The field of cancer immunotherapy is advancing with innovations in precision medicine, including adoptive cell transfer therapy, TCR-engineered T cells, and natural killer cell therapy. Therapeutic vaccines are also being developed to target specific cancer antigens, offering new treatment options for patients.
A study found that affluent households are twice as likely to shop online for groceries, while those in lower social grades opt for take-away meals. Users of food delivery apps are more likely to be living with obesity, the research suggests.
Researchers developed a new platelet-centric scoring system to predict platelet hyperreactivity and cardiovascular events. The Platelet Reactivity ExpresSion Score (PRESS) can detect hyperreactive platelets in patients at imminent risk of heart attack and healthy individuals with unknown future risk.
A new study by Kyoto University reveals that major companies relying on low-quality offsets undermine the effectiveness of the voluntary carbon market. The research finds that these companies collectively account for over one-fifth of all retired offsets, most of which fail to meet well-known quality standards.
Researchers unveil significant findings that could enhance BCI technologies, marking a crucial step towards more intuitive neuroprosthetic control. Key findings reveal distinct regions within the sensorimotor cortex for imagined tactile and motor tasks.
A commercial AI tool was effective in excluding pathology and had lower rates of critical misses on chest X-rays compared to radiologists. The study found that the AI tool could autonomously report more than half of all normal chest X-rays without decreasing standard of care.
Researchers developed a new 'pan-pathogen' deep sequencing approach to capture multiple bacterial strains simultaneously. This method enables faster and more comprehensive tracking of antibiotic-resistant bacteria, potentially preventing and managing common hospital infections quicker.
A cross-sectional study found that approximately 50% of cancer survivors experience financial hardship, with social vulnerability playing a key role in increasing levels of hardship. Younger, Medicare or Medicaid beneficiaries, and those with advanced disease are particularly vulnerable to financial strain.
A study published in Genome Biology and Evolution found that predation by protists increases the virulence of opportunistic pathogens like Serratia marcescens. The presence of the predator Tetrahymena thermophila led to stronger biofilm formation and greater antimicrobial resistance, resulting in higher mortality in honey bees.
A first-of-its-kind adaptive 3D printing system developed by the University of Minnesota Twin Cities researchers can identify organism positions and safely move them to specific locations for assembly. This technology saves time and money in bioimaging, cybernetics, and cryopreservation.
A novel negative-stiffness isolation device has been developed to provide multidirectional negative stiffness and energy dissipation, effectively mitigating earthquake impacts. The device's advanced design enhances seismic protection by offering a robust solution for safeguarding buildings in earthquake-prone areas.
A recent study found that approximately two-thirds of inhalers used by patients hospitalized with COPD were misused, leading to inadequate medication delivery and increased exacerbations. Regular therapeutic education and proper inhaler technique can improve health outcomes.
Researchers at the University of Vienna developed a software tool called MolCompass to identify areas of 'chemical space' where machine learning models are weak. This helps toxicologists and regulatory authorities increase confidence in these models, reducing the need for animal testing.
A study published in The Journal of Bone & Joint Surgery found a link between Modic changes and microbial diversity in the lumbar cartilaginous endplates. Patients with Modic changes had more severe lumbar disc degeneration and a distinct metabolite profile, suggesting potential contributors to its pathogenesis.
Researchers identified a long-postulated hidden spatial grammar embedded in DNA, which holds the key to understanding how gene activity is encoded. The study found that transcription factors have a complex function, acting both as activators and repressors, and their position relative to genes influences gene expression.
A recent study developed a new folded supramolecular polymer that spontaneously undergoes interchain aggregation, exhibiting potential applications in stimuli-responsive materials. The research team used atomic force microscopy to demonstrate the relationship between unfolding and aggregation.
The METTL family is involved in normal cell differentiation, maintaining mitochondrial function, and has implications in malignancies, neurodegenerative disorders, and cardiovascular ailments. Research directions include developing diagnostic and therapeutic markers.
A recent study analyzing data from 1.97 million participants found that consuming 50g of processed meat a day increases type 2 diabetes risk by 15%, while eating 100g of unprocessed red meat daily raises the risk by 10%. Poultry consumption was also associated with a higher risk, but to a lesser extent.
A study by Jin et al. found that re-cryopreservation in blastocysts results in impaired development potential, decreased implantation rates, and lower live birth rates. The researchers discovered an association between re-cryopreservation and activated endoplasmic reticulum stress pathway and induced apoptosis.
The American Society for Biochemistry and Molecular Biology has announced its annual awards, recognizing outstanding scientific achievements and community contributions. The winners will give talks about their research at the society's annual meeting in April, with cash prizes ranging from $2,000 to $35,000.
