A study led by Dr. Clint Cary found that traditional open surgery is the most effective approach for removing lymph nodes behind the intestines in patients with testicular cancer. The study showed excellent cancer cure rates and low blood loss, short hospital stay, and rare major postoperative complications.
The Real-World Evidence Data Enterprise (RWE-DE) combines longitudinal electronic health records with insurance claims data to improve the validity of studies on medical products in clinical practice. This new infrastructure will enable the FDA to conduct studies using granular clinical information to identify medication safety issues.
A clinical trial has begun to assess the safety and acceptability of a novel rectal HIV microbicide douche containing tenofovir for pre-exposure prophylaxis. The study aims to provide an 'on-demand' HIV prevention method for eligible individuals who engage in receptive anal intercourse.
Researchers synthesizing AI with biomarker analysis aim to detect early signs of aging and enable targeted interventions to delay disease. This approach has the potential to slow, prevent or reverse certain effects of aging.
A clinical trial found that two topical treatments, HPE and vitamin C, produce similar reductions in brown spot fractional area and improved skin luminosity and color evenness. The outcomes are comparable to those of more invasive treatments, suggesting a reliable and skin-friendly alternative to traditional cosmetic procedures.
A study by Macquarie University researchers found that plants can salvage resources from wilting flowers and reuse them to promote future reproduction. The study showed that plants transfer resources underground in corms and roots to produce new flowering stems in the subsequent season, often a year later.
Researchers from the University of Zurich have discovered a link between hepatitis E and kidney damage, finding that viral envelope-antibody complexes can accumulate in kidney filters and cause glomerulonephritis. The study uses tissue samples from patients to understand the disease mechanism.
Researchers developed a simple, repeatable printing technique to create periodic nano/microstructures on glass substrates with useful functions like water-repellency and structural colors. The technique enables fabricating materials without expensive equipment and complex processes, paving the way for innovative gas sensors.
Researchers found that cognitive behavioral therapy for insomnia (CBTi) during pregnancy significantly improves sleep patterns and reduces postpartum depressive symptoms. The treatment has been shown to be effective in reducing symptoms of depression similar to antidepressant medications.
A study analyzing social media posts found fast food restaurants and sugar sweetened beverages are the most common, with millions of mentions reaching billions of users. The research argues that normalizing unhealthy eating in the digital environment contributes to obesity challenges worldwide.
Binghamton University researchers have created artificial plants that can capture 90% of carbon dioxide from indoor air, reducing levels and generating oxygen. The plants use photosynthesis to drive the process, with an additional power generation capability of around 140 microwatts.
Researchers found that both methods restored blood circulation in about 30% of patients, with no difference in survival or quality of life. The study's results may impact future guidelines for cardiac arrest treatment.
Experts argue that current implementation of Biodiversity Net Gain policy is flawed, with localized offsetting leading to double conservation gains when targets are placed where they benefit biodiversity most. This approach can greatly improve benefits to wildlife and help nature-deprived areas.
Researchers from The University of Texas at Arlington are conducting a DNA analysis project to determine the genetic differences between the rare Dixon's whiptail and the common checkered whiptail. If the two species are found to be distinct, Dixon's whiptail may become eligible for endangered species protection.
Ancient cultural burning practices by Indigenous Australians limited fuel availability and prevented high-intensity fires in southeastern Australia. The research found a 50% decrease in shrub cover due to expanded Indigenous populations and cultural burning, leading to a decline in high-intensity fires.
A recent study found that early-life sugar restriction can protect against diabetes and hypertension later in life. The research, using post-World War II data from the UK, suggests that exposure to sugar rationing during the first 1000 days of life can lower the risk of chronic diseases by about 35% for diabetes and 20% for hypertension.
Researchers at Kumamoto University identified G-quadruplexes as a central role in promoting alpha-synuclein aggregation, leading to neurodegenerative diseases. Inhibiting G4 assembly may prevent the onset of synucleopathies and position it as a promising target for early intervention.
Researchers from Texas A&M University synthesized research findings to improve medical devices and therapy success rates. The review emphasizes the need to understand macrophage cell behavior to develop targeted immunotherapy treatments.
A new reinforcement learning framework, AVATARS, uses diverse sensor streams to track whales and predict their surface locations. The framework aims to minimize missed encounters and improve data collection for Project CETI.
A recent study has identified 51 amyotrophic lateral sclerosis (ALS)-associated mutations in mitochondrial DNA that could help diagnose the disease. The mutations, which include 13 that increase the risk of ALS and 38 protective ones, were found to be significantly associated with an increased or decreased risk of developing the disease.
