A new device developed by Brigham researchers detected an opioid-overdose in preclinical models and captured respiratory rates and heart rates in patients with sleep apnea. The study's results could transform how life-threatening events are monitored and prevented.
Researchers found an association between altered circadian rest-activity rhythms and increased risk of frailty incidence in older adults. The study used wearable devices to detect variations suggestive of future frailty over six years before incidence.
A new data-driven framework uses machine learning to identify keystone microbial species in human gut microbiomes, varying across communities. The study found that keystone species have context-dependent essentiality and can aid digestion, breaking down complex starches.
A team of researchers developed a vaccine that stimulates regulatory T cells to suppress harmful immune cells, prolonging allograft survival in mice. This discovery identifies an analogous pathway in humans, suggesting potential treatment for autoimmune disorders and organ transplant patients.
Researchers found large reservoirs of proviruses with mutations that help them evade detection, leading to low levels of residual viremia in individuals with HIV. Altered gene expression patterns also contributed to dampened immune responses and increased survival of infected cells.
Researchers found that removing aspirin from treatment while continuing vitamin-k antagonists in patients with modern left ventricular assist devices (LVADs) did not increase clotting-related risks or pump malfunctions. Aspirin avoidance was associated with a reduction in bleeding events, lower hospital days, and decreased cost of care.
A post-hoc analysis of the CANTOS trial found no effect of canakinumab on frailty incidence or self-reported function. The study suggests that inflammation may not be a causal factor in the development of frailty in these participants.
Researchers found that abelacimab, a Factor XI inhibitor, reduced bleeding compared to rivaroxaban in patients with atrial fibrillation. The study showed significant reduction in hospitalization due to bleeding and almost eliminated gastrointestinal bleeding.
A review of 15 years' worth of data found that prenatal vitamin D supplementation reduced rates of asthma and wheezing in children compared to standard prenatal multivitamin. Vitamin D levels during pregnancy were associated with a 50% reduction in asthma and wheezing.
Researchers at Brigham and Women's Hospital have developed an AI algorithm to measure muscle development in children using MRI scans. The tool provides a standardized growth chart, allowing clinicians to track muscle mass and detect signs of sarcopenia or low lean muscle mass, enabling early intervention to prevent negative effects.
Researchers analyzed over 314,000 cells from rheumatoid arthritis tissue to define six types of inflammation involving diverse cell types and disease pathways. The findings shed new light on the cellular causes of RA, potentially informing targeted and effective therapeutic approaches.
Researchers at Brigham and Women's Hospital analyzed data from over 7,500 patients to discover that suspected bronchiectasis in smokers is associated with a higher risk of mortality. The study suggests that lung imaging can help identify this condition, leading to improved patient care.
A meta-analysis of five clinical trials found that adding docetaxel to standard-of-care treatment reduced prostate cancer-specific mortality by 70% and improved overall survival to 80%. The study focused on high-grade prostate cancer patients with low PSA levels, who previously had limited effective treatment options.
A study by Brigham researchers found that the COVID-19 pandemic led to a sharp decline in surgical abortions for commercially insured patients, with no concurrent increase in medical abortions. The rate of surgical abortions remained below pre-pandemic levels through June 2022.
Researchers found associations between PTSD and dietary patterns, specifically a Mediterranean diet rich in plant-based foods and fish. The study identified Eubacterium eligens as a protective species that may help alleviate PTSD symptoms.
A study by Brigham and Women's Hospital researchers found no correlation between anxiety and depression in men on fertility treatment, nor was there a negative impact from antidepressant medication. Despite stress concerns, the study suggests men with anxiety should continue their treatment without fear of harming IVF outcomes.
In a phase I trial, an oncolytic virus treatment designed by Brigham researchers extended survival among patients with recurrent glioblastoma, especially those with pre-existing viral antibodies. The therapy reshaped the tumor's surrounding environment to stimulate an anti-tumor immune response.
