Researchers have created an online resource that maps the cell types and genes expressed in the human and mouse trigeminal ganglion, a key relay center for migraine and facial pain. The atlas identifies potential therapeutic targets that are selectively expressed in cells driving head pain.
A study of 318 physicians found that female physicians spent an average of 5.81 hours per day on the EHR, compared to 5.23 hours for male physicians. This disparity was observed even outside of work hours and among different specialties.
Researchers at Brigham and Women's Hospital discovered a tissue-modifying molecule that can target intestinal stem cells and signal them to create Paneth cells, a rare but important cell type. This could represent a new therapeutic pathway for diseases such as inflammatory bowel disease and graft-versus-host disease.
A metabolomic study of 14,000 individuals with asthma found that inhaled corticosteroid therapy leads to adrenal suppression, characterized by fatigue, headache, and abdominal pain. The study suggests that monitoring cortisol levels and prescribing the lowest effective dose may help mitigate side effects.
A pilot study suggests that an artificial intelligence system called CRANE can help cardiac experts diagnose rejection and estimate its severity more accurately. This could lead to faster diagnosis and treatment, as well as reduced variability in expert agreement, ultimately improving heart transplant outcomes.
A new study found that longer, more frequent daytime napping in older adults predicted worse cognitive performance and an increased future risk of Alzheimer's dementia. The researchers discovered a bi-directional link between the two, where excessive daytime napping sped up the increase in daytime napping during aging.
A randomized, placebo-controlled trial found that a cocoa flavanol supplement reduced cardiovascular death by 27% and total cardiovascular events by 10%. The study also showed no significant effect on cancer risk. Further investigation is warranted to understand the effects of cocoa flavanols on cardiovascular health.
A new study found that follicular T cells help balance out antibody diversity and affinity after COVID-19 vaccination. Deleting specific cell types altered the immune response, providing insights into strategies to enhance vaccine effectiveness later in life.
Researchers found that adjuvant radiation therapy compared to early salvage therapy reduced mortality risk in men with pN1 prostate cancer. The study, published in the Journal of Clinical Oncology, showed a 8% decrease in mortality for each additional positive pelvic lymph node found at surgery.
A pilot study by Brigham and Women's Hospital found that rehabilitation at home (RAH) can lead to lower costs ($8,404 vs. $9,215) and improved patient experiences, including increased activities of daily living. The study also showed signals towards greater functional status improvement.
Researchers at Brigham and Women's Hospital successfully differentiated vascular smooth muscle cells into endothelial cells using a miRNA cassette. The induced endothelial cells restored blood flow more quickly than conventional ECs in a murine hindlimb ischemia model.
A systematic review and meta-analysis of seven studies found no significant association between spironolactone use and increased risk of breast, ovarian, kidney, gastric, or esophageal cancers. However, treatment with the drug was associated with a decreased risk of prostate cancer.
A recent study published in BMJ Open found that many women with preeclampsia lack awareness about symptoms and long-term cardiovascular risks, underscoring the need for improved patient education and support. The research team surveyed over 800 pregnant women, revealing a significant gap in mental health support and preventive measures.
A new patient-centered intervention reduced severe asthma exacerbations by 15% in African American/Black and Hispanic/Latinx patients with moderate-to-severe asthma. The study also found improved asthma symptoms and days of impairment, mirroring previous recommendations for patients with similar conditions.
A randomized, double-blind study found suvorexant to be effective in reducing insomnia severity and night sweats in peri- and postmenopausal women. The medication showed promise as a treatment for chronic insomnia in midlife women.
Researchers at Brigham and Women's Hospital discovered a new function of miR-10b, interacting with U6 snRNA to alter global splicing in glioma cells. This study highlights the potential for miRNA-based treatments in cancer therapy.
A new longitudinal study found that frequent use of NSAIDs or acetaminophen, as well as regular use of COX-2 inhibitors, is associated with a higher risk of developing chronic persistent tinnitus. Low-dose aspirin use did not elevate risk, but moderate-dose aspirin use was linked to higher risk among women under 60.
