A cross-sectional study of 1,309 children found a significant association between low birth weight and the development of enamel defects. The study suggests that prenatal hypertension and prematurity may also contribute to the severity of these defects.
A study published at the International Association for Dental Research found that dental pain relief is accompanied by reduced activity in the posterior insula and enhanced connectivity to the midbrain. This discovery provides new insights into the neural mechanisms underlying dental pain.
Researchers examined the effects of Amitriptyline, Gabapentin, and Carbamazepine on human skin keratinocyte and oral keratinocyte cells. The study found that lower concentrations of Amitriptyline were more cytotoxic to HaCat cells, while Gabapentin and Carbamazepine had less toxic effects.
Researchers found increased pocket depth and clinical attachment loss in patients with rheumatoid arthritis, highlighting the link between gum disease and joint inflammation. The study also identified Porphyromonas gingivalis antibodies as biomarkers for identifying patients who may benefit from periodontal treatment.
A study by Bernhard Ganss and colleagues found that amelotin is essential for enamel mineralization and maturation. Ammelotin-deficient mice exhibited weak incisor-edge enamel that fractured and chipped, with delayed enamel mineralization and retention of organic matrix.
A special themed issue of the Journal of Dental Research covers recent developments in novel dental biomaterials and technologies, aiming to improve oral health outcomes. The issue highlights significant advances in materials engineering and their clinical applications.
A recent study published by the International Association for Dental Research found that sleeping in dentures doubles the risk of pneumonia in elderly individuals. The research, which followed over 500 seniors, identified that overnight denture wear was independently associated with a 2.3-fold higher risk of pneumonia incidence.
Severe periodontitis is the sixth most prevalent health condition in the world, affecting over 743 million people worldwide. The global age-standardized prevalence of severe periodontitis remained static at 11.2% between 1990 and 2010.
A retrospective cohort study found that SSRIs were associated with an increased risk of osseointegrated implant failure. The study revealed a significant association between SSRI use and higher failure rates, with small implant diameters, bone augmentation, and smoking habits also linked to increased failure risk.
A new study projects a continued decline in US edentulism prevalence through 2050, with high-income households experiencing the steepest reduction. However, tooth loss remains disproportionately prevalent among low-income populations, highlighting a need for targeted public health measures to address this issue.
A retrospective study found that children receiving non-dental primary care provider visits had lower tooth decay treatment rates and payments compared to those visiting dentists alone. The study suggests that preventive oral health services provided by non-dental providers may lead to a greater reduction in tooth decay treatment.
This review discusses four key physiologic processes in bone/tooth formation affected by rare bone diseases. The authors highlight causative mutations, etiopathology, and treatments for conditions like fibrous dysplasia, osteogenesis imperfecta, and hypophosphatasia.
Researchers identified salivary biomarkers associated with gingivitis, including PGE2 and IL-1. These findings have implications for personalized oral health care, suggesting potential discrimination between gingivitis and health through salivary biomarker analysis.
Researchers successfully delivered adeno-associated virus serotype-5 (AAV-5) to the rat trigeminal ganglion, demonstrating transduction efficiency in sensory neurons. The study's findings support the use of AAV-5 based gene therapy approaches for evaluating target proteins and potential treatments for trigeminal pain disorders.
Researchers developed polymorphonuclear leukocyte-derived novel pro-resolving medicines (NPRMs) to deliver a lipoxin A4 analog to the site of surgery, controlling inflammation and promoting tissue and bone growth. The mini-pig model revealed significant pocket depth reductions and new bone formation in NPRM+LXA4-treated sites.
A new antibacterial orthodontic cement containing dimethylaminododecyl methacrylate (DMADDM) inhibits biofilm formation and reduces lactic acid production. The results show that the DMADDM-containing cement is promising for reducing demineralization in enamel around orthodontic brackets.
The symposium explores the efficacy and cost-effectiveness of community water fluoridation, as well as assessments of fluoride ingestion risks. It aims to address knowledge gaps on fluorides and their impact on oral health.
The study found that resin infiltration successfully stabilized early non-cavitated lesions in a small population with high caries-activity. Continuing follow-up may further confirm its efficacy.
Research study examines association between cognitive function and tactile, taste perceptions in elderly. Results show positive correlation between cognitive function and oral perception, suggesting decline in cognitive function is related to impaired oral perception in independently-living octogenarians.
A nationwide survey found a strong association between tooth loss and depression, as well as anxiety. The study, which analyzed data from over 451,000 respondents, revealed that individuals with depression or anxiety were more likely to experience tooth loss, with adjusted odds ratios of 1.16 for depression and 1.23 for anxiety.
Researchers have identified six natural-products derivatives that can inhibit oral biofilm formation and quorum sensing in three indigenous oral Gram-positive bacteria. These compounds, structurally similar to S-ribosyl homocysteine, reduce bioluminescence in a Vibrio harveyi QS reporter, indicating inhibition of AI-2 based QS.
A large cohort of Swedish residents found no association between long-term fluoride exposure and the risk of hip fractures. The study included nearly half a million individuals exposed to varying levels of fluoride in their drinking water.
Gingival stem cells derived from cranial neural crest cells and mesoderm show distinct capacities for differentiation and immune modulation. These cells demonstrate superior effects in ameliorating inflammatory-related disease phenotypes when transplanted into mice.
A systematic analysis reveals that 3.9 billion people globally are affected by oral conditions, with untreated caries being the most widespread. The study estimates 15 million disability-adjusted life-years (DALYs) due to oral conditions worldwide.
Research published in the Journal of Dental Research shows that beta-catenin is crucial for odontoblast cell differentiation and root development. Tissue-specific inactivation of beta-catenin in developing odontoblasts resulted in molars lacking roots and thin incisors.
