Aging-US: Iron: an underrated factor in aging
Research suggests that iron is a key factor in aging, causing cellular damage and organ deterioration. By blocking iron absorption, people may be able to extend their lifespan.
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Aging-US: Green tea catechins enhance fitness and lifespan of Caenorhabditis elegans
Researchers found that green tea catechins EGCG and ECG enhance fitness and lifespan in C. elegans by inhibiting complex I activity, reducing fat content and enhancing antioxidant defenses. This study provides evidence for the potential health benefits of green tea consumption in extending human lifespan.
Aging-US: A systemic multidisciplinary approach to study aging in sled dogs
Researchers use 103 retired sled dogs to study aging-related diseases like arthritis and cancer. The study aims to characterize canine aging mechanisms and identify biomarkers for anti-aging treatments.
Oncotarget: Enhancing doxorubicin anti-tumor efficacy and ameliorating cardiotoxicity
This study found that aerobic exercise enhances doxorubicin's ability to kill cancer cells while minimizing its toxic effects on the heart. In addition, exercise has been shown to reduce the risk of breast cancer recurrence and improve quality-of-life parameters in cancer patients.
Oncotarget: Hyperprogression of a mismatch repair-deficient colon cancer
Researchers created a novel humanized mouse model to study hyperprogressive disease (HPD) and hyperprogression (HP) in mismatch repair-deficient colon cancer. The study found accelerated tumor growth after PD-1 blockade with pembrolizumab administration, and identified changes in human cytokine profiles.
Aging-US: Proliferation, migration, & invasion of pathways: gallbladder cancer
Researchers discovered melatonin's antitumor effects in gallbladder cancer cells, promoting ROS-mediated apoptosis and suppressing the PI3K/Akt/mTOR signaling pathway. The study suggests melatonin as a potential novel candidate for gallbladder cancer treatment.
Aging-US: Helicobacter pylori infection and risk for developing dementia
A meta-analysis of case-control and cohort studies found no causal link between H. pylori infection and Alzheimer's disease dementia, but may be associated with all-cause dementia. The study suggests future research on the pathogenic mechanism may lead to novel therapies.
Oncotarget: Hypertension and medication after maxillofacial tumors radical surgery
A study published in Oncotarget found that hypertension and irregular medication use were independent risk factors for postoperative delirium after maxillofacial tumors radical surgery. The incidence of postoperative delirium was 41% in the hypertension group, compared to 12% in the non-hypertension group.
Oncotarget: PD-L1 expression and MET gene amplification in non-small cell lung cancer
A positive correlation was found between MET gene amplification and PD-L1 expression in patients with NSCLC and no other actionable oncogenic driver. The study suggests that MET amplification up-regulates PD-L1 expression, which may impact treatment strategies for these patients.
Aging-US: Deductive reasoning & principles of particle physics applied to aging research
The study applies deductive reasoning and particle physics principles to establish a common framework for aging research. This framework could benefit the field by providing a shared understanding of aging's complex processes, allowing researchers to design longevity interventions.
Aging-US: Reduced uremic metabolites are prominent feature of sarcopenia
Researchers analyzed comprehensive metabolomic data to identify metabolic profiles distinguishing sarcopenia from frailty. The study found 22 sarcopenia markers that are largely distinct from 15 frailty markers, suggesting a shared metabolic basis for these two age-related diseases.
Oncotarget: Enhancing anti-tumor activity in triple negative breast cancer
Researchers found that combining selinexor with olaparib induces robust anti-tumor activity in vitro and in vivo in triple negative breast cancer cell lines. The combination therapy overcomes the poor prognosis associated with TNBC, characterized by low disease-free and overall survival rates.
Aging-US: Alleviating vascular dysfunction & amyloid burden in Alzheimer’s
Hyperbaric oxygen therapy alleviated cognitive dysfunction, improved cerebral blood flow, and reduced amyloid burden in Alzheimer's disease models. In elderly patients with significant memory loss, HBOT showed an increase in cerebral blood flow and improvement in cognitive performance, demonstrating its therapeutic effects.
