Researchers found that valacyclovir, an antiviral medication, was ineffective in treating early symptomatic Alzheimer's disease and may even worsen cognitive function. The study suggests that individuals with early symptomatic Alzheimer's disease and herpes simplex virus seropositivity should not be treated with valacyclovir.
Chronic pain prevalence differs between rural and urban adult cancer survivors, with rural areas showing higher rates despite having fewer resources. Limited access to pain specialists and insurance challenges contribute to these disparities.
Studies show that patients with advanced ovarian and metastatic breast cancer dedicate approximately 7 hours per week to cancer-related tasks. Most participants report performing these tasks daily, impacting their time burden. The use of a mobile app facilitated the collection of detailed time-use data.
Behavioral health spending in the US increased significantly between 2017 and 2022, reaching 40% of child health spending. This shift is associated with high family financial burdens due to expanded access to services and supports through insurance coverage and clinician availability.
A case-crossover study found that air conditioning in nursing homes reduces mortality among older adults during extreme heat. The study suggests that AC provision may be crucial for preventing mortality in congregate care settings.
This study found that vaccination before and during COVID-19 diagnosis in pregnancy significantly lowers the risk of severe maternal illness and premature birth. The results suggest that COVID-19 vaccination plays a crucial role in protecting pregnant individuals from serious health complications associated with the virus.
A randomized clinical trial found digital cognitive behavioral therapy to be significantly beneficial for adults with generalized anxiety disorder. The treatment provided sustained benefits and has the potential for public health impact due to its accessibility.
A secondary analysis of the WISDOM trial found a substantial number of women with clinically actionable genetic variants, many not qualifying for current guidelines. This study supports broader access to genetic testing for personalized breast cancer risk assessment.
The WISDOM randomized clinical trial found risk-based breast cancer screening to be equally effective as annual screening in detecting advanced cancers. However, it did not reduce breast biopsy rates. The study suggests a safer and more efficient approach to breast cancer screening.
A cross-sectional study found that state-level SNAP policies associated with higher program enrollment also lowered county-level food insecurity rates. The study suggests that these policies may help address rising food insecurity rates.
Approximately one-third of US adults met criteria for metabolic syndrome in 2023, with no significant change in prevalence between 2013 and 2023. Triglyceride levels demonstrated a modest increase over the past decade.
A repeated cross-sectional study found a significant increase in stimulant prescribing for ADHD, with the largest acceleration observed among female adolescents and young adults aged 18 to 64. The study's findings are consistent with prior research but provide new insights into population-level trends.
A study published in JAMA Network Open reveals low adherence to cervical cancer screening guidelines among commercially insured US adults, with only 7.3% following recommended guidelines. The findings suggest that guideline confusion and lack of incentives are contributing factors to this issue.
Using GLP-1 receptor agonists may lower the risk of vertebral compression fractures and related surgical interventions in people with type 2 diabetes. The study suggests that these medications have a bone-protective effect, offering benefits for patients.
A recent study published in JAMA found that initiating resuscitation of preterm infants with fraction of inspired oxygen levels of 0.6 versus 0.3 did not affect the risk of death or brain injury by 36 weeks' corrected gestational age.
A study published in JAMA found that expectant management resulted in higher survival rates compared to active treatment for patent ductus arteriosus in extremely preterm infants. The protocol-defined study showed no significant difference in mortality or bronchopulmonary dysplasia between the two groups.
A cohort study found that older Medicare beneficiaries with common metastatic cancers had a mean of 40 to 62 health care contact days after diagnosis. Health care contact days increased from 2008 to 2019, highlighting the need for oncology teams to discuss expected burdens when developing care goals and treatment plans.
A study found that certain physical activities temporarily increase the risk of low back pain flares in individuals with existing conditions. Conversely, long-term functional limitations were not associated with increased activity levels among these patients.
Early automated closed-loop ventilation did not increase ventilator-free days at day 28 compared to protocolized conventional ventilation. Critically ill adults receiving invasive mechanical ventilation showed no significant difference in ventilator-free days between the two ventilation protocols.
A study published in JAMA found that cryopreserved platelets were less effective than liquid-stored platelets in achieving hemostasis, particularly at 24 hours after ICU admission. The research suggests that alternative storage methods may be needed for efficient surgical bleeding treatment.
A study found cryopreserved platelets to be a cost-effective option for managing surgical bleeding in cardiac surgery, dominating liquid-stored platelets in this setting. Further investigation is required to assess the economic benefits of cryopreserved platelets in broader populations.
Precision immunotherapy targeting macrophage activation–like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo. The study suggests that this approach can be a promising treatment option for sepsis patients.
Health insurance premiums rose at rates close to hospital prices during the COVID-19 pandemic but have since stabilized, reflecting shifts in healthcare utilization. Insurance premiums increased 3 times faster than workers' earnings since 1999, accompanied by rising hospital costs.
A cohort study found that participation in New York's medical cannabis program was associated with lower rates of opioid prescription during a 18-month follow-up. The study controlled for unregulated cannabis use, suggesting that medical cannabis may be an effective alternative to opioids for managing chronic pain.
A cohort study of adults aged 45 or older with RSV infection found a significant excess risk of cardiovascular events over 1 year, comparable in magnitude to influenza infection. This highlights the importance of RSV as a potential risk factor for cardiovascular morbidity and underscores the need for vaccination to mitigate this burden.
