Articles tagged with Dementia
Patients hospitalized with COVID-19 pneumonia are at a higher risk of developing new-onset dementia compared to those with other types of pneumonia, according to a recent study. The median time interval between infection and dementia diagnosis was 182 days for COVID-19 patients.
A cross-racial study of 1.87 million US veterans found significant differences in dementia incidence across five racial groups, with Hispanic and Black veterans at highest risk. Rates were significantly higher for Hispanics (99%) and Blacks (55%), while Asian veterans showed a 24% increase compared to whites.
A new IU training program will focus on social and behavioral science training in Alzheimer's disease, leveraging IU's strengths in aging research infrastructure. The five-year T32 grant aims to grow the pipeline of scientists tackling complex clinical issues.
Researchers at UT Health San Antonio have identified a novel mechanism by which tau protein causes neurons to die, which can be altered pharmacologically. This discovery provides a new framework for studying vertebrate models of tauopathy and eventually clinical trials.
A healthy lifestyle is associated with longer life expectancies and reduced time spent living with Alzheimer's. For women and men with a healthy lifestyle, 10.8% (2.6 years) of the remaining years were lived with Alzheimer's, compared to 19.3% (4.1 years).
A new study from the University of Eastern Finland found that frontotemporal dementia patients with extrapyramidal symptoms have significant brainstem atrophy and reduced metabolism, facilitating differential diagnostics for FTD. This can help distinguish between FTD and other diseases causing extrapyramidal symptoms.
A new study published in the Journal of Alzheimer’s Disease found that the Virtual Behavioural Medicine (VBM) program successfully reduced the proportion of patients who needed admission to a specialized inpatient unit by 60%. This suggests that VBM is highly effective for managing severe neuropsychiatric symptoms of dementia without p...
A new study reveals that firearm retailers and law enforcement agencies in Colorado and Washington support providing temporary, voluntary firearm storage options. The concept aims to increase safety by limiting access to firearms during times of crisis, such as suicidal thoughts or Alzheimer's disease. However, concerns about civil lia...
A study by University of Gothenburg researchers has identified two biomarkers that can distinguish between patients with subcortical small-vessel disease, Alzheimer's disease, and mixed dementia. The discovery opens up new possibilities for diagnosis, treatment, and medication development.
A study of 273,240 women found that life events influencing estrogen levels may be linked to a higher risk of dementia. Ever having been pregnant or having had an abortion was associated with a lower risk, while early or late menopause increased the risk.
A new study found that vitamin K2 supplementation improved spatial memory, learning ability, and reduced evidence of cognitive impairment, depression, and anxiety in rats. The researchers suggest that vitamin K may help preserve cognitive functions by affecting biological pathways involving inflammation and antioxidant activity.
A study published in PLOS Medicine found that certain reproductive events, such as shorter estrogen exposure, may be associated with increased dementia risk in women. However, the association between the number of children and dementia risk was similar for women and men, suggesting social and behavioral factors may play a role.
Research finds that late-onset alcohol abuse may be a presenting symptom of dementia, particularly in patients with frontotemporal dementia. The study identified that up to 7% of patients with frontotemporal dementia started abusing alcohol late in life, and 5% did so as the first symptom of the disease.
Researchers have discovered a significant association between acute kidney injury and an increased risk of developing dementia in patients hospitalized with AKI. Early detection and monitoring may lead to improved outcomes for this high-risk population.
A study of 3.5 million Medicare decedents found the percentage of dementia diagnoses at end-of-life increased from 35% in 2004 to 47% in 2017. This rise may be attributed to heightened awareness and changes in billing practices.
A new study reveals that nearly half of all older adults now die with a dementia diagnosis listed on their medical record, a 36% increase from two decades ago. This rise may be attributed to better public awareness, more detailed medical records, and Medicare billing practices, rather than an actual increase in the condition.
Researchers developed a novel delirium severity score to assess its impact on patient outcomes. The DEL-S score is associated with longer hospital stays, increased costs, and mortality in older patients with delirium.
A new wireless implant has the potential to treat neuropathic pain resistant to medical therapy, offering a minimally invasive alternative to surgery. The device uses bioelectronic therapy to stimulate peripheral nerves from within blood vessels, providing precise placement and predictable outcomes.
A study published in Nature found that people raised in rural areas outperform those from cities, particularly grid-pattern streets, in navigating spatial environments. This suggests that the simplicity of rural street networks influences navigational abilities.
Researchers found that high levels of both amyloid and tau proteins impair memory functions, but only when amyloid burden is also high. The study suggests that anti-amyloid therapies may be beneficial in reducing memory impairment in the early stages of Alzheimer's disease.
