Researchers discovered that krill oil protects dopaminergic neurons from age-related degeneration through temporal transcriptome rewiring and suppression of several hallmarks of aging. Krill oil increases neuronal resilience, promoting anti-oxidative stress and anti-inflammation, and abrogating multiple aging hallmarks.
Researchers identified USP7 as a novel cyclin F-interacting protein that stabilizes cyclin F protein. The study also found that USP7 regulates cyclin F mRNA, with pharmacological inhibition resulting in downregulation of cyclin F mRNA.
A study published in Oncotarget found that APOE genotype is associated with the presence and severity of cancer treatment-related side effects and symptoms, as well as the response to exercise-based interventions in cancer survivors. ApoE4 carriers showed a lower fall rate after exercise intervention compared to non-carriers.
A new study analyzed tumor biopsies from patients with newly-diagnosed germinal center B cell lymphoma and found that CREBBP mutations were associated with lower disease-free survival rates. The researchers identified CLMA as a practical tool to translate experimental findings into clinical applications.
Researchers found that IGF1 gene therapy increases kisspeptin expression and GnRH release, and alters microglial cell numbers, suggesting a potential protective effect against reproductive decline. This could lead to new strategies for optimizing lifespan and combating age-related health problems in women.
Researchers found drastic differences in microglia marker Iba1 and factors influencing Sirt1 levels and activity between elder groups. Preserving microglia and Sirt1 functional efficiency is crucial for longevity.
Researchers found that MK256 induced differentiation and maturation in leukemia stem cells, inhibiting proliferation of AML cell lines. The study also showed dose-dependent inhibition of the STAT pathway in both in vitro and in vivo studies.
A new study suggests that prelamin A, a precursor of lamin A, accumulates with age and may drive normal aging. Researchers propose this protein as a target for intervention strategies to extend healthspan and lifespan.
A retrospective study found that tumor hyaluronan levels are associated with improved time to progression in non-small cell lung cancer patients. HA-high tumors showed a trend towards improved clinical benefit, suggesting its potential as a prognostic biomarker and therapeutic target.
A study using mRNA and miRNA expression profiles identified molecular signatures that can differentiate muscle invasive bladder cancer patients who respond to neoadjuvant chemotherapy from those who do not. The research found distinct gene pathways and subtypes associated with response, which may lead to more effective treatment delivery.
Researchers found that overexpressing matriptase reduced myeloma cell proliferation and inhibited migration. Matriptase also blocked Src kinase activation, supporting its potential as a tumor suppressor in multiple myeloma. The study provides new insights into the role of matriptase in hematological malignancies.
Researchers found that rapamycin treatment during developmental growth phase decelerates aging rate and extends lifespan in animals. A transient late-life treatment is not effective, but a transient early-life treatment can reprogram aging.
A recent study published in Oncotarget reveals that Nectin-4 is widely expressed in head and neck squamous cell carcinoma (HNSCC), with significant correlations to clinico-pathological parameters. Non-smokers and p16-positive HNSCC showed higher expression of Nectin-4, leading to better survival rates for positive tumors.
Researchers found that knockdown of secreted frizzled-related protein 4 (SFRP4) suppresses SASP and improves age-related skin phenotypes. This suggests a potential candidate for the development of new skin rejuvenation therapies.
Researchers found that centenarians have a lower epigenetic age than expected, suggesting slowed biological aging. The study used four epigenetic clocks based on small CpG sites to reveal these differences.
A new research paper has demonstrated that psychological factors, such as feeling unhappy or being lonely, add up to 1.65 years to one's biological age, significantly impacting overall health and longevity.
A new study has found associations between plasma miRNAs and cognitive function among cognitively normal men, including those with higher MMSE scores and slower rates of cognitive decline. These findings suggest that extracellular microRNAs may play a role in the early stages of cognitive decline.
Researchers found that mTOR inhibition is crucial for p53-mediated tumor suppression, delaying cancer and increasing lifespan. In the absence of mTOR inhibition, cancer-promoting senescent cells drive tumor growth.
