Articles tagged with Open Access
Researchers Elzbieta Izbicka and Robert T. Streeper discuss the evolution of cancer drug development, highlighting recent progress and emerging challenges due to environmental factors. They also examine how artificial intelligence may impact future drug development.
The invasive orange pore fungus has won the third BMC Ecology and Evolution image competition, highlighting its potential threats to Australian ecosystems. The winning image depicts bright orange fruiting bodies growing on deadwood in the Australian rainforest.
Researchers have identified a new species of leaf-tailed gecko from northern Madagascar, showcasing its exceptional camouflage skills. The discovery has shed light on the unique characteristics of this species, including its skin flaps and flattened tail.
The DRYRivERS app is a unique open-source project that enables citizen scientists to contribute to the study of flow intermittence in rivers. By logging observations on waterways around the world, users are helping to provide precious information to river managers and advance the science and management of intermittent rivers.
Researchers have developed a new measurement technique that uses the Kramers-Kronig relation to untangle complex helical light patterns from camera intensity measurements. This allows for single-shot retrieval of orbital angular momentum spectrum information, accelerating and simplifying the process compared to conventional on-axis int...
A new editorial explores the potential of machine learning to enhance early cancer detection in primary care, leveraging extensive patient data and improving risk stratification accuracy. The authors emphasize the need for responsible implementation, collaboration, and validation across diverse populations.
A recent analysis of published and unpublished studies found that Functional Family Therapy is not consistently more or less effective than other treatments, including individual, family, and group interventions. The available evidence also raises concerns about the quality of the therapy's evidence base.
The American Phytopathological Society has published a focus issue on critical biosecurity gaps in US plant disease diagnostics, highlighting the need for harmonized diagnostics within the agricultural biosecurity system. The focus issue addresses assay validation methods, including high-throughput screening and PCR/RPA techniques.
Researchers have made groundbreaking progress in confining light to subnanometer scales using a novel waveguiding scheme. The approach generates an astonishingly efficient and confined optical field with applications in light-matter interactions, super-resolution nanoscopy, and ultrasensitive detection.
The American College of Chest Physicians has launched CHEST Pulmonary, a new online publication dedicated to pulmonary and sleep medicine. The journal features original research, case series, and reviews on various topics, including implementation science and artificial intelligence applications.
A recent study found that GPT-3 can generate accurate information, but also produces highly persuasive disinformation. Participants struggled to distinguish between tweets created by the AI model and those written by real users.
The June issue of CHEST features 49 articles on clinically relevant topics, including asthma, COPD, and critical care. The journal offers web and multimedia resources to expand the reach of its research.
A new study found that most adults with Type 2 diabetes in Alabama Medicaid did not receive follow-up healthcare within the recommended two-week period after a heart failure hospitalization. African American and Hispanic adults were particularly affected, with worse follow-up care compared to white adults.
A retrospective study found a 24% response rate to Docetaxel among patients with stage IV non-small cell lung cancer who experienced progression on immunotherapy. The median progression-free survival was 3 months, suggesting chemotherapy may still play an important role in treatment after immunotherapy failure.
A retrospective case-matched study found prism adaptation therapy (PAT) to be beneficial for treating both right- and left-sided spatial neglect. PAT showed improvements in neglect symptoms for patients with right-sided neglect, suggesting greater potential benefits compared to those with left-sided neglect.
Researchers found that formalin fixation does not significantly alter the polarimetric properties of brain tissue, making it suitable for training machine-learning models. The study suggests that formalin-fixed brain tissue specimens can provide high-quality data for rapid and accurate diagnostic imaging in surgery.
A new study by Anglia Ruskin University found that people with sight loss in the UK are confused by a 'disjointed' certification system, creating barriers to accessing support and benefits. The research highlights inconsistencies in the process, long waiting lists, and lack of clarity around entitlements.
Researchers at the University of Washington have developed a multifunctional interface between photonic integrated circuits and free space, allowing for simultaneous manipulation of multiple light beams. The device operates with high accuracy and reliability, enabling applications in quantum computing, sensing, imaging, energy, and more.
The February 2023 Türkiye earthquakes were a devastating doublet, with two large aftershocks occurring within nine hours of each other. The first mainshock ruptured the East Anatolian Fault (EAF) bilaterally over 350 kilometers, creating surface fault offsets of more than six meters.
Three Amazonian Morpho butterfly species have been sequenced for the first time, revealing genetic differences that maintain reproductive isolation despite sympatry. The study found Z-chromosome rearrangements and genetic divergence among gene copies, suggesting a role in speciation.
