Articles tagged with Dementia
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Researchers found that people with low blood sugar events had a 75% greater risk of developing dementia, while those with high blood sugar events had more than twice the risk. People experiencing both types of events faced the greatest risk, with an incidence rate of 98.5 cases for every 1,000 person-years
Researchers found that disturbances in cholesterol catabolism are associated with increased risk of Alzheimer's disease and vascular dementia. The study also suggests that bile acid synthesis may impact brain signaling pathways, leading to sex-specific effects on dementia progression. Further studies are needed to confirm these findings.
A study found that the Tsimane indigenous people have slower brain atrophy than Westerners, suggesting their physically active lifestyle and high-fiber diet may hold the key to slowing down aging. The researchers enrolled 746 Tsimane adults in their study and compared their brain volumes with those in three industrialized populations.
Research suggests that spending moderate amounts of time watching television during midlife is associated with greater cognitive decline and lower brain volume. This could be due to prolonged sedentary behavior affecting brain health, which may impact overall well-being in later life.
Researchers found that adopting healthy lifestyle behaviors can significantly lower dementia risk for those at higher risk due to a family history of dementia. Participants who followed more healthy behaviors had lower rates of familial dementia and were less likely to develop dementia overall.
The Alzheimer's Drug Discovery Foundation and The Association for Frontotemporal Degeneration recommend adopting best practices in designing exploratory trials, including rigorous statistical analyses and biomarker selection. These recommendations aim to reduce costs and improve patient engagement in clinical trials.
A study of over half a million people found that certain mid-life cardiovascular risk factors are associated with dementia in both men and women. However, the relationship between blood pressure and dementia risk varies by sex, with higher blood pressure linked to increased risk in women.
A large study of plasma proteins and dementia found abnormal blood levels of dozens of proteins up to five years earlier may predict dementia, including Alzheimer's disease. High levels of one protein, SVEP1, are linked to the disease process.
A new study found that individuals experiencing pre-loss grief symptoms can adjust, but certain factors such as gender and caregiving burden exacerbate the experience. The research documented a significant correlation between dementia patients' family members and severe pre-loss grief.
People with dementia have twice the risk for developing COVID-19, with high hospitalization rates and mortality. Alzheimer Europe urges governments to prioritize these groups in vaccination campaigns to prevent further harm.
A large observational study by Karolinska Institutet researchers found a clear link between poor kidney function and increased risk of dementia. The study of over 325,000 individuals suggested that an eGFR score of 30-59ml/min was associated with a 71% increased risk of dementia.
A study analyzed 121 published studies on virtual and in-person cognitive assessments for diagnosing dementia or mild cognitive impairment. The analysis found good reliability and accuracy of virtual assessments for diagnosing dementia, but identified barriers to implementing cognitive assessments for older adults.
Researchers found that people with reduced kidney function have an increased risk of developing dementia, with those with moderate chronic kidney disease having a 71% higher risk. The study highlights the importance of identifying and treating cases of kidney disease to reduce the risk of dementia.
A new study published in Ageing Clinical and Experimental Research found that older people with vision loss are more likely to suffer mild cognitive impairment, a precursor to dementia. The research examined World Health Organisation data on over 32,000 people and found a significant correlation between vision loss and increased risk o...
A new algorithm developed by researchers from the University of Eastern Finland uses blood biomarker measurements to aid in early diagnosis and differentiation between types of dementia. This innovation aims to provide precise diagnoses, enabling targeted treatment and improving patient outcomes.
Using naturalistic driving data, researchers developed random forests models that accurately predicted mild cognitive impairment and dementia with 88% accuracy. The study identified age, trip patterns, and braking events as key predictors of the conditions.
A recent study examined the association between age at diabetes onset and subsequent dementia risk. The research found that younger individuals with type 2 diabetes were more likely to develop dementia compared to those who developed diabetes at an older age.
A new study used autopsy data to evaluate the AT(N) framework, a standard tool for assessing Alzheimer's risk. The researchers found that even in the highest-risk group, a third of individuals did not develop dementia, highlighting the complexity of Alzheimer's disease and the need for additional biomarkers.
A pilot program in five Australian nursing homes shows personalized music selections reduce resident agitation and staff stress levels, leading to improved wellbeing and reduced medication use.
A new UCLA study finds that a one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia. The therapy, developed from glial cells, stimulates the brain's own repair processes and enhances neural connections.