A new study from Brigham researchers reveals that women who struggle with getting enough sleep are at greater risk of developing hypertension. The research highlights the association between sleep difficulties and higher BMI, lower physical activity, and poorer diets.
Using data from Mass General Brigham’s electronic health records, researchers found that SARS-CoV-2 accounted for approximately 1 in 6 cases of sepsis during the COVID-19 pandemic. The mortality rate for patients with SARS-CoV-2-associated sepsis was initially high but declined over time.
Researchers at Brigham and Women's Hospital have identified a common brain network associated with substance use disorder, regardless of the substance used. The finding could lead to targeted neurostimulation therapies for addiction, such as transcranial magnetic stimulation.
A new model for producing human brown fat cells in vitro has been developed, providing a potential solution for treating obesity and type 2 diabetes. The researchers identified key cellular signaling cues that lead to brown adipocyte formation and successfully reproduced this process in human pluripotent stem cells.
A study found that gentrified neighborhoods have a 62% higher firearm injury incidence rate than non-gentrified communities. The researchers identified gentrification as a key factor contributing to the increased risk of firearm violence in these areas.
Researchers found that patients prescribed amoxicillin-clavulanate had higher rates of gastrointestinal symptoms and yeast infections than those prescribed amoxicillin. The study showed no difference in treatment failure rates between the two antibiotics, with treatment failure occurring in less than 2% of cases.
A team of scientists has developed a method to detect thousands of lipid molecules displayed to T cells in the human immune system. The study reveals rules about lipid size, shape, and chemical content that influence T cell responses.
Brigham researchers discovered a nasal immunotherapy approach that reduces inflammation and improves cognitive function in Alzheimer's mouse models. The treatment also expands regulatory T cells and changes gene expression patterns in the brain.
A study by Brigham and Women's Hospital found that evening 'chronotype,' going to bed late and waking up late, is associated with a higher risk of developing diabetes. Participants with later sleep and wake times had less healthy lifestyles and were at greater risk of developing diabetes than those with early-bird sleep habits.
Researchers have developed a device that can be implanted into tumors during surgery to test new treatments, providing unprecedented insight into the effects of drugs on glioma tumors. The device, which is designed to be used during standard of care surgery, caused no adverse effects on patients in a phase 1 clinical trial.
A study by Brigham researchers reveals a 37% increase in out-of-state residents seeking abortion care in Massachusetts after Dobbs, with an estimated 45 additional abortions. Non-profit funding for out-of-state residents increased by nearly ten percent, while in-state residents' use of funding remained relatively stable.
Researchers at Brigham and Women's Hospital have developed a cohesive framework for evaluating biomarkers of aging, providing a robust classification system for the identification and validation of molecular markers. The framework highlights key criteria for evaluation, including age-sensitivity and generalizability across cell types, ...
A global team of scientists has identified 39 genetic mutations associated with heart failure and pinpointed seven druggable proteins that may prevent its onset. The findings could help physicians identify and treat at-risk patients before heart failure occurs.
Researchers from Brigham and Women's Hospital evaluated ChatGPT's recommendations for cancer treatment aligned with National Comprehensive Cancer Network (NCCN) guidelines. They found that approximately one-third of the chatbot's responses were non-concordant, highlighting its limitations in clinical decision-making.
Researchers at Brigham and Women's Hospital linked MS brain lesions to memory problems by mapping white matter lesion locations in people with MS. The study found that lesions intersecting with a previously derived memory circuit centered on the hippocampus were associated with memory issues.
Researchers at Brigham and Women's Hospital have developed an AI model that screens electrocardiograms (ECG) for signs of atrial septal defects (ASD), a common adult congenital heart disease. The model correctly detected ASD in 93.7% of cases, outperforming traditional methods.
Researchers at Brigham and Women's Hospital have designed a probiotic to suppress autoimmunity in the brain, which is at the core of several diseases including MS. The treatment offers a more precise way to target brain inflammation with reduced negative side effects compared to standard therapies.
