Researchers found that Fgr binds to Numb, activating the signalosome and promoting cell differentiation and G1/0 arrest. The study provides insights into RA resistance and suggests potential therapeutic targets.
Researchers identified six novel molecular subtypes of thymic epithelial tumors that are independent of World Health Organization histologic type. The study used genomic information from The Cancer Genome Atlas dataset and the IU-TAB-1 cell line, and found no association between WHO histologic subtype and molecular subtypes.
Researchers analyzed DNA repair targeting in cutaneous apocrine sweat gland carcinoma (CAC) cells with a PALB2 aberration. They found sensitivities to BET-bromodomain inhibition and modest sensitivity to DNA-PKi, ATRi, WEE1i, and PARPi. The study also identified a potential therapeutic opportunity for targeting PALB2 deficient cells th...
The study found that AIM2 inflammasome is at the intersection of COPD and lung cancer, with higher expression correlating to lower survival rates in smoking COPD adenocarcinoma patients. This suggests that the AIM2 inflammasome may be a potential target for developing novel treatments for COPD patients who develop lung cancer.
The study found that cancer cells become less stiff after exposure to chemotherapy drugs, but the rate of stiffness change decreases under hypoxic conditions. Alteration in cytoskeletal structure influences overall cell functions, including signaling, communication, adhesion, transport, and tumor metastasis.
A study found that 50% of metastatic colorectal cancer patients treated with bevacizumab experienced RAS mutation disappearance, suggesting the drug's potential to revert tumors. This discovery may open new therapeutic avenues for primarily RAS mutant patients.
Researchers investigated CEA as a blood-based biomarker for anal cancer. Although CEA levels correlated with disease progression, they were not associated with survival outcomes or clinically relevant in managing the disease. Novel approaches with serum biomarkers are necessary for this rare and increasing diagnosed malignancy.
Researchers investigated the impact of EGCG on Tau glycation and its effects on advanced glycation end products in neuroblastoma cells. EGCG was found to inhibit methyl glyoxal-induced Tau glycation and reduce advanced glycation end products formation, while also modulating the localization of AT100 phosphorylated Tau.
Researchers identified LAPAS1 as a novel E2F-regulated lncRNA that plays a role in human cancer and regulates cell-cycle progression and cell proliferation. Inhibition of LAPAS1 expression delays cell progression through S phase and inhibits proliferation of human cancer cells.
Researchers evaluated Tomivosertib's therapeutic potential on AML cells and found it to be highly effective at blocking eIF4E phosphorylation. Combination with Venetoclax resulted in synergistic anti-leukemic responses. The study also identified novel putative MNK1/2 interactors.
This study suggests exploiting urine RNAs as diagnostic markers for bladder cancer, identifying novel marker candidates and validated amplicons. Deep transcriptome analysis of urine RNA revealed coding sequences, non-coding sequences, and circular RNAs, providing promising insights into bladder cancer diagnosis.
A recent study has identified specific miRNA signatures associated with EGFRI-induced skin rash, suggesting potential treatment-dependent biomarkers for this common side effect. The research found that miR-21 and miR-520e serum concentrations were negatively correlated with the severity of skin rash.
Researchers discovered that glioblastoma (GBM) causes epigenetic changes in CD4 T-cells, affecting their function and differentiation. The study found significant inter-patient variability in these changes, which could help select patients for immunotherapy.
Cells undergoing EMT promote tumor growth by acquiring an endothelial phenotype or contributing to vascular transdifferentiation. FOXC2 is crucial for these processes.
A prospective study analyzing plasma metabolomics during general anesthesia in patients with pancreatic malignancy reveals perioperative tryptophan depletion and increased taurine synthesis. This finding has implications for personalized perioperative management and may identify therapeutic windows for immunotherapy or chemotherapy.
The loss of expression of a microtubule/tubulin binding protein, centrosomal protein 4.1-associated protein, causes increased EGFR levels and signaling in oral squamous cell carcinoma cells. Depletion of CPAP enhances tumorigenicity, while EGFR depletion attenuates EMT features.
