Articles tagged with Open Access
Researchers discuss diverse BRAF alterations found in human cancers and strategies to inhibit them. Class I BRAF inhibitors represent a landmark achievement in precision oncology, with FDA-approved dabrafenib/trametinib for metastatic BRAF p.V600E-mutant solid tumors.
A global network will be created to protect Indigenous data collection and use, leveraging worldwide policies and practices to ensure control over data related to Indigenous communities. The project aims to establish an alliance among 12 Indigenous data sovereignty networks spanning the globe.
Researchers unveil retrotransposon-derived DNA zip codes that enable myeloma cell internalization, shedding light on cancer evolution and treatment response. The findings highlight the potential of zip-code technology in improving patient outcomes and advancing human health.
Researchers identified a potential antigen for TCR recognition in melanoma, suggesting that RNLS protein could be recognized by T cells leading to local immune responses against the cancer. The study found that chemical complementarity between melanoma-resident TCR CDR3s and renalase-1 protein correlates with increased melanoma survival.
A new study found that mTORC1 activity correlates with classical biometrics, such as height and macrocephaly, as well as specific neuropsychiatric diseases like anxiety and autism. The research suggests that human variability of mTORC1 gain of function may predict medication response.
Researchers discuss how PROM2 is a predictive biomarker of distant metastases and shorter survival among patients with stage III melanomas. They also demonstrate that runaway metastasis is closely linked to PROM2 overexpression, through increased epithelial-to-mesenchymal transition marker expression and ferroptosis resistance.
A new study found that meeting partners online is positively linked to relationship success among those who have social media presence on their relationships. However, the link was absent among individuals without this social media presence, particularly in marital relationships.
A collaborative effort between The Academy of Breastfeeding Medicine and Reaching our Sisters Everywhere identified key components of a successful breastfeeding journey as defined by parents and families. The findings aim to inform research priorities and promote patient-centered outcomes in infant and young-child feeding.
Empa researchers have developed a system to investigate up to ten different reaction conditions for producing synthetic fuels from CO2. The system accelerates the discovery process by generating a large number of high-quality datasets, enabling scientists to make accelerated discoveries.
A study by Virginia Tech researchers found that shelter dogs paired with suitable companions exhibited reduced stress levels and were adopted more quickly. The findings suggest that matching dogs with compatible roommates could alleviate stress and improve their adoptability, leading to better outcomes for animal shelters.
Researchers identify UBE2J1's role in degrading the androgen receptor, a key player in prostate cancer progression. The study suggests targeting this ubiquitination machinery may help overcome antiandrogen resistance in cancer therapy.
Researchers have developed a groundbreaking solution to overcome DAC challenges, achieving record-breaking data transmission performance. The innovative approach enables the transmission of signals at rates exceeding 124 GBd PAM-4/6 and 112 GBd PAM-8 over long distances using low-cost digital-to-analog converters.
A recent study discovered a critical brain signal mediated by dopamine and its 'D2' receptors that plays a crucial role in timing actions. The research team used novel imaging techniques to observe this activity before self-timed presses, finding a gradual increase in brain signals about half a second prior.
The American College of Chest Physicians' CHEST Critical Care and CHEST Pulmonary journals have been indexed with the Directory of Open Access Journals (DOAJ), enhancing their open access content's accessibility and usage. The indexation is attributed to strong editorial boards led by Hayley Gershengorn and Matthew Miles.
Researchers in Portugal have developed an innovative open-source platform called DL4MicEverywhere, providing life scientists with easy access to advanced artificial intelligence for the analysis of microscopy images. The platform enables researchers to easily train and use deep learning models on their own data, regardless of their com...
Residents in the UK have complex views on the introduced ring-necked parakeet, with acceptance of urban presence but resistance in rural areas. Concerns include competition with native birds and unknown impacts on local ecosystems. The study suggests a possible generational divide in perceptions.
A new study found extensive alternative splicing of messenger RNA in untreated multiple sclerosis patients compared to healthy controls. Interferon-ß therapy corrected dysregulated alternative splicing, linking it to future clinical exacerbations.
A unique collaboration between archaeologists and MeatEater highlights the prevalence of equifinality, where distinct processes can lead to the same outcome. The experiment tested Clovis stone tools' efficiency in processing a bison, offering insights into early human technologies.
This special issue highlights photonics developments in Latin America, the Middle East, Eastern Europe, India, and China, showcasing regional growth and progress. The papers emphasize the importance of global cooperation and collaboration to address challenges and seize opportunities in the field.
The TIER2 project is seeking consortia to establish a new Reproducibility Network (RN) in Widening participation countries. The selected consortia will receive 5,000 Euros each as seed money to support the kick-off meeting and promote reproducible research practices.
