Optic disc edema progression in spaceflight predicted using optical coherence tomography imaging, suggesting crew members without ODE on day 30 unlikely to develop concern on day 150. This technology offers opportunity for predicting ODE magnitude during longer missions.
Lung cancer screening has the potential to prevent 3 times more deaths and gain 3 times more life-years than current levels. Increasing awareness and accessibility of lung cancer screening could lead to wider adoption.
The study found a positive shift in the prevalence of adverse childhood experiences (ACEs) among U.S. children between 2016 and 2023, with an increase in individuals reporting 0 ACEs and a decrease in severe ACEs. This trend suggests a reduction in severe ACEs among specific racial and ethnic groups and low-income families.
Adults with higher levels of physical activity during midlife and late life have a lower risk of all-cause and Alzheimer's disease dementia. This cohort study, part of the Framingham Heart Study Offspring cohort, found similar reductions in risk across different age groups.
A state-level incentive program aimed at improving diet in SNAP participants showed no significant increase in fruit and vegetable intake. However, the study found benefits among existing high-fruit-and-vegetable consumers. Enhanced implementation strategies may be needed to maximize public health outcomes.
A US cohort study from 2012-2021 found persistent disparities in cesarean births by race and ethnicity, with non-Hispanic Black individuals facing increased risks. The study highlights the need for quality improvement efforts to address structural racism and reduce unnecessary cesarean births.
Approximately 1 in 30 clinical trials were disrupted due to grant funding terminations, disproportionately affecting infectious disease and prevention studies. The study emphasizes the need for sustainable financial support to ensure trial operations and participant safety.
A study found that lowered arsenic exposure was associated with a decrease in mortality rates from chronic diseases among populations exposed to contaminated drinking water. The findings support the importance of reducing arsenic levels in drinking water for public health benefits.
Rapid rise in early measles vaccination observed in February 2025, ahead of CDC guidelines. The study suggests clinician and parental concern drove increased vaccination rates.
Researchers found high-engagement social media posts lack essential risk information and promotional elements, potentially eroding patient decision-making. The study highlights the need for fair balance in online advertising to maintain informed consent.
A study found that higher consumption of ultraprocessed foods is associated with an increased risk of developing early-onset colorectal cancer precursors. The research highlights the importance of improving dietary quality to mitigate the rising burden of early-onset colorectal cancer.
This cohort study found a high risk of developing functional somatic disorder (FSD) in individuals with a history of sexual assault. The pooled analysis underscores the biopsychosocial consequences of sexual assault and highlights the importance of further research and targeted interventions to address this critical issue.
A study found that intimate physical contact reduces cortisol responses, while oxytocin administration promotes wound healing. This integration of relationship dynamics and neurohormonal modulation may lead to future interventions for improved health and recovery.
Risk-adjusted mortality declined significantly following the COVID-19 pandemic, resuming prior improvement trends. Patient acuity, measured by case mix index, remained elevated, suggesting a new postpandemic baseline.
A population-based study found that county-level access to maternity care inversely associated with infant mortality risk. The study highlights racial and ethnic disparities in mortality risk between full-access and no-access counties among white infants only.
A randomized clinical trial found that self-administered hypnosis significantly reduced hot flash scores and daily interference compared to sham hypnosis. The study suggests that hypnosis delivered through audio files is a clinically significant method for reducing hot flashes in postmenopausal women.
The FDA has revised the labeling for menopausal hormone therapy based on current evidence, which may affect patient safety and treatment options. The updated guidelines aim to provide more accurate information for healthcare providers and patients.
A cross-sectional study found significant associations between state-level firearm ownership and all-cause and firearm-specific homicide among pregnant women. The results suggest that prevention efforts should focus on women during pregnancy, particularly in states with higher firearm ownership rates.
Over the past two decades, nearly half of US states have reported firearm mortality as the leading cause of death in children aged 1-19. Gun violence has become the primary cause of death for this age group, with Alaska being the first state to report this trend in 2004.
The navigate-kidney study finds that community health workers enhance holistic, patient-centered care through improved patient engagement and emotional wellbeing. This integration into dialysis care teams may lead to better outcomes for patients with kidney failure.
A culturally tailored community health worker intervention modestly lowered interdialytic weight gain and improved dialysis adherence among Hispanic and Latino patients with hemodialysis-dependent kidney failure. This study suggests that such interventions can enhance patient outcomes for these vulnerable populations.
The study suggests that SGLT2 inhibitors can benefit patients with varying levels of kidney function and albuminuria. Routine use of these medications may lead to improved kidney outcomes across different patient groups.
Heat- and cold-related mortality burden in the US increased significantly between 2000 and 2020, with temperature extremes contributing to excess deaths. The study found that geographic location, cause of death, and demographic factors played a crucial role in differential vulnerability to temperature-related health risks.
Premature mortality among adults aged 18-64 increased by over 27% between 2012 and 2022, with racial disparities widening substantially. Despite contributing to Medicare, Black individuals are less likely to live long enough to reach the qualifying age for coverage, resulting in unrealized benefits.
The study found clear absolute benefits of SGLT2 inhibitors on kidney, hospitalization, and mortality outcomes regardless of diabetes status and level of urine albumin to creatinine ratio. This benefit suggests a potential therapeutic approach for patients with kidney disease.