A 20-year study found that climate change increased CO2 sources and sinks in permafrost forests, with a nearly 20% increase in CO2 sinks in the second decade. The growth of black spruce trees aided by wet conditions helped absorb increasing CO2 from human activities during photosynthesis.
A Cornell University research team found that strategically placing a mix of medium-speed and fast-charging stations in urban areas increases driver usage and improves investor profitability by 50-100%. The team used Bayesian optimization to analyze data from Atlanta, taking into account factors like traffic and road characteristics.
Researchers develop model to calculate ideal learning rate based on environmental change and life cycle. The optimal pace of learning increases in the same way regardless of environmental changes, suggesting a generalizable phenomenon underlying learning in various ecosystems.
Researchers have developed a large-scale drug screening technique that tracks drug targets inside cells, allowing for the identification of potential new drugs. The technology screens candidate drugs 100 times faster than standard manual techniques, enabling the discovery of previously unknown drugs.
A pilot randomized controlled trial found that telephone-delivered therapy reduced mental health symptoms and improved treatment completion rates among refugee children. The adapted programme, called t-CETA, was delivered by local trained lay counsellors and showed significant benefits compared to in-person treatment.
Researchers developed an algorithm to analyze high-resolution spatial data from Seq-Scope and other technologies, called FICTURE. This enables scientists to see how and where a gene is expressed at microscopic resolution, improving our understanding of gene expression.
A Michigan Medicine study of over 18,500 adults found that obstructive sleep apnea was associated with a higher risk of dementia symptoms or diagnosis at every age level. Women were more likely to be diagnosed with dementia than men, especially as they aged.
Researchers found a surprising link between high levels of methylmalonic acid and the weakening of CD8+ T cells, shedding light on potential pathways through which aging may promote lung cancer progression. Elevated methylmalonic acid levels disrupt energy production in immune cells, making it harder for them to fight cancer.
A full textile energy grid can be wirelessly charged, powering wearable sensors, digital circuits, and even temperature control elements. The system uses MXene ink printed on nonwoven cotton textiles, demonstrating its viability for integrated textile-based electronics.
A new study finds that restricting sugar consumption in utero and early childhood significantly reduces the risk of midlife chronic diseases like Type 2 diabetes and hypertension. Low sugar intake by mothers before birth and continued restriction after birth increased health benefits.
Researchers at the University of Maryland School of Medicine have created a large genomic database of Latin Americans to tackle health disparities. The Genetics of Latin American Diversity Database (GLADdb) includes genome-wide information from almost 54,000 individuals and allows other scientists to easily add population data to their...
Researchers at Universitat Autonoma de Barcelona found a 1.1 ºC temperature increase in the Roque de los Muchachos Observatory over 20 years, more than double predicted by climate models. The study also revealed an increase in diurnal temperature range and seasonal oscillations.
A new study from the University of Toronto finds that childhood neglect is associated with a range of mental and physical health problems in adulthood. The presence of a supportive adult and higher socioeconomic status largely attenuate this relationship.
The development creates thin-film solar cells with high light absorption efficiency, transforming the interaction between light and matter. This breakthrough has potential applications in thermoelectric clothing, onboard vehicle charging, and photo-sensing technologies.
Researchers have discovered a therapeutic approach that shows promise in preclinical models for treating cancers driven by RAS mutations. The study found that tri-complex inhibitors can restore the normal functioning of mutated RAS proteins, aiming to correct the defect that drives cancer growth.
Researchers studied fermium isotopes with different neutron numbers, revealing a steady increase in nuclear charge radius across the neutron number 152. The experimental results confirmed theoretical predictions on nuclear shell effects and paved the way for further laser spectroscopic studies of heavy elements.
A team of biomedical engineers from the University of Melbourne has developed a groundbreaking 3D printing system that can fabricate complex human tissues in just seconds. This technology significantly improves the potential to predict and develop new pharmaceutical therapies, reducing the need for animal testing.
A study published in JAMA found that drug-related reports of supply chain issues were 40% less likely to result in meaningful drug shortages in Canada compared to the US. This highlights the importance of global cooperation to curb the effects of drug shortages and strengthen pharmaceutical supply chains.
Researchers discovered a single key enzyme, ALDH3A2, fine-tunes red and yellow pigments in parrots' plumage, controlling the balance of hues. This simple mechanism offers insight into the rapid evolution of diverse colors in parrots, a process driven by a single gene with a large effect.
