Articles tagged with Dementia
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A study of 53.6 million Medicare enrollees found COVID-19 associated increased mortality in older adults with Alzheimer's disease and related dementias, especially in nursing homes and minority populations. The results suggest a potential association between the pandemic and accelerated mortality rates for these vulnerable groups.
A new study has found that research participation is associated with greater use of and adherence to medications for dementia, while also revealing significant racial/ethnic disparities. The research suggests that Black and Latino participants had lower rates of medication uptake and persistent use compared to White participants.
Researchers at MUSC and University of Florida successfully visualize the complete human brain lymphatic system in living humans using a new non-invasive MRI technique. This breakthrough enhances our understanding of brain function and may provide insights into neurodegenerative diseases such as Alzheimer's.
Phosphorylated α-synuclein first appears at synapses near the site of inoculation, then spreads to axons and forms aggregates in neuronal cell bodies. This process begins in the synaptic region and may provide insight into prion-like propagation.
Researchers discover a genetic mechanism linking ALS and dementia to UNC13A protein corruption, providing hope for new treatments by blocking corrupted instructions. The study found that genetic variants increase the risk of UNC13A mRNA corruption in patients with ALS and FTD.
Researchers found that higher levels of dietary fiber, particularly soluble fiber, are associated with a lower risk of developing dementia. The study suggests that a high-fiber diet may play a preventative role in reducing the incidence of dementia.
A new discovery by VUB professor Ann Massie's research group reveals a strategy that prolongs life expectancy and preserves hippocampal function in the aging brain. The absence of system xc- has positive effects on mouse longevity and cognitive function, challenging current understanding of the aging process.
A study of 1.7 million New Zealanders found that those with mental health issues had three and a half times the risk of developing dementia than those without. The link holds true for both early and late onset dementia, as well as Alzheimer's and non-Alzheimer's forms.
A new study identifies common genetic factors in depression and Alzheimer's disease, suggesting a potential causal role of depression on dementia. The research found that depression played a significant role in AD development, with those experiencing worse depression experiencing faster memory decline.
Researchers found AI/AN adults with dementia face high hospital costs & chronic conditions, highlighting need for outpatient care & home services. Existing resources are often inadequate due to rurality & social determinants, leading to disparities in access.
Researchers found that repetitive exposure to environmental hypoxia prevented memory loss and reversed impairments in nerve-to-nerve communication. Adult offspring also inherited this protection against dementia.
A study using an Alzheimer's disease mouse model found that female brains experience a faster decay in information processing ability compared to male mice. This results in weaker memory formation and increased memory loss, contributing to the increased vulnerability of females to Alzheimer's disease.
Researchers found a significant association between mental disorders and dementia in a 30-year New Zealand study involving 1.7 million citizens. The study suggests that individuals with mental health conditions may be at higher risk of developing dementia, highlighting the importance of mental health care in preventing cognitive decline.
Researchers will test the effectiveness of WeCAN, a group-based treatment designed to teach long-lasting management skills to individuals with traumatic brain injury and dementia. The study aims to identify behavioral, neuroimaging, and blood biomarkers that correlate with treatment efficacy.
The Hastings Center Report examines four key considerations for assessing risk-trade-offs in the pandemic, including education, economies, healthcare, travel, social engagement, and medical countermeasures. The report also challenges traditional notions of advance directives in end-of-life care, proposing a new principle of patient aut...
Scientists have engineered baker's yeast to produce D-lysergic acid, a medication used to treat neuro-cognitive diseases. This sustainable method could potentially produce up to five tons of DLA annually, reducing the environmental impact of industrial drug production.
A new study suggests that economic hardships exacerbated by COVID-19 and reliance on people outside their households for assistance increased older Latinos' exposure to the virus. Nearly 25% of Latinos reported a household member diagnosed with COVID-19, compared to 7% of non-Latino whites.
A Finnish twin study found that individuals with lower education are more susceptible to the negative effects of cardiovascular risk factors on late-life cognition. The study suggests that higher education can act as a cognitive reserve, helping to mitigate dementia risk.
A new study has found that Aboriginal Australians living in urban areas have high dementia rates comparable to those in remote areas. The study highlights the need for culturally appropriate and effective dementia risk reduction strategies due to ongoing social and health disparities.
A recent study found that using personal assistant applications on smartphones can significantly improve memory in older adults with dementia. The researchers trained participants to use the technology to receive reminders about daily events and activities, resulting in improved memory performance.
