Exposure to energetic heavy ions from deep space radiation impairs intestinal epithelial cell migration and triggers senescent signaling. This effect persists for at least a year after exposure, suggesting potential adverse impacts on astronaut GI function and health.
Researchers at University of Eastern Finland found ciprofloxacin inhibits topoisomerase 2, impairing mitochondrial DNA replication and transcription. This leads to impaired energy production and cellular differentiation.
A new study by Michigan State University finds that party polarization is at its worst level since the early 1970s. The research analyzed publicly available data on who sponsors bills in Congress and found that politicians co-sponsor legislation only about 200 times, viewing nearly half of their colleagues as opposition.
A study found that high school students who slept less than six hours per night were more likely to engage in risk-taking behaviors, such as substance abuse and carrying a weapon. The researchers also found a significant association between sleep duration and suicidal thoughts and attempts.
A team of Canadian scientists discovered a French-Canadian founder mutation gene linked to synucleinopathies, a group of neurodegenerative diseases including Parkinson's disease and dementia. The GBA mutation increases the risk of developing these diseases, particularly in people with other mutations.
Researchers found that even when participants couldn't identify a familiar voice, they still found it easier to understand than an unfamiliar voice. The study suggests that resonance is a critical acoustic feature for recognizing voices and improving understanding in noisy settings.
A new study suggests that weight loss can put type 2 diabetes into remission by improving pancreatic beta cell function. Nearly half of participants who lost fat from around the liver and pancreas achieved diabetes remission, compared to six in the control group.
The NSF-funded TRIPODS+X program at Lehigh University brings together top experts to leverage machine learning techniques for various academic pursuits. The workshops focus on areas such as chemistry, robotics, supply chain management, and cognitive neuroscience.
Research suggests that formal nursery care is associated with better psychological development, including lower emotional problems and better social skills. Children who attended nurseries for a year or more had even lower odds of emotional issues, difficulties making friends, and poor social skills.
Hurricane Walaka strengthened into a powerful hurricane with intense convective storms and rainfall rates of up to 6.5 inches per hour. The Global Precipitation Measurement mission's data revealed a well-organized storm with rapid intensification forecasted through Tuesday.
A French research project aims to repurpose Sargassum seaweed for composting in the French West Indies, addressing environmental concerns. Scientists will analyze pollutants and degradation processes to ensure safe applications.
A new model is proposed to generate ongoing automated updates for genetic test results, allowing clinicians to better communicate relevant information to patients. This could enable personalized medicine by providing continuous interaction between clinics and labs, reanalysis of changing data, and more accurate diagnoses.
A Dartmouth analysis of multiple studies found that playing violent video games is associated with increases in physical aggression over time. The effect varies across ethnicity, with the largest observed among white participants and some noted among Asians, but no effect seen among Hispanics.
A University at Buffalo sociologist's new study shows that neighboring interactions can positively affect residents' attitudes and behaviors, even in highly disadvantaged communities. The research reveals that community matters in the 21st century, with consistent interactions snowballing into neighborhood investment.
A new mathematical model describes the distribution of sensory errors in learning, revealing that animals explore and track a range of possibilities to compensate for variabilities. The study found that birds combine their hypotheses with new information from their ears while singing, surprisingly accurately.
A new study finds that delayed pregnancy may increase cardiovascular disease risk in both women and their children, with boys at higher risk. Researchers also found sex-specific differences in health risks of the offspring, highlighting the importance of assessing cardiovascular health during pregnancy.
A new study reveals that gastric bypass surgery reduces all-cause mortality risk by 49% and cardiovascular disease risk by 34% in obese patients with type 2 diabetes. However, it also increases the risk of anaemia, malnutrition, and psychiatric diagnoses.
Researchers examined farming practices' impact on European maize yields under climate change and found optimal flowering times could mitigate effects. Optimizing crop cycle durations increased yields by 4-7% in projected 2050 climate conditions.
A multi-center study of adolescents reveals that bariatric surgeries like gastric bypass and sleeve gastrectomy lead to substantial weight loss, while adjustable banding is less effective. The study, which included 544 teens, found comparable weight loss outcomes for gastric bypass and sleeve procedures.
A team of physicists has identified a way to create quantum bits in silicon carbide crystals, emitting photons at wavelengths near those used in data transmission. This breakthrough enables the potential for quantum communication through standard optical fibers, paving the way for superior computing powers and unbreakable cryptography.
Researchers have identified a rice strain with improved nutritional profile by thickening its aleurone layer. The mutation of the OsROS1 gene responsible for this change offers a strategy to enhance nutritional value in rice and other cereal crops.
