Researchers at Brigham and Women's Hospital have developed a dual-action cell therapy approach to eliminate established tumors and induce long-term immunity. The vaccine, engineered using CRISPR-Cas9, is designed to kill tumor cells and stimulate the immune system to destroy primary tumors and prevent cancer recurrence.
A new AI tool developed by Brigham and Women's Hospital improves the accuracy of time-critical pathology diagnostics during surgery. The tool, which leverages deep-learning technology, translates frozen tissue samples into high-quality images, increasing diagnostic accuracy and reducing the need for lengthy laboratory tests.
A randomized trial found that non-invasive interventions for treating spine pain improved disability and quality of life but did not decrease healthcare spending. Both treatments provided a small but significant reduction in pain-related disability at 12 months.
Researchers found dapagliflozin reduces primary composite outcome in patients with heart failure and improved ejection fraction. The SGLT2 inhibitor may benefit this growing patient population with high risk for adverse outcomes.
A recent study suggests that stimulating the intersection of two particular brain networks correlated with better patient outcomes than stimulating nearby sites for patients with Alzheimer's disease. Cognitive improvement was associated with DBS to the direct interface between the fornix and bed nucleus of the stria terminalis.
A pilot study conducted at Brigham and Women's Hospital found that a low-cost computer vision system was feasible and well-received by employees. The system accurately detected mask adherence 100% of the time, with most participants experiencing a positive interaction.
A large observational study found that Paxlovid is associated with a 44% reduction in hospitalization or death among highly vaccinated adults over 50. Even among patients with lower levels of prior immunity, Paxlovid showed an 81% reduction in hospitalization rates.
A randomized clinical trial found that two anti-inflammatory strategies reduced disease activity and arterial inflammation in patients with moderate to high rheumatoid arthritis. The treatments had no differences in cardiovascular risk reduction, highlighting the importance of specific clinical trials for this population.
A recent study found that the proportion of COVID-19 deaths among young people increased in 2021 compared to 2020, resulting in a 7.4% rise in Years of Life Lost due to the virus. The median age of COVID-19 deaths decreased from 78 years in 2020 to 69 years in 2021.
Researchers found that shingles increases the long-term risk of stroke and heart attacks by up to 30% in individuals aged 50 and older. The study followed over 200,000 participants for up to 16 years and suggests that vaccination may help reduce this risk.
A recent study by Brigham and Women's Hospital reveals that patients with Alzheimer's dementia and related disorders who also experience delirium incur significantly higher healthcare costs. The average additional cost for one delirium ADRD patient's year of care is $34,828 more than non-delirium ADRD counterparts.
The Mass General Brigham remote healthcare delivery program lowered blood pressure and LDL-cholesterol significantly in a study of over 10,000 participants. The program provided convenient care from home using digital solutions, improving health outcomes for traditionally underserved populations.
A recent study by Brigham and Women's Hospital found that dapagliflozin consistently improved outcomes for both men and women with heart failure, regardless of left ventricular ejection fraction. The treatment was safe and well-tolerated in both sexes, suggesting a lack of sex-specific indications for this class of HF therapies.
A study found that COVID-19 'test to treat' sites are less accessible to many marginalized communities, including American Indian and Alaskan Native people, who live over 60 minutes from the nearest site. The research highlights major disparities in geographical access to these treatment centers.
Researchers at Brigham and Women's Hospital identified eutectic gallium indium (EGaIn) as a biocompatible liquid metal for biomedical applications. The team found that EGaIn can be formulated to break down in the body, providing a controllable end-of-life for devices like drug delivery systems and stents.
The BEST-CLI trial found that patients who received Bypass had a 32% reduction in Major Adverse Limb Events and 65% fewer major re-interventions compared to Endo. Both treatments were effective, but individualized decision-making is crucial for optimal outcomes.
A study by Brigham and Women's Hospital found that specific immune system biomarkers are linked to the acquisition of both HIV and genital herpes. The researchers identified unique predictors for each disease, providing new targets for preventive treatments.
