Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at the University of Houston College of Pharmacy discovered key mechanisms of skeletal muscle regeneration and growth following resistance exercise. Increasing levels of Inositol-requiring enzyme 1 (IRE1) or X-box binding protein 1 (XBP1) in muscle stem cells may improve muscle repair and reduce disease severity.
Researchers have identified two new species of hillstream suck-loach, Beaufortia granulopinna and Beaufortia viridis, from the upper Pearl River system in southwest China. These species exhibit unique morphological specializations, including suction cup-like fins that enable them to adhere to rocky substrates.
Researchers found that five human bitter taste receptor types react to both free amino acids and peptides, as well as bile acids. This suggests that bitter receptors play additional roles in human health beyond food selection.
A new species of fossil snake, Hibernophis breithaupti, has been discovered in Wyoming, shedding light on the origin and diversification of boas and pythons. The discovery provides important new information on the evolution of small burrowing boas, specifically rubber boas.
Researchers have used CRISPR/Cas9 gene editing to improve groundcherry's growth habit and fruit characteristics. This breakthrough could lead to increased crop yields and reduce the need for pesticides. The study also highlights the potential of groundcherry as a model species for studying plant biology.
A recent study has identified the CpMYB62 transcription factor as a key regulator of female flower development in Cucurbita pepo. The researchers found that this gene mutation impairs female floral transition and can be partially reversed by ethylene, indicating its critical role in sex determination pathways.
Researchers found that rotifers acquire genes from bacteria and produce resistance weapons, such as antibiotics and antimicrobial agents. The team's findings suggest that rotifers could give important clues in the hunt for new antibiotics to treat human infections.
A study decoded the genetic factors governing highbush blueberry regeneration, identifying key auxin-related genes and transcription factors crucial to shoot regeneration. The discovery could transform plant regeneration techniques, offering new pathways for agricultural innovation.
Researchers uncover CsGPA1's role in regulating floral organ number and fruit shape in cucumbers through the CLAVATA signaling pathway. This breakthrough offers insights into genetic manipulation for crop breeding improvements.
Scientists assembled high-quality genome sequence of Amur grape, revealing its evolutionary journey and genetic secrets behind exceptional cold tolerance. The study identifies key genes responsible for resveratrol accumulation and sex determination, offering new avenues for grape breeding and cultivation.
A team of UCSF specialists predicts 24-hour seizure risk using brain activity patterns that foreshadow seizures. The discovery may improve quality of life for 2.9 million Americans living with epilepsy.
Astronomers at MIT and Penn State have discovered a new 'progenitor' of hot Jupiters, a highly eccentric planet with an orbit providing clues to its evolution. The planet, TIC 241249530 b, is expected to become a scorching hot Jupiter in about 1 billion years.
Researchers developed a new method to find breakthrough materials for quantum applications by combining theoretical screening with atomic-scale fabrication. The approach identified promising defects in materials such as tungsten disulfide, which have never been seen before.
A new study published in PNAS reveals that cancer patients who receive hematopoietic cell transplants from donors with lower socioeconomic status experience reduced overall survival and increased transplant-related mortality. The research highlights the profound impact of social inequality on health outcomes, particularly in cancer care.
A team of scientists at the University of Sydney has repurposed a commonly used blood thinner, heparin, as an inexpensive antidote for cobra venom. The discovery could drastically reduce the impact of snakebites worldwide, particularly in low- and middle-income countries where cobra species account for most snakebite incidents.
Studies in glassfish reveal that vision plays a crucial role in coordinated schooling behavior, with maturity also essential for developing this ability. Researchers discovered that older fish can distinguish between movement patterns of their social partners, allowing them to align their bodies and swim together effectively.
Pamela J. Bjorkman, K. Christopher Garcia, and Ian A. Wilson receive inaugural prize for their groundbreaking research in structural immunology, which has paved the way for novel disease treatments and revealed new insights into the immune system.
Physicists at Trinity College Dublin developed a new theory describing the energy landscape of collections of quantum particles. This work addresses decades-old questions and may help scientists design materials revolutionizing green technologies.
A team of scientists from Duke-NUS Medical School has identified interleukin-11 as a principal factor in ageing, linked to increased fat accumulation and muscle loss. Blocking the effects of IL11 could potentially increase healthy lifespan by up to 25%.
Researchers found deviations in pulse arrival times that indicate unseen concentrations of mass, which could be dark matter objects. The study improves pulsar timing data sample, shedding new light on dark matter distribution in the Milky Way.
Scientists have captured the first-ever image of an S-shaped jet coming from a confirmed neutron star, providing strong evidence for precessing jets. The discovery was made using the MeerKAT telescope and reveals valuable insights into the extreme physics behind the launching of the jet.
