Researchers support using antibiotics for uncomplicated acute appendicitis due to low recurrence rates at 10-year follow-up. The treatment option is recommended for adult patients, reducing the need for future surgery.
A comparative effectiveness study found that SGLT2 inhibitors were associated with a lower risk of chronic kidney disease and acute kidney injury compared to GLP-1 receptor agonists. These findings suggest that SGLT2 inhibitor treatment may be an effective strategy for preventing kidney disease in individuals with type 2 diabetes.
A case-control study found that even low-level air pollution in Sweden may increase the risk of developing motor neuron disease. Long-term exposure was also associated with poorer disease prognosis after diagnosis.
Population risk-based screening using 5-year invasive breast cancer risk is associated with similar or greater benefits than age-based screening, as well as reduced false-positive recalls. As personalized medicine advances, risk-based screening is poised to become a cornerstone of breast cancer prevention.
A large cohort study found no association between community water fluoridation and adverse birth outcomes, providing reassurance about its safety during pregnancy. The study highlights the importance of rigorous causal designs in evaluating public health interventions.
A Medicaid policy promoting high nursing home staffing levels was associated with modest improvements in patient health. The study estimates that similar reform nationwide could prevent 6,142 fewer hospitalizations annually.
A 2025 survey found that U.S. adults view opioid overdose as a serious problem, with differing opinions on who is responsible for reducing overdose rates. The study suggests varying preferences for future actions to address overdose among conservatives, moderates, and liberals.
Fine particulate matter and ozone exposure independently associated with poorer cardiac health outcomes in breast cancer patients treated with cardiotoxic therapy. Environmental exposure modifications are crucial to mitigate cardiovascular disease risk.
A cohort study found a 9-fold increased risk of suicide in Norwegian patients discharged alive after critical injury. Follow-up is recommended for possible psychological distress in this patient group.
Financial settlements from opioid epidemic lawsuits are being redirected to fund potentially lifesaving interventions. These efforts aim to curb overdose deaths and improve public health outcomes.
Post-intensive care syndrome (PICS) is a condition affecting ICU survivors, characterized by fatigue, cognitive impairment, and sleep disturbances. Treatment strategies focus on symptom management and prevention of complications.
The study reveals parental quality of life is compromised during the premature infant's hospitalization period. A family-centered approach with tailored support from the neonatal intensive care unit and postdischarge period can protect and promote parental well-being.
This study reveals an increase in nonmedical childhood vaccination exemptions from 2010 to 2024, driven by the COVID-19 pandemic, with wide regional disparities.
A nationwide study found that longer work hours were associated with increased stress and decreased self-perceived competency, but not with burnout. The study suggests that a comprehensive approach beyond work hour restrictions is needed to support resident well-being in training.
Women with a genetic predisposition to higher body mass index are at increased risk of all-cause mortality after breast cancer diagnosis. Targeted lifestyle recommendations can mitigate this risk.
From 2022 to 2025, US counties saw a population-level decline in child poverty rates overall. However, Black and Hispanic children continued to experience disproportionately higher poverty rates compared to white children.
The FDA's regulation of mifepristone involves characterizing its decision-making process and rationale for key components. The agency's approach has evolved over time, with notable changes to its regulatory framework.
A cohort study of students in grades 4-12 found that social media use varied by age and sex, with heavy use linked to poorer well-being. The study's findings suggest that abstinence from social media may not always be beneficial for adolescents.
A study found that older adults are prescribed potentially inappropriate central nervous system-active medications despite guidelines. Patients with cognitive impairment were more likely to receive these medications than those with normal cognition. The study highlights the need for better medication management in older adults.
A study found that TRAP laws increase maternal morbidity among fertility care patients, while states without such laws have better health outcomes. The study suggests a significant association between TRAP laws and adverse pregnancy outcomes.
Both bariatric surgery and semaglutide treatment were associated with significant fat mass loss, moderate fat-free mass loss, and an improved FFM to fat mass ratio. These findings support interventions aimed at preserving muscle mass while promoting weight loss.
A recent study found that the RSVpreF vaccine does not pose a significant risk to pregnant women, providing reassurance for those who wish to be vaccinated. The interim report presents data from a large cohort of pregnancies with vaccine-seeking behavior, and results suggest no notable adverse effects.
A study found that maternal vaccinations against influenza and pertussis are associated with reduced hospitalization or emergency department visits in infants under 6 months. Implementing maternal vaccination campaigns can enhance infant health outcomes, addressing low vaccination coverage.
A cohort study found that very high lipoprotein(a) levels increased the 30-year risk of cardiovascular disease among healthy women. Screening for elevated lipoprotein(a) may be warranted in the general population.
This randomized clinical trial found yoga to significantly accelerate opioid withdrawal recovery and improve autonomic regulation, anxiety, sleep, and pain. The study supports the integration of yoga into withdrawal protocols as a neurobiologically informed intervention addressing core regulatory processes.
A population-based cohort study found that U.S.-born individuals had significantly higher odds of infant mortality, particularly among full-term births. Sudden unexpected infant death was a major contributor to these disparities, highlighting the need for investigation into underlying factors contributing to these disparities.
