News on early, curiosity-driven science that opens new directions. Covers materials discovery, AI-guided research, pediatric research standards, and energy science.
A CHARMed collaboration has created a set of molecular tools called CHARMs that can turn off disease-causing genes, including those coding for the prion protein. The tools have shown promise in silencing the prion protein gene and improving or eliminating disease symptoms in animals.
Researchers at UNIST developed zeolitic imidazolate frameworks that mimic intricate machines, exhibiting precise control over nanoscale mechanical movements. The discovery has significant implications for applications in data storage, digital technology, and beyond.
Researchers developed a reliable marker for monocytes and dendritic cells, enabling clear identification and separation of different sample types. The new method unlocks exciting possibilities for cell isolation and quantification in diagnosing and monitoring various conditions.
Researchers uncover dark particles and lighter components with stones, suggesting asteroids played a key role in delivering water and life to Earth. The samples also contain unexpected minerals, offering insights into Bennu's evolution and the early solar system.
Scientists at IOCB Prague have developed two new types of catalytic DNA molecules that can reveal target molecule presence through fluorescence or color. The research uses directed evolution to discover novel fluorescent and colorimetric deoxyribozymes, with potential applications in diagnostic tests.
Researchers at Weill Cornell Medicine discovered that before committing to cell division, cells may stay in a reversible intermediate state for many hours, potentially up to a day. This pre-commitment state allows cells to sense and integrate fluctuating input signals, reducing the chance of inappropriate division.
Researchers at Cornell University have used a combination of almond analysis, pottery dating, and radiocarbon dating to determine the Kyrenia shipwreck's age. The team estimated that the ship sank between 296-271 BCE, with a strong probability it occurred between 286-272 BCE.
Neuroscientists have identified a region of the brain that regulates escape behavior in mice, revealing its role in anxiety and PTSD. The study found that inhibitory neurons can be turned up or down to control sensitivity to threats.
Researchers identified a kissing bug in Delaware with the Chagas disease-causing parasite Trypanosoma cruzi. Entomologists confirmed the insect's presence and found it was infected with the parasite, which can lead to serious heart problems if left untreated.
A new study published in Science Advances documents the first case of Down syndrome in Neandertals, named 'Tina', and reveals that they provided extensive care for a young child with severe hearing loss. The discovery sheds light on the existence of true altruism among Neandertals.
Researchers from PSI and ETH Zurich studied connexin-36 gap junction channels and found that antimalarial drug mefloquine binds to the channels, potentially explaining its severe side effects. The study provides new insights into how drugs interact with connexins and may lead to the development of therapies for neurological diseases.
The study reveals that supergranules, a flow structure in the sun's interior, challenge standard theories of solar convection. Researchers discovered that downflows appear weaker than upflows, suggesting an unseen component that could be small-scale plumes transporting cooler plasma into the sun's interior.
The FRONTIERS Science Journalism Initiative offers a residency program for journalists to develop independent journalism while working with scientists at the forefront of knowledge. Seven journalists from around the globe were selected for the first round and will receive Frontiers Residencies in various EU countries.
A new biomarker has been discovered that can help predict which patients with clear cell renal cancer are at higher risk of recurrence. The 15-gene signature was found to be independently associated with worse disease-free survival and disease-specific survival in two large validation datasets.
Scientists discovered that synthesis methods can alter calcite crystals' internal structure, affecting its reactivity and properties. This discovery has implications for long-term carbon storage and the development of durable materials.
The Collaborative Ethics model, developed by Jeantine Lunshof and Julia Rijssenbeek, aims to address ethical implications of emerging technologies from fundamental discoveries. By integrating philosophical and ethical reassessment into research processes, the model facilitates decision points for researchers and ethicists.
Researchers found raw material demand for electric vehicles will nearly double by 2050 if current trends continue. Implementing circular economy strategies such as ride-sharing, recycling, and solid-state batteries can halve resource demand or maintain it at 2015 levels.
The American Federation for Aging Research (AFAR) has received renewed funding of $4,626,500 from the McKnight Brain Research Foundation to support scientists pursuing groundbreaking studies in cognitive aging. The funding will support high-risk/high-gain research proposals that may yield transformative discoveries.
Researchers at Trinity College Dublin have discovered a novel method for forming bastnåsite, a crucial mineral in extracting rare earth elements. The study reveals that fluocerite can act as a 'seed' to promote the rapid formation of bastnåsite, with significant implications for efficient and cost-effective extraction methods.
Research by Lancaster University found that people in higher social grades, including corporate world and education sectors, are adopting each other's speech patterns to be more inclusive. This 'resonance' has increased over the past 20 years, particularly among those with high social status.