A study published in JAMA Network Open explores the experiences of individuals with young-onset dementia and their partners, highlighting the importance of open communication and mutual problem-solving. The research team developed a couples-based framework to describe coping patterns, which can inform new interventions and increase qua...
A recent Baycrest study found that engaging in household chores is associated with greater brain volume and improved cognitive health in older adults. Household activities such as tidying, meal preparation, and yard work may contribute to these benefits by promoting neural connections and reducing sedentary behavior.
Research suggests that social and economic conditions in neighborhoods can affect brain health, with people living in disadvantaged areas showing faster decline on cognitive tests and more brain shrinkage on scans. The study's findings may indicate the earliest stages of dementia and highlight the importance of monitoring for early signs.
Researchers have found that treatments to reduce levels of hydrogen sulfide in the brain may help ward off damage caused by the gas, which is involved in blocking key brain cell gateways. The study shows that H2S disrupts normal brain functioning and can lead to nerve cell death.
A recent study has discovered a profound loss of ability to experience pleasure in people with early-onset dementia, known as frontotemporal dementia (FTD). Grey matter deterioration in the 'pleasure system' of the brain was found, distinct from those implicated in depression or apathy.
A new study found that positive airway pressure therapy for obstructive sleep apnea reduces Alzheimer's disease and other types of dementia risk. Researchers analyzed Medicare claims of over 50,000 Medicare beneficiaries ages 65+, finding a significant association between PAP use and lower dementia risk.
The University of South Florida has received a five-year, $44.4 million NIH grant to conduct the largest primary prevention trial of computer-based cognitive training for preventing mild cognitive impairment and dementias like Alzheimer's disease in older adults. The study aims to test whether this type of training can reduce the risk ...
A new study published in Neurology found that losing function in both senses may put individuals at greater risk of dementia and cognitive decline years later. Researchers analyzed data from 6,520 people between the ages of 58 and 101, finding that those with both hearing and vision impairments were twice as likely to develop dementia.
Scientists at the University of Cambridge have demonstrated a new approach to gene therapy that may help repair damage caused by neurodegenerative conditions like glaucoma and dementia. The study, published in Science Advances, shows promise for treating chronic degenerative diseases.
A study led by Georgia State University researchers found that residents with dementia in assisted living facilities benefit from being included in activities and having caregivers meet them where they are. This approach improves quality of life for individuals with varying types of dementia and levels of functional ability.
A new study published in the Journal of Alzheimer's Disease found that COVID-19 patients with dementia were more likely to experience delirium and confusion compared to those without dementia. While dementia itself was not a primary driver of mortality, other factors such as age and comorbidities played a significant role.
Research published in British Journal of Ophthalmology found that normal-tension glaucoma is associated with an increased risk of cognitive impairment and possibly dementia. The study suggests that the disease pathways for normal-tension glaucoma may be similar to those for dementia.
Researchers at Flinders University in Australia have found a link between normal-tension glaucoma and cognitive impairment, with patients having this type of glaucoma being more than twice as likely to develop dementia. The study suggests that normal-tension glaucoma may share similar neurodegenerative pathways with dementia.
Researchers have discovered 12 genetic regions linked to lacunar strokes, which can lead to long-term disability and dementia. The study provides new hope for preventing and treating this devastating type of stroke.
Research suggests non-drug therapies like exercise and social interactions may reduce symptoms of depression in people with dementia. These interventions are found to be as or more effective than drugs in treating depression, suggesting a shift towards 'social' prescribing.
Researchers evaluated the association between a recent dementia diagnosis and suicide attempt among older adults. The study found that individuals with dementia were at a higher risk of attempting suicide compared to those without the condition.
Persistent midlife loneliness is linked to a higher risk of developing dementia and Alzheimer's disease, while transient loneliness may actually reduce the risk. Researchers found that recovering from loneliness after 18 years may also lead to lower risk of dementia onset.
A large proportion of dementia deaths in England and Wales may be due to socioeconomic deprivation, according to new research. The team found that socioeconomic deprivation was associated with younger age at death and poorer access to accurate diagnosis.
A study of 500,000 participants found that eating 25g of processed meat daily was associated with a 44% increased risk of developing dementia. In contrast, consuming 50g of unprocessed red meat daily was linked to a 19% lower risk of the disease.
Primary care professionals can identify and monitor risk factors early to prevent cognitive decline. The American Heart Association recommends addressing 13 key factors to optimize brain health, including Life's Simple 7 lifestyle targets.
