Tropical Cyclone Joaninha maintained its eye with visible thunderstorms surrounding it, with maximum sustained winds near 110 knots. The cyclone is forecast to weaken and transition into a subtropical cyclone over the next several days.
A study published in Nature identified a new approach to starve pancreatic cancer cells of molecular resources. The researchers found that the protein syndecan-1 plays a critical role in regulating macropinocytosis, a mechanism used by cancer cells to scavenge resources and divide.
Research highlights the development of next-generation CAR T-cells and immune profiling to overcome tumor resistance. SU2C presents work on cancer interception, convergence, and clinical trials for pancreatic, pediatric, brain, colorectal, lung, ovarian, and breast cancers.
Researchers developed a new method to distinguish between drug ingestion and external contamination of hair by analyzing single hairs from volunteers. The team found that splitting the hair lengthwise increased sensitivity for zolpidem detection, allowing them to separate ingestion from contamination.
A new study by UChicago scientists found significant river runoff persisted on Mars later into its history than previously thought. The intense runoff, which was wider than those on Earth today, occurred at hundreds of locations and suggests a complex climate with strong greenhouse effects.
A new simulation system, AADS, combines photos, videos, and real-world trajectory data to create a more realistic autonomous driving environment. This allows for safer testing of self-driving vehicles in the lab before hitting the roads.
The symposia series will focus on the gut microbiome's impact on health and disease, featuring speakers on topics such as gut-brain axes and antibiotic effects. Research highlights include studies on acetate, bioinformatics, and metabolomics.
A global study found that colder climates produce richer bacterial communities on amphibian skin than warmer environments. The American bullfrog was representative of this phenomenon, with lower minimum temperatures associated with greater bacterial diversity.
Scientists have discovered that USP25 is inactive in its isolated form and forms a tetramer, whereas USP28 exists as a constitutively active dimer. This knowledge provides the molecular basis for developing targeted anti-cancer drugs with low side effects.
Women with metastatic hormone receptor-positive breast cancer live longer when receiving fulvestrant and anastrozole compared to treatment with anastrozole alone. The combination therapy shows promise as a life-extending first line of treatment, particularly for women who received lower doses of fulvestrant.
The newly digitized maps provide details of glacial tills, sands, and gravels on the earth's surface, using a unique standard color for each material. The digital maps offer more accurate and convenient information for spatial analyses, with features such as layering and GIS overlay capabilities.
Researchers identify genomic regions affecting radiation use efficiency and biomass accumulation in spring wheat, providing a crucial resource for scientists and breeders. The study aims to increase wheat yield potential without sacrificing grain yield, addressing the challenge of sustainingably feeding a growing population.
A new study suggests that the brain uses sensory signals from the mouth and throat to temporarily quench thirst, but also relies on gut sensors to review this decision based on a drink's hydration potential. This helps regulate fluid balance within the body and may provide insights into diseases like high blood pressure.
Researchers at Sanford Burnham Prebys have created a mouse model of choroid plexus carcinoma (CPC), a challenging type of brain cancer that affects young children. The study identified three promising drug compounds with biological activity, including dinaciclib and flavopiridol.
Researchers at Caltech have identified specific neurons responsible for salt cravings in the mouse brain, which are triggered by oral sodium signals. These findings could potentially lead to new avenues for regulating sodium intake and mitigating health issues related to excessive salt consumption.
Artificial intelligence can accurately identify cardiac devices, including pacemakers and defibrillators, from X-ray images within seconds. The software surpasses current methods with a 99% accuracy rate, speeding up diagnosis and treatment for patients with faulty devices.
A new UTSA study documents the war's casualty statistics, mortality trends, and treatment advances. Key findings include increased injury patterns and severity, as well as a significant reduction in mortality rates thanks to interventions such as tourniquets and rapid hospital transport times.
Researchers have captured high-speed videos of kangaroo rats defending themselves against rattlesnake attacks, showcasing their record-breaking reaction times and evasive maneuvers. The data suggest that the kangaroo rats' powerful legs and mid-air kicks allow them to avoid being envenomated.
Scientists have developed a new triboelectric nanogenerator (TENG) called SLIPS-TENG, which can convert mechanical energy into electrical energy in harsh environments. The device uses a slippery lubricant-impregnated porous surface to address durability and biofilm coverage issues.
The new centre aims to advance health and medicine by understanding the fundamental nature of life, with a focus on designing and building artificial cells and minimal genomes. Researchers will also investigate protein design and the foundations of life.
