Researchers at UW-Madison developed silica nanocapsules that can carry CRISPR tools across the blood-brain barrier, enabling brain-wide gene editing for disorders like Alzheimer's and Parkinson's. The technology has potential for non-invasive delivery of gene therapies.
A Dartmouth-led study found that team-based coaching significantly improves the risk of acquiring post-procedural acute kidney injury (AKI) when compared to other interventions. The Collaborative with Surveillance intervention reduced the odds of AKI by 46 percent, making it a promising approach to address this prevalent adverse event.
Researchers developed a technique that introduces a phosphonic acid-functionalized fullerene derivative and a redox-active radical polymer to strengthen the perovskite crystal structure and increase conductivity. This approach improved the stability of perovskite solar cells, achieving efficiencies comparable to traditional solar cells.
Researchers found that metabolite changes were most evident in ripe fruit, with nitrogen deficiency increasing some compounds and phosphorus deficiency decreasing diversity. Salinity threshold above which metabolites change was identified, which could impact harvested pepper resistance to pathogens.
Researchers studied ancient sediment and microfossils to understand the Ocean Anoxic Event 2 (OAE2), a significant environmental disruption that choked oxygen from oceans. The team proposes a new hypothesis for the Plenus Cold Event, which briefly interrupted intense greenhouse temperatures due to ocean acidification.
A Cancer Research UK-funded clinical trial found that chemotherapy before surgery reduces the chance of colon cancer returning within 2 years by 28%. The study involved 1,053 patients and showed significant benefits in terms of preventing cancer recurrence.
A study from the University of Tsukuba has established a reliable way to assess the impact of COVID-19 on daily life and mental health. The analysis revealed that approximately one-third of participants experienced moderate or severe psychological distress, while seven out of ten individuals faced problems due to fear of COVID-19.
Researchers have identified the need for standardization of performance indices and a single frame for normalization methods to address concerns with bioelectrochemical systems. The study proposes strategies for up-scaling BES technologies, enabling resource recovery through on-site treatment of wastewater at an efficiency comparable t...
The fellowship will study the uneven nature of the UK economy across regions and their responses to global economic changes, including Brexit and the cost of living crisis. It will provide impartial knowledge about these issues, grounded in social scientific research.
Assistant Professor Stephen Hopkins received a year-long, $60,000 NEH fellowship to finish his book, The Infernal Laboratory: Vernacular Theology and Hell in the Medieval North Sea. The study explores how medieval writers developed their conception of hell as an experimental space for cultural and theological belonging.
The study, published in Nature Medicine, demonstrates the first-ever use of federated learning to train deep learning models on histopathology data from multiple hospitals without compromising data privacy. This breakthrough has the potential to unlock precision medicine through secure and AI-powered medical research.
A team at Harvard Medical School has created large-scale 2D and 3D spatial maps of colorectal cancer, layering molecular information on top of histological features. The maps reveal the interconnectedness of traditional isolated structures in colorectal cancer, allowing researchers to explore differences within individual tumors.
The night sky has increased in brightness by 7-10% per year, equivalent to a doubling of its brightness in less than eight years. This rapid growth is outpacing satellite estimates and highlights the urgent need for awareness about artificial light at night.
Recent national data analyzed by leading cardiology and cardiothoracic surgical researchers found that the rate of successful repair has reached over 90% in the US, with an extremely low risk of mortality across nearly all age ranges. A novel risk model was developed to predict 30-day outcomes based on patient health conditions.
A study found that human presence in Glacier National Park causes 16 out of 22 mammal species to change their movement patterns, using different areas or being more nocturnal. The researchers suggest that this effect is significant enough to impact population survival.
Researchers have developed a new pure silica zeolite with extra-large pores in all three dimensions, enabling efficient removal and recovery of volatile organic compounds from gas streams. The discovery has potential applications in catalysis and drug delivery, and could be used to decontaminate sites where harmful chemicals are produced.
Research identifies significant barriers in ER care for patients with mental health and substance use disorders, including emotional, diagnostic, and logistical challenges. Broad changes are needed to improve emergency care for this patient population.
Researchers at New York University captured extremely fast dynamics of water molecules moving around salt ions at a scale of over a trillion times per second. The findings allow for more reliable models of ion dynamics, which could improve rechargeable batteries and MRIs.
Researchers from Chinese Academy of Sciences provide panoramic view of global forest patterns, highlighting pervasive effect of human impacts on protected areas and intact forest landscapes.