Researchers propose combining osimertinib with gefitinib to increase progression-free survival rates in EGFR-mutant lung cancer patients. A comprehensive PC approach could dramatically boost PFS for 80% of patients, eliminating harm and improving treatment outcomes.
Researchers developed a custom-built, low-cost mesoscope that can adapt to different neuroimaging experiments in live mice and rats. The system offers excellent spatial and temporal resolutions, achieved through its reversible tandem lens configuration, which enables flexible experimentation.
A new study published in the Journal of Medical Internet Research found that sexual minority adults are more willing to use digital health tools for screening and tracking compared to heterosexual adults. The study, which analyzed data from a COVID-19 survey, highlights the need for diverse populations to be considered in the developme...
Researchers have created a computer using an array of VCSELs that leverages optical feedback to efficiently solve complex optimization problems. The system encodes information in linear polarization states, minimizing interactions between variables and overcoming the von Neumann bottleneck.
Researchers developed a high-speed modulation system combining digital display with super-resolution imaging, significantly improving lateral and axial resolution. This enables detailed study of subcellular structures in animal cells and plant ultrastructures, paving the way for future biological discoveries.
The MIT Press is accepting applications for its shift+OPEN initiative, which provides funding and support to convert subscription-based journals to diamond open access. Selected journals will receive three-year funding, professional publishing services, and sustainable funding model development support.
Researchers propose a novel augmentation regimen, IPIAD, combining five generic non-oncology drugs with standard chemotherapy for pancreatic ductal adenocarcinoma. The IPIAD regimen uses repurposed drugs like irbesartan and azithromycin to potentially slow disease growth and improve outcomes.
Researchers developed a compact microscope using a single photon avalanche diode array detector, enabling super-resolution imaging with improved signal-to-noise ratio and spatial resolution. The system also combines fluorescence lifetime measurements for enhanced structural specificity.
Dr. Mikhail V. Blagosklonny, a renowned oncologist, shares his personal journey with metastatic brain cancer and challenges conventional treatment approaches. He argues that targeted drugs alone cannot cure lung cancer, but preemptive combinations may offer hope.
A new technique using optical orbital angular momentum lattice (OAML) multiplexed holography boosts information storage capacity and offers novel approaches for implementing high-capacity holographic systems. The research unlocks supplementary encrypted dimensions, enhancing storage capacity and overcoming limitations of traditional me...
Researchers use water as a nonlinear medium to create a supercontinuum white laser covering an impressive spectral range from UV to far infrared. The resulting ultrabroadband source has potential in ultrafast spectroscopy, hyperspectral imaging, and scientific research.
Researchers from MD Anderson Cancer Center reported a case of a patient with an exceptional response to pazopanib treatment for over 5 years. The study shows that pazopanib prevents or delays the progression of additional metastasis in EWSR1-NFATC2 positive sarcomas. Further studies are warranted.
The report highlights key applications and pathways to commercialization for emerging PV technologies, including new materials and device concepts. It also discusses strategies to exceed current limits in solar PV energy conversion and challenges facing efforts to scale up globally.
A team of scientists used functional near-infrared spectroscopy (fNIRS) to measure brain activity in two key visual regions, the lateral occipital complex (LOC) and fusiform face area (FFA). The study found that fNIRS successfully measured LOC activity but had limitations in detecting FFA activity due to its depth. This research has th...
A study found that 64% of students did not engage in problematic behaviors, while 26% let participants take part despite knowing the hypothesis. Supervisors underestimated the prevalence of certain behaviors, highlighting the need for improved communication and Open Science education.
The European Societies and European Journal of Cultural and Political Sociology journals will transition to diamond open access with the MIT Press, starting in 2025. The move is driven by the growing acceptance of open access in academic fields and the European Union's new requirements.
A research team developed an innovative optical technique, 'spectrum shuttle,' to produce and shape GHz burst pulses. The method facilitates ultrafast imaging within subnanosecond timescales, enabling analysis of rapid phenomena.
A team of researchers at Ghent University and imec developed a silicon photonic temperature sensor that measures up to 180°C. The sensor was realized in the framework of the European SEER project, where partners focus on integrating optical sensors in manufacturing routines for composite parts.
A new study using Raman spectroscopy has identified Pseudomonas bacteria from turtle skin in just 5-30 minutes, offering a faster alternative to traditional methods. The technique provides detailed information about bacterial chemical structure and holds great potential for future research on other microorganisms.
Researchers found that BCMA-positive extracellular vesicles (EVs) in plasma levels correlated with myeloma patient responses to belantamab-mafodotin therapy. High EV levels preceded FLC progression and were associated with mafodotin-induced eryptosis.
