A team of researchers has successfully developed a novel method for live 3D printing osteogenic scaffolds into bone defects. The method uses nanobiosilica-based scaffolds with adequate 3D printing properties to improve implantability and rapid bone healing capability, resulting in nearly 55% bone defect healing after four weeks.
The American Dental Association sponsored a symposium on transforming oral health through science and evidence-based practice. The event aimed to build research capacity, improve treatment outcomes, and address key oral diseases such as dental caries and periodontal disease.
Researchers created a 3D bioengineered tooth bud model using Gelatin Methacrylate (GelMA) hydrogel and postnatal dental stem cells. Decellularized tooth bud extracellular matrix (dTB ECM) was introduced to enhance dental stem cell differentiation, resulting in whole tooth structures upon in vivo implantation
The symposium reviewed current developments and challenges in 3D printing and bioprinting for regenerating complex dental, craniofacial, and oral tissues. Researchers showcased their work on guided self-assembly, 3D-printed constructs, and geometric controls of periodontal tissue regeneration.
Kyounga Cheon, Assistant Professor at University of Alabama at Birmingham, receives the second AADR Anne D. Haffajee Fellowship for her research on Streptococcus mutans genotypes and tooth regeneration.
Researchers question the longstanding guidelines for fluoride intake, citing changes in sources and prevalence of dental caries and fluorosis. The symposium highlights research gaps, including measuring total fluoride intake and evaluating its effects on children and adults.
A special issue in the Journal of Dental Research explores recent scientific and technical advances in craniofacial development and genetics. The discoveries reported could improve diagnosis and treatment of challenging craniofacial and dental anomalies.
A study explores the relationship between Chédiak-Higashi syndrome and periodontitis, revealing that LYST mutations affect TLRs and lead to a dysregulated immune response. Classic CHS patients with bone marrow transplantation exhibited mild chronic periodontitis, while atypical CHS patients showed no evidence of aggressive periodontitis.
The American Association for Dental Research (AADR) suggests that dental schools prioritize research participation, collaboration with other departments, and flexible curricula. AADR also advocates for increased funding from various sources, including the National Institutes of Health, to support dental research and training.
Researchers have identified a potential method to screen for Zika virus exposure using proteomics in saliva. The study found that specific protein signatures can be detected in the saliva of infected individuals, allowing for earlier detection and treatment of the virus.
A systematic analysis examined the global burden of oral conditions between 1990 and 2015, finding a significant increase in disability-adjusted life years due to oral diseases. The study suggests that oral health goals should be developed to advance global public health.
Two studies examine NIH funding to US dental institutions between 2005-2014, revealing a 70% investment by NIDCR, with funding for oral cavity cancer research decreasing after 2009. A perspective piece highlights the need for increased focus on rectifying the gap in oral health research funding.
A new cognitive behavioral therapy (CBT) resource has been developed to manage children's dental anxiety. The study found a significant reduction in dental anxiety and an increase in health-related quality of life among children who used the guided self-help CBT resource.
Fluorides are effective in preventing caries, but their use alone cannot prevent the disease when combined with high sugars diets. The effects of reducing sugars intake are modified by fluoride, but the two approaches can work synergistically to reduce caries activity.
A Brazilian birth cohort study found that life-course overweight and obesity significantly increase the risk of unfavorable periodontal outcomes. The study suggests a cluster effect, where excess weight and unhealthy habits together exacerbate periodontitis risk.
The OPPERA study reveals that jaw injuries are strongly associated with temporomandibular disorder (TMD), with increased incidence rates found for extrinsic events, sustained mouth opening, and yawning. Single injuries were sufficient to increase risk of developing painful TMD.
A study found moderate-to-severe gingivitis to be common in pregnant women, particularly among younger mothers. Regular dental care is crucial for maintaining oral health during pregnancy, as gestational age and maternal age were significant factors in gingival bleeding.
Researchers at the University of Iceland have developed several new formulations for topical treatments of oral mucosal conditions. Topical application of doxycycline was effective in promoting healing of mucosal lesions, while monocaprin reduced counts of Candida rapidly and significantly.
A study found that annual application of SDF solution arrests root caries in community-dwelling elders, with higher effectiveness in non-fluoridated areas. The background water fluoride level had no statistically significant influence on the effectiveness of SDF.
The IADR/AADR published an issue on International Caries Consensus Collaboration's (ICCC) recommendations for managing carious lesions, focusing on evidence-based, patient-centered guidelines. The recommendations support less invasive carious lesion management by preserving tooth tissue and retaining teeth long-term.
A systematic review and meta-analysis published by the International Association for Dental Research reveals an association between tooth loss and reduced cognitive function in adults. Individuals with less than 20 teeth were found to be at a 20% higher risk of developing cognitive decline and dementia compared to those with more teeth.
Researchers identified microRNA-146a in osteoclast-derived extracellular vesicles, which regulate bone cell function. The study suggests that miR-146a-rich EVs may act as a potential biomarker for osteoclast presence and regulate target cells.
Researchers explore small molecule replacement therapy to rescue craniofacial defects by manipulating Wnt and Eda/Edar signaling pathways. The study provides novel candidates for therapeutic treatment of patients with craniofacial defects.
A study presented at the American Association for Dental Research Annual Meeting found that saliva liquid biopsy accurately detected EGFR mutations in lung cancer patients, with high accuracy rates. The test showed promise as a non-invasive diagnostic tool for detecting actionable EGFR mutations.
Researchers developed a caries risk tool to identify toddlers at risk of developing caries by age four through medical settings. Minority, Medicaid, and rural children had higher caries rates at 30 months-of-age, with several questionnaire items associated with cavitated caries.