Exposure to single and mixtures of perfluoroalkyl substances (PFAS) was associated with higher odds of endocrine disruption (ED) among women. Certain PFAS compounds, particularly n-PFOS, were found to disrupt endocrine function and harm health.
A survey study found that US voters generally support government role in ensuring safe vaccines, with high partisan divide among Trump and Harris supporters. Vaccine requirements for schools show similar support across parties.
A recent study suggests that adverse childhood experiences may increase the risk of obesity in Latinx and Hispanic youths. The study found that promoting resiliency-focused skills may help improve pediatric weight trajectories among these populations, potentially mitigating the impact of adverse experiences on health outcomes.
A survey study found that overall trust in scientists as sources of cancer information is high, but ideologically diverse. The results suggest the need for tailored messaging and trusted messengers to reach diverse audiences with evidence-based cancer information.
A growing trend of antipsychotic medication prescription increases in older U.S. adults, with long-term care pharmacies being a primary source. Non-psychiatrist prescribers contribute to the trend, highlighting concerns over medication accessibility and oversight.
A randomized clinical trial shows that semaglutide improves glycemic control and weight outcomes in individuals with schizophrenia. The study suggests using glucagon-like peptide-1 receptor agonists as an early intervention strategy to reduce cardiometabolic risk in this population.
Revising newborn hepatitis B vaccination guidelines may lead to increased perinatal infections, according to infectious disease experts. The study estimates that revoking the policy could result in a significant number of new infections.
A cohort study found that maternal plasma vitamin D levels inversely associated with offspring early childhood caries. Vitamin D supplementation before or during pregnancy may reduce the risk and severity of childhood dental caries.
Continuous glucose monitoring (CGM) has been associated with improved long-term clinical outcomes in insulin-treated older adults with diabetes and Alzheimer disease. This pragmatic trial aimed to assess the feasibility of CGM use in this population, highlighting its potential benefits for managing chronic conditions.
A study found that individuals with childhood overweight had a similar risk of coronary heart disease as those with normal weight throughout childhood and young adulthood. This has significant implications for public health planning, emphasizing early detection and treatment of childhood obesity.
A randomized clinical trial found that home hospital care in rural settings resulted in improved patient activity and experience, but not in reduced costs or readmissions. Late transfers to home likely attenuated the intervention's effect on cost outcomes.
A cross-sectional study found disparities in health care access for immigrant children, which decreased in states with more inclusive insurance eligibility policies. Inclusive state policies may improve health care access for immigrant children, reducing disparities compared to U.S.-born peers.
The study reveals a significant burden of metastatic disease in adolescents and young adults with cancer. The findings expand knowledge on metastatic recurrences, improving care for adolescent and young adult survivors.
A cohort study found an association between GLP-1 receptor agonist use and chronic cough. Researchers are now seeking to confirm the link's existence, strength, and mechanisms.
The prevalence of injecting methamphetamine only or both methamphetamine and opioids increased among people who inject drugs entering treatment in the US between 2012 and 2023. This trend is consistent with prior work showing increases in opioid and methamphetamine co-use before the COVID-19 pandemic.
Disrupted federal funding for extramural cancer research has substantial monetary consequences, impacting states and institutions nationwide. Many grant terminations affected junior faculty and research trainees, jeopardizing career trajectories and the research workforce.
The study highlights the need for clear guidance from clinicians to support safe cannabis or cannabinoid use. Clinicians should weigh benefits against risks when engaging patients in informed discussions about these therapeutic options.
The 2025 Los Angeles wildfires led to substantial increases in acute health care utilization, particularly through virtual care-seeking. This study emphasizes the importance of monitoring healthcare preparedness and response in the face of rising climate-related disruptions.
A substantial prevalence of avoidant/restrictive food intake was found in the general pediatric population, with affected children at risk of developmental difficulties across multiple domains. The study suggests a need for broad support interventions and advances understanding of the genetic underpinnings of this condition.
The study found that GLP-1 receptor agonists are increasingly used for postpartum weight loss in overweight women without a documented diabetes diagnosis. The primary indication for use was weight reduction, suggesting a potential shift in treatment guidelines.
A 1-week social media detox in young adults was associated with reduced symptoms of depression, anxiety, and insomnia. The study's findings suggest a potential therapeutic benefit of reducing social media use for mental health concerns.
A cross-sectional study found that US population faces significant challenges with nervous system disorders, impacting 180.3 million people, mainly due to stroke, Alzheimer's disease, diabetic neuropathy, and migraine conditions.
A study found that women with obesity who stopped using GLP-1 receptor agonists experienced more gestational weight gain and a higher risk of preterm delivery, gestational diabetes, and hypertensive disorders. The research suggests that discontinuation of these medications may impact pregnancy outcomes.
Withdrawal of tirzepatide after 36-week treatment led to 25% or greater weight regain in most participants within a year, reversing initial cardiometabolic parameter improvements. Continued obesity treatment is crucial for sustained benefits.
Current USPSTF guidelines exclude two-thirds of patients from age-based screening, disproportionately affecting women and never-smokers. Age-based screening has been shown to improve detection and demonstrated superior cost-effectiveness compared to existing programs.