A study led by City University of London researchers suggests that people with 'visual ears' may have a disinhibited flow of signals around the brain, allowing them to hear silent flashes or movement. Musicians were more likely to report experiencing visual ear than non-musicians.
Researchers have engineered HBV-specific T cells to treat Hepatocellular carcinoma, a commonly occurring liver cancer. The treatment was individualised and showed promise in reducing tumour size in patients with HBV-related liver cancer.
The university will conduct research on the health and well-being of migrant children using an evidence-based parenting program. The goal is to improve parent-child relationships, alleviate stress, and boost children's social-emotional health. The center will work with community partners to design and implement projects.
Two new Emmy Noether Independent Junior Research Groups at Charité will explore the use of deep brain stimulation to treat neurological disorders and the regulation of immune responses in the nervous system. The groups, led by Dr. Andreas Horn and Dr. Christoph Klose, will receive over €1.7 million in funding for three years.
A study on turtle ants found that gynes have larger brain volumes than soldiers and minor workers, while their brains differ in regions associated with cognitive processing. The authors suggest that these differences may aid in performing specialized tasks, and could provide insight into the evolution of caste specialization.
Researchers used an algorithm to model the decision-making of C. elegans in response to a sensory stimulus, achieving predictions that matched experimental results. The Sir Isaac platform demonstrated improved accuracy compared to prior models, offering insights into the potential of artificial intelligence in scientific discovery.
Researchers discovered a novel gene mutation that reduces activity of the FAAH gene, which is involved in pain sensation and anxiety. The mutation is associated with enhanced wound healing, reduced anxiety, and fearlessness, potentially leading to new treatments for post-surgical pain and anxiety.
Researchers at the University of Utah Health found that pairing music with pain medications improved analgesic outcomes by up to 90% in mouse models. The study showed significant reductions in inflammation and pain responses, suggesting a potential therapeutic strategy for managing pain.
A new smartphone app called OnTrack can predict when users are likely to lapse in their weight loss plan and send personalized coaching messages to help them stay on track. The study found that participants who used the app reported high levels of satisfaction and experienced a significant reduction in unplanned lapses.
An investigation by The BMJ found that many NHS trusts are keeping secret details of their partnerships with drug companies, despite official guidance for transparency. Joint working arrangements between the NHS and industry have spent over £7.5m on projects such as ADHD medication reviews and age-related macular degeneration treatments.
A new computer-based model developed by Johns Hopkins researchers accurately predicts which patients with a rare heart condition will benefit from an implanted defibrillator. The model identifies patients most likely to benefit from the device while preventing unnecessary surgery, potentially saving thousands of lives annually.
A new study uses crop models and local expertise to pinpoint communities most in need of support for adaptation and mitigation. The tool assesses climate risk vulnerability and projects impacts by 2050 on crops like rice, maize, and coffee.
Researchers found that offspring from older mothers are more responsive to dietary interventions known to increase lifespan. However, caloric restriction did not improve overall fitness in these offspring.
Scientists create novel polymeric material with fullerenes, boosting power conversion efficiency of organic solar cells by three-fold. The new interlayer material improves device stability and electrode performance, overcoming intrinsic problems related to combining hard and soft materials.
Dr. Amy Kind will deliver a marquee presentation at #AGS19 on the social determinants of health, reorienting research, policy, and clinical practice to broader systemic factors. Her work focuses on improving health equity and has led to the development of the 'Neighborhood Atlas,' a neighborhood map assessing socioeconomic factors.
A new study finds that shoreline erosion can transform freshwater wetlands from carbon-storage pools to carbon sources, with a large mismatch between accumulation and erosion rates. The researchers developed a model to assess the impact of freshwater coastal erosion on global carbon budgets.
Researchers have successfully transplanted adult spinal cord grafts into spinal cord transected rats to improve locomotor function, promoting the recovery of motor function and survival of neural cells.
A study published in The BMJ suggests that non-surgical brain stimulation techniques, such as ECT and rTMS, may be effective as alternative or add-on treatments for adults with severe depression. However, more research is needed to fully understand their benefits and potential side effects.
Researchers have developed a portable mini microscope that allows for real-time brain imaging in living mice, reducing costs and enabling more detailed studies of diseases such as cancer, stroke, and Alzheimer's. The device records images from active brains of mice moving naturally around their environments.
Researchers at HSE Institute of Cognitive Neuroscience propose preoperative training to enhance neurobiomechanical patterns for better motor activity. The study focuses on autotransplanting latissimus dorsi muscle for elbow flexion, showing promising results in accelerating rehabilitation.
