Researchers found that reduced expressions of E-cadherin and P120 were associated with tumor grade and patient survival in cholangiocarcinoma. These biomarkers may serve as potential diagnostic and prognostic indicators for ICCs.
Researchers found that fecal levels of FC and MPO can be used as surrogate markers for successful treatment outcome in IBD patients. The study also showed that elevated fecal markers are associated with relapse, but normalized FC level may indicate successful treatment.
Two novel histone deacetylase inhibitors, NVP-LBH589 and NVP-LAQ824, have been shown to suppress the growth of human pancreatic cancer cells and induce apoptosis in vitro and in vivo. Further studies are recommended for their potential treatment.
Astronomers have discovered a mysterious celestial object emitting visible-light flashes before disappearing. It is likely to be a missing link in the family of neutron stars, exhibiting powerful magnetic activity.
A recent survey found that most infertility patients support using leftover embryos for stem cell research, with 73% in favor. However, there is a growing demand from patients who want to sell their extra embryos to others, with 56% approving of the practice.
Scientists at Georgetown University Medical Center identified a new way to limit brain cell damage by reducing microglial activation. They found that a selective activator of a key receptor can turn off microglial activity, potentially treating conditions like stroke, Alzheimer's disease, and Parkinson's disease.
A study by Baylor College of Medicine researchers reveals a critical function of the MeCP2 protein in regulating neuronal behavior, particularly in relation to stress, aggression, and obesity. The findings demonstrate that MeCP2 is essential for tempering neural responses, enabling appropriate behavior in novel social situations.
The Swiss Institute of Bioinformatics has produced an encyclopaedic knowledge capturing the functions and interactions of human proteins. The dataset covers 20,325 human proteins and will speed up scientific work aimed at improving quality of life, particularly in combating genetic-based diseases.
Researchers have discovered two new species of bacteria growing on the walls of Rome's ancient tombs, which may help preserve these sites. The bacteria, belonging to the Kribbella group, can produce enzymes and antibiotics with useful properties.
A US neurosurgeon reports promising results treating soldiers with severe brain injuries in Iraq, where aggressive therapies led to unexpected survival rates. In contrast to predicted dire outcomes, some patients showed remarkable recovery, challenging the predictive value of standard neurological assessments.
The metagenomics field is gaining traction, allowing researchers to reconstruct metabolic profiles of microbes from environmental samples. DOE JGI's advancements in this area are crucial for understanding microbial diversity, as they have characterized many metagenomes across various ecosystems, including acid mine drainage and gut env...
Scientists developed a new method to control and image individual fluorescent electron transfer molecules, revealing mavericks that shine when they shouldn't. This study aims to better understand electron transfer reactions central to photosynthesis and biofuel production.
Researchers found that probiotic bacteria can efficiently mature monocyte-derived dendritic cells, leading to the production of specific cytokines. The maturation process was triggered by different bacterial strains, with some inducing pro-inflammatory and others anti-inflammatory responses.
Climate change is expected to cause significant economic impacts on US states, with total costs running into billions of dollars for North Carolina, North Dakota, Pennsylvania, and Tennessee. The studies also highlight the need for quick action to mitigate these effects, as delayed action will only worsen the situation.
A novel case of coexisting small cell neuroendocrine carcinoma and villous adenoma in the ampulla of Vater is reported. The patient underwent Whipple's operation, but unfortunately died from pneumonia three months post-surgery.
Researchers found a significant relationship between loss of heterozygosity (LOH) frequencies on the D4S3018 locus and larger tumor size. Additionally, LOH at the D4S1534 locus was linked to liver metastasis in sporadic colorectal carcinoma patients.
Researchers developed a secretory Apoptin fusion protein that induces apoptosis in hepatocellular carcinoma HepG2 cells, offering new potential for cancer gene therapy. The study's findings suggest the therapeutic usage of Apoptin may be increased with its secretory characteristic.
Researchers at NC State University have developed a video game program called GRADUATE to help North Carolina high school students fulfill the state's new graduation project requirement. The program aims to foster science achievement and IT skills while motivating students to pursue STEM degrees and careers.
The study found that CAPHOSOL treatment significantly limits the occurrence and severity of oral mucositis, with high levels of medication compliance and patient/physician satisfaction reported. Compliance was very high, with nearly all patients rinsing with CAPHOSOL at least once daily.
Studies found that people with high sociability tend to migrate to urban areas over long distances, while those with high activity have a tendency to move both urban and rural locales. Emotional individuals are more likely to move away from home but don't migrate far or often.
