Articles tagged with Dementia
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A new study published in PNAS has identified 33 metabolic compounds associated with dementia, which could aid in diagnosis and treatment. The researchers found that levels of these metabolites differed significantly between patients with dementia and healthy elderly individuals.
A large Swedish study found a link between ADHD and dementia across generations. Parents of individuals with ADHD had a 34% higher risk of dementia compared to those without ADHD, while grandparents had a 10% increased risk.
Rates of aortic valve replacement among individuals with Alzheimer's disease and related dementias increased over time, driven by TAVR. Mortality rates after aortic valve replacement declined in this patient population.
The National Institute on Aging has expanded its network of cutting-edge Alzheimer's disease and related dementias centers, with two new centers in North Carolina and Texas. The Duke/University of North Carolina ADRC will focus on understanding age-related changes across the lifespan and identifying disparities in dementia among differ...
A study led by Ruixue Zhaoyang found that frequent and pleasant social interactions can boost cognitive performance in older adults. Participants who reported more social interactions had better cognitive performance on the same day and for days following.
Researchers at the University of Helsinki have identified two distinct patterns of alpha-synuclein accumulations in the olfactory bulb, associated with differing disease types of dementia with Lewy bodies. These findings support the classification of the disease into two distinct forms, one progressing to the amygdala and another to th...
A new study highlights significant disparities in dementia care availability by gender, race, ethnicity, education level, and family structure. The findings emphasize the importance of family caregivers, with those having available spouse or adult child support being less likely to move into nursing homes.
A study from Denmark found that long-term exposure to road traffic and railway noise is associated with a higher risk of developing dementia, especially Alzheimer's disease. The researchers estimate that up to 1,216 cases of dementia in 2017 could be attributed to these noise exposures.
Researchers created tiny human midbrain-like organoids that mimic the major pathological features of Parkinson's disease. These organoids enable scientists to study how the human brain develops and communicates, providing insights into the progression of the disease and potential new treatments.
A UNSW psychology researcher recommends a set of neurocognitive and mental health questionnaires to harmonize the assessment of long COVID patients. These tests can be used internationally and in various cultural settings to address key questions about the problem, including brain fog and dementia risks.
Research found a strong correlation between Aβ42 peptide levels in companion dog brains and cognitive decline, supporting the use of dogs as models for Alzheimer's disease. The study's results demonstrate the potential of canine cognitive dysfunction as a tool for understanding human aging and age-related diseases.
A recent study found that fine particle pollution, specifically PM2.5, may contribute to the disproportionate number of African American women affected by dementia. Despite adjusting for various risk factors, Black women still had double the risk of developing Alzheimer's disease compared to white women.
Researchers created Community ASAP to help locate missing people with dementia, engaging community citizens as volunteers. The app aims to address the lack of alerts for this population, which has a high risk of wandering and experiencing serious injury or death within 24 hours.
The Cleveland Alzheimer’s Disease Research Center will receive funding to accelerate research on Alzheimer’s disease and related dementias. The center aims to develop individualized treatment approaches for individuals with aging-associated brain disorders.
The Alzheimer's Drug Discovery Foundation has provided NeuroVision Imaging Inc. with additional funding to accelerate the development of a novel blood-based lab test that can predict dementia before clinical onset. This technology has the potential to make diagnostic testing more practical, less invasive and less costly.
A new study published in Neurology found that people with lower scores on a dementia risk test may have lower thinking skills, more brain changes, and a higher risk of cognitive impairment. The study also showed associations between high scores on the test and poor memory function and markers of brain shrinkage in men.
Research suggests that people with mentally stimulating jobs have a lower risk of dementia in old age compared to those with non-stimulating jobs. Cognitive stimulation is associated with lower levels of proteins that may prevent brain cells from forming new connections.
A new study from King's College London found that exercise and poor nutrition can influence the risk of cognitive decline and dementia. The research suggests that altered neurogenesis in the brain could potentially represent an early biomarker for both conditions.
Research finds widespread pain associated with a heightened risk of all types of dementia, including Alzheimer's disease, and stroke. People with widespread pain were 43% more likely to have any type of dementia and 47% more likely to have Alzheimer's disease compared to those without widespread pain.
Researchers discovered that skin fibroblasts from FTD patients exhibit pathological RNA foci, p62 protein-containing vesicles, and defective energy metabolism, which could lead to the development of novel biomarkers and treatments. These findings may also be useful in testing drug effects on FTD patients.