A recent study found that people with both diabetes and dementia are 67% more likely to die after experiencing dangerously low blood sugar. The researchers call for strategies to prevent and reduce hypoglycaemia in older adults with these conditions, prioritizing continuous glucose monitoring devices.
A specific protein called TEAD1 has been identified as a key regulator of tumor migration in glioblastoma, a devastating form of brain cancer. By deactivating this protein, researchers may be able to stop tumor cells from migrating away from the main tumor mass, increasing the success rate and overall survival time for patients.
A new study reveals that diuretic drug use in individuals with type 2 diabetes is associated with a significantly increased risk of serious problems in their lower limbs, leading to amputation. The research found that diuretics should be used cautiously in patients at risk of amputations.
The Cell Model Passports hub provides a central platform for accessing high-quality cancer cell models and genomic data. This will streamline the process of finding relevant models for research, enabling scientists to accelerate cancer research and develop new treatments.
A new screening process, called Fast Indication of Nanoparticle Discovery (FIND), allows researchers to identify nanoparticles suitable for delivering therapeutic RNA into living cells. The technique inserts unique DNA snippets and a red-glowing Cre protein to verify nanoparticle entry into specific organs and cells.
A recent study identified three genetic mutations that improve cholesterol profiles and reduce the risk of heart disease, abdominal aortic aneurysms, or diabetes. The PDE3B mutation has shown significant benefits, with a lower risk of heart disease and improved triglyceride levels.
Researchers found that plants with thicker leaves under high CO2 levels may exacerbate climate change by reducing carbon sequestration. This response could lead to an extra 5.8 petagrams of carbon in the atmosphere per year, similar to human-generated emissions.
Patients with respiratory tract infections receiving antibiotics had significantly shorter telemedicine encounters than those not receiving antibiotics. Researchers found that antibiotic prescriptions were about 33 seconds shorter, while non-antibiotic prescriptions resulted in longer encounters of approximately 1 minute and 12 seconds...
A new study by Boston University School of Public Health researchers found that higher levels of stress are associated with lower odds of conception for women, but not for men. Women with high perceived stress were 13% less likely to conceive than those with low perceived stress.
Researchers deployed machine learning methods to predict facility risk scores and detect potential violations under the Clean Water Act. The approach predicted catching two to seven times as many infractions as current approaches, with limitations including algorithmic bias and strategic behavior by facilities.
Researchers found a combination of liraglutide and enalapril effectively addresses all symptoms of postmenopausal polycystic ovary syndrome (PCOS), including metabolic syndrome. The treatment promotes significant weight loss, reduces insulin resistance, and normalizes blood pressure.
A new study developed a novel concept that overcomes the critical heat flux limit, allowing for more efficient cooling in extreme conditions. The researchers discovered that coating hot surfaces with nanoscale bimorphs enhances boiling heat transfer, potentially preventing nuclear power plant accidents.
A world-first electronic capsule measures gaseous biomarkers in the gut to diagnose common and debilitating conditions, offering rapid, non-invasive diagnosis. Phase 2 clinical trials will pursue enhanced technology and target related biomarkers for improved treatment and reduced healthcare costs.
Researchers at Mount Sinai Hospital have found a link between high doses of sildenafil citrate and irreversible damage to color vision. The study used advanced imaging technology to visualize the structural changes in the retina caused by excessive use of the drug.
A new paper by Cornell University researchers suggests dating apps should encourage users to filter out race and ethnicity, promoting inclusive community messages and algorithms. Simple design decisions could decrease bias against marginalized groups, the authors argue.
Climate projections suggest China's drought intensity and area will increase, leading to significant economic losses. Limiting future warming to 1.5°C could save trillions of dollars in drought-related losses
A recent study by Brigham Young University's Laura Padilla-Walker found that teenagers who had regular conversations with their parents about sex were more likely to have safe sexual activity at age 21. The study also showed that ongoing communication between parents and teens can improve the parent-child relationship.
Researchers found that East Japan populations of Castanopsis sieboldii survived in situ during the LGM on both Japan Sea and Pacific coasts. Genetic diversity studies suggest these groups had already been established before the LGM, indicating separate survival in different regions.
A recent analysis suggests that improving health care in Canada requires expanding public funding for cost-effective treatments, investing in primary care, and embracing technology. The authors propose engaging patients to determine services and standardizing quality-improvement tools to improve healthcare quality.
