Articles tagged with Discovery Research
A study analyzing data from 6,010 English practices between 2018 and 2022 found that the national average dropped from 29.3% to 19% of patients able to see a preferred doctor. Practices with more doctors and higher same-day appointment rates showed slower declines in continuity.
A new study published in GEN Biotechnology describes the establishment of a 3D hydrogel-based platform for producing functional T-cells from hematopoietic stem and progenitor cells. The platform was engineered with key thymic components to direct T-cell development, producing cytokine-producing T-cells.
The RENEW system, launched in 2022, uses new research discoveries to pinpoint genetic variants causing rare diseases. Researchers successfully diagnosed 63 patients out of 1,066 undiagnosed cases with an average diagnosis time of 20 seconds.
A new version of the OPTIMADE standard enables easier access to large materials databases, facilitating AI modeling and prediction of material properties. The international collaboration involves over 30 institutions worldwide, aiming to advance materials research and development.
The ARMMS-T2D study found that bariatric surgery yields greater long-term improvements in quality-of-life compared to medical management, with sustained weight loss correlating with better health and reduced pain.
Researchers have discovered unusual transport phenomena in ultra-clean SrVO3 samples, contradicting long-standing scientific consensus. The study's findings challenge theoretical models of electron correlation effects and offer insights into the behavior of transparent metals.
The NIH and NSF have partnered to provide funding for RNA research, focusing on structures, functions, and interactions of ribonucleic acid (RNA). Research groups will explore RNA sequencing, mapping of RNA modifications, and development of RNA-based technologies.
A platform called Open-ST enables scientists to reconstruct gene expression in cells within a tissue in three dimensions, capturing molecular and (sub)cellular structures. The platform was used to study cell types at subcellular resolution in tissues from mice brains, tumor tissue, and healthy lymph nodes, providing insights into cance...
Researchers have discovered that gallium's bonds disappear at melting point but reappear at higher temperatures, leading to a new explanation for its low melting point. This breakthrough has important implications for advances in nanotechnology and materials science.
A study by TUM researchers discovered four subtypes of Amyotrophic Lateral Sclerosis (ALS) with different molecular processes, including sex differences. The findings suggest repurposing an approved cancer drug targeting the MAPK pathway as a promising therapeutic approach for ALS.
Researchers created an integrated cellular map of a mouse model heart, pinpointing cells and pathways involved in fibrosis. The study identified myofibroblasts as the major drivers of scarring, but also discovered a 'matrifibrocyte' form that may prevent scar resolution.
Scientists have discovered that ADGRF5 helps maintain the integrity of the glomerular filtration barrier, which is critical for filtering waste from the blood. The study found that disrupting ADGRF5 expression led to abnormalities in the glomerular basement membrane and increased albuminuria.
Researchers are exploring inflammation caused by COVID-19 as a trigger for Long Covid, a condition characterized by persistent symptoms like fatigue, brain fog, and shortness of breath. The study aims to identify potential causes and treatments for Long Covid, with findings that could lead to enhanced immune function in patients.
Researchers used modern technology to estimate the number of rock gardens on Easter Island and food production, revealing that the island couldn't sustain a large population. The study's findings contradict the long-held notion of an ecological catastrophe and instead suggest a more sustainable approach to agriculture.
Researchers at Chalmers University of Technology discovered a powerful rotating magnetic wind in galaxy ESO320-G030, suggesting its role in supermassive black hole growth. The study reveals similarities between this process and the birth of stars.
Researchers have discovered a new source of resistance to the devastating wheat blast disease, leveraging a gene that also protects against powdery mildew. The Pm4 gene, found in European wheat varieties, confers dual protection against the pathogen and its effector molecule AVR-Rmg8.
Researchers have identified a potent and unique way to kill drug-resistant bacteria using a repurposed compound called LEI-800. The compound targets the bacterial enzyme DNA gyrase, which is essential for bacterial growth and has not been targeted by existing antibiotics.
Chimpanzees have been observed seeking out specific plants with medicinal properties to treat their ailments, and further pharmacological testing has confirmed the presence of anti-inflammatory and antibiotic compounds. These findings highlight the importance of studying animal behavior in discovering new medicines.
Lokiceratops rangiformis, a plant-eating dinosaur with large horned frill and asymmetrical caribou-like antlers, has been discovered in Montana. The species' unusual features may have played a role in mate selection or species recognition.
Researchers developed a unique electrochemical ultrasonic force microscopy (EC-UFM) technique to observe sodium-ion battery interfaces during operation. The new method guides passivating layer formation, preserving charge carrier transport and enhancing battery performance.