A USC survey of 7,000 EverQuest II players found that older players were more typical, with playing time increasing with age. Women logged more hours in the game and were less likely to quit, while also exercising regularly. The study suggests that online gaming may not compromise mental health, contrary to stereotypes.
A new study has found that cochlear implantation in children is a safe procedure, with complications occurring at a rate below 3%. The researchers also reported very low device failure rates, making the procedure an attractive option for families. Continuous follow-up is critical to ensure optimal outcomes.
A study by University of Rochester Medical Center researchers found that physicians' personalities, particularly dutifulness and vulnerability, influence their approach to assessing depression. High dutifulness is associated with fewer questions about depression, while high vulnerability is linked to more accurate diagnoses.
Research found that kidneys from older donors exhibit a 32% depression in glomerular filtration rate, leading to shortened survival after transplantation. The study suggests that selecting organs with more functioning glomeruli could improve graft survival rates.
Researchers discovered financial contracts between tobacco companies and Hollywood stars, revealing a commercial link between the two industries. The study found that studios controlled their stars' agreements and timed ads to promote specific cigarette brands.
Researchers investigate how tree vegetation influences local weather patterns and air quality in the Rocky Mountains. A four-year field project, BEACHON, aims to understand interactions between plants, atmosphere, and climate change.
A study published in World Journal of Gastroenterology found that patients with ineffective oesophageal motility exhibiting different contractile patterns experience distinct symptoms, including heartburn and dysphagia. The research suggests the possibility of tailored treatment strategies for selected IOM patients.
Research published in Archives of Disease in Childhood found that an infant diet including fish before 9 months significantly cuts the risk of developing eczema. The study also discovered that owning a pet bird was associated with a reduced risk of the condition.
A new study published in JAMA found that black Americans have a higher occurrence of colon polyps compared to white patients. The research suggests that black men and women are at greater risk for serious polyps, emphasizing the importance of regular screening among this demographic.
A new Northwestern University study finds that liberals fear a barren, lifeless world without deep feelings and intense experiences, while conservatives fear chaos and societal collapse. The research sheds light on why conservatives prefer authoritarian leaders and may explain differences in political orientation.
Primary aortoenteric fistula (PAEF) is a rare but life-threatening condition that can cause massive gastrointestinal bleeding. PAEFs often present with a herald bleed prior to exsanguination, making early diagnosis challenging. The incidence of PAEF is likely higher than estimated, and prompt surgical intervention is crucial for survival.
A new CU-Boulder study reveals that air quality regulations primarily target primary particles, while secondary particles formed by oxidized VOCs contribute significantly to poor air quality in the Los Angeles region. The study suggests that regulations need to focus on reducing VOC emissions from gases such as gasoline vapors.
Researchers found that children who grow up in aggressive households learn to process social information differently, leading to a higher likelihood of conflict in their own romantic relationships. The study provides insight into the developmental link between childhood exposure and adult aggression.
High-profile meeting at UN General Assembly tackles financing issues surrounding MDG 4 and 5; authors emphasize need for innovative financing to reduce maternal and child mortality. A child dies every 3 seconds, a mother every minute, the statement reads.
A new study reveals that ENT medical journals severely underreport side effects and harms, with nearly a third of clinical research articles containing no mention of adverse events. The study found that over 53% of articles failed to explicitly describe these events.
Research reveals nm23H1's role in predicting digestive system cancer, with MSI serving as an early biological marker and enhanced nm23H1 expression inhibiting metastasis. LOH appears in late stages, indicating higher malignancy.
Research by Daniel Ansari at the University of Western Ontario is exploring brain differences between children with math difficulties and those with both math and reading problems. Children with developmental dyscalculia show atypical activation patterns in the parietal cortex, which may lead to remediation tools to improve their lives.
Bisphosphonate osteonecrosis, a debilitating jaw condition, affects millions of seniors taking osteoporosis treatments. The American Academy of Otolaryngology warns of this risk, which can cause pain, swelling, and loose teeth.
A team of plant geneticists has identified a gene called sparse inflorescence1 (spi1) essential in controlling the development of the maize plant's growth hormone auxin synthesis. This discovery sheds light on the complex process of organ formation and development in maize.
A study found that extreme flood events in 2002 had a significant impact on carabid beetle and mollusc populations, but not on plant species. The vegetation was the least affected by the flood, with some species benefiting from the increased water.
A new study found that American children are three times more likely to be prescribed psychotropic medication than their European counterparts. The differences in practice may be attributed to various factors, including diagnostic classification systems, government cost restrictions, and the use of direct-to-consumer drug advertising.