Researchers found that combining BCL-2 inhibitors can selectively eliminate senescent cells, improving efficacy and reducing toxicity by targeting high-MCL-1 expressing subpopulation of cells. This synergistic approach enables lower doses of drugs to be used, overcoming resistance to monotherapy.
Researchers have discovered that reduced TGFBR2 abundance is significantly associated with hepatocellular carcinoma (HCC) in patients with cirrhosis. An AI-based process accurately identified HCC tissue, confirming the biomarker's potential for early detection.
Researchers identified differences in PTK activity between normal and cancer kidney tissue, with Src family kinases and PI3K pathways exhibiting high activity. Ex vivo treatment of clear cell RCC with TKIs revealed that tivozanib and cabozantinib were more potent inhibitors than sunitinib or pazopanib.
Researchers found that Merkel cell carcinoma (MCC) Glypican-3 (GPC3) is expressed in nearly 70% of MCC tumors and up to 90% of MCPyV-negative cases. GPC3 expression is associated with worse prognosis, including increased risk of death from MCC. This makes GPC3 a promising target for chimeric antigen receptor T cell therapy.
Researchers analyzed data from over 3,000 participants and found no association between electrocardiogram measures and telomere length. The study suggests that ECG prolongation is age-dependent but not a marker of biological aging.
Researchers identified toll-like receptor (TLR) signaling as a novel pathway regulating GLI3 expression, which plays a role in inflammatory cytokine production and cancer. They found that IRF3 directly binds to the GLI3 promoter region, increasing its expression upon TLR4 stimulation.
SLFN11 acts as a surveillance factor for protein homeostasis by alleviating proteotoxic stress derived from protein synthesis and maturation. Its lack makes cells vulnerable to anticancer drugs inducing ER and proteotoxic stress, leading to chemoresistance. SLFN11 is also involved in regulating immune response and inflammation.
Researchers investigated the effects of neoadjuvant chemoradiotherapy on CD8+ tumor-infiltrating lymphocytes, PD-L1, and mucin expression in rectal cancer patients. The study found that nCRT exposure was associated with higher mucin expression and a non-significant difference in PD-L1 expression, suggesting an immunosuppressive phenotype.
A new study introduces a novel epigenetic predictor, PCBrainAge, that captures aging heterogeneity across multiple brain regions. The tool demonstrates stronger associations with AD dementia and pathologic AD compared to existing age predictors.
A new study found that HIV-1 Tat expression accelerates age-related diseases in male mice by disrupting neuroendocrine function. Researchers discovered that Tat alters steroid hormone levels, leading to anxiety-like behavior, cognitive errors, and reduced grip strength.
Researchers identified CUDC907 as a dual phosphoinositide-3 kinase/histone deacetylase inhibitor that promotes apoptosis in NF2 schwannoma cells. The compound reduced viability and induced cell cycle arrest in human merlin deficient Schwann cell models.
A new study uses machine learning models to predict cancer patients' responses to immunotherapy based on their gut microbiome features. The research identifies common gut bacterial taxa associated with responders versus non-responders, providing a potential tool for distinguishing and predicting immunotherapy responders.
Researchers found associations between perceived discrimination and epigenetic aging in US middle-aged and older adults. Depressive symptoms were identified as a potential mediator in these relationships, particularly among women and White adults.
Researchers analyzed germline variants in breast cancer patients to identify their role in metastasis development. The study found that host genetic makeup contributes to metastasis through dysregulation of gene expression, promoting the dispersion of metastatic seeds and establishing a conducive environment for their growth.
Abemaciclib, a CDK4 & 6 inhibitor, showed profound inhibition of cell proliferation and triggered senescence and apoptosis in breast cancer cells. Continuous dosing provided sustained inhibition with irreversible effects through apoptosis, supporting the differentiated safety and efficacy profile.