Oncotarget: Impact factor and citation metrics in phase III cancer trials
Trials that met their primary endpoint were more commonly published in journals with higher impact factors, suggesting a correlation between trial outcome and publication quality. Additionally, publications of trials leading to FDA approvals and those in high-impact journals were associated with increased Research Citation Rates.
Aging-US: Cerebrovascular abnormalities in Alzheimer’s disease: adrenergic approach
Aging-US review highlights cerebrovascular dysfunctions as a core feature of AD, contributing to pathogenesis and progression. Adrenergic system modulation may serve as a key approach to modulate these abnormalities.
Oncotarget: Decreasing DNA repair and genomic instability
Research found that Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in AML cells with FLT3-ITD. This approach may enhance chemotherapy drug induction of DNA DSBs and apoptosis.
Oncotarget: Inducing apoptosis in T-cell acute lymphoblastic leukemia
Researchers found that inhibiting the MAP2K7-JNK pathway with 5Z-7-oxozeaenol induces apoptosis in T-cell acute lymphoblastic leukemia. The study used murine models and human patient-derived xenografts to evaluate the anti-leukemic capacity of 5Z7O, which showed synergistic induction of cytotoxicity when combined with dexamethasone.
Aging-US: Cerebrovascular abnormalities in Alzheimer’s disease: adrenergic approach
Recent findings highlight the prevalence of cerebrovascular disorders in AD patients and suggest that cerebral vascular alterations contribute to pathogenesis. The adrenergic system may serve as a key approach to modulate these abnormalities and progressive neurodegeneration.
Oncotarget: The role of circulating miRNAs and CA19-9 in pancreatic cancer diagnosis
A study found that plasma cell-free miR-181c and tissue expression of miR-21, -210 accurately diagnose pancreatic adenocarcinoma (PA) with high accuracy. Further research is needed to validate its utility as a biomarker for PA diagnosis and monitoring.
Oncotarget: Association of four genetic variants with colorectal cancer
A study published in Oncotarget identified four genetic variants linked to an increased risk of sporadic colorectal adenocarcinoma in the Kazakhstani population. The findings suggest that these variants, including rs10506868, may contribute to CRC development and highlight the importance of understanding genetic factors in this disease.
Oncotarget: TAK1-inhibitors are cytotoxic for multiple myeloma cells
Researchers found that TAK1-inhibitors NG25 and 5Z-7 reduce the viability of multiple myeloma cell lines and primary cells, inducing apoptosis through various mechanisms. The combination of TAK1 inhibitors with DNA-damaging agents increases cytotoxicity in a synergistic or additive manner.
Oncotarget: BRCA1 mRNA expression in breast and colorectal cancer
High BRCA1 mRNA levels in breast cancer correlate with better survival, while LMNB2's role in CRC reveals conflicting results. Young CRC patients exhibit low p21 expression, suggesting a link between BRCA1 mRNA and tumor progression.
Oncotarget: Integrating genomic profiling into clinical care: a nation-wide survey
A nationwide survey of Australian medical oncologists found that most were confident consenting patients for genomic profiling, but less confident discussing secondary germline findings. The study suggests that understanding oncologists' perspectives is crucial to integrating genomic profiling into routine care.
Oncotarget: Cytokinome screen of colon cancer cell responses to oncology drugs
Researchers analyzed the effects of small-molecule drugs on colorectal tumor cells, finding that treatment with Imipridones decreased certain cytokines and increased others. The study highlights the complexity of cytokine signaling and its potential as a biomarker for diagnosis and prognosis in colon cancer.
Oncotarget: Technology for the identification of MYC:TRRAP inhibitors
The study proposes a new approach to inhibit MYC's essential interaction with TRRAP, a protein required for efficient histone acetylation. This disruption could lead to cancer-specific targeted therapies with minimal effects on normal cells.