Researchers from Polytechnic University of Valencia and Ingheritag3D have digitized the Nasrid sword attributed to Ali Atar, a 15th-century warlord. The study utilizes photogrammetry and 3D modeling techniques to document the intricate filigree and ornaments on the sword.
A study analyzing nearly 57,000 US military casualties found that the use of tourniquets, blood transfusions, and faster prehospital transport significantly reduced mortality. These interventions accounted for a large part of the increase in survival rates among critically injured soldiers.
Nadkarni's Ambassador Model training program empowers scientists to engage the public through meaningful connections, promoting shared values and community involvement. The program's effectiveness is demonstrated through high ambassador participation rates and increased interest in science among participants.
A team of researchers has identified a 'druggable' mechanism for pathological tau protein aggregation, which could lead to new treatment options for devastating neurodegenerative diseases. The discovery focuses on the RASD2 gene and its potential as a target for farnesyl transferase inhibitors.
Researchers at Iowa State University found that practicing loving-kindness and extending good wishes to others reduces anxiety, increases happiness, and fosters social connection. The study suggests that this simple strategy is effective regardless of personality type.
Scientists at Duke-NUS Medical School have made a breakthrough in heart muscle regeneration by priming stem cells to become heart tissues. The novel method uses the laminin protein to promote differentiation of human embryonic stem cells into cardiovascular precursor cells, which can then differentiate into cardiac muscle fibers.
Researchers have developed a drone-based system to spot treat weeds, reducing the risk of pesticide drift. The system uses AI-powered imaging and neural networks to identify weeds and deliver targeted pesticides.
The EU-STANDS4PM forum aims to develop standardized transnational frameworks for data integration and in silico modeling in personalized medicine. This will facilitate the use of life science data in clinical research and accelerate growth of the European data-driven economy.
A team of researchers has successfully generated ultra-short spin waves in an astoundingly simple material, opening up new possibilities for the development of spintronics. The achievement uses a magnetic material shaped into circular disks to create spin waves with wavelengths as short as 80 nanometers.
An international study found that wastewater treatment plants in seven European countries have varying levels of antibiotic resistance, with southern Europe showing higher rates. The study suggests that modern treatment plants are effective in removing resistant bacteria, but older or poorly managed plants may contribute to the problem.
A new study reveals that pulsed electromagnetic fields (PEMFs) increase osteoblast precursor cell proliferation and induce osteogenic gene expression, but do not enhance calcium deposition. Careful selection of PEMF parameters is crucial for inducing a favorable effect.
Increasing the legal age for tobacco purchase would protect younger children from exposure to older pupils who smoke and remove a potential source of supply within schools. A 'polluter pays' tax and other measures, such as retail licensing schemes and mass media education campaigns, could also help reduce smoking rates among young people
Research highlights chronic opioid use among older adults undergoing spinal surgery for degenerative spine disease, and intensified hypertension treatment at hospital discharge poses a risk without benefits. A practical two-stage frailty assessment also predicts poor outcomes after aortic valve replacement.
Replanting urban environments with native flora could help address chronic health problems by promoting healthy microbial diversity. Restoration of urban biodiversity is estimated to have generational health benefits and huge savings for healthcare sectors.
A new national study found that social media had only a small influence on how much people believed falsehoods about candidates and issues in the last two presidential elections. Interestingly, Facebook users were actually more accurate in their beliefs than those who consumed only other social media.
Researchers found a significant increase in tweets about embarrassment since Trump's election, with peaks around high-profile events like debates and controversies. The study suggests that people feel vicarious embarrassment due to Trump's norm violations as president, threatening their social integrity.
Researchers have shown that gene transfer therapy can improve left ventricle function and glucose disposal in mice with diabetes. A single injection of a hormone called urocortin 2 increased heart function and reduced blood sugar levels, offering a potential new treatment for cardiovascular disease.
A research team at Korea Brain Research Institute has developed a technology to produce dorsal cortical neurons utilizing induced pluripotent stem cells and tropical fish collagen. The breakthrough could lead to the treatment of brain diseases such as Parkinson's Disease by mass producing neurons using stem cells.
A novel iron catalyst has been discovered to simplify and streamline organic chemical synthesis, reducing costs and waste. This breakthrough could have huge implications for industries such as pharmaceuticals and petrochemicals.
Scientists discovered that microglia, a type of nervous system cell suspected to cause retinal damage, surprisingly had no damaging role during prion disease in mice. Microglia might delay disease progression, providing new insights into inherited photoreceptor degeneration diseases.