Hurricane Rosa is weakening as it approaches the US southwest, with its clouds and rains stretching into Arizona. Infrared data shows that rainfall potential is high, and the storm's cloud tops are as cold as -63 degrees Fahrenheit.
Researchers have developed a way to convert low-intensity infrared beams into high-intensity X-ray beams, enabling ultra-fast probes for molecular dynamics studies. By enhancing higher-order oscillations in laser sources, they achieved attosecond-level resolution, opening the door to new insights into electron behavior.
Researchers identified specific genes and cells associated with CKD, including the adaptor protein DAB2 in the TGF-β pathway. Further experiments confirmed that reducing DAB2 expression protected mice from CKD. The findings could inform treatment options for this complex disease.
Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago report successful surgical techniques and outcomes for single ovary removal in girls as young as 5 months old. The procedure causes no complications and can be performed on an outpatient basis without delaying cancer or other therapies.
Researchers at the University of North Carolina Health Care discovered that medical providers in central North Carolina frequently neglect to test for Ehrlichia when treating tick-borne infections. The study found nearly 80% of patients were tested for Rocky Mountain Spotted Fever, but only one-third were tested for Ehrlichia. This dis...
Nematodes transmitted during copulation and from mothers to offspring alter brood ball communities, boosting plant-digesting bacteria. This discovery supports the notion that nematodes are mutualists rather than parasites.
A new Caltech study finds that the brain's anterior cingulate cortex and striatum are involved in decision-making when faced with too many options, leading to a 'choice overload' effect. The ideal number of options is estimated to be between 8 and 15, depending on perceived reward and individual characteristics.
A study published in PNAS has reversed symptoms of Smith-Magenis syndrome in mice by reactivating the RAI1 gene. This breakthrough may lead to new treatments for this neurodevelopmental disorder. Researchers used optogenetic stimulation to restore social interaction deficits, providing hope for improved patient outcomes.
Typhoon Trami was located about 157 miles west-southwest of Camp Fuji, Japan and moving northeast at 28 knots (32 mph/52 kph). Maximum sustained winds were near 75 knots (86 mph/139 kph) as it tracked very rapidly over Honshu.
The project aims to increase access to certified sexual assault nurse examiners (SANE) for people who have been sexually assaulted in 12 southeast Louisiana parishes. The grant will train 140 nurses, with a minimum of 75 SANE-certified nurses.
Researchers from the University of Minnesota's Sustainable Healthy Cities Network found that one in five metropolitan areas have sufficient milk and egg production to meet residents' demands, while about one in ten can fully meet fruit and vegetable needs. This challenges common assumptions about local food self-reliance in urban areas.
Astronomers using MUSE instrument on ESO's VLT detected an unexpected abundance of Lyman-alpha emission in the Hubble Ultra Deep Field region, covering nearly the entire field of view. This discovery suggests that almost all of the sky is invisibly glowing with Lyman-alpha emission from the early Universe.
Scientists from the University of Liverpool have synthesized a highly active organic photocatalyst that can harness sunlight to produce hydrogen fuel. The discovery was made through a combination of experiment and computation, revealing basic design principles for future catalysts.
Harmful algal blooms have become a serious problem for marine life, affecting humans and wildlife. UCLA researchers created a new flow cytometer that analyzes water samples instantly, providing real-time insight into algal bloom locations and severity.
Researchers found that men have a three-fold higher risk of sustaining a secondary fracture within one year of a first fracture compared to women. Engaging in at least moderate physical activity can help reduce this risk and improve bone strength.
A patient-partnered genomics study identified immune checkpoint inhibition as a potential treatment option for patients with angiosarcomas of the head, face, neck, or scalp. The study found that patients with these tumors have high mutational burdens and may respond to immunotherapy.
Researchers at the University of Nottingham have discovered a characteristic of the Descemet membrane that can cause difficulties for surgeons performing corneal transplants. The study found that elastin, an elastic-like fiber, governs the direction of the membrane's roll and may be responsible for its unidirectional behavior.
A study using machine learning and data from 550 children with varying learning difficulties identified four clusters of cognitive challenges that did not match previous diagnoses. The researchers found that working memory and phonological skills deficits often overlap, affecting both reading and math abilities.
A new cancer vaccine targeting HER2 has demonstrated clinical benefits in a phase I clinical trial, with six out of eleven evaluable patients experiencing improvements in their condition. The vaccine provided complete or partial responses and stable disease in some cases.
The conference features cutting-edge research studies to answer urgent questions in cancer immunotherapy, aiming to advance progress more rapidly for patients. New approaches to identifying responders and non-responders to immune checkpoint inhibitors are being developed.