A study published in Science Advances reveals a special group of 'first responder' cells in the pancreas that trigger blood sugar response. These cells respond to glucose quicker than others, initiating the response and regulating the activity of other beta cells.
Researchers at Memorial Sloan Kettering Cancer Center found that the spatial arrangement of three immune cells - dendritic cell, cytotoxic T cell, and helper T cell - is crucial for effective killing of cancer cells. This discovery has immediate therapeutic implications for immunotherapy treatments.
Researchers grew crystals containing actinium and studied its atomic structure, revealing how it interacts with surrounding atoms. The study could help design better targeted alpha therapy for cancer treatment.
Researchers have made a groundbreaking discovery that faulty cell function in veterans with Gulf War Illness (GWI) is likely caused by intense exposure to hazardous biological and chemical agents during war service. This breakthrough provides clear scientific evidence for the condition, offering hope for new treatments.
A team of international scientists has demonstrated the existence of a lunar lava tube cave, with radar reflections indicating an underground conduit in Mare Tranquillitatis. This discovery provides crucial evidence for safe site selection on the Moon and supports future exploration missions.
Researchers have made significant advancements in understanding the complex dynamics of soliton molecules, revealing quasi-periodic behaviors and chaotic transitions. The study also discovers intrinsic frequency entrainment, a phenomenon showcasing synchronization within optical resonators.
Researchers detected distinct 'morning' and 'evening' sides on the exoplanet WASP-39b using James Webb Space Telescope data. The study found that the morning side was significantly cooler (600°C) compared to the evening side (800°C), with cloudier conditions also prevalent in the morning.
A novel tool called BitterMasS harnesses mass spectrometry to predict bitterness without prior knowledge of chemical structures. The tool achieved remarkable precision and recall rates in internal and external tests, streamlining compound screening processes.
Researchers at Texas A&M University uncovered how domestic rabbits become feral in the wild through natural selection. They found that all European, South American, and Oceania rabbits had a mix of feral and domestic DNA, explaining why they quickly adapted to living in the wild.
Anaerobic bacteria have survived for ages in oxygen-free niches, influencing human health and environment. The 'AnoxyGen' project aims to unlock their biosynthetic potential using molecular and synthetic biology tools.
A study by Sant Pau Research Institute identified a new mutation in the ARPP21 gene linked to amyotrophic lateral sclerosis (ALS) in 10 patients from 7 unrelated families. The finding suggests that ARPP21 is a novel ALS-causing gene with potential for personalized therapies and diagnosis.
A University of Maryland study reveals how the brain adapts to different listening situations, with the orbitofrontal cortex playing a central role. The findings may have implications for human health and well-being, particularly in conditions such as autism, dyslexia, or schizophrenia.
A new species of dinosaur, Comptonatus chasei, has been discovered in the UK with over 149 bones found at Compton Bay. The skeleton is around 125 million years old and represents a unique genus and species, with distinctive features such as a straight lower jaw and large pubic hip bone.
A recent study found that the cerebellum plays a crucial role in regulating thirst, with the hormone asprosin activating Purkinje neurons to enhance water intake. This discovery has significant implications for managing thirst disorders such as polydipsia and hypodipsia, for which current treatments are scarce.
Scientists at the University of Malaga have uncovered a natural quicksand trap in the 'elephant graveyard' of Orce, dated to over 1.4 million years ago. The discovery provides insights into human presence in Western Europe and competition with large carrion hyenas for meat resources.
Researchers have identified microproteins exclusive to liver tumors that can stimulate the immune system against cancer cells. These small molecules, generated from previously non-coding genes, could be used to develop new treatments, including vaccines that stop or reduce tumor growth.
Researchers at the University of Utah and Max Planck Institute have discovered an intermediate-mass black hole in the Omega Centauri cluster, providing crucial evidence for a long-theorized class of black holes. The discovery offers insights into galaxy evolution and the formation history of globular clusters.
Scientists have discovered a new hormone, CCN3, that helps maintain bone density and strength in breastfeeding women. In mice, CCN3 increased bone mass and strength, even when estrogen levels were low. The hormone also accelerated bone healing in fracture models, offering hope for treating osteoporosis and other bone conditions.
Scientists have discovered that planted mangroves can store a significant amount of carbon, reaching levels comparable to those in intact stands after just 20 years. The study used logistic models compiled from over 700 planted mangrove stands worldwide and found that the trees' carbon stock reached 71-73% of that found in intact stands.
A team of researchers has created a molecular atlas of the human brain's vasculature, revealing how endothelial cells regulate interactions between the bloodstream and surrounding tissues. The study provides insights into the growth patterns of blood vessels in early development, adulthood, and disease stages.