A study found a three-fold increase in dementia risk among lonely Americans younger than 80 who didn't carry the APOE ε4 allele. Loneliness was associated with poorer executive function and changes in brain structure indicating vulnerability to Alzheimer's disease.
A study published in PLOS Medicine found that reducing air pollution exposure can slow cognitive decline in older women, with benefits seen across various demographics. The research followed 2,232 women for up to 20 years, revealing a significant association between improved air quality and reduced cognitive decline.
A new study reveals that bilateral oophorectomy may increase a woman's risk for dementia, with a 55% higher risk from age 65 years onward compared to men. Estrogen levels are suspected to play a key role in this association.
A UMass Amherst study found associations between oral contraceptive use and certain tubal ligation methods with lower levels of antimüllerian hormone (AMH), a biomarker for ovarian aging. This may suggest an increased risk for early menopause in women who have used oral contraceptives or undergone specific types of tubal ligation.
A large study of British adults found that having two or more chronic conditions in middle age increases the risk of dementia later in life. The study, published by The BMJ, highlights the importance of prevention and management of chronic diseases over adulthood to mitigate adverse outcomes.
University of Kentucky researchers found enhanced ApoE proteins in dementia patients without the APOE ε4 allele. The correlation between dementia diagnosis and ApoE peptides was stronger than that seen for Tau, Aβ, or α-Synuclein, suggesting an active disease-driving role for ApoE.
Dorothee Dormann and Rosa Rademakers are collaborating on a research project to understand the causes of frontotemporal dementia, a group of brain disorders affecting the frontal and temporal lobes. The researchers aim to identify the role of the FUS protein in this disease and its interactions with other proteins.
Researchers at University of California San Francisco have catalogued over 40 previously unknown cell types in the human brain's blood vessels. These findings connect hemorrhagic stroke with novel immune cells, offering new targets for therapies.
A national survey of over 2,000 adults aged 50-80 found that most support steps to reduce firearm injury risk, including safety counseling and background checks. The study highlights opportunities to help older adults recognize and address risks in their homes, particularly for those living with children or experiencing cognitive decline.
Researchers found that non-mutated Apolipoprotein E was strongly enriched in dementia patients' brains, correlating with dementia diagnosis. Even those without the disease-driving APOE ε4 allele showed significant levels of ApoE peptides.
A UCLA-led study found that aducanumab's ancillary care services, such as MRIs and neurologist visits, account for nearly 20% of total Medicare costs. The estimated annual spending on the drug could increase Medicare premiums.
A new study found that staff assumptions about minoritized groups contribute to variability in nursing home care for residents with advanced dementia. Remedies include addressing staff biases, increasing funding, and standardizing advance-care planning.
A new study found that people with dementia who see the same GP consistently have lower rates of health complications and fewer emergency hospital admissions. They are also less likely to develop delirium and incontinence, and receive safer prescribing.
During the first wave of the COVID-19 pandemic in Canada, researchers found increased health service use and higher death rates among adults with dementia and Parkinson disease. The study examined changes in these populations compared to older adults without neurodegenerative diseases.
A study published in Alzheimer's & Dementia: The Journal of the Alzheimer's Association found that 12 to 14 intervention sessions can improve cognition in older adults at risk of dementia. The optimal dose was determined by analyzing data from the Multidomain Alzheimer Preventive Trial, taking into account individual characteristics su...
Researchers at University of Arizona Health Sciences discovered a potential treatment to reduce post-stroke dementia risk by targeting the immune response to dead brain tissue. Cyclodextrin, an FDA-approved ingredient, was found to reduce inflammation and accumulate less cholesterol in the brain.
Researchers at West Virginia University are investigating the link between chronic stress and Alzheimer's disease using animal models. They aim to understand how xanthine oxidase may sabotage brain blood vessels in Alzheimer's patients, and explore whether a medication can block this pathway to keep the brain healthy.
Researchers have discovered that heart disease causes early brain dysfunction, leading to reduced blood flow and increased risk of dementia. A combination of heart disease and a genetic predisposition for Alzheimer's Disease also trebles the amount of beta-amyloid protein in the brain.
A successful intervention combining education and workflow increased primary care screenings for geriatric conditions, improving attitudes towards older adults. The program leveraged teamwork to integrate these important screenings into care delivery, resulting in significantly higher screening rates.
A study published in Neuron found that inflammatory markers are elevated even before dementia symptoms appear, suggesting a potential role in neuroprotection. The researchers discovered two proteins linked to a damage control program, which may support the development of new drugs for early detection and treatment.