Daily physical activity has been associated with a lower risk of disabling dementia among Japanese adults. Researchers found that moderate-to-vigorous physical activity was inversely related to the risk of developing severe cognitive decline.
Mayo Clinic researchers propose a novel computational model that links Alzheimer's disease symptoms to brain anatomy, revealing a complex relationship between mental processing and brain function. The model uses machine learning to analyze patient brain imaging data and compresses complex brain anatomy into a conceptual framework.
A new American Heart Association scientific statement finds that timely treatment can help avoid additional disability and health impacts in people with pre-existing disabilities or dementia. The statement also highlights the need for increased awareness of potential biases and improved patient-centered care.
This year's Experimental Biology 2022 meeting features groundbreaking studies on COVID-19 vaccine-associated symptoms in non-menstruating people, a plant compound showing promise for alleviating food allergies, and the potential of omega-3s to boost immunotherapy's cancer-fighting power. Researchers also explore the safety of using CBD...
Researchers have identified a blood biomarker called glial fibrillary acidic protein (GFAP) that may uniquely aid prediction of dementia in Mexican Americans. The study analyzed 745 participants over four years, finding that higher levels of GFAP predicted increased risk of developing dementia.
A new study finds that clinics supporting patients throughout the entire FIT process improve return rates and reduce colorectal cancer-related illness. Additionally, a telephone survey for dementia detection shows promise as a low-cost diagnostic tool, especially in primary care settings.
A telephone survey called Telephone Interview for Cognitive Status (TICS) was found to be effective in detecting dementia in primary care patients. TICS scored well as a low-cost diagnostic tool, with a score of less than 30 indicating a positive screen for dementia.
This cross-sectional study investigated the association between adverse childhood experiences and poor neuropsychiatric health in former NFL players. Football-related concussions were found to be significantly associated with increased risk of dementia and poor neuropsychiatric health among these athletes.
Research from the University of Minnesota found that lower left atrial function was associated with higher risk of developing dementia. Atrial myopathy, characterized by abnormal left atrial function and size, was identified as an independent risk factor for dementia.
A new study found that longer, more frequent daytime napping in older adults predicted worse cognitive performance and an increased future risk of Alzheimer's dementia. The researchers discovered a bi-directional link between the two, where excessive daytime napping sped up the increase in daytime napping during aging.
A new study found that excessive daytime napping among seniors is associated with an increased risk of developing dementia and Alzheimer's disease. After a diagnosis of mild cognitive impairment or Alzheimer's, daytime napping duration triples, suggesting that the brain's wake-promoting neurons may be affected by dementia pathology.
A retrospective analysis of nearly 30,000 patients found that those who received lithium were less likely to develop dementia. The study supports the possibility that lithium could be a preventative treatment for dementia.
Researchers at UC San Francisco have identified five genes that enable efficient sleep, contrasting with current thinking that lack of sleep accelerates neurodegeneration. These genes may confer protections against neurological disease and improve sleep quality, paving the way for new treatments.
A recent study found that individuals with a history of neurological or psychiatric conditions are at increased risk of developing a second condition. Women and men differ in their risk, with women being more likely to develop dementia after experiencing an earlier stroke.
Researchers found that brains from patients with Alzheimer's disease had higher levels of the protein Fli-1 and fewer pericytes lining their smallest blood vessels, leading to leakage. Blocking Fli-1 improved memory in mice, suggesting a promising new approach to treating the disease.
A recent study from the University of Kentucky's Sanders-Brown Center on Aging has shown promising results for a blood test that could identify Alzheimer's changes in the brain before symptoms appear. The test detects proteins associated with Alzheimer's and brain damage, which may indicate preventative treatments can be used.
A new study led by UC San Francisco reveals that 87% of seniors with dementia would stop at least one medication if their doctor said it was possible. Polypharmacy contributes to challenges with adherence and adverse interactions, but most patients are willing to reduce their medications.
Researchers at the University of Cambridge found that people with dementia have difficulty responding to unexpected situations, which is a symptom seen across every type of dementia. The study used magnetoencephalography to analyze brain activity in patients and healthy controls while listening to changing sounds.
Cedars-Sinai researchers identified two types of brain cells that divide continuous human experience into distinct segments, enabling the brain to recall memories. The discovery provides new hope for treatments of memory disorders like dementia and Alzheimer's disease.
Researchers have discovered a common thread between multiple neurodegenerative diseases, including Alzheimer's, dementia with Lewy bodies, and frontotemporal lobar degeneration. A protein called TMEM106B forms fibrils in diseased brain tissue, potentially hobbling cells.