Scientists discovered beige fat cells mediate subcutaneous fat's brain protection and provide anti-inflammatory effects. Beige fat transplantation restored cognitive function in obese mice with dementia-like behavior.
The National Institute on Aging's $280 million investment in small businesses has advanced research on care interventions, diagnostic tools, and therapies for Alzheimer's disease. This funding has enabled the commercialization of technologies such as ActivePERS and PrecivityAD, which aim to improve care and diagnosis.
The University of North Florida will lead a six-site study using computerized cognitive training to improve cognition and potentially prevent dementia. The five-year study aims to recruit 1001 participants from the Jacksonville area, with a focus on African American and Hispanic populations.
A recent study discovered that brain cells cannot maintain the myelin sheath in the absence of the TDP-43 protein. Restoring cholesterol levels has been proposed as a potential therapeutic strategy for neurodegenerative diseases associated with TDP-43. The research found that oligodendrocytes, responsible for producing myelin, have def...
Researchers from the University of Washington identified a strong link between fine particulate air pollution and an increased risk of dementia. A 1 microgram per cubic meter difference in PM2.5 pollution was associated with a 16% greater incidence of dementia, highlighting the potential neurodegenerative effects of air pollution.
Researchers at City of Hope developed a powerful miniature brain platform to study the causes of Alzheimer's disease and test dementia drugs in development. They used human stem cell technology to model sporadic Alzheimer's disease, finding that exposure to serum from blood can induce multiple symptoms.
A new study has found that harmful body fat can increase the risk of dementia and stroke, with grey matter atrophy being a key indicator. The research used genetic data from over 336,000 individuals to establish a link between obesity and declining brain health.
The NIH has launched Outreach Pro, an online tool designed to improve recruitment of underrepresented populations in Alzheimer's clinical trials. The platform provides customizable participant recruitment communications and culturally appropriate outreach materials.
Researchers estimate global dementia cases will nearly triple to 152 million by 2050 due to a combination of factors, including aging population growth and increasing risk factors like obesity and heart health issues. The highest increase is projected in eastern sub-Saharan Africa, North Africa, and the Middle East.
Reducing fine particulates and traffic-related pollutants in the air may lower dementia risk by 14-26% and slow cognitive decline. Studies found that older women living in cleaner areas experienced fewer cases of dementia and slower brain function deterioration.
Researchers recreated damage seen in a widely studied form of frontotemporal dementia by growing special types of cerebral organoids. The study found that the mutated tau protein triggers the death of specific class of neurons, which can be prevented with an experimental drug.
A large study found that high coffee consumption is associated with reduced brain volume and an increased risk of dementia. Researchers warn that excessive coffee drinking, beyond six cups a day, may put individuals at risk for brain diseases such as dementia and stroke.
A clinical trial found pimavanserin significantly improves sustained symptom benefit and reduces relapse rate in people with dementia-related psychosis. The treatment also showed fewer serious side effects compared to other antipsychotics.
A meta-analysis of 74 studies found young-onset dementia affects approximately 4.3% of people under age 65 worldwide. The study's results provide a more precise estimate of dementia's global occurrence in younger populations.
Andrea Gilmore-Bykovskyi, a UW Professor and researcher, wins Terrie Fox Wetle Rising Star Award for her work on social and behavioral communication patterns among individuals with moderate to advanced dementia. Her research aims to improve care and outcomes for persons living with Alzheimer's disease and related dementias.
A study of 1,978 people with an average age of 80 found that those who engaged in cognitively stimulating activities such as reading and playing card games delayed the onset of Alzheimer's dementia by up to five years. The research suggests that it may be beneficial to start doing these things, even in your 80s.
The American Academy of Neurology provides ethical guidance for neurologists caring for people with Alzheimer's disease and other dementias. The position statement emphasizes the importance of respecting patient autonomy, involving families in care decisions, and addressing ethnic disparities in dementia diagnosis and treatment.
A new study published in Age and Ageing found that hypothetical adverse life scenarios, such as dementia and chronic pain, significantly reduce people's desire to live into older ages. The study analyzed data from Norway, where the average preferred life expectancy was 91.4 years.
A new grant from the NIH is supporting the development of an AI-powered smartphone app that scans speech and vocabulary patterns to catch early signs of Alzheimer's disease. The app aims to provide affordable and accessible self-assessment technology, potentially encouraging patients to seek help sooner.
The National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) at IU School of Medicine has been renewed with a $30 million NIA grant over five years. The repository supports research on causes, early detection, and therapeutic development for Alzheimer's and other dementias.
