The in vivo approach eliminates laboratory manipulation, leveraging viral and nonviral vectors for genetic modification of T cells. This method preserves T cell functionality, enhancing therapeutic efficacy compared to in vitro-produced CAR T cells.
Natural compounds normalize tumor vasculature, inhibiting pathological angiogenesis and reducing tumor growth. These agents complement conventional therapies, reduce toxicity, and enhance delivery of chemotherapeutic drugs.
Researchers have developed innovative strategies combining oncolytic viruses with immunotherapies to overcome limitations of OV monotherapy. These synergistic treatments amplify the body's natural defenses, creating a powerful dual attack against cancer cells while minimizing adverse effects.
Dr. Steven B. Heymsfield joins an elite group of scholars recognized for advancing knowledge and transforming their fields. He has authored over 1,300 scientific publications with nearly 79,000 citations, placing him among the top 500 most-cited researchers globally.
A new method called spVelo calculates RNA velocity to understand how cells become specialized. By incorporating spatial information and processing multiple batches at once, the method overcomes previous challenges.
Head and neck cancer's intricate connection between energy metabolism and immune regulation holds potential for effective therapies. Tumor cells' metabolic reprogramming fuels growth and supports invasion, while altering glucose transporters and lipid metabolism promotes immune evasion.
Dr. Julian Schrader will investigate the interaction between climate change and plant species spread on islands using a 1.5 million euro grant. He aims to close the knowledge gap on migration processes and their consequences for species communities.
Researchers have discovered that eels rely on signals from their bodies, like stretch and pressure, to adjust to different environments. These signals, combined with the nervous system's built-in rhythm, enable movement coordination even after a spinal cord injury.
The Mediterranean Sea is warming at a faster rate than the open ocean, posing significant risks to marine ecosystems. The study highlights the urgent need for action to protect these unique ecosystems, which could collapse or remain functional depending on political decisions made now.
A new study found that reducing dual antiplatelet therapy duration after coronary artery bypass grafting (CABG) improves graft patency while decreasing bleeding risk. Patients who received de-escalated DAPT had similar ischemic benefits and better bleeding safety compared to those on longer DAPT periods.
A new trial found that P2Y12 inhibitor monotherapy may reduce bleeding while preventing recurrent ischaemic events compared to 12 months of DAPT. However, the study failed to demonstrate noninferiority for death and ischaemic events between P2Y12 inhibitor monotherapy and dual antiplatelet therapy.
Researcher Manuel Krannich has been awarded a five-year ERC starting grant to investigate the connections between symmetries of high-dimensional manifolds and laws of algebra. His project, 'Manifolds and Functor Calculus' (MaFC), combines manifold theory with higher-level algebra.
Researchers have developed an immunotherapy drug STF-1623 that safely prevents cancer cells from hiding from the immune system's first responders. The drug works by inhibiting ENPP1 proteins that destroy cGAMP, allowing it to trigger a broader immune response and suppress tumor growth.
A research team from Tohoku University has developed a new organic redox polymer that addresses material compatibility issues in aqueous electrolytes. The polymer retains high hydrophilicity and can be broken down into its raw components under mild conditions, reducing resource consumption and plastic pollution.
A recent breakthrough in MXene nanomaterials could enable bespoke design tailored by AI. Researchers have discovered the thermodynamic forces underlying their unique structure and behavior, setting parameters necessary for AI-guided design.
Researchers at Max Planck Institute for Chemistry investigated α-pinene ratio in Amazon rainforest before, during, and after drought period. The results show that increasing drought stress shifts the ratio to higher values, indicating ecosystem stress.
A recent study has found that ivabradine, a medication used to treat angina and heart failure, was ineffective in preventing myocardial injury (MINS) after noncardiac surgery. In the trial, patients who received ivabradine had a higher risk of MINS compared to those who took a placebo.
A retrospective cohort study found system-based disparities in pre-dialysis nephrology care contribute to 1/3 of incident vascular access disparities among Hispanics. Targeted policies are needed to improve timely identification and referrals for equitable improvements in kidney failure outcomes.
Researchers found that beetle-attacked forests can heat up by as much as two degrees during summer days, but deciduous trees help to cool down these stands. Mixed stands with more deciduous trees are less vulnerable to beetle outbreaks and can keep the forest cooler afterwards.
A new ultrasound device has been developed to precisely stimulate areas deep in the brain without surgery, offering new possibilities for neurological research and treatment. The technology features a special helmet with 256 elements that target specific parts of the brain, and includes a soft plastic face mask to keep the head still.
Reintroducing native African catfish into Lake Victoria significantly reduced the number of snail hosts and lowered the intensity of schistosomiasis infections among primary school-age children. This biocontrol method provides an effective way to combat this parasitic disease in the region.
