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JAMA Network


AI model for imaging-based extranodal extension detection and outcome prediction in HPV−positive oropharyngeal cancer

An AI model successfully automates lymph node segmentation and extranodal extension classification from pretreatment CT scans in HPV-associated oropharyngeal carcinoma. Predicted extranodal extension is independently associated with worse oncologic outcomes, highlighting the potential for improved treatment planning.

SourceJAMA Network·JournalJAMA Otolaryngology–Head & Neck Surgery·DateSep 30, 2025

Olfactory dysfunction after SARS-CoV-2 infection

A cohort study investigated olfactory dysfunction in US adults with and without prior SARS-CoV-2 infection. The study found a significant association between prior infection and persistent olfactory dysfunction. High variability was observed among individuals, highlighting the need for individualized assessment and treatment strategies.

SourceJAMA Network·JournalJAMA Network Open·DateSep 25, 2025

Alcohol consumption per capita and suicide

A systematic review and meta-analysis found a strong association between alcohol consumption per capita and an increase in suicide mortality rates. The study suggests that targeting alcohol consumption may be a useful strategy for comprehensive national suicide prevention efforts.

SourceJAMA Network·JournalJAMA Network Open·DateSep 22, 2025

Country of birth, race, ethnicity, and prenatal depression

A cross-sectional study found that prenatal depression diagnosis and moderate to severe depression symptoms differ by maternal nativity and racial/ethnic background. Non-U.S.-born mothers tend to have better neonatal outcomes, but this association may not hold true for prenatal mental health conditions.

SourceJAMA Network·JournalJAMA Network Open·DateSep 15, 2025

Home training for cerebellar ataxias

Home high-intensity aerobic training outperforms home balance training in improving ataxia symptoms, fatigue, and aerobic fitness among those with cerebellar ataxias. Regular training maintained benefits at 1 year.

SourceJAMA Network·JournalJAMA Neurology·DateSep 14, 2025

Acupuncture for chronic low back pain in older adults

A randomized clinical trial found that acupuncture provided greater improvements in back pain-related disability compared to usual medical care alone. The study suggests that acupuncture needling is an effective and safe treatment option for older adults with chronic low back pain.

SourceJAMA Network·JournalJAMA Network Open·DateSep 12, 2025