Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Studies in mice reveal that orexin plays a key role in deciding between physical activity and consuming food, particularly when both options are available. By understanding this process, scientists aim to develop strategies to overcome exercise barriers and address the global obesity epidemic.
Researchers at Linköping University have created soft electrodes made of gold nanowires and silicone rubber, capable of stimulating nerve signals and capturing electrical signals. The material is expected to last for at least three years and has potential applications in medical devices.
Researchers developed a novel clustering technique that considers both basic characteristics and target material properties, enabling the categorization of over 1,000 oxides into material groups. This approach uses machine learning to predict target properties and incorporates basic feature information into the analysis.
A University of Michigan-led study found that higher levels of metals in blood and urine are associated with a greater risk for ALS and shorter survival. Occupational exposure to metals was also linked to increased metal levels, emphasizing the need for accounting for environmental factors when evaluating overall exposure risk.
Dr. Elks' research focuses on the communication loop between fat cells and immune cells, which promotes inflammation and insulin resistance when disrupted. The grant aims to uncover patterns in cell communication that can be used to treat obesity and other metabolic diseases.
A research team has identified novel biomarkers in cervical mucus samples that show high diagnostic power for detecting cervical cancer. The findings suggest that analyzing local expression levels may offer a superior diagnostic strategy, potentially reducing the need for invasive procedures.
Liheng Cai, a UVA engineering professor, has received a $1.9 million NIH grant to create advanced biomaterials that can be used to repair living tissues and build organ structures. His lab aims to develop polymers that mimic human biology and integrate healthy cells into the human body.
A new hybrid contrast agent has been developed to combine the benefits of MRI and PET imaging techniques, offering improved accuracy and opening new diagnostic applications. The agent has shown potential in detecting kidney problems and other conditions, paving the way for personalized diagnostics and precise imaging.
Researchers believe a hydraulic lift system could have been used to raise and lower building stones, while water treatment facilities would have filtered sediment from the water. The discovery provides new insights into the construction of ancient Egyptian pyramids.
Scientists at St. Jude Children's Research Hospital identified age-related differences in B-ALL treatment outcomes, with children being more sensitive to certain drugs. The study suggests that both age and individual genomics must be considered to predict treatment response, leading to the need for tailored treatment strategies.
Researchers at Tokyo University of Science discovered a natural tyrosinase inhibitor from Corynebacterium tuberculostearicum that inhibits melanin synthesis and provides an alternative to toxic hydroquinone-based products. The compound, cyclo(L-Pro-L-Tyr), exhibits low toxicity and potential benefits for hyperpigmentation treatment.
Researchers at the University of Tokyo have discovered a new species of starfish off the coast of Japan, shedding light on the country's marine biodiversity. The newly named Paragonaster hoeimaruae is a distinctive red and beige color with five arms and spans over 10 centimeters.
Researchers at WashU Medicine have developed a novel compound that effectively clears bacterial infections in mice, including those causing rare and potentially fatal 'flesh-eating' illnesses. The compound targets gram-positive bacteria, reducing virulence and speeding up post-infection healing.
Researchers from Singapore General Hospital and A*STAR's Genome Institute of Singapore have discovered a new Candida auris clade, bringing the total to six. The fungus is highly transmissible and affects patients with severe underlying medical conditions.
A study by EMBL researchers found that gut bacteria can convert carcinogenic chemicals like BBN into BCPN, leading to tumour formation. The team discovered 12 bacterial species involved in this process, with individual differences in human gut microbiome affecting the risk of cancer development.
The paper explores evolving landscape of genetics research into obesity, emphasizing both new discoveries and challenges. Researchers highlight complexity of body weight regulation and advocate for precise phenotyping methods targeting relevant and refined phenotypes related to adiposity.
A new analysis found that people hospitalized for heart disease, stroke, or cardiovascular diseases are 83% more likely to be diagnosed with anxiety, depression, or other psychiatric conditions within the first year after hospitalization. Early mental health screening and intervention are crucial for patients and their loved ones.
Scientists used AI to identify genes that can convert brain cancer cells into immune cells, increasing survival chances by up to 75% in mouse models. The approach bypasses the blood-brain barrier, offering new hope for aggressive cancers.
Researchers deployed an unmanned submarine 'Ran' under thick ice in Antarctica, revealing high-resolution maps of the glacier's underside. The findings indicate that stronger underwater currents and flowing water influence the melting process, with complex patterns and formations resembling sand dunes.