Researchers found that Eurasian jays settle for less preferred food options when rivals are present, while New Caledonian crows consistently choose the better, delayed reward. The study suggests that species' social tolerance and competition levels influence self-control in animals.
The portal brings together genomic data from different biodiversity projects to aid conservation and biodiversity efforts. It allows researchers to understand genetic factors that make a species unique, including its vulnerabilities and strengths in adapting to changing environmental conditions.
Researchers developed three diffractive deep neural networks using orbital angular momentum to recognize objects in images, achieving accuracy comparable to wavelength and polarization-based models. The technology has potential for real-time processing applications like image recognition and data-intensive tasks.
A recent study on psychic channeling experiences found little correspondence among channelers' answers to scientific questions, yet common themes emerged in the qualitative analysis. The results raise important questions about the complex phenomenon of channeling and its potential usefulness for future research.
A new study found that people's reported media preferences often don't match their actual news consumption, highlighting the need for more accurate measurement. The researchers also discovered that those with divergent media preferences tend to visit similar online news outlets, challenging common assumptions about media polarization.
A new deblurring algorithm has been developed to improve the resolution of microscopy images without amplifying noise. This breakthrough technique, called 'deblurring by pixel reassignment,' uses local gradients to sharpen images while preserving larger structures.
A Dartmouth study analyzing declassified Cold War satellite imagery identified 396 previously undocumented Roman forts across the northern Fertile Crescent. The forts were constructed from east to west, contradicting Father Antoine Poidebard's north-south axis claim and suggesting a more complex distribution along Rome's eastern frontier.
A new method called TWC-Swin effectively restores holographic images even under low spatial coherence and arbitrary turbulence, surpassing traditional convolutional network-based methods. The study demonstrates strong generalization capabilities, extending its application to unseen scenes.
Researchers developed an AI tool for automatic colorectal cancer tissue analysis, refining neural networks to offer faster and more precise classification. The tool's public accessibility aims to spur further advancements and breakthroughs in colorectal cancer research.
Researchers have developed an integrated THz vortex beam emitter to detect rotating targets with remarkable precision. The system uses spiraling electromagnetic waves with orbital angular momentum to accurately measure the speed of a rotating object, with a maximum margin of error of just around 2 percent.
The development of a new photonic technique enables the precise control of photonic angular momentum, allowing for the efficient recognition and real-time control of total angular momentum modes. The technique, which involves the symmetrical cascading of two units, has been experimentally demonstrated to recognize up to 42 individual T...
Researchers at Nanjing University have developed a miniaturized FSO system achieving an astonishing 9.16 Gbps bandwidth over 1 km link using readily available commercial fiber transceiver modules. The system enables automatic tracking and precision acquisition, eliminating the need for optical amplification.
A Texas A&M University team, led by Dr. Terri Pantuso, is developing an open-access writing curriculum to prepare high school students for college-level English courses. The project aims to improve TSI readiness and incorporates digital instructional tools, AI-powered learning resources, and intervention strategies.
The MIT Press is expanding its shift+OPEN initiative with a $275,000 NSF grant to flip two high-impact subscription-based journals to diamond OA. The program aims to accelerate STEM and HSS research by providing barrier-free access to scholarly works.
The Intergovernmental Negotiating Body Bureau emphasizes the importance of social media regulation and digital health literacy in managing infodemics, which can spread false information on public health matters. Effective infodemic management is seen as a critical component of the Pandemic Accord to safeguard lives worldwide.
Researchers have developed high-resolution near-eye displays with integrated light field technology, overcoming limitations of earlier displays. The new designs feature improved resolution, pixel density, and vision correction capabilities, resulting in enhanced visual comfort and immersive VR experiences.
The Open Encyclopedia of Cognitive Science (OECS) is a dynamic web reference that will equip readers with essential tools to grapple with the profound implications of cognition and intelligence in today's society. With generous funding from James S. McDonnell Foundation and the Allen Institute for AI, the first set of articles will be ...
A new species of spiny mouse, Neacomys marci, has been identified in northwestern Ecuador. The discovery sheds light on the previously underestimated diversity of the Spiny Mouse genus.
Biodiversity researchers can now incorporate nanopublications into their manuscripts to future-proof their assertions on biological taxa and organisms. The newly released nanopublication workflow enables authors to create machine-actionable, FAIR data that can be easily traced back to its origin.
A new species of orb-weaving spider, Venomius tomhardyi, has been described from Tasmania. The genus belongs to the Araneidae family and is distinct from related genera due to its unique behavior and genitalia.