A new source-device-independent quantum random number generator (QRNG) protocol has been developed, operating securely and independently of source devices. This allows for practical applications in secure quantum information tasks, with a reported generation rate of 4 megabits per second.
Global experts have developed a new checklist called iCHECK-DH to standardize the quality of reporting and improve implementation standards for digital health technologies. The 20-item checklist aims to aid researchers and practitioners in ensuring complete, accurate, and consistent reports.
A new UH study reveals that third-grade girls are initially enthusiastic about coding and computer science, with equal interest and confidence as boys. However, by middle school age, negative stereotypes and a decrease in confidence among girls become prevalent, limiting their participation in these fields.
A recent study found that online art breaks can significantly improve mood and reduce anxiety in participants. The research team discovered that individuals with high levels of aesthetic responsiveness benefit more from interactive art experiences, suggesting a personalized approach to online art interventions for well-being.
Researchers developed a calculator to identify patients with multiple myeloma and primary systemic amyloidosis who have a more benign profile, allowing for personalized treatment. The tool predicts survival based on clinical-biological characteristics and has been validated in international series.
bioRxiv has partnered with PaperPlayer to offer audio versions of preprint abstracts in the Neuroscience category, enhancing accessibility and providing an alternative way to consume research. The new feature is being piloted to assess its value and collect user feedback.
Researchers from HKUST and CityU developed a metasurface to generate time-varying OAM beams with a time-dependent phase profile. This allows for a higher-order twist in the envelope wavefront structure, increasing capacity for applications such as dynamic particle trapping and information encryption.
Researchers develop a new technique to measure blood attenuation using a fluorophore-coated guidewire, improving the accuracy of near-infrared fluorescence in cardiovascular imaging. The method provides accurate information on vessel walls and outperforms existing correction methods.
A new study found that a handful of key Twitter influencers effectively countered vaccine misinformation and promoted accurate information about vaccines. Social media influencers can use their social capital to challenge the spread of conspiracy theories.
Cancer-associated fibroblasts (CAFs) are a type of cell that plays a crucial role in the tumor microenvironment. The authors suggest that understanding CAFs is essential for developing effective cancer therapies. Research targeting CAFs has shown promise, but challenges remain due to their complex nature.
Impact Journals' Oncotarget participates in the AACR Annual Meeting 2023, highlighting its focus on oncology and biomedical sciences. The meeting theme of Advancing the Frontiers of Cancer Science and Medicine aligns with Oncotarget's research goals.
Impact Journals will participate as an exhibitor at the AACR Annual Meeting 2023, showcasing Aging's growth in impact factor to 5.955. The meeting theme focuses on Advancing the Frontiers of Cancer Science and Medicine.
Researchers have developed an online tool, the 'Tree-Based Alignment Selector (T-BAS) toolkit', to identify and monitor plant pathogens, including Phytophthora species responsible for devastating plant diseases. The tool provides a living 'tree of life' with genetic sequence data, evolutionary history, and relationships within groups.
Researchers from Kessler Foundation found that transcutaneous spinal stimulation does not interfere with implanted intrathecal baclofen pump delivery systems. However, communication between the pump and its interrogator may be briefly affected due to electromagnetic interference.
A traditional Mediterranean-type diet rich in seafood, fruit, and nuts is associated with a lower risk of dementia. Individuals with higher adherence had up to 23% lower risk compared to those with lower adherence. The study, published in BMC Medicine, analyzed data from 60,298 individuals from the UK Biobank.
Researchers found that increasing melanin levels in human skin reduces Cherenkov emission intensity, while blood concentration affects different color channels. The study suggests using multispectral signatures to correct attenuated signals based on patient's blood volume or skin color.
Researchers developed temporal compressive super-resolution microscopy (TCSRM) to overcome optical diffraction's spatial resolution restriction. TCSRM achieves high-speed imaging at 1200 frames per second with a spatial resolution of 100 nanometers, enabling observation of fast dynamics in fine structures.
The Janelia FlyLight Project Team has released over 74,000 images of fruit fly brain neurons, generated from more than 5,000 different genetically modified fly strains. These images are now freely available for scientists to quickly and easily find the neurons they need to test theories about the nervous system.
Researchers re-examine molecular characteristics of WNT-subgroup patients to identify optimal treatment strategies for low-risk medulloblastoma. Key findings suggest that therapy-related late toxicity remains a concern, despite comparable survival rates between children and adolescents with this disease subtype.
Researchers have identified three novel pathogenic variants of the ATR gene as predisposing to male breast cancer. These variants were found in a cohort of individuals with early onset and familial breast cancers, using a combination of exome sequencing and functional investigations. The study suggests that extended genetic analysis ca...