Researchers uncover the importance of kainate receptors in enabling synaptic plasticity and transmission in the cerebellum. The study's findings have significant implications for understanding neurological disorders and developing new treatments.
A team of researchers from the University of Kansas has discovered a microscopic mechanism that explains why a new class of organic semiconductors outperforms others. This breakthrough could lead to more efficient solar cells and photocatalysts for producing solar fuels, revolutionizing the clean energy sector.
Scientists have identified a critical genetic mechanism driving cardiac fibrosis and found a novel target for its reversal. The discovery sheds light on the role of transforming growth factor-beta (TGFβ) and ATP-citrate lyase (ACLY) in promoting excessive tissue scarring, providing hope for new heart failure treatments.
Researchers identified a fundamental imbalance in immune responses that patients with lupus make, leading to insufficient activation of the aryl hydrocarbon receptor pathway. This imbalance can be corrected by reprogramming disease-causing cells into Th22 cells promoting wound healing, offering a potential cure for lupus.
Non-flowering bryophytes, including mosses, have sophisticated immune receptor repertoires that can be transferred between flowering and non-flowering plants. This discovery offers a new source of resistance genes against pathogens for major crops facing climate change threats.
Researchers at the University of Plymouth have discovered that administering a HDAC6 inhibitor prior to radiotherapy can inhibit cellular growth and increase cell death in meningioma samples. This promising approach could lead to improved treatment outcomes for malignant meningioma patients.
A new software platform has been developed to investigate viral genomes of the world, revealing unique viruses that may impact human health and exacerbate conditions like irritable bowel disease. The 'Hecatomb' project also provides a robust method for identifying viruses in all animals, plants, and environments.
Researchers at University of California San Diego have found that genetically modified NK-cell therapy can effectively target and treat hepatocellular carcinoma, a highly treatment-resistant form of solid tumor. The therapy works by disabling the inhibitory protein TGF-β, allowing immune cells to kill cancer more efficiently.
Researchers from Max Planck Institute tracked the heart rates of male common noctule bats during flights, revealing a significant increase in heart rate from 6 to 900 beats per minute. The study found that bats consume up to 42% more energy in summer compared to spring, and develop unique strategies to survive in different seasons.
Mayo Clinic's surgical team successfully performed the rare procedure, which included multiple organs, on a Massachusetts man with a rare form of laryngeal cancer. The landmark surgery, conducted as part of a clinical trial, marks a significant step towards making larynx transplantation available to a wider population.
Cultivated rice has also evolved into weedy varieties that shatter and are successful in limiting production worldwide. A long abscission zone is a key factor in ease of shattering across various weedy groups, indicating humans' management inadvertently selects for these traits.
The Marine Biological Laboratory has introduced two new microscopes for biological and biomedical research, providing a valuable resource for scientists and students. The instruments enable correlative imaging, allowing researchers to confirm results in different ways, and are expected to influence further development of advanced imagi...
Dr. Sanaz Memarzadeh and her team aim to improve treatment outcomes for patients with platinum-resistant ovarian cancer using adoptive T-cell therapy and natural killer cells. They hope to identify new targets and biomarkers for effective treatments.
Kim Sawyer, a seasoned executive with extensive experience in leadership and strategy, has been appointed as the new director of Jefferson Lab. Sawyer brings a proven track record of driving organizational effectiveness, innovation, and safety culture to her new role.
Researchers at Wayne State University aim to develop improved treatments for ovarian cancer by targeting dual-specificity phosphatase 1, a protein involved in drug resistance. The four-year grant will support the study's efforts to improve survival and remission rates.
Researchers found that removing the choroid plexus leads to a reduction of newly born immature neurons and fewer repairing damage caused by a stroke. The study suggests that the choroid plexus keeps regenerative cells ready to deploy to injured areas in animal models.
A deep metagenomic sequencing study in Berlin wastewater reveals common viruses like RSV and flu, seasonal visitors like asparagus-infecting viruses, and astroviruses with potential for gastrointestinal tract infections. The analysis also identifies novel enzymes with biotechnological potential, expanding our knowledge of viral diversity.
Researchers have identified a novel type of T cell that can recognize and respond to multiple bacterial strains in the gut. This breakthrough finding has significant implications for treating diseases such as cancer and inflammatory bowel disease. The discovery was made by Kazuki Nagashima, winner of the NOSTER & Science Microbiome Prize.
Scientists at Stanford University discovered that pancreatic cancer cells become resistant to chemotherapy due to stiff tissue and high hyaluronic acid levels. By altering the matrix, they found it possible to make cancer cells sensitive to chemotherapy again.