A study analyzing data from 6,010 English practices between 2018 and 2022 found that the national average dropped from 29.3% to 19% of patients able to see a preferred doctor. Practices with more doctors and higher same-day appointment rates showed slower declines in continuity.
A new study published in GEN Biotechnology describes the establishment of a 3D hydrogel-based platform for producing functional T-cells from hematopoietic stem and progenitor cells. The platform was engineered with key thymic components to direct T-cell development, producing cytokine-producing T-cells.
The RENEW system, launched in 2022, uses new research discoveries to pinpoint genetic variants causing rare diseases. Researchers successfully diagnosed 63 patients out of 1,066 undiagnosed cases with an average diagnosis time of 20 seconds.
A new version of the OPTIMADE standard enables easier access to large materials databases, facilitating AI modeling and prediction of material properties. The international collaboration involves over 30 institutions worldwide, aiming to advance materials research and development.
The ARMMS-T2D study found that bariatric surgery yields greater long-term improvements in quality-of-life compared to medical management, with sustained weight loss correlating with better health and reduced pain.
Researchers have discovered unusual transport phenomena in ultra-clean SrVO3 samples, contradicting long-standing scientific consensus. The study's findings challenge theoretical models of electron correlation effects and offer insights into the behavior of transparent metals.
The NIH and NSF have partnered to provide funding for RNA research, focusing on structures, functions, and interactions of ribonucleic acid (RNA). Research groups will explore RNA sequencing, mapping of RNA modifications, and development of RNA-based technologies.
A platform called Open-ST enables scientists to reconstruct gene expression in cells within a tissue in three dimensions, capturing molecular and (sub)cellular structures. The platform was used to study cell types at subcellular resolution in tissues from mice brains, tumor tissue, and healthy lymph nodes, providing insights into cance...
Researchers have discovered that gallium's bonds disappear at melting point but reappear at higher temperatures, leading to a new explanation for its low melting point. This breakthrough has important implications for advances in nanotechnology and materials science.
A study by TUM researchers discovered four subtypes of Amyotrophic Lateral Sclerosis (ALS) with different molecular processes, including sex differences. The findings suggest repurposing an approved cancer drug targeting the MAPK pathway as a promising therapeutic approach for ALS.
Researchers created an integrated cellular map of a mouse model heart, pinpointing cells and pathways involved in fibrosis. The study identified myofibroblasts as the major drivers of scarring, but also discovered a 'matrifibrocyte' form that may prevent scar resolution.
Scientists have discovered that ADGRF5 helps maintain the integrity of the glomerular filtration barrier, which is critical for filtering waste from the blood. The study found that disrupting ADGRF5 expression led to abnormalities in the glomerular basement membrane and increased albuminuria.
Researchers are exploring inflammation caused by COVID-19 as a trigger for Long Covid, a condition characterized by persistent symptoms like fatigue, brain fog, and shortness of breath. The study aims to identify potential causes and treatments for Long Covid, with findings that could lead to enhanced immune function in patients.
Researchers used modern technology to estimate the number of rock gardens on Easter Island and food production, revealing that the island couldn't sustain a large population. The study's findings contradict the long-held notion of an ecological catastrophe and instead suggest a more sustainable approach to agriculture.
Researchers at Chalmers University of Technology discovered a powerful rotating magnetic wind in galaxy ESO320-G030, suggesting its role in supermassive black hole growth. The study reveals similarities between this process and the birth of stars.
Researchers have discovered a new source of resistance to the devastating wheat blast disease, leveraging a gene that also protects against powdery mildew. The Pm4 gene, found in European wheat varieties, confers dual protection against the pathogen and its effector molecule AVR-Rmg8.
Researchers have identified a potent and unique way to kill drug-resistant bacteria using a repurposed compound called LEI-800. The compound targets the bacterial enzyme DNA gyrase, which is essential for bacterial growth and has not been targeted by existing antibiotics.
Chimpanzees have been observed seeking out specific plants with medicinal properties to treat their ailments, and further pharmacological testing has confirmed the presence of anti-inflammatory and antibiotic compounds. These findings highlight the importance of studying animal behavior in discovering new medicines.
Lokiceratops rangiformis, a plant-eating dinosaur with large horned frill and asymmetrical caribou-like antlers, has been discovered in Montana. The species' unusual features may have played a role in mate selection or species recognition.
Researchers developed a unique electrochemical ultrasonic force microscopy (EC-UFM) technique to observe sodium-ion battery interfaces during operation. The new method guides passivating layer formation, preserving charge carrier transport and enhancing battery performance.
