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Science News Archive 2023 - Page 434


Page 434 of 444

Researchers fix ‘fundamental flaw,’ improving pandemic prediction model

Researchers from North Carolina State University identified a fundamental flaw in a commonly used pandemic model that causes it to severely underestimate disease spread. By modifying parts of an existing model, they substantially improved its accuracy when compared to real-world data on the COVID-19 Omicron variant.

SourceNorth Carolina State University·JournalProceedings of the Royal Society A Mathematical Physical and Engineering Sciences·TypeComputational simulation/modeling·DateJan 11, 2023

Transcranial magnetic stimulation measured cortical inhibition provides insight into interindividual differences in progressive myoclonic epilepsy

A new study has found that abnormality of intracortical inhibition in patients with progressive myoclonic epilepsy type 1 is associated with the magnitude of genetic change. The results suggest that transcranial magnetic stimulation could be useful in assessing patient prognosis and may have use as a marker of GABAergic impairment.

SourceUniversity of Eastern Finland·JournalEpilepsia·DateJan 11, 2023

Discovery of metabolic switch could lead to targeted treatment of obesity, cancer

Researchers at Iowa State University have identified a metabolic switch that can be modified to control fat production, which could lead to more effective treatments for childhood obesity and cancer. The discovery involves altering the acetylation levels of fatty acid synthase, an enzyme critical to de novo lipogenesis.

SourceIowa State University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJan 11, 2023

An investigational T-cell therapy shows promise against six viral infections common after stem cell transplants

A phase II study found that posoleucel, an off-the-shelf T-cell therapy, demonstrated promising antiviral efficacy and safety in patients with blood cancers and other hematologic disorders. The therapy reduced viral load by an average of 97% and showed limited rates of graft-versus-host disease.

SourceAmerican Association for Cancer Research·JournalClinical Cancer Research·DateJan 11, 2023

Covid-19 conspiracy theories led to lower uptake of vaccine and testing among Black community, research by Kingston University, London finds

A study by Kingston University found that Covid-19 conspiracy theories led to a lower engagement with health prevention methods among the UK Black community. The research revealed that perceived racial injustice and mistrust of institutions contributed to this phenomenon.

SourceKingston University·JournalBritish Journal of Health Psychology·TypeSurvey·DateJan 11, 2023

Study reveals obesity-related trigger that can lead to diabetes

Researchers at WashU Medicine discovered a link between obesity and diabetes, highlighting the importance of an enzyme in fatty acid processing. The study suggests that defects in this enzyme contribute to insulin hypersecretion and beta cell failure, paving the way for potential therapeutic interventions.

SourceWashU Medicine·JournalCell Metabolism·TypeExperimental study·DateJan 11, 2023

Some hospitalized patients’ infections may develop from their own bacteria

Researchers discovered that urinary tract infections can arise after sterile tubes are inserted into the urinary tract, even when no bacteria are detectable beforehand. This study suggests that screening patients for hidden reservoirs of dangerous bacteria could supplement infection-control efforts and help prevent deadly infections. B...

SourceWashU Medicine·JournalScience Translational Medicine·TypeExperimental study·DateJan 11, 2023

‘Soft laws’ see more women in the boardroom

Research by Anglia Ruskin University found that soft laws in over 14,000 companies across 99 nations led to a 20% average percentage of women on corporate boards. Quotas increased female directors by 11.7%, but only when sanctions were applied. Firms complied better with realistic targets and sufficient time.

SourceAnglia Ruskin University·JournalInternational Journal of the Economics of Business·TypeSurvey·DateJan 11, 2023

Surgery first for colon cancer? Not so fast, according to new study in JNCCN

Researchers discovered that pre-surgery immunotherapy significantly improved patient outcomes for locally advanced colorectal cancer. The treatment showed substantial longer survival benefits, including low recurrence rates, in patients with mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) CRC.

SourceNational Comprehensive Cancer Network·JournalJournal of the National Comprehensive Cancer Network·DateJan 11, 2023

Scientists sequence and annotate majority of Red Perilla’s genome, a step toward harnessing more of its medically valuable bioactive chemicals

Hiroshima University researchers have generated a high-quality genome assembly of red perilla, allowing scientists to harness its abundance of potentially useful bioactive chemicals. The study enables targeted gene editing for enhanced phytochemical production, paving the way for new medical applications.

