracy comparable to wavelength and polarization-based models. The technology has potential for real-time processing applications like image recognition and data-intensive tasks.