University of California San Diego researchers used cryo-electron microscopy to capture the first 3-D images of a key muscle receptor, shedding light on why newborn humans develop slowly while cows mature quickly. The study's findings may help develop future treatments for muscular disorders.
Researchers at Argonne National Laboratory have made significant strides in understanding the mesoscale properties of a ferroelectric material under an electric field. The breakthrough holds potential for advances in computer memory, lasers, and sensors.
Researchers at the University of Bath have discovered a new optical phenomenon called hyper-Raman, which can penetrate deeper into living tissue and yield images with better contrast. This effect has significant potential applications in pharmaceutical science, security, forensics, environmental science, art conservation, and medicine.
Research from the University of Illinois highlights the potential of organic nanozymes for broader applications beyond traditional uses of inorganic nanozymes. The development of sustainable, environmentally friendly materials offers a promising solution for various industries.
Researchers at U of T mapped the spatial distribution of long non-coding RNAs in testes, finding higher levels than previously estimated. The study suggests lncRNAs play a more significant role in male reproduction and may influence sperm development and behavior.
Researchers at UBC created a new super-black material using plasma etching, absorbing up to 99% of visible light. The material, called Nxylon, has potential applications in astronomy, solar cells, and luxury consumer goods.
This study demonstrates that genomewide prediction effectively targets russet formation in apples, a complex quantitative trait controlled by many small-effect QTLs. Moderate predictive abilities were observed across various models, with the inclusion of previously detected QTLs as fixed effects not significantly enhancing predictions.
Researchers at UVA discovered an unknown cause of long COVID inside lung tissues, promoting chronic inflammation that drives lasting respiratory symptoms. They found that immune cells can go haywire and promote tissue scarring, leading to conditions like interstitial lung disease.
A study analyzed photosynthesis-related traits in 71 citrus accessions, identifying four distinct clusters and 125 genomic loci associated with these traits. The findings enhance our understanding of the genetic and physiological factors in photosynthesis.
Scientists at National University of Singapore have created electron-hole crystals in an exotic quantum material, paving the way for advancements in computing technologies. The breakthrough was achieved using scanning tunneling microscopy and reveals two distinct ordered patterns at different energy levels.
A research team identified 12 VAP27 genes in the grapevine genome revealing their diverse subcellular localizations and roles in disease resistance. The study highlights the induction of VAP27 genes in response to downy mildew and their ability to inhibit Phytophthora capsici infection.
Researchers have discovered evolutionarily conserved trans-lncRNA pairs in tea plants that enhance disease resistance through the jasmonic acid signaling pathway. These findings provide new insights into genetic mechanisms for improving crop resilience and agricultural sustainability.
A 15-year study found that apple breeding programs prioritize inner cortex firmness, leading to enhanced storability. The selected cultivars exhibited superior firmness retention, especially those influenced by 'Cripps Pink' and 'Honeycrisp'.
Researchers designed a molecule, MTX-531, that impairs signaling drivers of cancer therapy resistance. In mouse models, MTX-531 led to tumor regressions in multiple head and neck cancers, showing a favorable toxicity profile.
Researchers developed more resilient varieties of cotton by analyzing its genes and physical traits. They found two key regulatory genes that help cotton plants manage water stress while maintaining fiber production.
Researchers at Purdue University have trapped alkali atoms on an integrated photonic circuit, enabling photons to interact with the atoms and gate their transmission. This breakthrough demonstrates a potential for quantum networks based on cold-atom integrated nanophotonic circuits.
Researchers measured dielectric properties of 11 polyimides to establish correlation between molecular structure and dielectric behavior. The study revealed that higher fluorine content resulted in lower dielectric constant values, enabling potential applications for 6G technologies.
Researchers successfully applied atomic pair distribution function (PDF) analysis at X-ray free-electron laser facilities to study ultrafast material transitions. They discovered a new material phase, resolving years-long scientific debate and paving the way for designing novel transitioning materials with commercial applications.
A rhodium-catalyzed [2+2+1] cycloaddition reaction expands the possibilities for creating complex organic molecules. The researchers achieved high enantiomeric excess values of 94-99% using phosphine ligands, enabling the synthesis of diverse compounds.
Researchers investigated the effects of initial microbiota on microbial succession during eggplant fermentation, finding two distinct patterns of LAB dominance. They also identified Lactiplantibacillus plantarum as a primary contributor to lactic acid production and nutrient content.
The Wake Forest University School of Medicine has been awarded a $28.2 million grant from the National Institutes of Health to accelerate the translation of scientific discoveries. The grant will support initiatives such as rapid response to health emergencies and the recruitment of diverse academic learning health system workforce.