The article reviews the outlook of atomic layer deposition (ALD) based oxide semiconductor thin film transistors (TFTs), highlighting four benefits: in-situ composition control, vertical structure engineering, chemical reaction and film properties, and insulator and interface engineering. Despite these advantages, challenging issues re...
A recent study suggests that routine evaluation of HER2 expression in ductal carcinoma in situ (DCIS) is crucial to avoid under or overtreatment. The research found a significant association between HER2 overexpression and a higher risk of recurrence, as well as improved radiotherapy outcomes.
Researchers have developed a novel prognostic index to predict survival outcomes in gastric cancer patients. The inflammation-combined prognostic index (ICPI) combines three biomarkers - lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio - to provide a personalized prognosis for each patient.
Decades of wars and conflict in Iraq have led to a catastrophic rise in antibiotic resistance due to destroyed healthcare infrastructure, medicine shortages, and high levels of heavy metal contamination. Research is urgently needed to understand the link between armed conflict and AMR to prevent millions of needless deaths.
The Ecological Society of America showcases the contributions of Black scholars to 21st-century ecology, exploring historical erasure and public health injustices. The virtual collection features open-access articles addressing disparities in environmental engagement and conservation.
A severe begomovirus-satellite DNA disease complex has been detected in okra fields in the lower Rio Grande Valley area of Texas, posing a significant threat to cotton production. The complex involves the exotic cotton leaf curl Gezira virus and its associated satellite DNA molecules.
Researchers from Nanjing University have proposed the first scheme to practically generate N-photon states deterministically using a lithium-niobate-on-insulator platform. The scheme involves deterministic parametric down-conversion and demonstrates feasibility for generating multiphoton qubit states.
Scientists develop eigenmodes of structured light that remain undistorted even in turbulent channels, enabling robust transmission through noisy media. This breakthrough paves the way for future work in quantum light communication and imaging through complex systems.
A team of researchers developed a model-free approach using deep reinforcement learning to optimize estimation of multiple parameters in quantum sensors. The protocol achieved significantly better estimations compared to nonadaptive strategies, demonstrating enhanced performance in resource-limited regimes.
A new open-access syllabus is training professors in public administration to develop the digital skills needed for post-pandemic governance. The project, initiated by Ines Mergel and David Eaves, provides teaching materials and resources to support instructors in adapting to the digital age.
Researchers at Kessler Foundation are conducting a double-blind randomized clinical trial to evaluate the impact of their strategy-based cognitive training program on new learning and memory in individuals with multiple sclerosis. The study aims to assess the efficacy of this protocol, which is based on the KF-STEM protocol.
A recent study published in Zoo Biology found that flamingo flocks should be between 50-100 individuals to encourage successful reproduction and sustain populations. Adding new individuals can increase reproductive success, while climatic variables play a limited role.
Researchers developed BrightEyes-TTM, an open-source stopwatch to study molecular interactions inside living cells. The platform records the lifetime of fluorescent molecules, providing insights into cellular structure and function.
A global consensus has been reached on 19 open science practices to be implemented and monitored by biomedical institutions. These practices, including open access publishing and data sharing, aim to ensure transparent and accessible research.
Research published in BMJ Open found that carrying excess weight from mid-life onwards increases the risk of physical frailty in older age. The study tracked over 4500 participants and found that obesity and high waist circumference were associated with a higher risk of pre-frailty/frailty, highlighting the importance of maintaining a ...
A study found that Tibetan Buddhist monks with long-term deep meditation practice had distinct gut microbiome profiles, associated with lower risks of anxiety, depression, and cardiovascular disease. Their gut microbiota was enriched with beneficial bacteria that may influence mental health.
Researchers have developed shortwave-infrared and thermal imaging techniques to accurately diagnose active dental caries. SWIR-based approach shows superior results in detecting lesions, while thermal imaging proves less effective.
The three-year effort aims to establish a widely accepted protocol for comparing lidar performance. The first year's tests evaluated range, accuracy, and precision of eight automotive-grade lidars using a survey-grade reference. Results showed the distribution of measured values was not Gaussian, with significant errors in some cases.
A new open-access Raman spectral library enables scientists to detect molecular 'fingerprints' of particles and better trace sources of ocean plastic pollution. The database adds 42 polymer types, including those from non-plastic particles, to improve accuracy.
Researchers have developed a new spectroscopy technique called filament- and plasma-grating-induced breakdown spectroscopy (F-GIBS), which improves the sensitivity of trace metal detection in liquid samples. The technique uses fluid jets to analyze aqueous solutions and achieves high precision by avoiding detrimental influences of liqu...