The study found that combining mTORC1 and PLK1 inhibitors showed high antitumor activity in NSCLC, with synergistic effects observed. The combination may target specific biomarkers of resistance to Pi3K-based monotherapies, offering a promising therapeutic approach.
A study evaluated a panel of 142 mutation-signature–associated metrics for predicting cancer progression in patients. The P142 panel successfully predicted cancer progression status in some, but not all, analyzed cancer types.
The study investigated the association of the IGF/CTP score with overall survival and progression-free survival in CTP class A patients with advanced HCC treated with sorafenib. In these patients, IGF/CTP score B was associated with shorter PFS and OS, indicating a more accurate predictive tool for treatment outcomes.
Researchers found 556 novel markers of colorectal tumors with microsatellite instability, which are differentially expressed genes. These markers were identified by incorporating cell composition into their regression model, indicating a potential role in disease prognosis.
Research shows that relacorilant enhances paclitaxel-driven apoptosis in various cancer cell lines and xenograft models, providing a basis for its potential as an adjunct therapy. The study's findings support clinical benefits observed with relacorilant addition to paclitaxel-containing therapy in ovarian and pancreatic cancers.
A recent study has found a possible link between prostate cancer and schizophrenia, with certain gene polymorphisms correlated to disease prognosis. Polymorphisms in genes controlling neurotransmitter metabolism were studied in patients with prostate cancer, revealing a potential protective effect against schizophrenia-like symptoms.
A study evaluating 22 patients with recurrent Anti-hormonal granulosa cell tumors found low-to-moderate FDG uptake and variable ERα/ERβ expression. FES-PET/CT showed promising results in identifying treatment-eligible patients, with stable tumor locations decreasing in size during anti-hormonal treatment.
Research found that Filipino-Americans are more likely to be diagnosed with advanced thyroid cancer, while European Americans tend to have early-stage disease. DBP expression was also linked to cancer staging in both groups, suggesting a protective role for the protein.
A study on Saudi Arabian breast cancer patients identified somatic mutations in tumor suppressor genes, including BRCA1, BRCA2, and PIK3CA. The findings highlight the importance of routine genetic sequencing for precision therapies in the region. Novel mutations were also discovered, with potential implications for targeted treatments.
Researchers analyzed 36 patients with skin squamous-cell carcinoma, finding that CD8+ T cells infiltrated tumors with lymphatic endothelial cells. Perineural infiltrated sSCC without metastasis showed low lymphatic endothelial cell density, suggesting a link to tumor microenvironment biology.
This study investigated the effect of culturing hepatocellular cancer cells in more native conditions, revealing slower doubling times, increased glycolytic enzymes, and mutations in mitochondrial DNA. The results showed increased resistance and sensitivity for cells cultured in native conditions, highlighting new insights into tumor b...
The study found that hepatocellular carcinoma develops on a background of chronic inflammation and fibrosis, with tumor-associated macrophages playing a key role. The researchers characterized the inflammatory microenvironment in two HCC mouse models, revealing divergent phenotypes of liver macrophage subsets and their contribution to ...
Researchers analyzed 430 lung squamous tumors and identified mutations in genes such as TP53, CDKN2A, and FGFR1. The study found that 13.5% of patients with druggable mutations had lower median overall survival.
Research identifies novel E6 inhibitors with potential for targeted therapy in HPV-positive head and neck squamous cell carcinomas. The study reveals the key role of E6 in tumor formation and growth, highlighting its importance as a strategic approach for HPV-positive HNSCC treatment.
Researchers employed iTRAQ based quantitative proteomics to characterize protein alterations in fibroepithelial lesions (FELs) of the breast. The study identified three candidate biomarkers: MUCL1, HTRA1, and VEGFD, which were uniquely expressed in FAD, borderline, and malignant PTs, respectively.
The study reveals that 1B3, a novel synthetic miR-193a-3p mimic, consistently suppresses several pro-tumorigenic phenotypes in vitro, including reduced cell proliferation, viability, and induced apoptosis. The pleiotropic mechanism of 1B3 action supports its development as a novel therapeutic agent for cancer treatment.
Research found that activating plasmacytoid dendritic cells with interferon-beta increases CD40 expression and induces CD38 upregulation on AML cells, leading to antibody-mediated killing. This mechanism may provide a novel therapeutic approach for acute myeloid leukemia.
