Articles tagged with Dementia
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A new program will continue dementia surveillance and invigorate the brain donation program using FHS participants' cognitive assessments and brain imaging. The program aims to identify genetic and biomarker factors related to Alzheimer's disease and develop strategies to preserve cognition.
Scientists have discovered a potential effective treatment for Frontotemporal Dementia (FTD) using Ursodeoxycholic Acid, an already approved liver medication. The drug has been shown to increase protective proteins in neurons and prevent cell death, offering new hope for patients.
The Alzheimer's Disease Programs Initiative (ADPI) aims to build upon existing home and community-based social supports to enable people with Alzheimer's Disease and Related Dementias to remain independent in their communities. People with ADRD and their caregivers will receive coaching, training, and support services.
Researchers found that older people without cognitive problems who experience a fall may have already begun neurodegeneration leading to Alzheimer's dementia. The study suggests that falls in this population are linked to brain changes that can be prevented with environmental modifications.
A new study suggests that lifestyle improvements can lessen cognitive decline in older adults by improving their lifestyles and boosting cognition. The results indicate that brain neuroplasticity can be retained through targeted interventions, enabling individuals to bounce back from decline.
The National Institute on Aging has funded four new exploratory Alzheimer's Disease Research Centers to broaden current research initiatives with underrepresented populations. These centers will prioritize rural communities and focus on specific scientific areas such as vascular risk factors and disparities in the Deep South region.
Researchers found that Medin protein deposits reduce blood vessel elasticity in aging brains, contributing to vascular dementia. These deposits also cause sluggish vessel expansion, affecting blood flow and oxygen supply.
A large observational study found that both overall alcohol consumption and alcohol-induced loss of consciousness are associated with an increased risk of developing dementia. The study of over 131,000 adults suggests that limiting or avoiding heavy drinking may be beneficial for preventing cognitive decline.
A pre-clinical study suggests that an investigational drug reduces the buildup of toxic poly(GR) proteins and TDP-43 clumps, which contribute to neurological decline in patients with ALS and FTD. The study found that treatment with a pipeline drug reduced neurodegeneration in mouse models.
A University of Houston researcher is investigating the adverse effects of mixing cholinesterase inhibitors and antimuscarinics in patients with Alzheimer's disease. The study aims to evaluate drug interactions and their effects on severe adverse events, ultimately improving the quality of medication use in dementia care.
Older caregivers of newly diagnosed dementia patients experience a 30% increase in depressive symptoms, which persists over two years. This is significantly higher than those without a partner diagnosis, with an additional 27-33% increase depending on the length of caregiving time.
Researchers at Newcastle University propose a new theory that links hearing loss to dementia, suggesting that the auditory system's impact on brain function may trigger Alzheimer's disease. The study identifies key aspects of this connection, including memory centers and cognitive impairment.
A new study by Max Planck Institute researchers found that the risk of cognitive impairment and dementia in US men and women increased over two decades. The analysis controlled for learning effects when repeating the same test, revealing a trend reversal compared to previous studies.
A new study found that robotic support pets for older adults and people with dementia acquire bacteria over time, posing a risk of illness. However, a simple cleaning procedure involving anti-bacterial products and wipes can effectively reduce microbial loads to safe levels.
A new study finds that dementia may be the underlying cause of nearly three times more deaths in the US than previously thought. The study estimates that 13.6% of deaths are attributable to dementia, which is 2.7 times more than the 5.0% of death certificates that indicate dementia as an underlying cause of death.
Researchers have identified a new form of dementia, LATE disease, which shares symptoms with Alzheimer's but is caused by different brain processes. The study provides criteria to differentiate between frontotemporal dementia and LATE disease, offering hope for future therapy development.
A new dementia education program has shown significant improvements in dementia knowledge and attitudes among primary school students. The intergenerational program brings together children and older adults, promoting empathy and understanding.
A new study found that nearly three-quarters of older adults with dementia have filled prescriptions for medicines not designed for dementia, posing special risks. Antidepressants, opioids, and other drugs were commonly prescribed, often without addressing the underlying issues, and may even worsen cognitive symptoms.
A new diagnostic definition for Functional Cognitive Disorder (FCD) has been established, allowing researchers to better characterise the condition and its prognosis. The criteria also hold promise for strengthening research into dementia by identifying patients for trials.
Baycrest researchers are studying the effects of COVID-19 and social isolation on cognitive health, finding a potential link between respiratory symptoms and decreased oxygen to the brain. The study aims to identify factors predicting dementia development in older adults.