The newly discovered Lokiceratops rangiformis is a massive horned dinosaur found in the badlands of northern Montana. It boasts two enormous blade-like horns on its frill, as well as an asymmetric spike, making it one of the most ornate species ever found.
Researchers have developed a new 3D method for fast-moving object tracking at unprecedented speeds, with potential applications in autonomous driving, industrial inspection and security surveillance. The approach uses single-pixel imaging to calculate the object's position in real-time, reducing data storage and computational costs.
Researchers found that carrying just one copy of the Christchurch variant delayed cognitive decline and dementia in family members, with some showing lower levels of tau proteins. The study suggests potential benefits for drug development targeting this genetic pathway.
Scientists have identified a mechanism that enables enzymes to communicate and produce organic molecules with disease-fighting properties. This breakthrough could aid in the discovery of new drugs by allowing researchers to design or modify enzymes to create novel natural products.
Scientists have identified a new mechanism by which cells counteract a key cancer-promoting protein using an 'invisible' protein called RAI2. In cancer cell lines and patient samples, RAI2 levels are reduced in more severe and treatment-resistant forms of prostate cancer.
Researchers developed a technique to study electrochemical processes at the atomic level, revealing unexpected transformations in a popular copper catalyst. The technique, called polymer liquid cell (PLC), enables scientists to observe composition changes during reactions in real time.
Scientists have created mirror-image cyclodextrins in the laboratory, which could make it easier to formulate and deliver complex medications. These discoveries may also lead to improved treatment of cardiovascular diseases caused by atherosclerotic plaques.
Researchers from CWRU and NJIT have made a significant breakthrough in understanding how the body adapts to COVID-19 infection. The study suggests a potential link between elevated hemoglobin levels and the body's response to the virus, shedding light on the enigmatic phenomenon of silent hypoxemia.
Researchers discovered a new way to effectively treat melanoma using nutrients to reactivate suppressed metabolic pathways in cancer cells. The innovative treatment, involving tyrosine nanomicelles, showed promising results in mice and lab-derived human cells, inhibiting tumour growth and reducing glycolysis.
Researchers found that toddlers with profound autism had larger embryonic brain cortical organoids (BCOs) compared to neurotypical controls. The BCO size was positively correlated with the child's later social symptoms, indicating that a larger brain may be the first sign of autism.
A team of scientists at Argonne National Laboratory has discovered that a lithium nickel manganese cobalt (NMC) oxide degrades rapidly with charge-discharge cycling due to changes in its lattice structure. This finding could lead to the development of lower-cost electric vehicles with longer driving ranges.
A decade-long study has discovered a vast untapped genetic potential in modern wheat varieties, revealing that at least 60% of the genetic diversity found in a historic collection is unused. This discovery provides an unprecedented opportunity to improve modern wheat and sustainably feed a growing global population. The study used a cr...
The number of US individuals with chronic hypertension in pregnancy increased significantly, while medication treatment remained low, according to a new study. The findings highlight the need for improved maternal health strategies to address high blood pressure and cardiovascular complications.
Scientists at Case Western Reserve University have discovered that the rotation curves of galaxies remain flat for millions of light years, defying expectations and challenging traditional understanding of cosmology. This finding suggests that dark matter may not exist or that alternative gravity theories could explain this phenomenon.
Researchers have discovered that phosphorylation of the birch tree BpNAC90 gene plays a crucial role in conferring drought tolerance. The study found that phosphorylation at Serine 205 enhances BpNAC90's ability to regulate genes involved in stress tolerance, leading to improved drought resistance.
Scientists at St. Jude Children's Research Hospital discovered that NLRC5 plays a crucial role as an innate immune sensor, triggering PANoptotic cell death. The findings suggest that targeting NLRC5 could lead to therapeutic development for infections, inflammatory diseases, and aging.
A new study finds that periods of fasting can reprogram the immune system's natural killer cells to better fight cancer. The research suggests that fasting may help improve immune responses and make immunotherapy more effective by training NK cells to survive in the tumor environment and produce more cytokines.
The Kids First DRC has introduced an upgraded data portal to streamline big data search and analysis, improving collaborative pediatric research outcomes. The new portal integrates diverse datasets, including genomic information from the Children's Brain Tumor Network, to foster cross-disciplinary research.
Researchers developed an AI-powered method to train robotic exoskeletons, enabling users to save energy while walking, running, and climbing stairs. The new approach allows for rapid development of exoskeleton controllers without lengthy human-involved experiments, offering promise for aiding individuals with mobility challenges.
The 2024 Kavli Prize Laureates have made significant contributions to our understanding of exoplanet atmospheres, nanoscale materials for biomedical applications, and the localization of brain areas specialized for face recognition. Their work has broadened our knowledge of planetary life beyond Earth.