A study by researchers at the University of Waterloo found that higher education and advanced language skills can protect against dementia in people with mild cognitive impairment. Almost one-third of participants reverted to normal cognition, while over 80% never developed dementia.
Researchers found that mislocalization of TDP-43 protein alters genetic instructions for UNC13A, providing a possible therapeutic target for treating ALS and FTD. The studies suggest that increasing UNC13A or stathmin 2 levels may prevent neuron death in these diseases.
A study of 53.6 million Medicare enrollees found COVID-19 associated increased mortality in older adults with Alzheimer's disease and related dementias, especially in nursing homes and minority populations. The results suggest a potential association between the pandemic and accelerated mortality rates for these vulnerable groups.
A new study has found that research participation is associated with greater use of and adherence to medications for dementia, while also revealing significant racial/ethnic disparities. The research suggests that Black and Latino participants had lower rates of medication uptake and persistent use compared to White participants.
Researchers at MUSC and University of Florida successfully visualize the complete human brain lymphatic system in living humans using a new non-invasive MRI technique. This breakthrough enhances our understanding of brain function and may provide insights into neurodegenerative diseases such as Alzheimer's.
Phosphorylated α-synuclein first appears at synapses near the site of inoculation, then spreads to axons and forms aggregates in neuronal cell bodies. This process begins in the synaptic region and may provide insight into prion-like propagation.
Researchers discover a genetic mechanism linking ALS and dementia to UNC13A protein corruption, providing hope for new treatments by blocking corrupted instructions. The study found that genetic variants increase the risk of UNC13A mRNA corruption in patients with ALS and FTD.
Researchers found that higher levels of dietary fiber, particularly soluble fiber, are associated with a lower risk of developing dementia. The study suggests that a high-fiber diet may play a preventative role in reducing the incidence of dementia.
A new discovery by VUB professor Ann Massie's research group reveals a strategy that prolongs life expectancy and preserves hippocampal function in the aging brain. The absence of system xc- has positive effects on mouse longevity and cognitive function, challenging current understanding of the aging process.
A study of 1.7 million New Zealanders found that those with mental health issues had three and a half times the risk of developing dementia than those without. The link holds true for both early and late onset dementia, as well as Alzheimer's and non-Alzheimer's forms.
A new study identifies common genetic factors in depression and Alzheimer's disease, suggesting a potential causal role of depression on dementia. The research found that depression played a significant role in AD development, with those experiencing worse depression experiencing faster memory decline.
Researchers found AI/AN adults with dementia face high hospital costs & chronic conditions, highlighting need for outpatient care & home services. Existing resources are often inadequate due to rurality & social determinants, leading to disparities in access.
A study using an Alzheimer's disease mouse model found that female brains experience a faster decay in information processing ability compared to male mice. This results in weaker memory formation and increased memory loss, contributing to the increased vulnerability of females to Alzheimer's disease.
Researchers found a significant association between mental disorders and dementia in a 30-year New Zealand study involving 1.7 million citizens. The study suggests that individuals with mental health conditions may be at higher risk of developing dementia, highlighting the importance of mental health care in preventing cognitive decline.
Researchers found that repetitive exposure to environmental hypoxia prevented memory loss and reversed impairments in nerve-to-nerve communication. Adult offspring also inherited this protection against dementia.
The Hastings Center Report examines four key considerations for assessing risk-trade-offs in the pandemic, including education, economies, healthcare, travel, social engagement, and medical countermeasures. The report also challenges traditional notions of advance directives in end-of-life care, proposing a new principle of patient aut...
Researchers will test the effectiveness of WeCAN, a group-based treatment designed to teach long-lasting management skills to individuals with traumatic brain injury and dementia. The study aims to identify behavioral, neuroimaging, and blood biomarkers that correlate with treatment efficacy.
A new study suggests that economic hardships exacerbated by COVID-19 and reliance on people outside their households for assistance increased older Latinos' exposure to the virus. Nearly 25% of Latinos reported a household member diagnosed with COVID-19, compared to 7% of non-Latino whites.
A Finnish twin study found that individuals with lower education are more susceptible to the negative effects of cardiovascular risk factors on late-life cognition. The study suggests that higher education can act as a cognitive reserve, helping to mitigate dementia risk.
A new study has found that Aboriginal Australians living in urban areas have high dementia rates comparable to those in remote areas. The study highlights the need for culturally appropriate and effective dementia risk reduction strategies due to ongoing social and health disparities.