Researchers have successfully transformed existing optoelectronic devices, including LEDs, into spintronics devices by injecting spin-aligned electrons without ferromagnets or magnetic fields. The breakthrough uses a chiral spin filter made from hybrid organic-inorganic halide perovskite material, overcoming a major barrier to commerci...
Researchers found that a cancer drug can restore phagocytosis, a process crucial for brain health, in individuals with Rett syndrome by targeting microglia. The study highlights the potential therapeutic target of microglia in neurological conditions and may lead to new treatments.
Researchers found that folded peptides are more electrically conductive than their unfolded counterparts due to the formation of a specific secondary structure called the 3_10 helix. This discovery has implications for the design and development of molecular electronic devices.
Cancer cells can attach themselves to liver cells when specific proteins are present, allowing them to colonize and form new tumors. This discovery provides insights into the metastatic process and may lead to potential treatments that prevent cancer from establishing new tumors.
Researchers at the Rijksmuseum and University of Amsterdam have found evidence of pararealgar (yellow) and semi-amorphous pararealgar (orange/red) pigments in Rembrandt's The Night Watch. These unique pigments, combined with other materials, created a golden luster effect in the painting.
A recent study has identified a blood protein called fibrin as the root cause of developmental delays and brain damage in preterm infants. The researchers found that fibrin interferes with a cell-signaling pathway essential for neuron creation, particularly in the cerebellum.
Researchers have discovered a protein function that could guide novel cancer treatment options and improve diagnostic procedures for various cancers. The tumour-suppressing protein p16 has the ability to dramatically alter its structure and function, with potential implications for cancer formation and therapy response.
Scientists successfully mapped transcriptomes from 1.3 million brain cortex cells to gain molecular insights into Alzheimer's vulnerability and resilience. The resulting atlas holds promise for gene and molecular discovery across pathways affecting brain health.
A team of researchers has developed a comprehensive ranking of genes and proteins involved in Alzheimer's disease, providing a roadmap for more targeted research and drug discovery. The study integrates findings from multiple fields and identifies thousands of potential therapeutic targets.
Researchers analyzed rocks collected from seafloor, finding they date back to at least 2.5 billion years ago and have retained a stable oxidation state since then. The discovery provides new evidence on Earth's geologic history and sheds light on the planet's evolution.
Researchers at the Mayo Clinic Comprehensive Cancer Center discovered a new treatment approach that improved survival rates for patients with B-cell precursor leukemia by nearly 60%. The study found that adding blinatumomab to chemotherapy reduced the risk of leukemia recurrence and death.
Researchers at Argonne National Laboratory have developed a faster and more energy-efficient way to manufacture propylene, a key chemical in producing polypropylene. The new process uses zirconium combined with silicon nitride, yielding higher catalytic activity and lower operating temperatures.
Two proteins, NAP1 and SINTBAD, have been discovered as regulators of mitophagy in cells. This discovery opens a new area of focus for researchers targeting drug therapies to boost mitophagy activity and promote mitochondrial and neuronal health.
The A4 study, a large clinical trial of pre-symptomatic Alzheimer’s disease, has yielded key insights into the condition. Researchers have collected extensive data on brain scans, blood samples, genetic information and cognitive tests from over 7,500 participants.
Pagliarini's research aims to shed light on the underlying genetic causes of mitochondrial disorders, which affect one in 5,000 people. He will use this funding to expand his work on mitochondrial proteins and their functions, with a focus on coenzyme Q.
A recent study at the University of Missouri discovered that oxytocin and corticotropin-releasing hormone cause the brainstem to become overactive, leading to hypertension. This finding can help develop targeted drugs to reduce high blood pressure in sleep apnea patients.
Scientists have successfully created element 116 using a beam of titanium-50, marking a crucial step towards creating the heaviest element yet, element 120. This achievement validates the method of production and provides a promising path forward for researchers to explore elements at the extremes.
Researchers at Curtin University used a new geochronology technique to accurately date iron oxide minerals, finding the Hamersley deposits formed between 1.4 and 1.1 billion years ago. This discovery enhances our understanding of ancient geological processes and improves predictions for future exploration.
A study published in Circulation found that adults aged 50-54 with severely narrowed leg arteries had a higher risk of amputation after emergency surgery than those aged 80-84. This contradicts the traditional belief that older people are at increased risk.
A new study has identified CCL27 and TNFRSF14 as genetic markers in inflammation that may contribute to stroke recurrence. These findings could lead to novel drug targets to mitigate disability and mortality after a first stroke.