A conservative dialysis approach resulted in faster and more complete kidney function recovery in patients with acute kidney injury. The study's findings suggest that this strategy could be a viable option for treating dialysis-requiring AKI, warranting further investigation.
A study published in JAMA finds that using different methods to estimate glomerular filtration rate (eGFR) can lead to significant discrepancies, particularly for those with chronic kidney disease. The findings suggest that cystatin C-based eGFR may be more accurate in predicting clinical outcomes.
Pharmacists play a key role in providing medication abortion services when mifepristone is regulated as a routine prescription. This study's findings inform policy initiatives to enhance pharmacist referral networks and improve access to medication abortion.
A large sample of first-time mothers in the US reported informal human milk sharing, with 1 in 27 participants feeding their infants shared milk. Pediatric practitioners should be aware of this trend and counsel families on risks and recommended risk-reduction strategies.
This study confirms the role of negative reinforcement in chronic opioid use, contributing to addiction development. The findings suggest that this mechanism is present even after regular opioid use, highlighting potential for more effective prevention and treatment strategies.
The increasing use of unregulated psilocybin mushrooms poses a pressing need for public education, potency testing, and age-specific risk assessment. Existing clinical data are insufficient to guide harm reduction or policy, highlighting the need for real-world research on psilocybin use.
A nationally representative survey found that frequent parent-teen communication is associated with increased teen self-efficacy for sexual and reproductive health information. Teens whose parents feel comfortable discussing topics are more likely to seek services, highlighting the importance of accurate information and open dialogue.
A cohort study finds nearly 10-fold increase in facility-based screening among 45-49 year olds after USPSTF guideline changes. This rapid growth highlights early implementation by practitioners and patients, far exceeding growth among those ages 50 to 75.
A modeling study suggests that achieving systolic blood pressure equilibrium would significantly decrease the number of cardiovascular disease events and fatalities experienced by non-Hispanic black U.S. adults. Initiatives to maintain normal blood pressure and control hypertension could substantially improve health equity in the U.S.
The JAMA Summit Report outlines policies and interventions proven to reduce firearm violence, including community-based initiatives, technologies, and collaborative policing. Experts recommend five essential actions to drive progress in the coming years.
Exposure to childhood adversity is associated with elevated all-cause mortality risk among adults with diabetes, hypertension, or mild-to-moderate emergency department visits. The study found a significant link between childhood trauma and increased mortality risk in these adult populations.
A recent study found that US youth nicotine vaping has become increasingly represented by daily use and unsuccessful quit attempts, a growing concern for clinicians and policymakers. The findings highlight the need for awareness and targeted interventions to address this trend.
A cross-sectional study found associations between structural racism and inequities in neighborhood cardiovascular health, highlighting the need for targeted prevention efforts. The study's findings underscore the critical role of addressing systemic inequalities in promoting health equity.
This cross-sectional study found an increase in GLP-1RA prescriptions, with Tirzepatide and semaglutide growing the fastest due to their superior glycemic, weight loss, and guideline-emphasized cardiorenal benefits. However, coverage for obesity is limited, especially among off-label semaglutide use in non-T2D patients.
Frequent continuous glucose monitoring (CGM) use is associated with better glycemic control in people with type 2 diabetes. Clinicians should encourage CGM use and monitor its impact on therapy.
A study found that many US adults believe alcohol has no effect on cancer risk, despite growing evidence linking alcohol use to an increased risk of various cancers. This persistent misbelief contributes to the rising burden of alcohol-related cancers in the country.
A cohort study found that poor olfaction is associated with a higher risk of coronary heart disease in older adults. The study suggests that assessing olfaction may be an important factor in identifying individuals at risk for cardiovascular disease.
A study found that maintaining moderate physical activity over three decades can significantly reduce digestive system cancer risk. The optimal level of physical activity was around 17 metabolic equivalent task-hours/week, equivalent to 5 hours of brisk walking or 2 hours of running per week.
A recent study found that over 11,000 physicians were sponsored for H-1B visas in the US, representing 1% of the workforce. Notably, rural counties had nearly twice the percentage of H-1B-sponsored physicians compared to urban areas.
Patients with schizophrenia, bipolar disorder, or major depressive disorder are at higher risk of postacute sequelae of COVID-19. Coordinated mental health and COVID-19 care is crucial to mitigate these effects.
A new study finds that an AI-powered lifestyle intervention is noninferior to human coaching in achieving a composite outcome in adults with prediabetes and overweight or obesity. The AI-led Diabetes Prevention Program was noninferior to the human-led program in terms of weight reduction, physical activity, and HbA1c levels.
The study found that stillbirth rates are higher in low-income communities compared to more affluent areas, highlighting the need for targeted interventions to address social determinants of health
The 2024-2025 COVID-19 vaccines demonstrated effective protection against severe disease and similar effectiveness against different subvariants. However, their effectiveness declined over time.
A randomized clinical trial found that an unsupervised online Tai Chi intervention improved knee pain and function compared to the control group at 12 weeks. This free web-based intervention offers a safe, accessible, and scalable option for guideline-recommended osteoarthritis exercise.
Automated external defibrillators (AEDs) in private homes show effectiveness in improving patient outcomes for those with shockable rhythms during cardiac arrest. However, considering the rarity of cardiac arrest at home and current AED pricing, general purchase is not deemed cost-effective.