A new study proves that the McKee CTE staging scheme accurately represents the progression of tau pathology in CTE, correlating with clinical dementia and age at death. Researchers found five brain regions with increasing p-tau pathology that conform to CTE stage, age, and years of football play.
A new study published in Neurology found that people who experience a sudden drop in systolic blood pressure when standing up may be at higher risk of developing dementia years later. The study also showed that controlling these blood pressure drops could be a promising way to help preserve people's thinking and memory skills as they age.
The Dementia Friendly Church programme has had a significant impact, improving interactions between church attendees and people with dementia. The project involves making practical changes to church layouts, worship, and hospitality to create 'friendly spaces' for those living with dementia.
Experts identify 12 modifiable risk factors that can be targeted throughout life to delay or prevent dementia. The report highlights the potential for preventive measures to reduce dementia risk, particularly in low- and middle-income countries.
Researchers have identified measurable Alzheimer's risk factors in adolescents and young adults, emphasizing the need for early interventions targeting heart health and education. Studies found that high blood pressure, diabetes, and poor educational quality are associated with worse late-life cognition, particularly in African Americans.
A new report from the Lancet Commission identifies 12 modifiable risk factors that can delay or prevent 40% of dementia cases. These include reducing excessive alcohol intake, limiting air pollution, and promoting physical activity throughout life.
A study of 8,275 participants found that those with severe gum disease had twice the risk for mild cognitive impairment or dementia. People with minimal tooth loss and mild gum disease were no more likely to develop thinking problems than those with no dental issues.
A phase 3 trial found pimavanserin to be effective in reducing psychotic symptoms in people with dementia, regardless of underlying dementia subtype or severity. The treatment works differently than other antipsychotics, showing promise for improving the lives of those affected by psychosis.
Two studies indicate that WTC responders are at risk for developing dementia, with reduced gray matter thickness in the brain consistent with neurodegenerative conditions. Researchers found protein changes in blood consistent with Alzheimer's disease in responders with PTSD and mild cognitive impairment.
Research reveals flu vaccinations can reduce Alzheimer's incidence by up to 17%, with pneumococcal vaccination showing a similar protective effect. Vaccination also found to reduce mortality in people with dementia.
Research finds concussion associated with increased risk of developing ADHD, mood and anxiety disorders, dementia and Parkinson's disease. Concussions upsets brain function and blood flow, potentially leading to long-term consequences.
A recent study found that over 40% of hospitalizations among older adults with dementia were for potentially preventable conditions, such as pneumonia and heart failure. The study's lead author emphasized the importance of addressing sepsis and implementing patient-centered programs to improve outpatient care.
A new Boston University School of Public Health and School of Medicine study finds that genetic risk factors for dementia can be lowered by improving cardiovascular health. Participants with a high genetic risk score were 2.6 times more likely to develop dementia, but those with good cardiovascular health were half as likely.
A UCSF study found that older adults with retained senses of hearing, vision, and touch have half the risk of developing dementia compared to those with marked sensory decline. The study tracked over 1,800 participants in their seventies for up to 10 years, revealing a stronger association between olfaction and lower dementia risk.
Research identified 21 evidence-based suggestions for preventing Alzheimer's disease, with a focus on vascular risk factors and lifestyle modifications. Targeting factors such as cognitive activity, high blood pressure, depression, diabetes, and stress may help reduce the risk of developing Alzheimer's disease.
Researchers found that high genetic risk scores, including apolipoprotein E ε4, increase dementia risk by 2.6 times, while favorable cardiovascular health reduces the risk by 0.45 times.
Researchers discovered that individuals with Alzheimer's disease and dementia experience more severe delirium and increased risk of hospitalization compared to those without ADRD. Targeted strategies can help prevent or reduce delirium severity, particularly in patients with ADRD.
Research reveals that many caregivers of individuals with Alzheimer's and Related Dementias (ADRD) lack guidance on firearm safety, despite high rates of accidental shootings. The study emphasizes the need for healthcare providers to address firearm safety in the context of ADRD, providing routine counseling and access to resources.
Researchers have identified a new biomarker, asymmetric dimethylarginine (ADMA), associated with cognitive decline in old age. The study found that ADMA levels were linked to decline in cognitive performance assessments after four years.
Research suggests that antioxidant treatment after acute ischemic stroke could delay the onset of Alzheimer's dementia by reducing oxidative stress and promoting mitochondrial function. Studies have shown promising results with molecules like edaravone and nerinetide, but more research is needed to confirm these findings.
