Researchers at Northern Arizona University have discovered a partnership between algae and bacteria that creates a clean-nitrogen machine, turning atmospheric nitrogen into food for river ecosystems. This discovery boosts populations of aquatic insects, which young salmon rely on for growth and survival.
Researchers found that apolipoprotein D reduces the protective antiviral type I interferon response in older individuals, leading to more severe disease outcomes. This discovery offers a potential target for therapeutic intervention to protect against severe influenza virus infection in the elderly.
A new study argues that adolescents and young adults are the main drivers of language change, rather than young children. The research finds little evidence that early learning mistakes spread through communities and highlights the role of everyday language use among older speakers.
This study reveals the complex relationships between rheumatoid arthritis and various organs, including the cardiovascular, respiratory, and gastrointestinal systems. The findings suggest that RA functions as a hub within an expansive web of interacting disorders.
A novel drug target, CD300a, has been identified to suppress immune cell activation and prevent chronic heart and kidney failure after acute tissue injury. The treatment preserves cardiac function and reduces renal fibrosis in mice with genetic deficiency of CD300a.
A new study published in the American Cancer Society's journal reveals that nearly 1 in 10 patients undergoing surgery for early-stage cancer will initiate opioid prescriptions long-term. The research found that those with a prior history of chronic pain, comorbidities, and lower socioeconomic status were at higher risk.
Concurrent durvalumab therapy did not improve overall survival compared to consolidation alone in unresectable stage 3 NSCLC patients. The trial enrolled 662 patients and showed median OS was 41.5 months in the concurrent arm versus 39.4 months in the consolidation arm.
A UK study found that lung cancer screening can benefit older adults up to age 80 who are eligible for surgery. The research, presented at the International Association for the Study of Lung Cancer World Conference on Lung Cancer, showed comparable survival rates between younger and older patients treated with surgery.
A meta-analysis of randomized trials comparing video-assisted thoracoscopic surgery (VATS) and open lobectomy found a 21% reduced risk of death in VATS patients. The study also showed no difference in disease-free survival between the two groups.
The NADIM ADJUVANT Phase III trial suggests that adding nivolumab to adjuvant chemotherapy can reduce recurrence risk and may offer meaningful clinical benefit for patients with completely resected stage IB–IIIA non-small cell lung cancer. The three-year relapse rate was 26.7% in the experimental arm versus 40.1% in the control arm.
A phase III trial found hypofractionated radiotherapy (HypoRT) with concurrent chemotherapy provides similar survival outcomes and reduced toxicity compared to the standard six-week conventional fractionated radiotherapy (ConvRT) schedule for patients with limited-stage small cell lung cancer (LS-SCLC). Patients receiving HypoRT experi...
Researchers at ETH Zurich found that exergame training improved cognitive performance, memory, and structural brain changes in individuals with mild cognitive impairment. The study suggests a potential causal effect of the training on disease-modifying effects and plans for longer-term studies are underway.
The Phase 1CA240-0007 trial demonstrates a 29% overall response rate and 80% disease control rate for BMS-986504 in heavily pretreated patients with MTAP-deleted NSCLC. The agent selectively targets the PRMT5-MTA complex while sparing normal tissue.
Problem gambling in minors is linked to a higher risk of suicide, substance use disorder, theft, and assault. The Canadian Medical Association Journal urges the federal government to expedite legislation to regulate sports betting advertising and protect young people from its harms.
New research published in CMAJ found that Black adolescents with mental distress are less likely to access mental health care, with Black girls being the least likely. The study highlights the need for culturally responsive and sex-specific adaptations to care, as well as policy changes to equalize mental health service use.
Researchers have developed a patterned layer of material that can dynamically tune advanced optical processes at visible wavelengths. The breakthrough enables adaptive camouflage, biosensing, and quantum light engines, leveraging the unique properties of van der Waals materials.
A new propulsion system developed by Tohoku University's Kazunori Takahashi has successfully demonstrated the ability to remove space debris without physical contact. The system uses a bidirectional plasma ejection type electrodeless plasma thruster, which can decelerate targeted space debris and force it out of orbit in about 100 days.
A new study from UTS highlights the emotional and mental toll on teachers managing student pain in classrooms, finding educators often feel helpless, emotionally drained, and unsupported. The research identifies three key areas where pain science education can create meaningful change for both teachers and students.
A new hydrogel sensor has been developed to enable long-term, high-fidelity EEG recording and attention assessment. The PGEH patch uses machine learning-powered attention decoding and reusable skin adhesion, making it a potential game-changer for wearable neuromonitoring.
A study found that memories acquired while awake are stored in a more permanent form during REM sleep, requiring the reactivation of only three adult-born neurons involved in memory formation. This process is synchronized with theta rhythm activity and essential for proper memory function.