A team of investigators developed a novel technology to diagnose immunothrombosis, a major cause of morbidity among patients with sepsis or severe COVID-19. By measuring thrombin activity through breath gas, they can provide unprecedented knowledge of key enzymatic activity anywhere in the body.
Researchers identified a specific type of CD8 T cell that characterizes inflammatory arthritis induced by ICI therapies. A unique population of CD8 T cells was found to promote joint inflammation and persist in the bloodstream, explaining why ICI-arthritis continues after therapy is discontinued.
The Brigham team designed nanoparticles that deliver stimulator of interferon genes (STING) agonists to immune cells, training them to recognize and eliminate future tumors. This approach eradicates active tumors in mice with melanoma, colon cancer, and breast cancer, while preventing future tumor formation.
Researchers at Brigham and Women's Hospital found that depression after traumatic brain injury (TBI) has distinct abnormalities in brain circuitry compared to traditional major depressive disorder. The study proposes a new name for TBI-associated depression: 'TBI affective syndrome.'
A new study by investigators from the Brigham and Women’s Hospital found that lesions associated with epilepsy are connected to a common brain network, suggesting the brain connections disrupted by the lesions are key. This discovery may have clinical implications for predicting epilepsy risk and targeting treatments.
A recent study found that around one in three older frail patients survive surgical CPR, with significant association between frailty and mortality. Frail patients were more likely to die from cardiac arrests during non-emergency procedures than non-frail individuals.
Researchers have developed a biodegradable fluorescent nanoprobe to detect diabetic retinopathy (DR) at its early molecular stage. The nanoprobe binds to VEGFR-2, expressed in the retinal microvessels, allowing for early diagnosis and intervention.
A study by Brigham and Women's Hospital found associations between phenol biomarkers and altered thyroid hormone levels in women attending a fertility clinic. The presence of certain environmental chemicals, such as bisphenol A and triclosan, was linked to changes in thyroid function, potentially affecting female fertility.
A multi-nation cohort analysis found that mothers with higher BMIs have shorter breastfeeding durations due to inflammation and cesarean section deliveries. The study identified dietary and systemic inflammation as modifiable factors associated with longer lactation duration in people with high BMI.
Researchers used a new transgenic mouse model to study the impact of oxidative stress on neurons and blood vessels, revealing that high levels of stress can cause sensory neuron degeneration and cardiac hypertrophy. This combination is associated with Friedreich's ataxia, a progressive neurodegenerative disease.
A study by Brigham and Women's Hospital found that higher levels of diglycerides and triglycerides are associated with an increased risk of primary open-angle glaucoma. The research suggests that these lipid metabolites play a role in the disease's pathogenesis, highlighting potential new targets for prevention or treatment.
A review article by senior investigators at Brigham and Women's Hospital found that long COVID and chronic fatigue syndrome share similar symptoms, including brain, immune system, heart, lung, gut, and energy metabolism abnormalities. The study aims to identify areas requiring further research for improved diagnostic tests and treatments.
Researchers at Brigham and Women's Hospital identified distinct brain network connections for visual and motor anosognosia, as well as a shared network for awareness of deficits. The study found that the hippocampus and precuneus play a key role in memory-based recognition of neurological deficits.
Researchers from the BabySeq Project found that over 10% of newborns had unanticipated mutations in disease-associated genes, all medically actionable. The study prompted genetic testing, specialty consultations, and procedures among at-risk family members, including risk-reducing surgeries for mothers.
A recent study has identified 53 pesticides linked to an increased risk of Parkinson's disease, with exposure to multiple chemicals combined being more toxic than any single pesticide. The researchers also found that specific pesticides can directly harm dopamine neurons, a key finding for the development of new therapeutic strategies.
A new study from Brigham and Women's Hospital confirms the use of robotic-assisted resection of gastric GISTs in hard-to-reach locations, ensuring complete tumor removal while preserving organ function. The procedure offers superior visibility and steadier arms, reducing error and damage to surrounding tissue.