A new study published in Neurology suggests that deep brain stimulation for Parkinson's disease does not significantly increase the risk of developing dementia. Researchers found that factors such as age, hallucinations, and cerebral hemorrhage during surgery were associated with a higher risk of dementia.
A new study will test a training model for primary care nurses to improve the lives of dementia patients by enhancing assessment, management, and coordination of care. The researchers aim to reduce emergency room visits, health care costs, and improve quality of life for patients and caregivers.
A recent study by the University of Kentucky's Sanders-Brown Center on Aging has identified a previously under-recognized form of dementia, quadruple misfolded proteins (QMP), linked to TDP-43 proteinopathy. The study found that about 20% of participants with dementia had QMP, resulting in the most severe dementia cases.
Researchers at the Allen Institute in Seattle are building a high-resolution map of Alzheimer's disease by comparing brain cells across patients with different stages of the disease. By identifying specific neurons and cell types affected by the progressive disorder, they aim to find new drug targets and potential therapies.
Researchers propose that elevated pulse pressure in blood traveling to the brain can cause inflammation, oxidative stress, and cellular dysfunction, leading to brain damage and cognitive decline. The study suggests reducing elevated pulse pressure could prove synergistic with other therapeutic approaches to treat dementia.
Research links inflammatory bowel disease (IBD) to a doubled risk of developing dementia, with diagnoses occurring 7 years earlier. The study suggests that an imbalance in gut bacteria and chronic inflammation may contribute to cognitive decline.
A new study published in the International Journal of Epidemiology found that obesity is associated with a higher risk of dementia, with women facing a 39% increased risk. The study suggests that weight management could play a significant role in reducing this risk.
New Zealand centenarians exhibit low rates of chronic diseases such as diabetes, depression, and hypertension. Socially active participants showed similar patterns across age groups, while exercise improved health without significant effects on ageing.
The Vietnam Era Twin Study of Aging will continue to follow and document risk factors for cognitive and brain aging in 1,600 male twins. The study aims to identify early signs of Alzheimer's disease and mild cognitive impairment.
A study found that an undergraduate service-learning course using music and filmmaking helped students connect with people with dementia, share unique stories, and process new experiences. The creative approach has the potential to humanize dementia and motivate a new generation of healthcare professionals.
A new UCL-led study found that repetitive negative thinking is linked to cognitive decline and increased risk of Alzheimer's disease. The research, published in Alzheimer's & Dementia, suggests that psychological tools like mindfulness or meditation may help reduce dementia risk.
The new app, called neureka, uses brain games and self-reflection challenges to collect data on mental health and dementia research. It aims to identify modifiable risk factors for disorders of the mind and capture complex datasets to develop individualized understanding of brain health.
A $2.6M NIH award will examine how sex differences impact cognitive impairment and dementia, with a focus on the brain vascular system. The project aims to uncover personalized molecular targets for therapy and improve treatment of dementia.
Researchers have developed an antibody that can accurately detect and quantify toxic amyloid-beta oligomers, a hallmark of Alzheimer's disease. This discovery could lead to improved diagnostic methods and ultimately help monitor the progression of the disease.
NUI Galway research shows that taking blood pressure medications can reduce the risk of developing dementia and cognitive impairment by 7%, and cognitive decline also by 7% over a four-year period. The study highlights the critical importance of controlling blood pressure in maintaining brain health, combined with a healthy lifestyle.
Researchers found that individuals with higher cardiovascular risk burdens experienced faster declines in episodic memory and working memory, as well as smaller hippocampal volumes. Maintaining heart health may be key to preventing cognitive decline, according to the study's findings.
A study of 7,000 adults aged 65 found that those with dementia and poor vision experience significant limitations in self-care, mobility, and household activities. The research highlights the need for better support systems to address these challenges.
An undergraduate course curriculum combined music, filmmaking, and reflective writing to help students connect with people living with dementia. More than half of the students continued engaging with participants after the course, highlighting the potential of arts and music courses in shaping perceptions about dementia.
A study of 2,800 people aged 50 and older found that low intake of flavonoid-rich foods was linked to a higher risk of developing Alzheimer's disease. Consuming more berries, apples, and tea may help prevent the condition, with even small amounts providing benefits.
A team of Emory scientists compared the most common inherited form of amyotrophic lateral sclerosis and frontotemporal dementia with spinocerebellar ataxia type 36. They discovered that protein products can poison cells in one disease but not the other, providing new insights into their pathological mechanisms.