Researchers developed Pr0.5Ae0.5FeO3−δ perovskites to investigate the impact of electronic structure tuning on high-temperature OER performance. Alkaline earth metal doping enhanced Fe3d-O2p hybridization, lowered charge-transfer energy, and promoted oxygen ions migration.
A team of researchers from the Dalian Institute of Chemical Physics realized complete perfluoroalkyl mineralization using microclouds enriched with wollastonite-bearing microdroplets. This process prioritized defluorination over C-C scission, resulting in minimal PFAS byproducts and efficient fluoride immobilization.
A 30-year study reveals East Antarctica's interior is warming at a rate of 0.45-0.72°C per decade, faster than global average, driven by changes in the Southern Indian Ocean. This warming process may underestimate future Antarctic ice loss predictions.
A study of 344 Japanese women found that a diet rich in fermented foods, soy products, mushrooms, and seaweed was associated with improved gut microbiota and reduced depressive symptoms. Traditional Japanese cuisine may hold the key to preventing postpartum depression.
A novel 'heteroatoms synergistic anchoring vacancies' strategy has been introduced to create phosphorus-doped CoSe2 with rich selenium vacancies, resolving the long-standing 'activity-stability trade-off' of catalysts. This innovation enables Li-S batteries with exceptional performance and brings commercialization closer.
New research from Edith Cowan University found that increased muscle temperature enhances the speed and power of muscles, especially in explosive movements. The study showed a 3.5% improvement in performance for every 1°C increase in muscle temperature.
A new review highlights three pathways through which roots absorb micro- and nanoplastics, with leaves also taking up microplastics deposited from the atmosphere. This can lead to plant toxicity, altered soil microbial communities, and transfer through food webs.
Researchers found that combining arbuscular mycorrhizal fungi with biochar can reshape soil microbiomes, reduce cadmium uptake, and improve plant growth. The treatment resulted in up to 320% greater shoot biomass compared to untreated controls.
Researchers developed a new method to create nickel-based Prussian blue analog nanocages that retain an intact skeleton, boosting specific surface area and ion transfer distance. This improves the performance of aqueous nickel-zinc batteries, achieving high energy density and power density.
Researchers have introduced a novel electron localization strategy to create Ni-MXene composites with enhanced polarization, leading to boosted electromagnetic wave attenuation. The composites achieve an ultra-wide effective absorption bandwidth of 6.8 GHz and set a new benchmark for MXene-based EMW absorbers.
The premium flounder Matsukawa, cultivated using innovative Third Water technology, is now available at Kurasushi's Osaka Expo 2025 branch. The fish boasts thick flesh, rich fat content, and natural sweetness, making for an exceptional dining experience.
Researchers developed Pickering emulsion-derived MXene/silk fibroin hydrogels with programmable hierarchical structures, delivering exceptional EMI shielding and solar evaporation performance. The synergistic effects of amphiphilic silk fibroin and MXene nanosheets enable precise control over hydrogel microstructures.
The Longevity Education Hub has launched a new chapter in Brazil, offering a free accredited course in Healthy Longevity Medicine. The course, developed by Dr. Fabiano Serfaty and Fernanda Calvo-Fortes, aims to equip physicians with the latest tools and knowledge to close the gap between lifespan and healthspan.
Researchers study impact of interactions on population distribution in topological trimer array, observing formation of nonlinear edge states. They extend domain of nonlinear topological photonics to ultracold atomic systems.
A new study introduces two-dimensional biphenylene oxide as a promising candidate for next-generation metal-ion batteries, offering high energy density and storage capacity. The material's unique properties make it an exceptional alternative to traditional materials like graphite.
Researchers developed a novel robust saturable absorber by integrating a nanocavity heterostructure onto the fibre end facet, achieving single-pulse generation in approximately 85% of configurations. This enhances environmental tolerance and compactness for communication systems, high-precision sensing, and bio-photonics.
A team of researchers has developed high-reliability artificial thermoreceptors that mimic human nociceptors, enabling robots to detect harmful thermal stimuli with exceptional accuracy. The devices use photo-induced patterning thermoelectrics and exhibit minimal temporal and spatial variations.
A large sample of U.S. children born between 1959 and 1966 showed a consistent association between higher blood pressure at age 7 and greater risk of premature cardiovascular disease mortality. The findings are supported by similar associations found in siblings, reducing concerns about confounding factors.
A recent study found that AI voice agents can improve the accuracy of blood pressure measurements in older adults, leading to better patient outcomes. The technology also identified patients who needed follow-up medical care based on their readings, resulting in an 88.7% lower cost-per-reading.
The Phase 2 IDeate-Lung01 trial demonstrated a confirmed objective response rate of 48.2% and disease control rate of 87.6% in patients with recurrent or progressive ES-SCLC. Ifinatamab deruxtecan showed manageable safety and high response rates, supporting further investigation in small cell lung cancer.