Researchers developed a method for efficient atomic migration under ambient conditions using molecular monolayers and localized surface plasmons. The process regulates atom movement through dipole-dipole interactions, enabling scalable atomic patterning.
Dilip Soman's Behaviourally Informed Organizations (BI-Org) partnership examined how behavioural insights can improve organizational processes and stakeholder engagement. The project led to significant direct impacts, including increasing pension contributions in Mexico and redesigning Ontario's organ donation system.
A recent trial found that shorter durations of dual antiplatelet therapy (DAPT) after a heart attack showed equivalent efficacy in reducing recurrent events, with a lower risk of major bleeding. The study suggests limiting DAPT duration to 3 months may be safer for patients.
Professor Joshua Gans, a renowned economist at the University of Toronto's Rotman School, has been elected a fellow of the Royal Society of Canada. He is recognized for his outstanding scholarly achievement in understanding economic drivers of innovation and scientific progress.
The new guidelines provide evidence-based recommendations for patient management, identifying high-risk individuals and enhancing outcomes. The guidelines address specific ILD management algorithms for underlying rheumatic diseases, supporting comprehensive care for patients with CTD-ILD.
Researchers at Tohoku University discovered a way to strengthen legs through daily etiquette, known as Rei-ho, which emphasizes slow and controlled movements. The study found that those who practiced Rei-ho for five minutes daily increased their knee extension strength by an average of 25.9%, compared to only 2.5% in the control group.
A new trial found sacubitril/valsartan to be superior to enalapril for heart failure patients with Chagas disease, driven by a significant reduction in NT-proBNP levels. The study provides evidence for a pharmacological treatment specifically for this high-risk population.
Researchers at the University of Colorado Boulder have created a new type of time crystal that can be observed directly under a microscope and even by the naked eye. The team used liquid crystals to achieve this feat, which could lead to technological applications such as counterfeiting prevention and data storage.
A recent study has found that surgical left atrial appendage occlusion does not reduce the risk of ischaemic stroke, transient ischaemic attack, or cardiovascular mortality in high-risk non-atrial fibrillation patients after valvular surgery. In contrast, there may be a slight benefit for high-risk patients with CHA₂DS₂VASc ≥3.
Using advanced microscopy and molecular biology, researchers visualized axis reconstruction in sea urchin embryos, tracking cellular movements and gene activation to understand self-organizing ability. This discovery sheds light on the long-standing question of monozygotic twinning emergence from one fertilized egg.
A randomized trial found that intravenous cangrelor provided immediate and effective platelet inhibition without increasing major bleeding, improving outcomes for patients with cardiogenic shock. The study's results suggest that IV cangrelor could represent a major advancement in treating this life-threatening condition.
Researchers at Case Western Reserve and the Cleveland VA are conducting a clinical trial to test sensory-enabled neural-controlled prostheses developed since 2015. The study will enroll 12 people with upper-limb amputation to compare standard prosthetic arms and hands to the sensory-enabled neural-controlled prostheses.
Scientists developed hollow microspheres with adjustable pore size, adhesion, and lubricity properties using mucus and polydopamine. These spheres can be used as drug delivery agents and may prevent tissue damage or provide a protective coating.
The addition of progesterone to gender-affirming hormone therapy leads to increased breast growth for transgender individuals. Progesterone, a key female sex hormone, was found to be safe and effective when added to oestradiol, with participants experiencing up to a 37% increase in breast volume.
Tayfun Tezduyar's space-time computational flow analysis enables accurate modeling of complex systems, from designing parachutes for astronauts to simulating blood flow through heart valves. The approach provides high-fidelity representations in both space and time, allowing for more realistic solutions.
The return of beavers in southern Finland has increased habitat biodiversity and created diverse habitats for species like moose and voles. Over a 54-year period, the habitat suitability index grew almost tenfold, thanks to beaver activity that improves habitat connectivity.
Researchers have discovered a large pipe swarm with remnants of hydrogen hydrothermal activity west of the Mussau Trench. The discovery suggests that a huge amount of hydrogen may have been formed deep in the ocean lithospheric mantle, potentially leading to economically mineable reserves.
Two trials found that drug-coated balloons and stents did not reduce the risk of amputation or improve quality of life compared to uncoated devices. Target vessel reinterventions were reduced in the first year, but differences disappeared with longer follow-up.
In a randomized trial, pulsed field ablation (PFA) showed comparable efficacy to radiofrequency ablation (RFA) for treating symptomatic paroxysmal atrial fibrillation in patients resistant to antiarrhythmic drugs. PFA also had a shorter procedure time and fewer complications.