A study found that adjunctive use of minocycline microspheres significantly reduced levels of subgingival bacterial species and improved clinical outcomes for patients with peri-implantitis. This resulted in a greater reduction in pocket depth compared to mechanical debridement alone.
The National Dental Practice-Based Network (PBRN) has been established as a learning health system, leveraging data infrastructure to advance scientific knowledge and improve patient care. The network's collaborative processes have enabled over 25 studies, 100 peer-reviewed papers, and demonstrated practice change since its inception.
Researchers conducted focus groups with children (8-12 years) and adolescents (13-17 years) to elicit perceptions of oral health. Three themes emerged: maintaining good oral health for longevity, positive associations between oral health and relationships, and benefits of orthodontic treatment. These findings inform the development of ...
The symposium highlights opportunities to utilize federal big data initiatives in dental research, such as BD2K, to advance research and practice. Panelists will discuss the potential of linked data for dental providers.
Researchers developed a novel RNA-based hairpin molecule to inhibit microRNA activity in cells and mice. The plasmid-based microRNA inhibitor system effectively knocks down endogenous miRs, revealing roles for miRs in developmental pathways and cellular processes.
Researchers analyzed six years of dental claims data to evaluate the longevity of restorations in primary molars. Sealants showed better survival rates when applied to children under three years old, while one-surface composite had similar longevity to one-surface amalgam.
A study found that Canadian First Nations children with severe early childhood caries had a distinct oral microbiome, with higher levels of cariogenic microorganisms and population shifts in their oral microbial communities. This may explain the high prevalence of S-ECC in Indigenous children.
The AADR/ADA symposium aims to bridge the gap between research evidence and clinical decision-making. Participants will learn how to quickly access research evidence, interpret its findings, and apply them to patient care.
A recent study by researchers at Kyushu Dental University found a significant evidence-practice gap for sealant application among Japanese dentists. The findings suggest that dentists' beliefs about the effectiveness of caries risk assessment are strongly associated with their recommendation of dental sealants.
Researchers identified eight functional variant mutations in the ADCY9 gene associated with non-syndromic oral clefts (nsCL/P) in Puerto Rican children. The study found three rare missense mutations, including rs52791170/K564Q and rs372048350/A811V, which were not previously reported in Puerto Ricans.
Research shows that aging alters antibody responses to oral bacteria, with significant positive correlations observed across the population. Specifically, antibody levels to Porphyromonas gingivalis and Treponema denticola increased with age, while those to Aggregatibacter actinomycetemcomitans did not.
The workshop reviews literature on body weight and oral health, teaching participants to measure and interpret weight, height, and other body size indices. It highlights the importance of documenting obesity and underweight in dental settings to identify risk factors for periodontal diseases and dental caries.
Researchers found that transient activation of the Hedgehog pathway after irradiation rescued salivary gland dysfunction by preserving stem/progenitor cells and parasympathetic innervation. Shh gene transfer improved saliva flow rates in mice, while also preserving acini marker Aqp5 expression.
The IADR/AADR have released the first issue of JDR Clinical & Translational Research, a journal focusing on the translation of research into clinical practice. The inaugural issue covers various topics in applied oral health research, with an emphasis on rapid dissemination and application.
Researchers investigate non-invasive sealing as a means to postpone restorative intervention for occlusal dentin caries in young permanent teeth. The study found that sealings showed better survival rates, but over half of sealed lesions remained untreated after seven years.
A study of 6,885 adults found that tooth loss and untreated caries are associated with limited food intake, affecting quality of life. Researchers used NHANES data to examine the relationship between dentate status and number of teeth with untreated decay on reported limited food intake.
Researchers estimate US periodontitis prevalence at state and local levels using a novel SAE method, revealing high risk areas in the southeast and southwest, including Native American reservations. The study informs oral health policy decisions and intervention strategies to increase access to care for populations at higher risk.
New evidence on dental implants reveals the importance of tooth preservation in patients with gum infections. The studies suggest that teeth compromised by periodontal disease or endodontic problems may have a longer longevity than average implants.
Direct treatment costs of dental diseases worldwide total US$298 billion yearly, while indirect costs due to productivity losses amount to US$144 billion. The combined economic impact amounts to US$442 billion in 2010.
Smiling Brazil launched in 2004 and incorporated oral health into the public healthcare system, adopting an integral care approach. The policy has shown positive results in oral health epidemiological indicators, financial investment, and professional development.
Recent studies published by the International Association for Dental Research (IADR) highlight the significant link between sugar intake and dental caries. The findings emphasize that even low sugars intakes can contribute to the development of caries, underscoring the need for effective health policies.
The International Association for Dental Research published a case report on the first application of 3D printed scaffolds for periodontal tissue engineering in humans. A review also discussed various 3D bioprinting methods, biomaterials, and their potential applications.
A study of children with nonsyndromic orofacial clefts and their relatives found that affected families do not have a significantly higher genetic risk for dental anomalies. Instead, the prevalence of dental anomalies is primarily due to physical consequences of the cleft and surgical interventions.
A recent study reveals a significant association between hair disorders and susceptibility to dental caries. The research found that polymorphisms in hair keratins are associated with increased risk of dental defects and caries, highlighting the importance of keratin components in tooth enamel structure.
A cross-sectional analysis of 3,255 US non-smokers found a significant association between environmental tobacco smoke exposure and an increased risk of moderate/severe periodontitis. Serum cotinine levels were used to classify participants as exposed to ETS, with results showing a higher odds ratio among exposed individuals.