Articles tagged with Dementia
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Researchers assessed modifiable risk factors for Alzheimer disease and related dementias in the US population, finding significant differences by sex, race, and ethnicity. The study highlights the importance of addressing these disparities to prevent cognitive decline.
A study analyzing Medicare claims data found that policy changes reduced the share of patients receiving hospice care for Alzheimer's disease and related dementias. The changes also slowed growth in hospice care use by these patients.
Researchers at the University of Cambridge have identified a new mechanism that appears to reverse the build-up of aggregates in neurodegenerative diseases, such as Alzheimer's and Parkinson's. By stressing cells, they found that protein misfolding was eliminated, potentially allowing for the refolding of correctly folded proteins.
A study published in Neurology found that people with higher levels of antioxidants lutein and zeaxanthin and beta-cryptoxanthin in their blood were less likely to develop dementia. The study associated a 7% decrease in risk of dementia with every standard deviation increase in lutein and zeaxanthin levels.
A new study found that half of older adults with both hearing and vision impairment have serious cognitive decline, compared to 28% with only vision impairment. The study highlights the importance of considering sensory impairments in identifying those at risk for cognitive decline.
Researchers presented studies on reducing medication errors, improving hospital mobility, and predicting mortality risk in older adults with dementia. The EQUiPPED study showed a significant decrease in potentially inappropriate medication prescribing, while the Comparative Effectiveness study found improvements in delirium scores and ...
Researchers discovered a novel mutation in the alpha-synuclein gene that causes severe Lewy body pathology, revealing distinct mechanisms of neurodegeneration. The E83Q mutation influences alpha-synuclein's structure and aggregation properties, leading to increased pathology formation and toxicity.
Researchers found that seven hours of sleep per night is associated with improved cognitive performance, better mental health, and reduced symptoms of anxiety and depression. Disrupted slow-wave sleep may contribute to cognitive decline and memory consolidation issues.
Researchers found that people with advanced Alzheimer’s disease and related dementias who live in the community experience similar symptom burdens to those in nursing homes. The study suggests that palliative care interventions could ease symptom burden and improve quality of life for patients and caregivers.
A Boston University study found that living in areas with more greenery may boost cognitive function, particularly in middle-aged women. The research suggests that exposure to greenspace could improve processing speed and attention, as well as reduce depression, a risk factor for dementia.
A new microsimulation model projects that the Japanese population will live longer and experience a decrease in years spent living with dementia. However, older women with less than a high school education are more likely to be affected by both dementia and frailty.
A study led by Richard Isaacson found that individualized, multi-domain interventions improved cognition and reduced Alzheimer's risk in both men and women. Women demonstrated greater improvements in certain risk scores and biomarkers compared to men.
A new Cochrane Review paper reveals that talk therapy can alleviate depression and improve quality of life for people with dementia. The study found that psychological interventions, such as Cognitive Behavioural Therapy (CBT), are effective in reducing symptoms of depression and improving wellbeing.
A new study finds that people with faster accumulation of cardiovascular risk factors have an increased risk of developing Alzheimer's disease dementia or vascular dementia compared to those with stable risk factors. Researchers suggest earlier interventions could be effective in preventing further memory decline.
Researchers at Einstein Aging Study are investigating how social forces contribute to inequalities in cognitive health, particularly among Black and Hispanic Americans. The new grant will enable the tracking of over 700 Bronx adults with mobile technology to measure cognition directly as they engage in everyday activities.
Researchers from The University of Texas Health Science Center at San Antonio have identified 33 genes associated with Alzheimer's disease, doubling the known list. This discovery adds 42 new genetic variants to the existing gene list, shedding light on emerging pathways of Alzheimer's biology and potential treatment targets.
A cross-racial study of 1.87 million US veterans found significant differences in dementia incidence across five racial groups, with Hispanic and Black veterans at highest risk. Rates were significantly higher for Hispanics (99%) and Blacks (55%), while Asian veterans showed a 24% increase compared to whites.
A study of 118 PPA autopsies found five diseases causing language impairments, each impacting a distinct part of the language network. The findings can inform targeted interventions and treatment approaches for patients with PPA.
Researchers found plasma neurofilament light levels were elevated in all types of frontotemporal dementia, and in people who had mutations but hadn't shown symptoms yet. Higher levels of the protein were associated with greater disease severity and increased just before symptom onset.
Patients hospitalized with COVID-19 pneumonia are at a higher risk of developing new-onset dementia compared to those with other types of pneumonia, according to a recent study. The median time interval between infection and dementia diagnosis was 182 days for COVID-19 patients.