Researchers at Brigham and Women's Hospital found that olpasiran, a small interfering RNA drug, significantly reduces lipoprotein(a) levels in patients with established cardiovascular disease. The treatment was associated with minimal serious side effects apart from injection site reactions.
A major randomized trial of pemafibrate found no reduction in rates of heart attack, stroke, or cardiovascular death over a five-year period, despite lowering triglycerides by 26 percent. Pemafibrate was effective at reducing remnant cholesterol levels but failed to demonstrate clinical benefits.
A study analyzing 16,083 colorectal biopsies found that 2.65% of rectal adenocarcinoma patients have mismatch repair deficiency, challenging earlier estimates. The analysis also highlighted the importance of screening at all ages for this condition.
Researchers from Brigham and Women's Hospital found that circulating tumor HPV DNA levels are linked to lymph node presence, making the test less effective for screening. This limits the use of ctHPV DNA testing for early diagnosis and treatment of oropharynx cancer.
Researchers at Brigham and Women's Hospital developed a novel bioink capable of constructing functional and mechanically strong blood vessels. The bioink enables bioprinting of conduits with key physiological characteristics similar to native vessels, potentially serving as vascular models for grafts in surgeries and disease studies.
A retrospective cross-sectional study found that VA-financed hospice services were associated with higher rates of concurrent dialysis among veterans with end-stage kidney disease. Patients who received VA-financed hospice services lived approximately 43 days after stopping dialysis, compared to just four days for those who stopped dia...
The study will gather data from over 500 adults with monkeypox to determine the effectiveness and safety of tecovirimat. Participants with severe disease or high risk of severe disease will receive open-label tecovirimat, while others will be randomly assigned to receive either tecovirimat or placebo.
A new study identifies environmental chemical agents that influence gastrointestinal inflammation and may boost the risk of inflammatory bowel disease. The research found a common herbicide, propyzamide, to interfere with the aryl hydrocarbon receptor, leading to increased intestinal inflammation.
Researchers developed a new computational tool that creates a picture of brain activity during sleep, providing an enhanced way to characterize the activity of the brain. The approach identified new potential biomarkers in people with schizophrenia, suggesting new ways to understand the disorder and develop targeted treatments.
A cross-sectional study of 291 primary care physicians found a significant positive relationship between EHR time and certain ambulatory quality measures. Increased EHR time was associated with improved panel-wide hemoglobin A1C level control, hypertension control, and breast cancer screening.
Research from Brigham and Women's Hospital found that Black and Hispanic women are most likely to face functional limitations after a traumatic injury. The study identified that these disparities are largely driven by the intersection of being female, minority, and experiencing trauma.
Researchers at Brigham and Women's Hospital identified ganglioside GM2 activator (GM2A) as a protein that may contribute to Alzheimer's disease progression. The protein reduces neuronal firing and induces loss of neurite integrity, suggesting its potential role in AD pathogenesis.
Researchers developed an alternative method of immunotherapy delivery, intraventricular treatment, to administer multiple therapeutic doses in mouse models of human metastatic medulloblastoma. This approach significantly extended survival and reduced toxicity compared to direct tumor inoculation methods.
Researchers have created a novel antibiotic cement that demonstrates high efficacy and potency against drug-resistant bacteria. The new approach uses a locally delivered combination of antibiotics and bone cement to target infections, promising decreased bacterial resistance development.
The initiative vaccinated a significantly higher rate of young people, non-white populations, and Hispanic people than the average for the state and target communities. The program used a 'double equity' model to engage with local transportation companies and administered over 20,000 COVID-19 vaccination doses.
A new AI algorithm, SISH, uses self-supervised learning to find similar cases in large pathology image repositories, assisting with the diagnosis of rare diseases. The algorithm outperforms other methods in retrieving interpretable disease subtype information from vast databases, even at large scales.
A new variant of adeno-associated virus (AAV) shows significant improvement in delivering gene therapies to the central nervous system (CNS), potentially treating brain cancers and genetic diseases. The AAV variant, identified as CPP.16, demonstrates enhanced delivery efficiency across the blood-brain barrier in preclinical models.