This review explores the key signaling pathways driving multiple myeloma and highlights their potential as therapeutic targets, including PI3K/AKT/mTOR, RAS/MAPK, JAK/STAT, Wnt/β-catenin, and NF-κB pathways.
A new textured heart valve implant has been shown to be less likely to cause clotting, improving health outcomes for patients who receive the implant. Certain conditions such as cancer and smoking elevate the risk of blood clots after heart surgery.
A new study published in Nature Medicine shows that precision therapy can improve survival for men with metastatic castration-resistant prostate cancer. The treatment, which involves analyzing the genetic profile of the tumor, has been shown to be more effective than chemotherapy in patients whose tumors have specific mutations.
Kids are missing out on local content due to algorithmic curation and platform interfaces. Researchers found US-based global streaming video platforms like Netflix and YouTube restrict children's access to available local options.
Researchers found significant differences in effect sizes depending on studies' approach, emphasizing the importance of a comprehensive understanding of ACEs' multifaceted impacts. The study suggests a critical need for varied strategies to understand, prevent, and reduce ACEs' effects on individual development and societal well-being.
Researchers at Singapore University of Technology and Design designed a vacuum-actuated hybrid soft gripper to handle delicate objects of varying sizes and shapes. The gripper features soft composite fingers and a palm, enabling wide grasping potential and adaptability to specific tasks.
Researchers have developed a new method to predict protein movements by teaching AI about energetic frustration. This improves the accuracy of tools like AlphaFold2 in predicting alternative structures and functional movements. The study has significant implications for drug design, enzyme engineering, and disease mechanisms.
A novel model integrating utility loss aversion explains low demand for cyber-insurance due to optimistic decision-making and reluctance to invest in supplementary strategies. This has broader consequences for corporate risk management, public policy, and systemic cyber risks.
A team of researchers found that James Joyce's 'Finnegans Wake' exhibits a unique structure in its use of punctuation, with sentence lengths following an orderly curve. This symmetry is rare in nature and suggests a well-organized complex hierarchical structure.
A new theropod dinosaur, Alpkarakush kyrgyzicus, has been discovered in Kyrgyzstan with a unique 'eyebrow' feature. The species belongs to the metriacanthosaurids and is closely related to large predatory dinosaurs of East Asia.
Researchers developed a novel ratchet mechanism that converts random motion into ordered movement using asymmetric surface wettability. The gear demonstrated one-way spin with vertical oscillations at restricted frequency and amplitude ranges.
Researchers have designed a shunt that can expand when activated by light, potentially reducing the number of open-chest surgeries needed to accommodate growing children. In lab experiments, they found the shunt could be expanded incrementally, with adjustments customizable to each child.
A new study by Northwestern University found that PrEP users frequently perceive others using the medication as promiscuous, despite knowing those who use it. The authors suggest sex-positive messaging to address this stigma and encourage a broader understanding of PrEP's benefits among vulnerable populations.
A new AI model developed by Karolinska Institutet can predict autism in young children with an accuracy of almost 80% for those under two years old. The model uses a combination of limited information to identify patterns and strong predictors of autism, such as age of first smile and eating difficulties.
A study found that participants who consumed greater amounts of protein and fiber had the greatest success at losing weight. Personalization and flexibility were key in creating plans that dieters could adhere to over time.
Research finds that weather patterns play a crucial role in triggering complex air pollution in Dongying, China. The study identifies specific synoptic patterns that contribute to the formation of fine particulate matter and ozone pollution, highlighting the need for targeted strategies to mitigate these issues.
A study published in Scientific Reports suggests that emphasizing positive messages within a party is more effective for political communication on social media, fostering a cohesive and supportive online community. This approach counters the negative effect of out-party hostility, promoting engagement and constructive dialogue.
Researchers at Technical University of Denmark developed a new biopolymer, PAMA, derived from bacteria to heal tissue. The PAMA bactogel shows significant muscle regeneration properties and nearly 100% mechanical recovery in rats.
Researchers have identified dozens of potential new antibiotics in the human gut microbiome, with one candidate showing promise against multidrug-resistant infections. The discovery uses artificial intelligence to analyze vast amounts of biological data and mine the world's biological information as a source of antibiotics.
Researchers at Stanford University have designed an electrified thermochemical reactor capable of generating immense heat using electricity, replacing fossil fuels in industrial processes. The design is smaller, cheaper, and more efficient than existing technology.