Research suggests that children with higher blood pressure at age 7 may be at increased risk of dying of cardiovascular disease by mid-50s. Monitoring blood pressure as an important metric of cardiovascular health in childhood is recommended.
A Phase 1 study of SHR-4849 demonstrated early signs of anti-tumor activity in patients with relapsed small cell lung cancer, with an objective response rate of 59.5% and disease control rate of 90.5%. The drug showed manageable safety and favorable pharmacokinetics.
The ACROSS 2 Phase III trial demonstrates that combining aumolertinib with platinum-pemetrexed chemotherapy significantly improves progression-free survival in patients with advanced/metastatic NSCLC harboring EGFR sensitizing mutations and concomitant tumor suppressor gene mutations. The treatment regimen showed a manageable safety pr...
A Phase 3 trial found that crizotinib did not prolong disease-free survival in patients with resected early-stage ALK+ NSCLC. The study included 166 patients and followed them for a median of 58.3 months.
Zidesamtinib demonstrated clinically meaningful activity and durability in patients with ROS1-positive NSCLC who had progressed on prior TKI therapy. Durable responses were observed in patients with CNS involvement, ROS1 G2032R mutations, and multiple prior ROS1 TKIs.
The FLAURA2 trial shows osimertinib plus chemotherapy significantly improves overall survival compared to osimertinib monotherapy in patients with EGFR-mutated advanced NSCLC. The combination also demonstrates a manageable safety profile, extending survival for these patients.
The global Phase 3 HARMONi trial found that ivonescimab plus chemotherapy significantly prolonged progression-free survival (PFS) in patients with advanced non-small cell lung cancer (NSCLC) harboring EGFR mutations. Median PFS was 6.8 months, and the overall response rate was higher in the ivonescimab group.
Researchers developed a technique that uses infrared light and machine learning to determine the sex of blow fly larvae, improving time-of-death estimates. The method achieved over 90% accuracy and has potential applications in forensic entomology, agriculture, and biosecurity.
A novel antibody-drug conjugate iza-bren demonstrated an objective response rate of 66.0% and a confirmed ORR of 56.0% in EGFR-mutated NSCLC patients, with manageable safety profile. The median progression-free survival was 12.5 months.
A combination of iza-bren and osimertinib demonstrated a 100% objective response rate in patients with first-line EGFR-mutated locally advanced or metastatic non-small cell lung cancer. The regimen was also manageable from a safety perspective, with most treatment-related adverse events being hematologic.
The COMPEL trial demonstrates that patients with EGFR-mutated advanced non-small cell lung cancer benefit from continued osimertinib treatment in combination with platinum-based chemotherapy. This approach is associated with improved progression-free survival and overall survival compared to placebo plus chemotherapy.
The CheckMate 77T trial confirms that perioperative nivolumab does not compromise health-related quality of life in patients with resectable non-small cell lung cancer, including those with Stage III N2 disease. Nivolumab also reduces risk of symptom deterioration in these high-risk patients.
A new study validates the use of Sybil, a deep learning artificial intelligence model, for predicting future lung cancer risk in a predominantly Black population. The model demonstrated high predictive accuracy for lung cancer risk up to six years after a single low-dose CT scan.
The study found that adding baxdrostat to standard care can lower blood pressure and delay kidney damage in patients with chronic kidney disease and uncontrolled high blood pressure. Participants experienced a significant reduction in urine albumin levels, indicating potential benefits for delaying kidney progression.
Physicians rely on nuclear medicine scans to watch the heart pump, track blood flow and detect diseases. The new perovskite-based detector can capture individual gamma rays with record-breaking precision, leading to sharper, faster, cheaper and safer scans.
A new study in the Bulletin of the Seismological Society of America identifies 13 attributes of resilience in disaster response and preparedness. Agility and diversity are found to be crucial in both phases, while creativity and connectivity become vital during the response phase.
A team of scientists has estimated that an average cell line acquires and retains roughly 13 percent of its genes every million years through lateral gene transfer. This process enables microbes to adapt to new environments and access essential nutrients. The study provides the first quantitative analysis of gene transfer rates across ...
Researchers propose a new theory, Socio-Technical Exchange, to better understand human interaction with technology in the workplace. The study found that people form cognitive representations for both human and machine work partners and develop interdependence with machines.
Researchers found that individuals from African American, Hispanic and Asian groups were less likely to have elevated amyloid in the brain based on blood levels of p-tau217. This finding suggests that these groups may have a lower prevalence of amyloid and are not at sufficient risk to qualify for amyloid-lowering trials.
SkyNano, backed by Innovation Crossroads, receives $1.25M contract from U.S. Air Force to develop low-cost graphite for battery-grade applications. The project aims to create a secure domestic supply chain for lithium-ion battery materials.