Scientists have developed a new tool to precisely target cancer cells by distinguishing them from neighboring cells. The Co-LOCKR system uses synthetic proteins to detect specific combinations of cell surface markers, allowing for more precise targeting and improved safety for cancer-killing CAR T cells.
The researchers created a lightweight eye mask called Chesma with two kinds of fabric electrodes to track electro-oculography and cardiac signals. The mask can be integrated into various garments and tested for performance after multiple washings.
A new Oregon State University study suggests that firefighters are more likely to be exposed to potentially harmful chemicals while on duty compared to off duty. The researchers found 18 PAHs that have not been previously reported as firefighting exposures, and exposure levels increased with the number of fires responded to.
A new dementia education program has shown significant improvements in dementia knowledge and attitudes among primary school students. The intergenerational program brings together children and older adults, promoting empathy and understanding.
A new study reveals broad inconsistencies in COVID-19 data presentation across national public health institutes' websites, limiting its usefulness. Researchers recommend a standardized format and content sharing to improve data aggregation and inform future research, clinical decisions, and policy-making.
Researchers developed a new vaccine called 4X-SA-GP, which uses fungal β-glucan particles loaded with S. aureus proteins to stimulate antifungal immunity in mice. Vaccination induced protective T cell and antibody responses, protecting mice from staph infection.
Researchers from Tohoku University discovered a novel iron-based superelastic alloy capable of withstanding extreme temperatures. The new alloy can operate within a wider temperature range than conventional metal-based SEAs, making it suitable for outer-space exploration and other demanding applications.
Researchers at Case Western Reserve University have developed a new class of metalenses that can be reconfigured using liquid crystals, allowing for the creation of flexible and tunable lenses. This innovation holds promise for revolutionizing optics and enabling new scientific and technological endeavors.
Dr Stefania Maggi, a leading geriatrician and epidemiologist, has been awarded the ESCEO-IOF Herbert Fleisch Medal for her groundbreaking work in advancing the epidemiology of chronic conditions associated with aging. Her research focuses on healthy ageing and disease prevention programs.
Researchers have developed an efficient method to estimate camera movement, reducing the number of hypotheses generated from up to five to one. The new approach allows for real-time execution of pose estimation, with a complete algorithm taking only 29 milliseconds per frame.
A new study suggests that COVID-19 is causing significant dilation of the lung's blood vessels, contributing to low oxygen levels and unusual respiratory behavior. The dilation was detected using a non-invasive ultrasound technique, and its correlation with oxygen levels may help explain why some patients experience 'happy hypoxia.'
Researchers at University of Minnesota and University of Washington found a statistical association between COVID-19 hospital bed usage and reported mortality rates across 23 US states. The study used actual state-level data to examine this relationship, providing insights for hospitals on assessment and preparedness.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism highlights the impact of anorexia nervosa on young women's growth. The research found that girls with anorexia nervosa tend to have stunted growth, which may affect their overall health and well-being.
Researchers at Aarhus University have developed a new equation to describe the activity of enzyme cascades in cells. This breakthrough could lead to a better understanding of how enzymes control cellular signaling and potentially improve drug development for cancer treatment.
A study found that belief in negative vaccination misperceptions has a strong impact on policy views, with 20% of Americans holding negative views about vaccination. Strong support for mandatory childhood vaccinations was observed, but opposition to religious and personal belief exemptions remained significant.
Scientists create genetically engineered, off-the-shelf therapeutic T cells that can recognize and kill specific cancer cells without requiring personalized training. The 'off-the-shelf' approach solves limitations of original cell immunotherapy methods by avoiding time-consuming processes and resulting in more potent cells.
A study found that a bacteriophage infecting enterococcus bacteria stimulates an immune response improving the efficacy of cancer treatments. Administration of enterococcus containing the bacteriophage boosted T cell responses in mice, and its presence was associated with improved survival following PD-1 immunotherapy.
Scientists have discovered an ancient gene family in Chlamydomonas algae that produces glycerol to protect against salt and cold stress in Antarctica. The gene family is necessary and sufficient for glycerol synthesis, suggesting its ancient origin and importance for survival in extreme environments.
A new study discovered that GULP1 is a key regulator of the NRF2-KEAP1 signaling axis in urothelial carcinoma. GULP1 knockdown led to increased tumor growth and resistance to cisplatin treatment.
Researchers have discovered stable, synthetic STING agonists that induce anticancer immune responses in mice. These non-nucleotide small molecule STING agonists show robust anti-tumor activities and may represent an attractive approach for targeting the STING pathway.