A review of bermudagrass growth and stress response mechanisms has made significant progress, emphasizing recent advances in molecular biology. Future research aims to refine genetic transformation techniques, identify key genes and regulatory pathways involved in stress tolerance.
The Illinois researchers developed a new index called the Circularity Index (CI), which measures circularity on a scale from 0 to 1. It includes eight categories: take, make, distribute, use, dispose, recover, remake, and reuse. The CI can be used to evaluate strategies and impacts in bioeconomic systems.
A Leipzig study found that chronic kidney disease (CKD) activates microglial cells, disrupting potassium balance in nerve cells and leading to cognitive impairment. Researchers identified a mechanism involving the blood-brain barrier and potential therapeutic targets.
Researchers tested lecanemab, an anti-amyloid drug, on brain tissue samples from individuals with Down syndrome, finding it effectively targeted amyloid plaques but also bound to blood vessels. The study highlights the need for careful consideration of safety and potential hemorrhagic complications in people with Down syndrome.
Researchers at Weill Cornell Medicine have discovered a connection between DNA markers and the aging process. The study found that specific retroelements in the human genome can act as epigenetic clocks predicting chronological age and may be involved in aging.
A multidisciplinary team at UC Davis Health has developed a real-time action plan to support patients with preexisting respiratory diseases affected by poor air quality from wildfires. The plan, which considers social, economic, environmental and behavioral factors, aims to mitigate the health threat posed by wildfires.
Research has shown that winners of a fight are more likely to win subsequent contests, while losers tend to lose their following fights. In humans, winner and loser effects can guide individuals to behave according to their apparent social rank.
Researchers at Rutgers University have identified a natural molecule called phosphatidic acid that can reduce the activity of touch-sensing ion channels in the body. Increasing phosphatidic acid levels in cells makes them less sensitive to touch, and inhibiting its formation leads to increased sensitivity.
A new biosensor prototype can measure biomarkers for heart failure in saliva, promising a more accessible and affordable way to screen for the condition. The device, which resembles a COVID-19 test, could enable people with limited access to medical facilities to check on their health regularly.
A new study from the Cusack group sheds light on how avian influenza virus can mutate to replicate in mammalian cells. The key enzyme polymerase must adapt to overcome two main barriers: entering and replicating within host cells, as well as acquiring human transmission capabilities.
Researchers found that an orb-weaving spider manipulates the flashing signals of male fireflies to mimic female signals, luring more males into its web. The study suggests that animals can use indirect signaling to target specific prey in nature.
Researchers have created the first spatial map of malaria infection in the mouse liver using Spatial Transcriptomics and single-cell RNA-sequencing. This discovery sheds light on the parasite's lifecycle, revealing changes in host cell gene expression near infected areas.
A new study by The Pennsylvania State University and the University of Birmingham found that organizational support policies do not reduce retaliation intentions among 'stuck' employees. Stuck employees, who want to leave their jobs but cannot due to barriers, are more likely to retaliate against perceived organizational injustice.
Scientists created a wearable sensor that can monitor cholesterol and lactate levels on dry skin, enabling early disease detection. The sensor overcomes existing challenges of traditional methods, promising new opportunities for remote patient monitoring and population-wide health screening.
A recent study by Columbia University Mailman School of Public Health found that Generative artificial intelligence (LLM) can't yet reliably read and extract information from clinical notes in medical records. The AI, ChatGPT-4, performed well only when given highly detailed prompts and struggled to replicate its work across trials.
Vascular Adhesion Molecules (VAMs) are linked to inflammation, endothelial dysfunction, and plaque formation. Targeting these molecules could improve CVD prevention and biomarker-guided treatment. The study explores the potential role of VAMs in CVD development.
A randomized clinical trial tested the effectiveness of two eight-week telehealth mindfulness-based interventions, finding they improved pain and overall well-being among veterans with chronic pain. The scalable format made it accessible for patients, suggesting a potential solution to accelerate non-medication pain treatment.
Researchers developed Porous-DeepONet, a deep learning framework that efficiently captures complex features of porous media and learns solution operators. It outperforms traditional FEM methods in solving parameterized reaction-transport equations in porous media, handling complex domain geometries and multiphysics coupled equations.
Researchers discuss the role of gut microbiota in regulating basal inflammation levels and promoting healing of the bowel after surgery. Weakened gut barrier function may lead to persistent low-grade inflammation and increased risk of cancer recurrence.
A recent study published in EMBO Reports found that embryonic stem cells exhibit high origin activity and slow forks to coordinate replication with cell cycle progression. This challenges the assumption that these cells experience high levels of intrinsic replication stress.