This cohort study found that exposure to Migrant Protection Protocols was associated with higher rates of trauma during migration among asylum seekers. The Migrant Protection Protocols may have potential downstream implications for U.S. public health and security, including adverse health outcomes for asylum seekers.
This study found that US youth spent more than an hour using smartphones during school hours, primarily for social media use. Objective findings from a large sample confirm previous self-report studies, highlighting the need for responsible smartphone use among adolescents.
The new guidelines update past recommendations to focus on 30-year-old women with risk factors, while simplifying screening for younger and older populations. The changes aim to reduce overtreatment and improve health outcomes for cervical cancer patients.
A recent study found a substantial COVID-19 burden in the US between October 2022 and September 2024, with adults 65 years and older particularly affected. The study's results underscore the importance of continued prevention efforts to mitigate the impact of COVID-19 on this vulnerable population.
A cohort study found that most children received their first dose of MMR vaccine on time, but the proportion not receiving it by age 2 has increased. Children who missed early vaccinations were more likely to not receive any MMR vaccine by age 2.
A population-based study found that US preterm birth rates have increased among low-income households, with racial disparities exacerbating the issue. The study highlights the need to address racism in reducing preterm birth disparities.
A recent study found that adolescents with overweight or obesity who take glucagonlike peptide-1 receptor agonists (GLP-1RA) have a lower risk of acute asthma exacerbations. This association suggests a potential dual benefit, where GLP-1RA use could address both weight management and asthma prevention in this population.
A survey study found that exposure to medical misinformation was common among breast cancer patients, yet fear of recurrence was not associated. Further research on how patients process medical misinformation is essential to improve survivorship communication and reduce misinformation spread.
A cohort study found higher fine particulate matter (PM2.5) exposure associated with lower birth weight, particularly in early and mid-pregnancy. The study's findings suggest that understanding windows of susceptibility to environmental exposures can inform strategies for limiting exposure during critical periods.
A national longitudinal cohort study found consistently worse mental health outcomes among middle-aged and older adults at high risk of obstructive sleep apnea. Integrated screening and intervention strategies are needed to address this association.
A simulation study forecasted potential injury reductions in the US with AV adoption, suggesting a possible decrease in road traffic injuries. However, predicted confidence intervals remain broad, and no scenario reduced injuries outside of these bounds.
In a prespecified exploratory analysis of the SELECT randomized clinical trial, semaglutide demonstrated significant reductions in hospital admissions and overall time spent in hospital. This finding suggests that semaglutide has broader health benefits for patients with obesity and established cardiovascular disease.
The study found a significant increase in alcohol-related hospitalizations between 2016 and 2022, with rising mortality rates and extended lengths of stay. Preventive efforts are needed to reduce population-level alcohol consumption and improve treatment outcomes for individuals with alcohol use disorder.
A population-based surveillance study found both maternal RSV vaccine and nirsevimab effective in protecting infants from RSV hospitalizations. The studies results show that these products reduced RSV-associated hospitalization rates in newborns and infants under 11 months by up to half compared to previous seasons.
A meta-analysis found nirsevimab to be associated with reduced hospitalizations and emergency department visits for lower respiratory tract infections in young children. This suggests the potential of nirsevimab to decrease respiratory-related morbidity in this population.
A study published in JAMA found that nirsevimab was associated with lower risks of RSV-related hospitalization and severe outcomes compared to maternal vaccination with the RSVpreF vaccine. These findings suggest a potential benefit for passive infant immunization with nirsevimab in reducing RSV-related complications.
A cohort study found associations between exposure to multiple fine particulate matter components and increased depression risk among US Medicare population members. The study highlights the importance of targeted regulation to protect vulnerable populations from harmful air pollution.
A recent study published in JAMA Internal Medicine found that a significant majority of Americans will experience cost burdens due to healthcare expenses throughout their lives. The study suggests that policies aiming to reduce out-of-pocket costs could potentially improve the well-being of individuals in the US.
Researchers found large language models susceptible to malicious input manipulation, leading to potentially hazardous health recommendations. The study highlights the need for robustness testing and regulatory oversight before clinical deployment of these AI tools.
Ending federal support for housing first programs will lead to a significant increase in US homelessness, projecting a 5% rise within a year. This trend is part of an already increasing homeless population, resulting from the cessation of discretionary federal funding.
The Influenza A(H3N2) subclade K virus is a growing concern due to its antigenic variants and reduced vaccine effectiveness. Researchers emphasize the need for swift responses to protect public health.
A new study found that quadrivalent human papillomavirus (HPV) vaccination is associated with a reduced risk of high-grade vulvovaginal lesions. Expanding HPV vaccination, especially at younger ages, may help prevent these lesions.
A population-based cohort study found that virtual sick visits to primary care were associated with a small increase in emergency department use in children aged 3 months or older. The study suggests judicious use of virtual primary care to manage acute illness in children is warranted.
A study found that nearly 1 in 7 graduate medical education trainees experience food insecurity, which is associated with higher levels of burnout and social isolation. Academic institutions can address this issue by implementing systemic solutions to support resident well-being.