A new IU training program will focus on social and behavioral science training in Alzheimer's disease, leveraging IU's strengths in aging research infrastructure. The five-year T32 grant aims to grow the pipeline of scientists tackling complex clinical issues.
Researchers at UT Health San Antonio have identified a novel mechanism by which tau protein causes neurons to die, which can be altered pharmacologically. This discovery provides a new framework for studying vertebrate models of tauopathy and eventually clinical trials.
A healthy lifestyle is associated with longer life expectancies and reduced time spent living with Alzheimer's. For women and men with a healthy lifestyle, 10.8% (2.6 years) of the remaining years were lived with Alzheimer's, compared to 19.3% (4.1 years).
A new study from the University of Eastern Finland found that frontotemporal dementia patients with extrapyramidal symptoms have significant brainstem atrophy and reduced metabolism, facilitating differential diagnostics for FTD. This can help distinguish between FTD and other diseases causing extrapyramidal symptoms.
A new study published in the Journal of Alzheimer’s Disease found that the Virtual Behavioural Medicine (VBM) program successfully reduced the proportion of patients who needed admission to a specialized inpatient unit by 60%. This suggests that VBM is highly effective for managing severe neuropsychiatric symptoms of dementia without p...
A new study reveals that firearm retailers and law enforcement agencies in Colorado and Washington support providing temporary, voluntary firearm storage options. The concept aims to increase safety by limiting access to firearms during times of crisis, such as suicidal thoughts or Alzheimer's disease. However, concerns about civil lia...
A study by University of Gothenburg researchers has identified two biomarkers that can distinguish between patients with subcortical small-vessel disease, Alzheimer's disease, and mixed dementia. The discovery opens up new possibilities for diagnosis, treatment, and medication development.
A study of 273,240 women found that life events influencing estrogen levels may be linked to a higher risk of dementia. Ever having been pregnant or having had an abortion was associated with a lower risk, while early or late menopause increased the risk.
A new study found that vitamin K2 supplementation improved spatial memory, learning ability, and reduced evidence of cognitive impairment, depression, and anxiety in rats. The researchers suggest that vitamin K may help preserve cognitive functions by affecting biological pathways involving inflammation and antioxidant activity.
A study published in PLOS Medicine found that certain reproductive events, such as shorter estrogen exposure, may be associated with increased dementia risk in women. However, the association between the number of children and dementia risk was similar for women and men, suggesting social and behavioral factors may play a role.
Research finds that late-onset alcohol abuse may be a presenting symptom of dementia, particularly in patients with frontotemporal dementia. The study identified that up to 7% of patients with frontotemporal dementia started abusing alcohol late in life, and 5% did so as the first symptom of the disease.
Researchers have discovered a significant association between acute kidney injury and an increased risk of developing dementia in patients hospitalized with AKI. Early detection and monitoring may lead to improved outcomes for this high-risk population.
A study of 3.5 million Medicare decedents found the percentage of dementia diagnoses at end-of-life increased from 35% in 2004 to 47% in 2017. This rise may be attributed to heightened awareness and changes in billing practices.
A new study reveals that nearly half of all older adults now die with a dementia diagnosis listed on their medical record, a 36% increase from two decades ago. This rise may be attributed to better public awareness, more detailed medical records, and Medicare billing practices, rather than an actual increase in the condition.
Researchers developed a novel delirium severity score to assess its impact on patient outcomes. The DEL-S score is associated with longer hospital stays, increased costs, and mortality in older patients with delirium.
A new wireless implant has the potential to treat neuropathic pain resistant to medical therapy, offering a minimally invasive alternative to surgery. The device uses bioelectronic therapy to stimulate peripheral nerves from within blood vessels, providing precise placement and predictable outcomes.
A study published in Nature found that people raised in rural areas outperform those from cities, particularly grid-pattern streets, in navigating spatial environments. This suggests that the simplicity of rural street networks influences navigational abilities.
Researchers found that high levels of both amyloid and tau proteins impair memory functions, but only when amyloid burden is also high. The study suggests that anti-amyloid therapies may be beneficial in reducing memory impairment in the early stages of Alzheimer's disease.
Daily physical activity has been associated with a lower risk of disabling dementia among Japanese adults. Researchers found that moderate-to-vigorous physical activity was inversely related to the risk of developing severe cognitive decline.
Mayo Clinic researchers propose a novel computational model that links Alzheimer's disease symptoms to brain anatomy, revealing a complex relationship between mental processing and brain function. The model uses machine learning to analyze patient brain imaging data and compresses complex brain anatomy into a conceptual framework.