A cluster randomized trial found that an intervention to enhance sense of coherence (SOC) improved oral health-related quality of life (OHRQoL), oral health beliefs, and gingival health in children. The study suggests that SOC may be an avenue for oral health promotion.
A recent study published in the Journal of Dental Research estimates that approximately 47.2% of US adults have periodontitis, with higher rates among males, Mexican Americans, and those with lower education levels. The study also found significant disparities in periodontal disease prevalence across different age groups.
Researchers propose a new classification of severe early childhood caries, which affects mostly young children living at or below poverty levels. The condition is characterized by structurally damaged primary teeth and is linked to developmental dental defects such as enamel hypoplasia.
A three-year longitudinal study found that periodontal treatment reduced hospital admissions, physician visits, and overall medical care costs in diabetics by an average of $1,814 per patient annually. This significant reduction was attributed to a 33% decrease in hospital admissions.
Isabel Garcia, NIDCR deputy director, receives the 2012 AADR Jack Hein Public Service Award for promoting oral health research interests. Dr. Garcia's work benefits both dental and craniofacial researchers and the general public.
Dr. Ronald Dubner, a professor at University of Maryland, Baltimore, received the 2012 AADR Distinguished Scientist Award for his groundbreaking work on neurobiological mechanisms of orofacial acute and chronic pain. His research has been recognized for translating findings to improve healthcare.
A symposium on TMJ stem cell biology and engineering presents novel clinical therapy approaches for TMJ disorders. Researchers discuss the origin, homeostasis, differentiation, hormonal regulation, and bioengineering of temporomandibular joint tissues.
The American Association for Dental Research (AADR) has renamed its award to honor Dr. Irwin D. Mandel's contributions to dental research and mentorship. The newly named Irwin D. Mandel Distinguished Mentoring Award recognizes outstanding efforts to foster and promote research training and career development.
The AADR William B. Clark Fellowship will support Dr. Palomo's research on bisphosphonates and their effect on the periodontium in postmenopausal women. The award aims to advance knowledge for the improvement of oral health through clinical research.
The American Association for Dental Research awarded Page Linae Collymore a $4,000 student fellowship to encourage research on Sjögren's Syndrome. She is a student at Southern Illinois University and will be recognized at the AADR's 41st Annual Meeting in March 2012.
Dr. Richard H. Carmona receives AADR's Honorary Membership for his dedication to promoting oral health as U.S. Surgeon General and beyond. The American Association for Dental Research recognizes Dr. Carmona's significant contributions to dental research.
Research on dental therapy workforce development aims to improve oral health care delivery through non-traditional settings. The symposium presents findings on the role of dental therapists in community care, highlighting their potential impact on oral health outcomes.
Recent studies have increased interest in salivary biomarkers for diagnostics, but challenges persist in collection, storage, and quantitation of biomarkers. Researchers will discuss standardization procedures and address issues with proteomic methods.
The AADR has awarded the 2012 Neal W. Chilton Fellowship in Clinical Research to Bing-Yan Wang, an associate professor at the University of Texas Health Science Center. The fellowship will support Wang's clinical testing of a mouthwash effective against oral bacteria.
The symposium discusses best practices for using educational research in the promotion and tenure process, facilitated by AADR's Education Research Group and the American Dental Education Association. Key findings highlight the importance of recognizing and applying educational research to advance teaching practice.
Researchers found that specific microRNAs are up-regulated in obese individuals with healthy periodontium and non-obese subjects with periodontal disease. The study suggests microRNA modulation may play a role in modulating inflammatory pathways within periodontal tissues.
Researchers demonstrate that an anti-caries DNA vaccine, pGJA-P/VAX, combined with a Salmonella protein adjuvant, enhances saliva IgA responses and protects against dental caries. The study shows that the adjuvant promotes specific immunoglobulin A responses in saliva and offers better protection against caries.
The IADR/AADR published the proceedings of the 3rd AADR Fall Focused Symposium on Salivary Diagnostics, featuring scientific posters and invited speakers from leading institutions. The symposium explored cutting-edge technology and techniques in salivary diagnostics research.
A recent study published in the Journal of Dental Research investigated the link between bone fluoride levels and osteosarcoma risk. The research found no significant association between the two, contradicting previous controversies over fluoride's potential role in increasing osteosarcoma risk.
Researchers analyzed 772 tweets related to dental pain and found that 83% were general statements about toothache, with 44% reporting visiting the dentist and 43% taking medication. The study suggests using social media platforms like Twitter for collecting public health data.
A symposium on tissue injury and pulp regeneration has published proceedings that highlight the potential of dental pulp engineering for regenerating functional dentin. Researchers present data on stem cells, scaffolds, and differentiation factors, demonstrating proof of principle for pulp/dentin regeneration.
Two studies published in the Journal of Dental Research found significant income-related inequalities in dental service utilization and tooth loss among Europeans aged 50+ and US adults. Income inequality was associated with higher odds of reporting greater tooth loss, highlighting the need to address social determinants of health.
Researchers developed biodegradable tooth-binding micelles that effectively bind to teeth and inhibit the growth of Streptococcus mutans, a primary cause of tooth decay. These micelles showed promising results in reducing biofilm formation on hydroxyapatite particles.
Researchers compared two pulp extraction techniques on dental pulp stem cells (DPSC) quality and quantity. The study found that the second technique resulted in higher stem cell integrity, growth rate, and quality, while also improving quantity.
Researchers validated three salivary mRNA biomarkers (B2M, GIP2, MNDA) and three protein biomarkers (B2M, SSA, SSB) for detecting Sjogren's syndrome in the US population, expanding clinical utility of existing biomarkers.