Advanced X-ray imaging reveals details on ancient cat, bird and snake mummification, including possible causes of death and complex ritualistic behavior. The technique provides insights into conditions in which animals were kept and their relationships with humans.
A study of post-mortem examinations found that COVID-19 patients had diffuse alveolar damage, thrombosis in major organs, and kidney injuries. The research aims to inform clinicians on treating complications and develop new monitoring strategies.
Scientists have developed a technique that can detect and quantify viral RNA in living cells, as well as minor changes in RNA sequences. This could help identify superspreaders and understand how viruses evolve to become more infectious.
Fatty acid binding proteins (FABPs) are chaperones that coordinate fatty acid transport between cells. Research by University of Louisville immunologist Bing Li reveals their role in lipid metabolism, obesity, and disease development.
LONs have shown outstanding properties in designing membrane-anchored biosensors and synthetic membrane channels due to their information-transfer and self-assembly abilities. They also have great potential in making contributions to developing new therapies and controllable nanoreactors.
A new study published in Nutrition and Metabolism found that an eight-week very low-carbohydrate diet improved body composition, fat distribution, and metabolic health in older adults with obesity. The diet also preserved skeletal muscle mass without intentional caloric restriction.
A new modular iridium catalyst allows unprecedented control over fatty acid derivative modification, enabling the production of valuable compounds from renewable resources. This breakthrough opens up new avenues for pharmaceuticals and plastics synthesis.
Researchers at Johns Hopkins Bloomberg School of Public Health found that states with handgun purchaser licensing laws had lower firearm homicide and suicide rates. Connecticut's law, enacted in 1995, was associated with a 28% decrease in firearm homicides and a 33% decrease in firearm suicides.
A comprehensive pediatric study shows children can carry high levels of the virus and spread infection, contradicting previous assumptions. The study's findings have implications for reopening schools and daycare centers, highlighting the need for increased precautions to keep kids, teachers, and staff safe.
Researchers developed a novel thermometer based on quantum entanglement that can accurately measure ultra-cold temperatures in clouds of atoms, known as Fermi gases. The new method uses a probe atom to infer temperature by exploiting the unique properties of fermions at extremely low temperatures.
Cyclohexyl phenyl sulfide cleavage studied for degradation of sulfur-containing heavy oil. Copper compounds are found to be the most effective catalysts for heavy oil extraction, followed by cobalt and nickel.
A new vaccine candidate has been developed for HHV-6B, a virus that causes exanthem subitum in infants. The vaccine targets the gH/gL/gQ1/gQ2 complex and induces strong immunity against the virus. Animal experiments have shown that the vaccine prevents HHV-6B infection and activates dendritic cells to induce innate immunity.
A team of researchers from the University of Kansas blames a series of supernovae explosions for triggering the end-Devonian extinction event. The ionizing radiation caused internal damage in large animals and organisms, leading to mass extinctions of armored fish and trilobites.
A new kirigami-based shoe sole has been designed to reduce the risks of slips and falls by adjusting as a person steps, increasing friction with pop-up spikes as necessary. The study found that the new grip could achieve a greater friction than standard winter boots by two- to three-fold.
Three experts, Professor Maria-Luisa Brandi, Dr. Lee Joon-Kiong, and Professor Ego Seeman, have been awarded the IOF President's Award for their contributions to osteoporosis research, education, and public awareness. The award recognizes their efforts to expand the Foundation's programs and outreach in the scientific and policy spheres.
A small Italian town's transformation into a major hub for medical device production is attributed to one man's entrepreneurial spirit and vision. The study, led by Professor Simone Ferriani, highlights the 'anchor entrepreneurship' framework as a catalyst for rapid development in small communities.
Scientists at Okayama University developed a new technique to analyze dendrite formation in rechargeable batteries, improving safety. They discovered that quasimetallic Li clusters act as a buffer for dendrite formation in hard carbon electrodes, providing valuable insight into overcoming lithium dendrite formation limitations.
Researchers discovered that Klotho protein deficiency causes aging-associated hypertension through high salt intake, with supplementation preventing hypertension development. Klotho levels may serve as a predictive marker for hypertension risk.
Researchers studied 25 immature chimpanzees learning to use tools, discovering they acquire complex termite-extracting skills over time. The study provides insights into how technology evolved in human culture and highlights the sophistication of Central African chimpanzee tool-using skills.
A new study identifies two genes, TMEM106B and RBFOX1, that regulate gene expression in the aging brain and are linked to both Alzheimer's disease and Limbic-predominant Age-related TDP-43 Encephalopathy (LATE). The findings suggest a shared molecular basis for these diseases, which may lead to new treatments and prevention strategies.