A new study shows that a quantum data channel and classical optical signals can co-propagate in the same fiber with low error rates, reducing the cost of implementing quantum key distribution. Researchers tested a commercial multiplexed QKD system on a wavelength-division multiplexing link and achieved a total data rate of 6 Tb/s.
Researchers in Japan have developed a novel method to assign workplace locations to individuals in synthetic populations, addressing a significant limitation of previous models. This breakthrough enables more accurate social simulations, which can be used to assess various social issues and inform policy decisions.
A study by US Department of Agriculture scientists has identified a specific metabolic pathway controlling energy and immune response in honey bees under cold stress. This pathway is strongly connected to large overwintering colony losses, making it a promising avenue for new therapeutic strategies to mitigate these losses.
Researchers at Baylor College of Medicine discovered a novel mechanism of gene expression regulation involving enhancers and promoters. They found that enhancers and promoters are tightly interconnected through a process called enhancer-promoter entanglement, which affects transcription.
A new study reveals that US pregnancies are shorter than those in England and the Netherlands, with average lengths declining by over half a week between 1990 and 2020. This finding suggests that reducing medical interventions during the birthing process could improve maternity care outcomes in the US.
Researchers found a protein called Rac1 that triggers milk production in breast cells when lactation stops and the breast returns to its pre-pregnancy state. This process involves cell death and autophagy, but can be reversed upon suckling, providing a fail-safe mechanism for mammalian survival.
Researchers successfully applied AlphaFold AI to an end-to-end platform, discovering a novel target and developing a potent hit molecule for liver cancer. The study demonstrates the potential of AI-powered drug discovery to accelerate treatment development.
Researchers have made significant progress in CRISPR genome editing, enabling applications in plants, animals, and humans. Despite challenges, the technology has shown promise for treating rare diseases and improving agriculture.
A new study reveals a novel cortico-thalamic connection that targets the thalamic reticular nucleus (TRN), which plays a crucial role in regulating inhibitory activity in the brain. The discovery provides insights into the neuronal basis of normal cognition and chronic neurological diseases linked to frontal cortex.
Researchers developed a multimodal imaging-based tool, the active biopsy guidance system (ABGS), to improve oral cancer diagnosis. The ABGS provides clinically actionable direct visible guidance for biopsies, enhancing precision and potentially saving lives.
A study led by Robert Dickson found that the gut microbiome plays a crucial role in regulating body temperature, both in health and during sepsis. The researchers discovered that certain bacteria from the Firmicutes phylum were strongly associated with increased fever response.
A study by Kennesaw State University researcher Weiwei Chen found that COVID surges led to poorer outcomes for non-COVID patients in hospitals overwhelmed with COVID cases. The odds of an in-hospital death were 1.2 times higher among non-COVID patients than before the pandemic.
Private landowners in southern and East African countries conserve hundreds of rhinos by generating revenues from wildlife tourism and trophy hunting. However, rising security costs due to accelerating poaching threaten the long-term viability of private rhino conservation.
Researchers at Hokkaido University developed a hybrid hydrogel combining natural squid tissues with synthetic polymers, exhibiting hierarchical anisotropy and toughness.
Researchers identified 14 pathogenic variants in genes related to mitosis and telomere integrity, suggesting alterations in these processes are key to sarcoma predisposition. The study provides new biological insight into sarcoma development and could inform better genetic risk profiles for the disease.
A University of Maryland-led team deciphered the first comprehensive genome for a parasite responsible for transmitting Lyme disease and other serious infections. The researchers identified thousands of novel genes and new protein functions, including proteins associated with tick immunity and disease transmission.
A study by University of Pittsburgh and Cornell University scientists found that states with recreational cannabis laws saw a significant reduction in pharmacy-based codeine distribution. This reduction is promising from a public health perspective, as prescription opioid misuse contributes to thousands of overdose deaths annually.
New research suggests that violence and warfare were prevalent in many Neolithic communities across Northwest Europe during the period of farming adoption. Over 10% of skeletal remains from 180 sites dating back to 8000-4000 years ago showed evidence of weapon injuries, including blunt force trauma and penetrative injuries.
Researchers at Brookhaven National Laboratory demonstrate a new color-shifting strategy that relies on interactions between lasers and vibrational energy in ionic liquids. The method offers an efficient and customizable approach to shift laser colors, with applications in science, industry, and medicine.
New research reveals elevated suicide rates among adults undergoing cancer surgery, with significant increases observed in certain cancers and demographics
Scientists have created a new class of nonvolatile memory devices using antiferromagnets that can store stable memory states and read them incredibly quickly. This breakthrough could lead to faster memory devices with performance beyond the terahertz regime.