The newly discovered Lokiceratops rangiformis is a massive horned dinosaur found in the badlands of northern Montana. It boasts two enormous blade-like horns on its frill, as well as an asymmetric spike, making it one of the most ornate species ever found.
Researchers have developed a new 3D method for fast-moving object tracking at unprecedented speeds, with potential applications in autonomous driving, industrial inspection and security surveillance. The approach uses single-pixel imaging to calculate the object's position in real-time, reducing data storage and computational costs.
Researchers found that carrying just one copy of the Christchurch variant delayed cognitive decline and dementia in family members, with some showing lower levels of tau proteins. The study suggests potential benefits for drug development targeting this genetic pathway.
Scientists have identified a mechanism that enables enzymes to communicate and produce organic molecules with disease-fighting properties. This breakthrough could aid in the discovery of new drugs by allowing researchers to design or modify enzymes to create novel natural products.
Scientists have identified a new mechanism by which cells counteract a key cancer-promoting protein using an 'invisible' protein called RAI2. In cancer cell lines and patient samples, RAI2 levels are reduced in more severe and treatment-resistant forms of prostate cancer.
Researchers developed a technique to study electrochemical processes at the atomic level, revealing unexpected transformations in a popular copper catalyst. The technique, called polymer liquid cell (PLC), enables scientists to observe composition changes during reactions in real time.
Scientists have created mirror-image cyclodextrins in the laboratory, which could make it easier to formulate and deliver complex medications. These discoveries may also lead to improved treatment of cardiovascular diseases caused by atherosclerotic plaques.
Researchers from CWRU and NJIT have made a significant breakthrough in understanding how the body adapts to COVID-19 infection. The study suggests a potential link between elevated hemoglobin levels and the body's response to the virus, shedding light on the enigmatic phenomenon of silent hypoxemia.
Researchers discovered a new way to effectively treat melanoma using nutrients to reactivate suppressed metabolic pathways in cancer cells. The innovative treatment, involving tyrosine nanomicelles, showed promising results in mice and lab-derived human cells, inhibiting tumour growth and reducing glycolysis.
Researchers found that toddlers with profound autism had larger embryonic brain cortical organoids (BCOs) compared to neurotypical controls. The BCO size was positively correlated with the child's later social symptoms, indicating that a larger brain may be the first sign of autism.
A team of scientists at Argonne National Laboratory has discovered that a lithium nickel manganese cobalt (NMC) oxide degrades rapidly with charge-discharge cycling due to changes in its lattice structure. This finding could lead to the development of lower-cost electric vehicles with longer driving ranges.
A decade-long study has discovered a vast untapped genetic potential in modern wheat varieties, revealing that at least 60% of the genetic diversity found in a historic collection is unused. This discovery provides an unprecedented opportunity to improve modern wheat and sustainably feed a growing global population. The study used a cr...
The number of US individuals with chronic hypertension in pregnancy increased significantly, while medication treatment remained low, according to a new study. The findings highlight the need for improved maternal health strategies to address high blood pressure and cardiovascular complications.
Scientists at Case Western Reserve University have discovered that the rotation curves of galaxies remain flat for millions of light years, defying expectations and challenging traditional understanding of cosmology. This finding suggests that dark matter may not exist or that alternative gravity theories could explain this phenomenon.
Researchers have discovered that phosphorylation of the birch tree BpNAC90 gene plays a crucial role in conferring drought tolerance. The study found that phosphorylation at Serine 205 enhances BpNAC90's ability to regulate genes involved in stress tolerance, leading to improved drought resistance.
Scientists at St. Jude Children's Research Hospital discovered that NLRC5 plays a crucial role as an innate immune sensor, triggering PANoptotic cell death. The findings suggest that targeting NLRC5 could lead to therapeutic development for infections, inflammatory diseases, and aging.
A new study finds that periods of fasting can reprogram the immune system's natural killer cells to better fight cancer. The research suggests that fasting may help improve immune responses and make immunotherapy more effective by training NK cells to survive in the tumor environment and produce more cytokines.
The Kids First DRC has introduced an upgraded data portal to streamline big data search and analysis, improving collaborative pediatric research outcomes. The new portal integrates diverse datasets, including genomic information from the Children's Brain Tumor Network, to foster cross-disciplinary research.
Researchers developed an AI-powered method to train robotic exoskeletons, enabling users to save energy while walking, running, and climbing stairs. The new approach allows for rapid development of exoskeleton controllers without lengthy human-involved experiments, offering promise for aiding individuals with mobility challenges.
The 2024 Kavli Prize Laureates have made significant contributions to our understanding of exoplanet atmospheres, nanoscale materials for biomedical applications, and the localization of brain areas specialized for face recognition. Their work has broadened our knowledge of planetary life beyond Earth.