Oncotarget: TP53 mutations determined by targeted NGS in breast cancer
This case-control study suggests that TP53 somatic mutations detected by next-generation sequencing are associated with an adverse prognosis in breast cancer. Co-existence of PIK3CA mutation was a common finding in TP53-mutant tumors.
Oncotarget: The protective role of prolyl oligopeptidase inhibition in acute lung injury
A study found that prolyl oligopeptidase inhibition with KYP-2047 treatment reduces collagen amount and lowers inflammatory protein levels in lung tissue. The treatment also modulates apoptosis, preserving lung function after intestinal ischemia-reperfusion injury.
Aging-US: Neurodegeneration in subjective cognitive decline
Research associates gray matter and white matter neurodegeneration with subjective cognitive complaints, highlighting potential non-AD pathologies. Neurodegeneration processes affect brain areas not typically targeted by Alzheimer's disease.
Oncotarget: CRISPR/Cas9-directed epigenetic editing
Researchers used CRISPR/dCas9 technology to target DNA methylation and study its effects on cancer cell behavior. The study found that the same epigenetic modification can lead to opposing expression profiles of a target gene in different cancer cell models.
Oncotarget: Scent test to screen for early-stage pancreatic cancer
Researchers used Caenorhabditis elegans to detect very-early-stage pancreatic cancer, achieving a reported sensitivity of 95.8%. The method showed promise for use in detecting patients with early PDAC, but the underlying mechanisms need further clarification.
Aging-US: Protein processing impairment in Parkinson’s disease
A study published in Aging-US reveals that protein processing impairment in Parkinson's disease is mediated by chromogranin/secretogranin, leading to decreased candidate proteins and peptides. This finding suggests a potential therapeutic target for the treatment of PD.
Oncotarget: Quantitative difference of oral pathogen with gastric cancer
Researchers have identified a significant association between periodontal disease, oral pathogens, and the development of gastric cancer. The study suggests that individuals with gastric cancer have a higher prevalence of oral pathogens, which may contribute to the risk of developing the disease.
Aging-US: N6-methyladenosine and its clinical relevance in cognitive dysfunctions
Research investigates m6A regulators in cognitive dysfunctions, identifying potential biomarkers like SNRPG and SNRPD2. The study also highlights the role of APOE ε4 allele and FTO expression in AD development.
Oncotarget: High CD39 expression is associated with human bladder cancer
Researchers found that high CD39 expression is associated with human bladder cancer, particularly in the non-muscle-invasive phenotype. CD39's involvement in tumor development and progression is still unclear, but its overexpression in early-stage tumors suggests a potential role in bladder cancer progression.
Aging-US: Cellular senescence in lymphoid organs and immunosenescence
Recent studies suggest that aging is a malleable process influenced by physiological, genetic, dietary, and pharmaceutical interventions. The relationship between cellular senescence and immunosenescence has been largely explored, with the goal of developing improved therapeutics to conserve vitality as we age.
Aging-US: The role of age at menarche and age at menopause in Alzheimer’s disease
The study found no significant causal relationship between genetically determined age at menarche or menopause and AD risk. However, an inverse association was detected between age at menarche and body mass index. Further studies are needed to validate these findings.
Aging-US: Senescence-associated hyper-activation to inflammatory stimuli in vitro
Researchers discovered that cellular senescent cells exhibit hyper-activation in response to inflammatory stimuli, leading to increased expression of inflammatory cytokines and chemokines. This phenomenon contributes to the age-related predisposition to severe infections and inflammation.
Oncotarget: Epigenetic signatures differentiate uterine/soft tissue leiomyosarcoma
Leiomyosarcomas are diverse, rare, and aggressive mesenchymal soft tissue sarcomas. Epigenetic profiling identified differential DNA methylation and gene expression patterns associated with subtypes. These findings suggest epigenetic profiles can be used to stratify patients and apply targeted therapies.