A new American Heart Association scientific statement finds that timely treatment can help avoid additional disability and health impacts in people with pre-existing disabilities or dementia. The statement also highlights the need for increased awareness of potential biases and improved patient-centered care.
This year's Experimental Biology 2022 meeting features groundbreaking studies on COVID-19 vaccine-associated symptoms in non-menstruating people, a plant compound showing promise for alleviating food allergies, and the potential of omega-3s to boost immunotherapy's cancer-fighting power. Researchers also explore the safety of using CBD...
Researchers have identified a blood biomarker called glial fibrillary acidic protein (GFAP) that may uniquely aid prediction of dementia in Mexican Americans. The study analyzed 745 participants over four years, finding that higher levels of GFAP predicted increased risk of developing dementia.
A new study finds that clinics supporting patients throughout the entire FIT process improve return rates and reduce colorectal cancer-related illness. Additionally, a telephone survey for dementia detection shows promise as a low-cost diagnostic tool, especially in primary care settings.
A telephone survey called Telephone Interview for Cognitive Status (TICS) was found to be effective in detecting dementia in primary care patients. TICS scored well as a low-cost diagnostic tool, with a score of less than 30 indicating a positive screen for dementia.
Research from the University of Minnesota found that lower left atrial function was associated with higher risk of developing dementia. Atrial myopathy, characterized by abnormal left atrial function and size, was identified as an independent risk factor for dementia.
This cross-sectional study investigated the association between adverse childhood experiences and poor neuropsychiatric health in former NFL players. Football-related concussions were found to be significantly associated with increased risk of dementia and poor neuropsychiatric health among these athletes.
A retrospective analysis of nearly 30,000 patients found that those who received lithium were less likely to develop dementia. The study supports the possibility that lithium could be a preventative treatment for dementia.
A new study found that longer, more frequent daytime napping in older adults predicted worse cognitive performance and an increased future risk of Alzheimer's dementia. The researchers discovered a bi-directional link between the two, where excessive daytime napping sped up the increase in daytime napping during aging.
A new study found that excessive daytime napping among seniors is associated with an increased risk of developing dementia and Alzheimer's disease. After a diagnosis of mild cognitive impairment or Alzheimer's, daytime napping duration triples, suggesting that the brain's wake-promoting neurons may be affected by dementia pathology.
Researchers at UC San Francisco have identified five genes that enable efficient sleep, contrasting with current thinking that lack of sleep accelerates neurodegeneration. These genes may confer protections against neurological disease and improve sleep quality, paving the way for new treatments.
A recent study found that individuals with a history of neurological or psychiatric conditions are at increased risk of developing a second condition. Women and men differ in their risk, with women being more likely to develop dementia after experiencing an earlier stroke.
Researchers found that brains from patients with Alzheimer's disease had higher levels of the protein Fli-1 and fewer pericytes lining their smallest blood vessels, leading to leakage. Blocking Fli-1 improved memory in mice, suggesting a promising new approach to treating the disease.
A recent study from the University of Kentucky's Sanders-Brown Center on Aging has shown promising results for a blood test that could identify Alzheimer's changes in the brain before symptoms appear. The test detects proteins associated with Alzheimer's and brain damage, which may indicate preventative treatments can be used.
A new study led by UC San Francisco reveals that 87% of seniors with dementia would stop at least one medication if their doctor said it was possible. Polypharmacy contributes to challenges with adherence and adverse interactions, but most patients are willing to reduce their medications.
Researchers at the University of Cambridge found that people with dementia have difficulty responding to unexpected situations, which is a symptom seen across every type of dementia. The study used magnetoencephalography to analyze brain activity in patients and healthy controls while listening to changing sounds.
Cedars-Sinai researchers identified two types of brain cells that divide continuous human experience into distinct segments, enabling the brain to recall memories. The discovery provides new hope for treatments of memory disorders like dementia and Alzheimer's disease.
Researchers have discovered a common thread between multiple neurodegenerative diseases, including Alzheimer's, dementia with Lewy bodies, and frontotemporal lobar degeneration. A protein called TMEM106B forms fibrils in diseased brain tissue, potentially hobbling cells.
A study by researchers at the University of Waterloo found that higher education and advanced language skills can protect against dementia in people with mild cognitive impairment. Almost one-third of participants reverted to normal cognition, while over 80% never developed dementia.
Researchers found that mislocalization of TDP-43 protein alters genetic instructions for UNC13A, providing a possible therapeutic target for treating ALS and FTD. The studies suggest that increasing UNC13A or stathmin 2 levels may prevent neuron death in these diseases.