A new study from Brigham and Women's Hospital found that female primary care physicians spend 20% more time working in the electronic health record than their male counterparts. The increased workload was attributed to a higher volume of messages received from staff and patients, which may contribute to burnout rates among female PCPs.
Researchers found that vitamin D and/or omega-3 fatty acid supplements significantly lowered the rate of autoimmune diseases like rheumatoid arthritis, polymyalgia rheumatica, and psoriasis. The largest benefit was seen after two years of supplementation with daily doses of vitamin D (2000 IU) and marine omega-3 fatty acids (1000 mg).
A study from Brigham and Women's Hospital investigated diagnostic pitfalls in primary care, identifying patterns of errors and creating a taxonomy of generic types. The findings highlight disease-specific and generic cross-cutting pitfalls that clinicians can use to inform educational and quality improvement efforts.
A study found that lung cancer screening among non-smoking women in Taiwan has led to a 6-fold increase in early-stage diagnoses, while late-stage cancer and death rates remain stable. The researchers estimate that between 7,000 and 12,000 Taiwanese women have been overdiagnosed with lung cancer.
Researchers at Brigham and Women's Hospital conducted a scoping review of 78 articles to identify key use cases for AI in preventing or mitigating adverse drug events (ADEs). Genetic information is thought to be critical in improving AI algorithm performance, but systematic evaluations are necessary to generate evidence for this field.
Researchers found that telemedicine usage increased among Black patients and women during the COVID-19 pandemic. However, disparities persisted, with older patients and those with lower education levels less likely to use video consultations. The study highlights the need for improved digital access and resources to bridge the gap.
A new study from Brigham and Women's Hospital identified the activation of PIEZO1 as a key trigger for thrombosis in patients with type 2 diabetes. Inhibiting PIEZO1 prevented clot formation, suggesting its potential as a therapeutic target for preventing thrombosis.
A study identified factors at midlife associated with a decline in women's physical health 10 years later. Higher body mass index, smoking, osteoarthritis, and depressive symptoms were found to be significantly linked to clinically important declines in physical health.
A new study found that translocation renal cell carcinoma (tRCC) is characterized by genetic alterations except for the gene fusion from which it gets its name. The research suggests that tRCCs may be responsive to treatment with immune checkpoint inhibitors, providing a potential roadmap for clinical action.
A study identified 17 military medical treatment facilities that can provide high-quality obstetric care, including emergency cesarean delivery. This collaboration could reduce preventable maternal mortality and improve care for pregnant patients in rural communities.
Researchers developed a single-cell epigenetic aging clock to profile biological age in individual cells. The technique revealed mechanisms driving aging, attenuation, and early embryogenesis-related rejuvenation, opening possibilities for clinical applications in mammalian cells.
Researchers have developed a technique that analyzes cell-free RNA in a mother's blood to predict healthy pregnancy outcomes and detect potential complications like preeclampsia. The approach showed promise in identifying patterns of gene expression associated with a healthy pregnancy and predicting preeclampsia risk with high accuracy.
Researchers have developed a technique called cryobioprinting that combines bioprinting with cryopreservation to create frozen, complex structures. The technology allows for the fabrication of anisotropic tissues with microscale pores aligned in specific directions, opening up new possibilities for muscular tissue engineering and beyond.
A COVID-19 antibody survey in Sierra Leone found significant underreporting of cases and low vaccination rates, posing a risk to populations with limited immunity. The study's findings call for rapid vaccine deployments and support for intellectual property waivers to address the pandemic's progression.
Researchers at Brigham and Women's Hospital discovered a new mediator, 4S, 5S-epoxy-resolvin, that resolves acute inflammation and stimulates tissue regeneration. The study found that this mediator also controls granuloma formation in human leukocytes.
Researchers compared injury patterns among men and women presenting to emergency departments with intimate partner violence (IPV) injuries. The study found that male victims were more likely to have severe injuries, such as lacerations and gunshot wounds. In contrast, female victims were more likely to have facial bruises.