Researchers at Curtin University have identified a new species of pterosaur, Haliskia peterseni, from 100-million-year-old fossilized bones found in western Queensland. The specimen is 22% complete and includes features such as complete lower jaws, teeth, and wing bones.
A growth factor called BMP7 has been found to promote cardiomyocyte proliferation and regeneration in both zebrafish and adult mice. This discovery offers a promising new approach to treating heart disease by stimulating cardiac muscle cell regrowth even in later stages of life.
Researchers at Johns Hopkins Medicine build a minimal synthetic cell that responds to external chemical cues, demonstrating symmetry breaking - a vital biological principle. The findings have potential applications in targeted drug delivery and environmental sensing.
Researchers at Wyss Institute develop subcutaneous scaffolds to restimulate CAR-T cells, increasing therapeutic efficacy in mice with aggressive blood tumors. The biomaterials increase CAR-T cell numbers and steer differentiation into tumor-killing T cells.
Scientists have discovered unique periodic structures in manganese germanide that behave like magnetic monopoles and antimonopoles. The researchers studied the collective excitation modes of these structures, revealing a way to experimentally determine their spatial configuration.
A multidisciplinary research team has developed a predictive tool for designing complex metal alloys that can withstand extreme temperatures. By analyzing the degradation of high-entropy alloys, the team discovered universal rules that can predict oxidation behavior in these alloys.
A team of researchers at Penn has developed an artificial intelligence tool that can mine the vast and largely unexplored biological data from over 10 million molecules to discover new candidates for antibiotics. The deep learning approach identified thousands of candidates in just a few hours, with many showing preclinical potential.
Researchers uncover new clues about the early universe, finding spiral galaxies were prevalent as early as 2 billion years after the universe formed. This discovery challenges previous theories and provides insight into how spiral galaxies like the Milky Way formed over time.
Researchers have discovered ancient termite mounds in Namaqualand, South Africa that date back a staggering 34,000 years. The mounds, which are still inhabited by termites, provide valuable insights into prehistoric climate conditions and natural carbon sequestration processes.
Texas A&M University has received a $1.5 million grant from the Environmental Protection Agency to develop a technology capable of separating hydrofluorocarbons (HFCs) in two ways: designing and testing a separation technology, and incorporating machine learning-based data-driven decision frameworks for reverse logistics.
A University of Adelaide research team used a new method to date garnet grains in South Australian pink sand, revealing they are around 590 million years old. This age does not match local geological events, suggesting the garnet originated from an unknown ancient Antarctic mountain belt beneath the ice sheet.
Dr. Jeetain Mittal's NIH grant will support multiscale computational models investigating phase separation in biology, particularly heterochromatin formation and its role in neurodegenerative diseases. The research aims to elucidate the molecular origins of phase separation using innovative models and methods.
Researchers have developed a method to create and control optical qubits in silicon with high precision, enabling the fabrication of reliable quantum computers. This breakthrough could advance quantum computing and networking capabilities, paving the way for breakthroughs in human health, drug discovery, and artificial intelligence.
Researchers discovered wind from a black hole's radiation blasting gas out of its galaxy at an unprecedented speed. The study sheds light on how active black holes shape their galaxies by spurting on or snuffing out new star formation.
Researchers discover that epigenetic marks, particularly H3K27ac, are crucial for instructing genes to express themselves and generate folds. The Cux2 protein is found to be a master factor that utilizes the epigenetic landscape to regulate gene expression, leading to the formation of folds in the cerebral cortex.
Researchers compiled over 100 investigators' data from more than two dozen countries, increasing human spaceflight data by 10-fold. The results revealed longer-lasting molecular and physiologic changes distinct between crew members, targeting new areas for aerospace medicine.
Researchers have discovered a better way to identify those at high risk of potential heart attacks and strokes by adding genetic information to health checks. The study found that combining clinical risk scores with polygenic risk scores significantly improves identification rates, especially among younger people.
A study at Nagoya University reveals the formation of a superlattice structure in gallium nitride and magnesium, leading to enhanced hole transport and compressive strain. This breakthrough has potential applications in improving GaN-based devices for energy-efficient electronics.
The Pennington Biomedical Research Center is conducting a clinical trial to better understand lipedema. Participants will undergo comprehensive assessments and imaging techniques to help advance medical knowledge related to chronic disease. Compensation of up to $475 is offered for participation in the three-month study.
Scientists at Johns Hopkins Medicine have discovered the mechanism of action of the widely-used epilepsy drug perampanel, which targets the AMPA receptor to dampen brain cell excitability. The study provides new insights into the potential applications of perampanel in treating other neurological conditions such as Alzheimer’s disease,...