Oncotarget: Treating unresectable intrahepatic cholangiocarcinoma
Ablative radioembolization has been found to have a high response rate and promising survival in patients with unresectable intrahepatic cholangiocarcinoma. The study also showed that the treatment is well-tolerated, with median overall survival not reached at 30 months.
Oncotarget: Tissue biodistribution and tumor targeting in preclinical multiple myeloma
Researchers evaluated the anti-tumor efficacy of DARA conjugated to DM1 via a non-cleavable linker, demonstrating enhanced therapeutic potency and in vivo stability. The study showed that conjugation did not affect the stability or activity of the biologic, and imaging techniques can be applied to other immunotherapies.
Oncotarget: PBMCs generate TEM/TCM for adoptive cell therapy in multiple myeloma
Researchers have developed a novel immunotherapy approach using PBMCs to generate TEM/TCM cells for adoptive cell therapy in multiple myeloma. The treatment targets WT1-specific cytotoxic T lymphocytes, which show high sensitivity to MM cells, providing a promising basis for an additional therapeutic strategy.
Oncotarget: Distinct differences between molecular profiles of 3D and 2D cultured cells
A new study compared the molecular profiles of lung cancer cells grown in 3D and 2D cultures, finding significant differences in protein expression and regulation. The research used a membrane proteomics approach to analyze the NCI-H23 cell line and identified exclusive expressions of CD molecules in 3D culture.
Oncotarget: Comparison of transcriptomic & cytokine responses in colorectal cancer
The study reveals vast differences in gene expression and cytokine response across different chemotherapy agents, shedding light on their mechanisms of efficacy and toxicity in colorectal cancer. The findings contribute to the understanding of molecular bases of response in CRC tumors exposed to these drugs.
Oncotarget: Cell cycle arrest and anaphase catastrophe in malignant T-cells
Researchers report that pevonedistat inhibits NEDD8-activating enzyme, leading to cell cycle arrest and anaphase catastrophe in malignant T-cells. This effect may be coupled with immunomodulatory activity, suggesting pevonedistat as a potential therapeutic approach for T-cell lymphoma.
Oncotarget: Low tumour-infiltrating lymphocyte density in glioblastoma
Researchers found low T cell infiltration in glioblastoma tissue, with higher CD8+ TIL density at recurrence. The study suggests that immune checkpoint inhibition may not be effective due to limited tumour-infiltrating lymphocyte density.
Oncotarget: Telomere dysfunction and chromosome instability in cancer cells
Researchers discovered that four terpyridine platinum compounds induce telomere dysfunction, leading to high levels of chromosome instability. This study provides promising leads for cancer treatment using these compounds alone or in combination with ionizing radiation.
Oncotarget: Epithelial-to-mesenchymal transition by association with NEAT1 lncRNA
The study found that NEAT1 lncRNA interacts with JunD to regulate tight junction assembly and promote EMT induction in head and neck cancer cells. Increased NEAT1 expression correlates with poor disease prognosis.
Oncotarget: Exosomal markers expression and their significance in rectal adenocarcinoma
Researchers explored exosomal markers CD63 and CD9 in rectal adenocarcinoma. Higher expressions correlated with high NAR scores, suggesting prognostic significance. Neoadjuvant chemoradiation impact on exosomal marker expression was found, warranting further studies.
Oncotarget: RNA expression differences between Black and White Americans
Researchers discovered downregulated immune responses and upregulated T cell-exhaustion pathways in African American patients compared to European Americans. These findings suggest striking differences in immunoregulatory gene activities that may contribute to the worse prognosis of prostate cancer in Black Americans.
Aging-US: Modulating cancer cell responses during drug-induced senescence
The study found that DNMT2/TRDMT1 gene knockout can affect the responses to senescence-inducing concentrations of doxorubicin and etoposide in different cancer cells. This may lead to diverse outcomes based on the type of cancer cells and anti-cancer drugs used.