SourceHiroshima University·JournalDNA Research·DateJan 11, 2023

Clinical trial shows boiled peanuts could help overcome child peanut allergy

A clinical trial found that boiling peanuts for up to 12 hours can desensitize children with peanut allergies. The therapy involved sequential doses of boiled and roasted peanuts, achieving high success rates in participants. While promising, the study's findings require confirmation in larger trials.

SourceFlinders University·JournalClinical & Experimental Allergy·TypeRandomized controlled/clinical trial·DateJan 11, 2023

Research brief: New “burden-free” study method finds two blood pressure drugs equally effective

Researchers at the University of Minnesota Medical School conducted a large clinical trial comparing two commonly prescribed generic drugs, chlorthalidone and hydrochlorothiazide. The study found that both medications were equally effective in preventing cardiovascular disease and non-cancer death, contradicting current clinical guidel...

SourceUniversity of Minnesota Medical School·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateJan 11, 2023

Moving water and earth

A new understanding of how particle shape controls grain flow can help engineers plan for downstream impacts of restoring a river or removing a dam. The MIT team's better formula estimates bed load transport by considering a grain's drag and friction, rather than its exact shape.

Cutting costs and emissions in beef production

A research team from the University of Queensland has developed a tool to guide the global beef industry in reducing costs and greenhouse gas emissions. The study found that as much as 85% of emissions could be cut without an overall economic hit, by opting for more efficient feeds and locations.

SourceUniversity of Queensland·JournalNature Sustainability·DateJan 11, 2023

Can boiled peanuts help cure peanut allergies?

A phase 2 clinical trial using boiled peanuts followed by roasted peanuts showed promising results in desensitizing 80% of children with peanut allergies. Treatment-related adverse events were reported in 61% participants.

SourceWiley·JournalClinical & Experimental Allergy·DateJan 11, 2023

Enzyme-metal-single-atom hybrid catalysts for efficient one-pot chemoenzymatic reactions

Researchers have developed a novel hybrid catalyst that combines enzymatic and single-atom catalysis, achieving high efficiency in one-pot chemoenzymatic reactions. This breakthrough simplifies chemical production and separation processes, offering a promising strategy for efficient synthesis of pharmaceutical intermediates.

Annual or biannual boosters are optimal for fighting endemic COVID-19, study shows

A study by Yale School of Public Health and University of North Carolina at Charlotte found that annual or biannual COVID-19 boosters significantly reduce the risk of future infection. Boosting every six months provides strong suppression of infection, with only one in 10 people projected to contract COVID-19 over a six-year period.

SourceYale School of Public Health·JournalJournal of Medical Virology·DateJan 11, 2023

Tailoring 'hollow' hydrogen molecule generation with two-color, bicircularly polarized laser pulses

A team of researchers has developed an experimental method to manipulate the Rydberg state excitation in hydrogen molecules using bicircular two-color laser pulses. By controlling the photon effect and field effect, they were able to generate Rydberg states while varying the extent to which each effect contributed to the process.

Artificial pancreas successfully trialled for use by type 2 diabetes patients

Researchers at the University of Cambridge developed an artificial pancreas that can help maintain healthy glucose levels in type 2 diabetes patients. The device doubled the time spent in the target range for glucose and halved the time spent with high glucose levels, reducing average glucose levels and glycated haemoglobin levels.

SourceUniversity of Cambridge·JournalNature Medicine·TypeRandomized controlled/clinical trial·DateJan 11, 2023

Sunlight pulps the plastic soup

Experiments show that UV light from the sun breaks down plastics on the ocean surface, turning them into smaller, invisible nanoplastic particles. This process could account for a substantial amount of the 'Missing Plastic Paradox', where plastic waste in the ocean is only a fraction of what has been littered.

SourceRoyal Netherlands Institute for Sea Research·JournalMarine Pollution Bulletin·TypeExperimental study·DateJan 11, 2023