Researchers found global redistribution of histone H3 modifications with time, particularly in intergenic regions and near transcription start sites. Caloric restriction diet feeding reduced the extent of changes occurring during the first year of life in these genomic regions.
This volume of Oncotarget features groundbreaking research on various cancers, including breast, lung, colorectal, and neuroblastoma, as well as novel drug targets for bladder cancer. The studies also delve into the role of BRCA in breast and colorectal cancers.
A recent study published in Aging-US reveals the crucial role of WRN in making choices between classical and alternative non-homologous end joining (NHEJ) DNA repair pathways. The research provides new insights into progeroid syndromes, such as Werner syndrome, and their connection to aging.
Researchers identified DNA damage-inducible transcript 4 (DDIT4) as a critical factor regulated by histone deacetylase 4 (HDAC4) in skin aging. Overexpression of HDAC4 rescued cells from senescence, while DDIT4 overexpression reversed changes associated with aging.
A recent study identified 34 novel genes that contribute to endocrine resistance in breast cancer using dynamic gene expression analysis. The researchers found that these genes are differentially expressed in both estrogen receptor-positive and triple-negative breast cancers, suggesting shared genetic mechanisms underlying resistance d...
Researchers investigated the effects of treatment with exogenous Humanin G on inflammation markers in AMD and normal retinal cells. The study found reduced levels of inflammatory proteins in AMD plasma and treated cybrids, highlighting the positive effects of Humanin G.
Research suggests that NF-κB over-activation is associated with improved outcomes in patients with HPV-positive head and neck cancer. An RNA-based classifier trained on tumors with specific mutations may improve prognostic classification, aiding in treatment personalization.
Researchers developed CancerOmicsNet, a graph neural network model that integrates multiple heterogeneous data to predict cancer cell growth rate after drug treatment. The model achieved significantly higher cross-validated accuracy than other approaches on the same data.
The article proposes a new framework for understanding the hallmarks of cancer and aging, highlighting their shared underlying principles. Dr. Blagosklonny's hyperfunction theory arranges these hallmarks in a hierarchical structure, revealing common signaling pathways involved in both aging and cancer.
Researchers studied naked mole-rats' skin using single-cell RNA-seq to understand its remarkable stability against aging. They found no changes in epidermal gene expression with age and a unique keratinocyte differentiation trajectory that remained intact.
Dr. Blagosklonny discusses the potential of combining rapamycin with other modalities to live long enough to benefit from future discoveries in cellular reprogramming. He emphasizes that Altos Labs needs to develop rapamycin-based drug combinations to achieve additional decades of life extension, potentially within 3-5 years.
Impact Journals will participate as an exhibitor at the American Association for Cancer Research (AACR) 2022 annual meeting, showcasing their prominent journals Oncotarget and Aging (Aging-US). The conference focuses on Decoding Cancer Complexity | Integrating Science | Transforming Patient Outcomes.
Researchers discovered chemerin, a multifunctional protein, has antitumoral properties in mouse models of cancer. Bioactive chemerin overexpression inhibits neoangiogenesis, a process distinct from normal tissue vasculature. This effect may provide a therapeutic application for targeting solid tumors.
Researchers found that dysregulation of enzymes in the glucuronidation pathway is associated with castration-resistant prostate cancer. The study suggests that reducing UGDH expression and/or activity can reverse castration resistance, potentially preventing or delaying therapeutic resistance.
This study reveals cellular composition changes in colon organoids exposed to smoking and red/processed meat carcinogens, suggesting an overlap between inherited and environmental CRC risk. The findings provide novel insights into CRC etiology and reveal potential avenues for future research.
Researchers developed nanoTCEs to target AML cells, showing high specificity and potency in treating the disease. The technology uses nanoparticles to bind to CD33, a marker present on AML cells.
This study found high expression of Myosin 1g in pediatric acute lymphoblastic leukemia, suggesting its potential role in disease pathogenesis, particularly in high-risk patients. The research also showed that Myo1g may serve as a biomarker for identifying patients with an increased risk of relapse.