Researchers at Tohoku University have identified a novel disease-modifying therapeutic candidate SAK3 that rescues neurons in most protein-misfolding neurodegenerative diseases. SAK3 administration significantly prevented progression of neurodegenerative behaviors, including cognitive impairment and motor dysfunction.
A new online calculator can predict an individual's risk of dementia in the next five years by assessing factors such as age, physical activity, diet, and stress. The tool, developed by Canadian researchers, aims to empower individuals to modify their lifestyle and reduce their risk.
A three-year study found significant changes in brain connectivity in older adults with subjective cognitive decline, which may predict dementia. The study suggests that brain alterations underlie the experience of decline and could emerge before cognitive assessments detect a deficit.
A study by University of Bath researchers found that augmented reality prompts with a 'ghosthand' are more effective for older adults, leading to faster completion and increased confidence. The study highlights the need for designers to prioritize inclusivity and usability in AR applications to cater to this growing demographic.
A third of Americans employ unregulated caregivers for older adults and those with dementia, highlighting gaps in access to care. Gray market caregivers often lack training and screening, increasing potential for exploitation or abuse.
A new study found that statin therapy is not associated with an increased risk of cognitive decline and dementia in older adults. Researchers analyzed data from the ASPirin in Reducing Events in the Elderly trial and found no significant difference in the incidence of dementia and mild cognitive impairment between statin users and non-...
A two-year study will explore the health benefits of older people adhering to a Mediterranean diet and undertaking daily walking. Early pilots show improved memory and thinking in participants who followed the MedWalk intervention.
Researchers found no protection against Parkinson's and Lewy body dementias when reducing tau protein in brain neurons. Instead, the study highlights distinct roles of tau in these diseases compared to Alzheimer's, where reducing endogenous tau levels is protective.
Studies of people with RA show a decline in dementia risk over time, from 12.7% to 6.2% between the 1980s and 2000s. Heart failure risks also decrease, with no excess risk seen in 2000s compared to general population.
A systematic review of 501 chatbot apps found that none performed well on all testing criteria, with linguistic biases and usability challenges. The apps' limited program content made it hard to have extended or varied conversations between users and chatbots.
Research found that lipophilic statins double the risk of developing dementia in patients with mild cognitive impairment. PET scans revealed a decline in brain metabolism, particularly in the posterior cingulate cortex.
A novel tau protein conformation, cis P-tau, is a toxic early driver of Alzheimer's disease and related dementias. Silencing of this protein through immunotherapy has been shown to prevent disease pathology and memory loss in preclinical models.
Researchers at the University of Bradford say naked mole rats' long lifespan and resistance to cancer could lead to new treatments for degenerative diseases like cancer and dementia. The animals' unique DNA repair mechanism may provide insights into preventing these conditions, with potential applications in humans.
A large-scale brain epigenetics study has identified 84 new genes linked to dementia, providing new insights into the disease. The study found that epigenetic changes in the brain can be consistently distinguished from those without the disease, with over 70% accuracy.
A personalized soundscape using AcustiCare can help individuals with dementia by providing clues about time of day and place. The system refines the sounds to reinforce time and space, improving sleep quality, reducing agitation and distress, and decreasing stress on caregivers.
A national panel of experts recommends recognizing seven major modifiable risk factors for dementia and taking steps to lower risk through medication, lifestyle changes, and interventions. By controlling vascular risk factors, people can preserve cognitive function and reduce heart attack and stroke risk.
A study of over 700,000 TBI patients found that those with sleep disorders had a 25% higher risk of developing dementia. The risk was similar for male and female patients, highlighting the importance of targeted awareness about sleep disorders in TBI patients.
A study published in Nature Communications has identified a single biomarker, neurofilament light chain (NfL), that can accurately reveal underlying neurodegeneration in people with cognitive issues. NfL levels in blood were found to be higher across all neurodegenerative disorders compared to those with no cognitive problems.
A new international study has identified a drug that can halt the progression of chronic traumatic encephalopathy (CTE) in sportspeople who sustain repeated head injuries. The treatment was successfully tested in animal models and shows promise for preventing neurological problems associated with CTE, which affects cognition and behavior.
Researchers found that patients with dementia and especially Alzheimer's are three times more likely to die from COVID-19. The risk is six times greater for those over 80. Chronic inflammatory conditions or defective immune responses may contribute to the increased vulnerability of these patients.