A nationwide study found significant disparities in cleft lip repair surgery outcomes among US children of different racial and ethnic backgrounds. Non-White children were more likely to experience delays, complications, and prolonged hospital stays than their White counterparts.
The Journal of the Royal Society of Medicine has been ranked as one of the world's top ten general medicine journals by Clarivate's Journal Citation Reports. With an Impact Factor of 16.3, the journal has seen a significant increase from its 2018 figure of 3.538.
Scientists at The University of Tokyo successfully observe the existence of space charge layers in solid electrolyte fuel cells, shedding light on their impact on ion conduction. By controlling grain boundary structure, they can eliminate these layers and improve material performance.
Researchers have designed a paper-aluminum laminate that could replace plastic layers in protective packaging, providing a more sustainable option. The material's mechanical properties were compared to conventional polyethylene-aluminum laminates and found to be nearly identical.
The emerging 'robot scientist' paradigm challenges traditional scientific research, leveraging AI technologies to automate the entire research cycle. Big data and AI complement intellectual approaches, enhancing research efficiency and automation.
Researchers at Empa's nanotech@surfaces laboratory have developed a method to link many spins in a controlled manner, enabling precise measurement of their interactions. This achievement brings theoretical models of quantum physics one step closer to reality.
Researchers have identified polyphosphate as a universal biomolecule that binds to the lysine-rich pocket of α-synuclein protofilaments. This binding contributes to the stability of the fibers, which are associated with synucleinopathy patient-derived fibrils.
Researchers found that Kuhl's pipistrelle bats can navigate over kilometers using echolocation alone and enhance their performance with vision. The bats' ability to identify their location and use environmental features as acoustic landmarks suggests they possess an acoustic mental map of their home range.
Researchers found recurrent severe droughts and erratic wet conditions in the Greater Mara-Serengeti ecosystem, with a 5 degree C temperature rise over six decades. The study highlights the importance of understanding regional climate trends to predict future climate conditions and mitigate their impact on wildlife populations.
Researchers found that individuals with stronger autistic traits displayed distinct exploration patterns and higher levels of persistence, leading to better performance in a computer game. These findings suggest that tailored learning environments can benefit individuals with autistic traits.
A new anti-cancer agent has been developed that targets glutathione in cancer cells, switching it off and causing tumor shrinkage. The catalyst-based therapy accumulates specifically in tumor tissue, showing promising results in animal studies and potential for further human trials.
Researchers found significant bias in AI-powered hiring systems, with LLMs favoring white-associated names 85% of the time, female-associated names only 11% of the time, and never Black male-associated names. The study highlights the need for intersectional analysis to ensure fairness in AI systems.
Researchers will focus on harnessing waste heat and renewable energy sources to power clean cooling technologies. The project aims to address the growing environmental impact of cooling in various industries, with demand expected to multiply in the coming years.
A new study reveals that ocean eddies off the leeward side of Hawaiian Islands supply nutrients to both sides of the island chain, stimulating blooms of phytoplankton and boosting biological productivity. This mechanism may also impact fisheries near Hawaii and other nutrient-poor regions.
Researchers found that echolocating bats create detailed mental acoustic maps of their surroundings, allowing them to navigate over several kilometers. The study also showed that bats use both echolocation and vision to improve navigation performance.
European hedgehog populations are declining by over 30% in several countries due to man-made threats such as traffic, agricultural practices, and habitat destruction. The species is now listed as Near Threatened on the IUCN Red List, highlighting the need for conservation efforts.
A new study found that foreign accents can mitigate judgment for grammatical errors, except in cases where listeners are highly conscientious. The research suggests that English speakers are generally tolerant of grammatical errors when the speaker has a foreign accent.
A new study proposes an ethics-based approach to medication decisions in pregnancy, combining existing evidence with a woman's values. The approach aims to balance the benefits and risks of medications for individual pregnant patients and fetuses.
The study demonstrates a solvothermal approach to in situ construct V–O–C covalent bonds between VS4 nanorods and surface oxidized CNTs interfaces, promoting ion diffusion and electron transfer. This results in excellent magnesium storage properties, including high reversible capacity and impressive capacity retention.
Researchers have developed a new batteryless and wireless sensor that can detect impending biliary stent obstructions without waiting for clinical symptoms, blood tests or imaging tests. The sensor is 8 millimeters long and has a signal-to-noise ratio of a million to one during testing.
Research suggests that Indigenous population expansion and cultural burning practices led to a 50% reduction in shrub cover in southeast Australia, limiting wildfire intensity. Reintroducing these practices could curb future fires.