A recent study has compared the results of RPA with or without modified blow-hole colostomy in patients with acute sigmoid volvulus. The findings suggest that RPA with modified blow-hole colostomy provides satisfactory results in preventing anastomotic leak, making it a promising approach for this condition.
A recent study published in the Journal of Robotic Surgery found that robotic surgery can significantly lower the risk of a rare but serious complication in patients who undergo gastric bypass surgery. The robotic-assisted procedure resulted in zero gastrointestinal leaks, compared to six leaks in the laparoscopic group.
New research found that many published clinical genomic signatures have high specificity but very low sensitivity, making them inadequate for most clinical applications. The study suggests that a rigorous approach to evaluating signature quality is necessary to improve the accuracy of sequence-based diagnostics.
Researchers found that ellagic acid increases programmed cell death and decreases proliferation of pancreatic cancer cells. The compound also reduces the activity of the pro-survival transcription factor NF-kB, which may help overcome resistance to radio and chemotherapies.
Neuroscientists identified Npas4 as the first known master switch to orchestrate inhibitory synapse formation and maintenance. This factor regulates over 200 genes involved in calming down over-excited cells, restoring balance that's thought to go awry in neurologic disorders.
The NIH's Genes, Environment and Health Initiative has awarded grants to six studies aiming to identify genetic factors associated with stroke, glaucoma, high blood pressure, prostate cancer, and other conditions. Genome-wide association studies will be conducted to rapidly scan DNA markers across large groups of people.
New research by Sugar Nutrition UK reveals that most children have sufficient levels of essential vitamins and minerals in their diets. The study found that even though children consume more added sugars than recommended, they still get the required amounts of most nutrients.
A study conducted by researchers at Emory University and Johns Hopkins University found that chronic infection is the primary cause of tonsillectomy in adults. Over 50% of adult patients who underwent the procedure had chronic infection as a contributing factor, while no trends in complications emerged.
Researchers successfully treated bleeding gastric varices using a novel sclerotherapy combining alpha-cyanoacrylate alkyl with aethoxysklerol, with no complications or re-bleeding observed in six months. The treatment was found to be an effective alternative for obliteration and eradication of gastric fundal varices.
A study by University of Warwick researchers found a radical 50/50 split in how people decide what makes two things seem similar. This could lead to advertisers and marketers reaching up to half of their potential audience, doubling the number of opportunities available in web advertising methods like Google AdWords.
A study published in Aging Cell found that calorie restriction did not lower IGF-1 levels in humans, unlike in animals. However, strict vegans had significantly less circulating IGF-1, suggesting a correlation between protein intake and longevity.
Researchers found that serum CA19-9 levels correlate with TNM staging and tumor size in patients with pancreatic cancer. The study used ROC curve analysis to evaluate the clinical value of serum CA19-9 levels in predicting respectability, revealing a high accuracy of 93.1% sensitivity and 78.3% specificity.
The study found that Qianggan-Rongxian decoction can inhibit hepatic fibrosis and prevent the development of cirrhosis in rats. It also showed a significant reduction in serum levels of ALT and AST, indicating liver cell protection.
Researchers found that administering a traditional Chinese medicine Dachengqi Decoction combined with Glauber's salt improved treatment outcomes for patients with severe acute pancreatitis and abdominal compartment syndrome. The study suggested that this therapeutic protocol can lower IAP, relax symptoms of ACS, slow disease progressio...
Researchers have developed a novel method to rapidly select anti-HBV agents for chronic hepatitis B patients with drug resistance. The approach involves replicating clinical HBV isolates in an in vitro model system, allowing for the identification of antiviral agents such as adefovir that can inhibit HBV replication.
The EuroQUASAR programme will develop next-generation quantum standards for precise optical clocks and inertial sensors. Researchers, including Professor Markus Arndt, are working on new methods for quantum interferometry to measure molecular details such as mass and geometry.
Urinary stress incontinence affects many young women's lives, impacting routine and recreational activities. The condition is relatively high among women, with around 1 in 7 experiencing symptoms, and can be triggered by physical activity such as basketball or athletics.
Researchers will examine genomes of 4,000 participants in the CARDIA Study to determine how genes influence rising blood pressure with age. The study aims to discover pathways for targeted therapeutic intervention and could lead to new treatments for cardiovascular disease.
Recent study findings suggest expanding thrombolysis window to up to 4.5 hours after acute ischemic stroke may lead to worsening outcomes due to irreversible tissue damage. The UCSD Stroke Center emphasizes the importance of timely treatment, highlighting the critical need for door-to-needle time during a stroke.