Researchers at the Max Planck Institute for Marine Microbiology reveal how a specific enzyme, Fsr, converts sulfite into sulfide, allowing methanogens to grow safely on toxic substances. This discovery opens opportunities for biotechnological applications and provides insights into the evolution of these microorganisms.
A study found that a small number of Varroa mites can infect many adult honey bees, with high-risk mites spreading pathogens through frequent host switching. This mechanism amplifies the vectorial capacity of Varroa destructor.
Researchers at the University of Maryland successfully guided a 45-meter-long beam of light through an unremarkable hallway, pushing the limits of an innovative technique. The team utilized ultra-short laser pulses to create a plasma that heated air, forming a high-density core and enabling efficient light delivery.
Researchers conducted a three-year field study to determine how black swallowwort responds to common controls. The study found that annual applications of glyphosate were effective in reducing aboveground biomass, but less effective in reducing cover and stem densities.
A team led by the University of Colorado Boulder discovered a unique microbial community on the newly formed Hunga Tonga Hunga Ha'apai island, which metabolizes sulfur and atmospheric gases. The microbes were found to be similar to those in hydrothermal vents, hot springs, and other volcanic systems.
A recent study found that people with a specific genetic variation have a lower risk of developing infectious mononucleosis after initial Epstein-Barr virus infection. The researchers identified an EBV-specific immune response as the cause and suggest it could be a target for vaccine development.
A recent study published in Respiratory Medicine found that older adults with asthma are at high risk of depression during the COVID-19 pandemic. Approximately half of those with a pre-pandemic history of depression experienced a recurrence, while one in seven without a history of depression developed depression for the first time.
Most children in the continental US have adequate access to pediatric cancer care, but disparities exist among racial and ethnic groups and in rural areas. Reducing these disparities requires innovative approaches such as expanding local facilities and partnerships with adult oncology centers.
Research finds that seniors living in R3 program sites have lower hospitalization rates, days, payments, and readmissions compared to control sites. The R3 initiative embeds wellness teams in senior housing, providing assessments, proactive check-in calls, risk stratification, and care coordination.
A new study found that anti-Asian discrimination during the pandemic led to a nearly 20-percent drop in business at Chinese restaurants, resulting in an additional $7.4 billion in lost revenue. The researchers also found a strong link between political rhetoric blaming China for COVID-19 and the decline in business.
Researchers have created a genetic map to identify important genes causing sarcoma, a common childhood cancer. The study found that one in 14 individuals with sarcoma carries a clinically significant gene, offering hope for earlier diagnosis and treatment.
A new study from Tufts University finds that dollar stores have doubled their share in rural areas, with households headed by people of color and lower-income households relying heavily on them. The growth of dollar stores raises concerns about the nutritional value of their food offerings and potential displacement of local grocers.
Researchers report the discovery of photonic hopfions, a new family of 3D topological solitons with freely tunable textures and numbers. These structures exhibit robust topological protection, making them suitable for applications in optical communications, quantum technologies, and metrology.
Researchers have developed a machine learning model that can predict the word about to be uttered by a subject based on their neural activity. The model achieved 55% accuracy using six channels of data and 70% accuracy using eight channels, comparable to other studies requiring electrodes over the entire cortical surface.
Researchers found that nearly half a million people missed starting medication to lower their blood pressure during the Covid-19 pandemic, leading to thousands of avoidable cardiovascular events. Identifying individuals who missed out on treatment could reduce these events by just over 2,700.
Researchers found that certain gene signaling pathways, such as interferon γ and beta-catenin, can lead to tumor hyperprogression after immunotherapy. Targeting these pathways may prevent hyperprogression in preclinical models.
Researchers found that regorafenib, a dual PDGFR α/β inhibitor, modifies the cancer microenvironment and enhances the efficacy of anti-PD-1 immunotherapy in advanced gastric cancers. This combination therapy boosts tumor infiltrating immune cells and reduces tumor fibroblasts.
Professor Klaus Boehnke sheds light on how uncritically transferring Western procedures to other regions distorts reality, leading to false assumptions about cultural differences.
Researchers at UCLA have created the first synthetic version of lissodendoric acid A, a sea sponge-derived molecule with potential therapeutic benefits for Parkinson’s disease and similar disorders. The team developed a method that employs cyclic allenes to produce only the desired enantiomer of the molecule.
Researchers at the University of Cologne discovered that bacterial membrane potential changes during biofilm formation, correlating with increased antibiotic tolerance. The study found characteristic patterns of polarization that evolve in space and time, which are linked to a change in oxygen availability.