A study published in Oncotarget found a distinct global DNA hypermethylation pattern and gene expression signature in liver cancer among patients with Indigenous American ancestry. This molecular subtype of HCC preferentially affects people with Indigenous ancestry, highlighting the importance of considering anthropological background ...
Researchers found a higher De Ritis ratio to be an independent risk factor for cancer progression in high-risk NMIBC patients. Non-BCG treatment was also identified as a risk factor for recurrence.
Researchers found that piperlongumine inhibits cell growth, impacts cell cycle, and triggers caspase-3 independent cell death in retinoblastoma cell lines. PL's toxicity was inhibited by a ROS scavenger treatment, suggesting its potential as an anticancer molecule for retinoblastoma treatment.
A novel ghrelin receptor inverse agonist was developed for positron emission tomography (PET) imaging of functional expression in health and disease, particularly in cancer. The compound demonstrated specific binding to the Ghrelin receptor and imaging of tumors and normal tissues expressing the receptor.
Research reveals STAT3 induces GLI1 expression in chronic lymphocytic leukemia cells, a finding that may lead to therapeutic interventions. GLI1 overexpression is associated with survival advantage in CLL, and its inhibition by specific compounds could increase cell death.
Researchers identify a new class of mibefradil-based DNA repair inhibitors, which could be further advanced into pre-clinical testing and eventually clinical trials for glioblastoma radiosensitization. The compounds retain potency as DNA repair inhibitors while demonstrating reduced hERG and CYP450 enzyme inhibition.
The acylfulvene alkylating agent LP-184 demonstrates highly potent anticancer activity in NSCLC cell lines, correlating with PTGR1 transcript levels. It targets tumors regardless of co-occurring mutations but is especially effective in KEAP1 mutant settings.
Researchers found that urine protein biomarkers IL-1α, IL-1ra, and IL-8 can distinguish bladder cancer from controls with high accuracy. These markers also show promise in discriminating between different stages of the disease.
Researchers evaluate expression of TAZ and YAP, the p53-MDM2 axis, and RABL6A in sarcomas, finding that elevated YAP and TAZ independently predict worse overall and progression-free survival. Network analysis reveals a possible functional relationship between biomarkers.
The GEM ExTra test uses whole exome sequencing and RNA sequencing to detect actionable mutations in patients with advanced solid tumors. It has been validated through clinical utilization and provides clinically actionable information to guide patient management decisions.
Research found that treatments with 6-mercaptopurine and/or 5-azacitidine do not reverse epithelial-to-mesenchymal transition, but instead sensitize cancer cells to chemotherapeutic drugs. This approach has potential for inhibiting highly resistant triple-negative breast cancer cells.
A Phase 1 study of Z-endoxifen in patients with solid tumors reported partial responses in three patients and prolonged stable disease in eight. The study suggests that Z-endoxifen can benefit patients who have progressed on tamoxifen treatment, particularly those with desmoid tumors.
Research reveals CABYR-a/b and CABYR-c proteins are expressed in a subset of colorectal cancers, making them potential targets for specific immunotherapy. The study found that these proteins are highly expressed in 70% of patients with relative expression ratios over 1.
Researchers propose a model of how caloric restriction contributes to yeast chronological aging delay by remodeling cellular metabolism. The study found that caloric restriction significantly lowers intracellular concentrations of methionine and S-adenosylmethionine, leading to a metabolic pattern of aging delay.
Oncotarget, a journal honoring achievements and accomplishments of local businesses, has received the 2021 Best of Orchard Park Award for its exceptional marketing success. The award recognizes companies that enhance the positive image of small business through service to customers and the community.
A Phase 1 study of Z-endoxifen in patients with solid tumors demonstrated antitumor activity and prolonged stable disease, even in those who had previously responded sub-optimally to tamoxifen. The trial found that 44.4% of patients at certain dose levels achieved partial responses or stable disease.
Researchers found that ibuprofen inhibits the alternative splicing event generating RAC1B, overexpressed in BRAF-mutated colorectal tumors. Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein kinase complex, promoting nuclear exclusion of SRPK1 and SRSF1.