Five University of Groningen scientists receive €1.5 million ERC Starting Grants to study brain waves and memory, develop robots with a sense of touch, create ultra-hard coatings for extreme conditions, simulate exoplanet evolution, and explore actin-based motility of human pathogens
A new study reveals that increased scrutiny of domestic fishing fleets at ports could help deter illegal fishing. The Port State Measures Agreement, which requires foreign vessels to undergo inspections when landing their fish in a country, has led to more vessels traveling longer distances to reach ports within countries that have rat...
A team of scientists developed a method to precisely control Dirac plasmon polaritons in two-dimensional materials, opening new possibilities for advanced nanophotonic technologies. By adjusting the spacing between coupled nanostructures, they increased the polariton wavevector by up to 20% and extended the attenuation length by more t...
Engineered cell lines are prone to misidentification, threatening scientific discoveries and intellectual property. Researchers at UT Dallas have developed a novel method to embed unique genetic identifiers, eliminating identification errors and safeguarding innovations with tamper-proof genomic tags.
A new study found that 89% of children and young people play video games, with loot box purchases linked to enhancement, distraction/compulsion, and FOMO. The yRAFFLE scale validated the motivations of children and young people who buy chance-based items in games.
Researchers have developed innovative electrochemical solid-state electrolyte (SSE) reactors that overcome limitations of traditional electrochemical reactors. These new reactors offer enhanced product purity, energy efficiency, and scalability, making them indispensable for next-generation electrosynthesis.
A randomized controlled trial demonstrated the safety of reconditioned pacemakers, with noninferior procedure-related infection rates compared to new devices. The study, led by Doctor Thomas Crawford, used a comprehensive protocol for cleaning and testing, and gained FDA approval for export to countries with permission.
Researchers at the University of Copenhagen have developed a method to convert plastic waste into a climate solution for efficient and sustainable CO2 capture. The new material, BAETA, can absorb CO2 out of the atmosphere efficiently compared to existing carbon capture technologies.
Researchers at the University of Gothenburg found that semaglutide reduced both cocaine use and relapse in rats, with motivation to keep taking cocaine decreasing by 52%. The study suggests that semaglutide may blunt cocaine's ability to raise dopamine levels in the brain.
Researchers at the Astrobiology Center and University of Texas at San Antonio successfully detected hydrogen emission lines from AB Aurigae b using the VLT/MUSE. The detection is interpreted as evidence of mass accretion from the circumplanetary disk onto the protoplanet.
A new study found that as more countries adopted the internationally binding Port State Measures Agreement, foreign fishing vessels needed to travel twice as far to reach a non-PSMA country. Meanwhile, domestic vessels' share of port visits globally rose from 31% in 2016 to 46% in 2021.
A study found that home-based hypertension care led to significant reductions in systolic blood pressure and improved hypertension control in rural South Africa. The intervention included technology-supported interventions and community health workers, resulting in over 80% of patients achieving hypertension control.
A new study found that better indoor air quality, proximity to natural spaces, healthy diets and strong social bonds are associated with reduced and better-regulated inflammation in childhood. The study used the Human Early Life Exposome (HELIX) cohort and identified three immune signatures linked to better overall health.
Researchers directly observe 'Floquet effects' in graphene, paving the way for innovative technology. The study reveals that Floquet engineering works in many materials, enabling targeted control over electronic states.
A Rutgers and RWJBarnabas Health study found that portable ultrasounds can lead to better diagnoses, shorter hospital stays, and significant cost savings. The technology requires additional training and workflow integration to be widely adopted.
Researchers have identified a potential new strategy for treating glioblastoma multiforme (GBM), the most common and aggressive type of adult brain cancer. Disabling a protein called ADAR1 can stall GBM cell proliferation while reprogramming the tumor microenvironment to an anti-tumoral state.
Duke-NUS Medical School is sharpening its focus on population health, driven by the need to address rising healthcare costs and chronic diseases in Singapore. The Health Services Research and Population Health (HSRPH) Programme aims to deliver scalable, cost-effective solutions that improve patient outcomes and inform national policies.
The UJI survey highlights issues with quantitative indicators, such as publication numbers and citations, that often overlook quality, social relevance, and working conditions. The university is addressing these concerns through its commitment to improving the scientific evaluation system.
Researchers found that changes in North America can drive atmospheric patterns that intensify rainfall in South and East Asia. The Tibetan Plateau also plays a role, but the North American impact is nearly half as strong as its influence on East Asian summer rainfall.
Researchers created a new material platform for non-volatile memories using covalent organic frameworks (COFs) and successfully installed electric-field-responsive dipolar rotors. The COFs' unique sln topology allows the rotors to flip without steric hindrance, enabling high thermal durability up to near 400°C.