Researchers examine the impact of unconventional monetary policy on bank risk-taking in the syndicated loan market, finding no additional interest rate reduction for riskier firms. This suggests that loose lending is not a concern under unconventional monetary policy measures.
A new study of 181 patients found that about 15% test positive for one or both newly discovered antibodies that attack the point of communication between nerves and muscle. Those who tested positive tended to be sicker when diagnosed and have a more severe disease course.
A region-wide study by Penn State researchers confirms that invasive shrubs have an advantage over native shrubs, contributing to their proliferation. The study found that invasive shrubs maintain leaves for 77 days longer than native shrubs, giving them a competitive edge in acquiring energy and creating shade.
Scientists at ESRF discover new type of critical point in liquid sulfur, allowing for better understanding of liquid-to-liquid transitions and their applications. This breakthrough could open doors to studying the complexity of other important systems like water.
A recent study by Vaishali Bhaumik and Dr Krushnamegh Kunte reveals contrasting effects of migration and dispersal on flight morphology in butterflies. Female butterfly populations that disperse over short distances have a higher egg load, but this declines rapidly as their thorax size increases, enabling stronger flight muscles.
The HEARTROID platform will assist the TTDD lab in validating device performance with pulsatile and anatomically precise 3D printed models, accelerating surgical device development. The partnership aims to create novel medical devices that enhance native biological functions.
A Rutgers study found that young gay men who experience healthcare discrimination or have providers lacking in knowledge about gay men's health issues are more likely to miss out on screenings and care. Creating safe spaces for disclosure can build trust and improve access to relevant services.
Researchers at the University of Alberta have found a way to accelerate nerve regrowth in trauma patients by three to five times, leading to better outcomes. The treatment, known as conditioning electrical stimulation (CES), involves electrically stimulating nerves before surgery, causing them to regenerate faster.
Researchers found that brain function remapping is impaired in Alzheimer's disease patients, causing spatial memory impairment. Improving brain remapping function may reverse spatial memory impairment using deep brain stimulation methods.
A new study reveals that female Emigrant butterflies selectively burden themselves with eggs during long-distance flights, whereas males travel light. This disparity stems from differences in predictability of habitat patches and larval host plants between migrating and dispersing species.
Researchers estimate that sustainable seafood production can increase by 21-44 million metric tons annually, accounting for 12-25% of global animal protein needs by 2050. Policy reforms and technological improvements can help address sustainability concerns and environmental limitations.
Researchers at Yokohama National University developed a new method to produce entangled photons compatible with quantum memories, allowing for long-distance quantum communication through optical fibers. This breakthrough could enable the creation of a quantum internet linking quantum computers.
The University of Nottingham is launching two new projects using satellite Earth Observation technology to tackle global development problems. The first project aims to develop an anti-trafficking system to support efforts in Uganda, while the second project focuses on monitoring sargassum seaweed affecting Mexico's Caribbean Coast.
A new database of 40 breast cancer cell lines will help speed the development of new gene-targeted therapies by providing genomic and proteomic information. Researchers aim to identify functional genes that drive cancer growth and develop targeted therapies based on unique gene changes in each patient's cancer.
Researchers have found that the shape and structure of muscle fibres in the heart impact its performance and risk of heart failure. The study, published in Nature, reveals how these 'trabeculae' work and develop, and their importance to human health.
Researchers at Hackensack Meridian Health identified a drug that improves survival in critically ill COVID-19 patients. The study found a statistically significant decrease in hospital-related deaths among those who received tocilizumab, a monoclonal antibody used to treat rheumatoid arthritis and cancer treatments.
Salk Institute scientists develop transplantable human insulin-producing pancreatic cell clusters that evade the immune system, providing sustained blood glucose control without immunosuppressants. The cells were created using stem cell technology and a protein called WNT4 to induce a genetic switch that makes them functional.
Researchers at Weizmann Institute of Science identify key molecule regulating biomolecular messaging in nerve cells, which plays a role in chronic pain. Targeting this molecule, importin alpha-3, could provide new options for treating chronic pain with fewer side effects.
The virtual WCO-IOF-ESCEO 2020 Congress featured over 210 live and pre-recorded sessions on new clinical research and advances in osteoporosis, osteoarthritis, and related diseases. The Congress attracted a record number of registrants and was accredited by the EACCME with 16 European CME credits.
Researchers developed a low-cost, visible-light activated coating for water filtration membranes that breaks down foulants and renders the membrane clean. The coating increases photocatalytic efficiency under sunlight by 24-fold compared to regular titanium dioxide.