A digital pill system has been found to be a feasible and accurate intervention for tracking HIV prevention pill adherence, with 98% accuracy. The system uses radiofrequency transmitters and wearable reader devices to track pill ingestion, providing a novel solution for individuals with low compliance.
A new analysis of the COVID Pass tool found that daily symptom attestation helped identify over 100 cases of COVID-19 among healthcare workers. The study suggests that these tools can play a crucial role in preventing transmission events, particularly when combined with testing and proper care.
A study by Brigham and Women's Hospital found that eating during the nighttime can lead to glucose intolerance due to a misalignment between central and peripheral circadian clocks. In contrast, limiting meals to the daytime maintains internal circadian alignment and prevents glucose intolerance in shift workers.
A survey of general surgery program directors found that only a quarter of programs had a formal paternity leave policy, and when they did, it was often inconsistent. Residents often took shorter leaves than desired due to stigma against male residents taking parental leave.
Research conducted by Brigham and Women's Hospital found that cervical cancer rates are significantly higher in low SES neighborhoods of New York City. The study analyzed data from two databases and calculated a 73 percent greater risk of cervical cancer in these neighborhoods compared to high-SES areas.
A study by Brigham and Women's Hospital found that transparent masks can facilitate easier communication between healthcare workers and patients, particularly for individuals with hearing loss. The results showed that 91% of deaf or hard-of-hearing health care workers preferred transparent masks over opaque ones.
Researchers at Brigham and Women's Hospital discovered that cancer cells can disarmed the immune system by forming nanotubes that pull out mitochondria from immune cells. This new mechanism gives a target to go after, leading to potential new combinations of therapies for improving cancer immunotherapy outcomes.
A new nasal vaccine, Protollin, is being tested in humans for the first time to prevent and slow Alzheimer's disease progression. The trial aims to determine safety and tolerability, as well as its effects on the immune system.
Researchers from Brigham and Women's Hospital presented a fast-acting antibody-based agent to reverse the antiplatelet effects of ticagrelor, showing immediate and sustained reversal. A remote monitoring program also improved blood pressure and cholesterol control in 10,000 patients with diverse cardiovascular risk profiles.
A new study published in The American Journal of Human Genetics found that 76.3% of participants who received actionable genomic results were unaware they carried increased risk variants, even though half met clinical criteria for genetic testing. Comprehensive sequencing revealed previously missed variants, emphasizing the need for mo...
Researchers developed a new compound based on Nobel Prize-winning discoveries that raised hemoglobin levels in patients with kidney disease undergoing dialysis and those not on dialysis. The oral medication was found to be as safe and efficacious as conventional treatment for anemia, offering a transformative approach to patient care.
Researchers found an association between prenatal PFAS exposure and late-onset preeclampsia, suggesting toxic effects outside placental development. The study analyzed data from pregnant women at Brigham and Women's Hospital, revealing a correlation between PFAS chemicals and the condition.
A genome-wide screening technique reveals the interrelated activities of genes controlling pluripotency and apoptosis in human embryonic stem cells. The study provides new insights into cancer genetics and a novel approach for regenerative medicine research, enabling the systematic mapping of genetic networks involved in tissue formation.
A recent study found that the number of surgical procedures contributing to military surgeon readiness decreased by approximately 25% between 2015 and 2019. This decline, attributed to reduced surgical volumes at military hospitals, poses a potential gap in care for deployed settings.
A new study suggests that newborns who get more sleep and wake up less throughout the night are less likely to be overweight in infancy. Researchers found a 26% decrease in infant obesity risks with just one additional hour of sleep.
Researchers found that excess carbohydrates can lead to metabolic distress by blocking the synthesis of important antioxidants and increasing insulin levels. This study provides new insights into the relationship between carbohydrate overfeeding and metabolic health.
A recent study by Brigham and Women's Hospital found that pandemic-related grief and depressive symptoms are associated with lower levels of mother-infant bonding. Higher self-efficacy and social support were also linked to better bonding outcomes, while anxiety symptoms were not a significant factor.