Researchers at Case Western Reserve University have determined the structure of protein fibrils linked to Lou Gehrig's disease and other neurodegenerative disorders. The findings provide clues on how toxic proteins clump and spread between nerve cells in the brain, potentially leading to the development of new treatments.
A recent study published in Annals of Clinical and Translational Neurology found that head injuries in people under 50 can lead to lower cognitive scores at age 70. The researchers discovered a small but significant impact on brain health and thinking skills, potentially accelerating the normal aging process.
Researchers found a strong association between ischemic stroke occurrence and severity with an increased risk of dementia. The study's findings emphasize the importance of preventing stroke to maintain high levels of physical and cognitive function and quality of life.
Research suggests that people with severe retinopathy are more likely to have a diseased-looking brain on MRI. The study found an association between retinopathy and increased risk of stroke, dementia, and mortality in adults.
A new study found that 1 in 7 people with dementia are taking at least three brain and nervous system medications, which can accelerate memory loss and increase the risk of falls, overdoses, and death. Regular prescription drug reviews could help spot risky combinations.
A new Penn Medicine research reveals that a single head injury can lead to dementia later in life, with the risk further increasing with more head injuries. Women and white participants are at higher risk of dementia after head injury compared to men and black participants.
Researchers found a significant association between estrogen receptor α PvuII polymorphisms and dementia in a Brazilian cohort. The study suggests that this polymorphism may contribute to the development of dementia, particularly in elderly populations.
Researchers from Kanazawa University developed a new computerized cognitive test that can accurately screen for mild cognitive impairment (MCI) and dementia in under 5 minutes. The test, called the C-ABC, has been shown to be effective in distinguishing normal cognition from MCI and dementia using scores from just two questions.
A recent analysis found a lack of consensus regarding palliative care referral in dementia patients, highlighting the need for standardized criteria. Specialist palliative care can optimize quality of life and provide relief from symptoms, but its application varies widely.
Researchers at UTA will match students with dementia patients for a two-year project using reminiscence therapy and digital memoirs to improve social and emotional well-being. The team hopes this intergenerational approach will promote better outcomes for older adults with Alzheimer's disease.
The report reviews recent changes in EU research policy, identifies key barriers and enablers for data sharing, and maps the Horizon 2020 dementia research portfolio. Key findings include a need to overcome technical, financial and motivational obstacles to data sharing, as well as involving people with dementia in research design.
Researchers discovered white matter hyperintensities are more common and severe in people with frontotemporal dementia compared to Alzheimer's disease and healthy controls. The study suggests these changes contribute to cognitive problems rather than vascular factors.
A genetic study of Lewy body dementia suggests that the disease is caused by a spectrum of problems seen in both Alzheimer's and Parkinson's diseases. Five genes have been identified as critical to the development of Lewy body dementia, with variations in these genes also linked to increased risk of Alzheimer's and Parkinson's diseases.
A study published in Journal of the American College of Cardiology found that mid-life cardiovascular disease prevention can protect against later dementia. The research suggests that controlling cardiovascular risk factors early on can reduce brain vulnerability to cognitive dysfunction.
A recent study published in Aging found that very short sleep duration, poor-quality sleep, and snoring were associated with a higher risk of incident dementia. The study also revealed an increased risk of all-cause mortality among participants who reported less than five hours of sleep per night.
A study found patients with dementia twice as likely to contract COVID-19 and experience worse outcomes. African Americans with dementia faced a near-threefold higher risk of infection. The researchers emphasized the need for strategies balancing safety from COVID-19 with protection from social isolation and health-related harms.
A recent 18-year study by Imperial College London reveals that cancer is now the leading cause of death among people with diabetes in England. Death rates from heart disease and stroke declined significantly during this period, but improvements were more modest for cancer-related deaths.
A research team from the University of Kansas is developing autonomous driving technology for people with cognitive impairments, aiming to increase mobility and independence. The team will refine highly automated driving systems designed for individuals with mild cognitive impairment and dementia.
Researchers at INRS have discovered two early plasma markers that can detect Alzheimer's disease five years before its onset, enabling earlier intervention. The study found that these markers are present in plasma extracellular vesicles and can be analyzed through a blood test, opening up new possibilities for studying the disease.
A new study suggests that people with enlarged fluid-filled spaces in the brain around small blood vessels are more likely to develop cognitive problems and dementia over time. Researchers found that those with severe cases were nearly three times more likely to develop dementia than those with fewer or no enlarged spaces.