The Five-item Frailty Index (5i-FI) accurately predicts postoperative complications after prostate surgery, particularly in men with high frailty scores. A study published in Urology found that a 5i-FI score greater than two is associated with increased risk of complications, hospital stays, and readmission.
A study found that eating late significantly affects hunger levels, calorie burn rate, and fat storage, with decreased leptin and increased adipogenesis. Late eating was also associated with slower energy expenditure and increased appetite.
A study by Brigham and Women's Hospital researchers surveyed parents and caregivers, finding that more than two-thirds believed in the top three most salient myths about sleep. The authors refute these myths, citing studies showing varying sleep schedules on weekends can worsen sleep, delayed school start times result in increased slee...
Researchers at Brigham and Women's Hospital and MIT have developed RoboCap, a robotic capsule that delivers drugs to the gut by clearing mucus and churning to enhance absorption. In preclinical models, RoboCap increased drug permeability by over 10-fold for insulin and vancomycin.
A recent study published in The Lancet HIV found that individuals with viral suppression through antiretroviral therapy (ART) medications can live longer and experience less disability compared to those with unsuppressed HIV. This research highlights the critical importance of maintaining support for HIV treatment programs to ensure op...
A new biomaterial has been developed to prevent bleeding complications after vascular surgeries, adhering to both human tissue and grafts, reinforcing suture lines, and withstanding high vascular pressures. The material outperforms existing products in terms of safety and efficacy, paving the way for clinical translation.
A study at Brigham and Women's Hospital found that war-zone related stress can alter the brain's limbic gray matter regions, affecting basic emotions and drives. These structural changes are associated with cognitive functioning, including improved verbal short-term memory and processing speed.
Researchers found that blood metabolites related to sugars were linked to older adults' global cognitive health, while a Mediterranean diet was associated with higher levels of beta-cryptoxanthin. This study expands on previous work and highlights the importance of diet in safeguarding cognitive function across different populations.
Researchers analyzed data from over 25,000 US adults in a clinical trial and found that vitamin D3 and omega-3 fatty acid supplementation had no effect on frailty scores. Healthy lifestyle habits such as regular exercise and the Mediterranean diet are recommended for preventing frailty instead.
A study found that eating at night increased depression-like mood levels among participants, while daytime eating reduced these levels. The researchers suggest that meal timing could be a novel strategy to minimize mood vulnerability in individuals with circadian misalignment.
Researchers identified increased incidence of early-onset cancers globally, linked to dietary changes and lifestyle factors. The study found that factors like highly processed foods, sugary beverages, and sedentary lifestyles contribute to the rising cancer rates among adults under 50.
Researchers at Brigham and Women's Hospital have developed a highly efficient method to generate human kidney cells, including principal and intercalated cell lines. This breakthrough could lead to new therapies for treating congenital abnormalities of the kidney and urinary tract, such as polycystic kidney disease.
A clinical trial has shown that full-dose anticoagulation therapy is more effective than standard-dose prophylactic anticoagulation in preventing blood clotting complications in COVID-19 patients. The study found a significant reduction in venous or arterial clotting complications among patients who received full-dose treatment.
A clinical trial found that long-term use of evolocumab led to further reductions in cardiovascular events compared to shorter treatment. Participants who received evolocumab for over 5 years had lower risk of cardiovascular death, myocardial infarction, stroke, and hospitalization.
A meta-analysis of clinical trials found that SGLT2 inhibitors, like dapagliflozin and empagliflozin, reduce cardiovascular death and hospitalization in patients with mildly reduced or preserved ejection fraction heart failure. These drugs may benefit a wide range of patients, regardless of age, sex, or medical history.
A deep learning algorithm can identify non-small cell lung cancer tumors on CT scans within seconds, reducing treatment planning time and improving consistency. Radiation oncologists using the algorithm worked 65% faster and with 32% less variation than those not using it.