A state-wide Massachusetts infection control program, implemented in 360 nursing homes, reduced COVID-19 infections among vulnerable residents, including those with dementia. Cohorting residents and proper adherence to infection control guidelines were key factors in this reduction.
A new study found that reducing air pollution can lower dementia risk among older women by decreasing their likelihood of developing dementia. The benefits were consistent despite differences among participants in age, geographic area, socioeconomic background, and other factors.
A recent study published in Alzheimer's & Dementia found that regular exercise enhances the connections between neurons in older adults, maintaining healthy cognition. The research, led by Kaitlin Casaletto and William Honer, suggests that physical activity may help boost synaptic functioning and safeguard against dementia.
A study found that cholinesterase inhibitors like donepezil increase the risk of overactive bladder in people with dementia. Galantamine and rivastigmine were not associated with this increased risk.
The number of adults living with dementia worldwide is expected to nearly triple from an estimated 57 million in 2019 to 153 million in 2050 due to population growth and aging. Improvements in global education access are projected to reduce dementia prevalence, but obesity, high blood sugar, and smoking are expected to increase cases.
A new clinical trial is enrolling young people with rare genetic mutations that cause early-onset Alzheimer's disease. The study will test gantenerumab to prevent the buildup of toxic protein amyloid beta, which can slow or stop the disease.
A large-scale new study found that frailty was a strong risk factor for dementia, even among people at high genetic risk, and that it can be modified through a healthy lifestyle. Over 10 years, dementia was detected in 1,762 participants, with those who were frail before diagnosis having a much higher risk.
The Arizona Alzheimer's Disease Research Center has received a $15.7 million NIH grant to support its efforts in advancing Alzheimer's disease research and care in Arizona. The grant will focus on establishing the role of promising blood tests in Alzheimer's research, clinical trials, and clinical care.
A new study published in JAMA Network Open found that artificial intelligence can predict which people attending memory clinics will develop dementia within two years with 92% accuracy. The machine learning algorithm analyzed data from over 15,300 patients and identified around eight per cent of dementia diagnoses as being made in error.
Two Canadian-led brain research teams will receive funding to develop and validate new measures of dementia care and outcomes, addressing existing measurement gaps. The projects aim to improve care practices and desired outcomes for individuals with dementia, in collaboration with the Alzheimer's Association and Brain Canada.
A study of 62,000 adults aged 65+ found that increased physical activity, including light-intensity levels, lowered dementia risk. Regular physical activity may help prevent or delay dementia onset in older age.
Researchers found that a combination of light exercise, connecting with loved ones, and engaging in hobbies reduces memory decline in adults between 65-89. The study's machine learning model analyzed 33 activities, showing increased impact with age.
A new study has made an Alzheimer's disease biomarker test available to all Canadians, enabling doctors to accurately diagnose the disease even when mild symptoms are present. The test aims to improve care and support for individuals living with Alzheimer's disease and their families.
Dr. Mario Masellis' international team is receiving $320,198 in funding to examine the interplay between genetic, demographic, and cardiovascular factors on dementia risk. The project aims to improve management and prevention of dementia, ultimately reducing its impact worldwide.
A Geisinger study found that adults with rare genetic causes of mental health disorders are more likely to have chronic illnesses like diabetes and dementia. The research also discovered that these individuals had twice as many annual emergency room visits compared to a control group without the genetic conditions.
Researchers have determined the molecular structure of TDP-43 aggregates extracted from human brains, shedding light on its role in neurodegenerative diseases like ALS. The discovery may lead to the development of targeted therapies and diagnostic tests.
Katherine Tucker, a renowned nutritionist, has been awarded the top honor at UMass Lowell for her exceptional teaching, research, and service to the university. She will deliver the annual Distinguished University Professor Lecture and continue to lead her research team in establishing long-term interventions for diverse populations.
A new study developed by researchers at Ohio State University Wexner Medical Center found that a simple, self-administered test can identify early signs of dementia sooner than the most commonly used office-based standard cognitive test. The Self-Administered Gerocognitive Examination (SAGE test) accurately identified patients with mil...
The study, published in Nature Aging, found that sildenafil reduces the likelihood of developing Alzheimer's disease by 69% compared to non-users. Sildenafil also shows promise in treating the disease by increasing brain cell growth and decreasing hyperphosphorylation of tau proteins.
A study of 3,000 adults with cataracts found that those who underwent cataract removal had a lower risk of developing dementia compared to those who didn't. The findings suggest a potential protective effect of cataract surgery on cognitive health.