A recent study estimated a significant increase in psilocybin use in Oregon and Colorado following decriminalization. The research suggests a potential shift in user behavior, with more individuals exploring the substance.
A cohort study found that adverse childhood experiences (ACEs) were associated with an increased risk of treatment-resistant depression in adults. Preventing ACEs and incorporating ACE history into clinical assessment may help identify individuals at elevated risk for treatment resistance.
Patients with type 2 diabetes and brain metastases who used GLP-1 receptor agonists showed a significant reduction in all-cause mortality. The use of these medications was associated with reduced neuroinflammation, preservation of the blood-brain barrier, and lowered oxidative stress and mitochondrial dysfunction.
The study found that wildfire exposure and its socioeconomic consequences were associated with increased psychological distress beyond the burn zone. Integrating mental health care, housing stability, and economic recovery are crucial for disaster response and climate resilience strategies.
A large cohort study found that fewer than 1 in 4 adults with overweight or obesity without diabetes remained on GLP-1RA treatment after 12 months. Treatment switching between GLP-1RA agents was common, reflecting active therapy management and the emergence of new formulations and weight management agents.
A population-level cohort study of 20 low-mortality countries found that females aged 35-60 have higher cancer mortality rates than males, despite similar treatment and diagnostic pathways. The study highlights the need for targeted action to improve the prevention, early detection, and treatment of female reproductive cancers.
A cross-sectional study found that smartphone use during school hours is associated with reduced cognitive control in youths aged 11-18. The study highlights the need for school-level policies and digital literacy programs to address habitual smartphone-checking behaviors that fragment attention.
A systematic review and meta-analysis found consistent associations between digital media use and risks to child health and development, particularly social media use. The study highlights the need for multifaceted policies and interventions to mitigate potential harms from digital media exposure.
A low-cost digital intervention increased expectation to adopt health behaviors among adults using GLP-1RAs, with effects persisting for 2 weeks. The written microsteps intervention plus short video boosters may play a role in promoting sustained behavior change.
People in states with abortion bans face limitations to obtaining care out of state, emphasizing the need for policy change, visible information, and resources. The study suggests supporting individuals through social support systems to address these limitations.
A study in Taiwan found a positive association between maternal prenatal acetaminophen use and increased risk of attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs) in offspring. However, associations were not observed in sibling-matched analyses, suggesting unaddressed sources of bias.
A cross-sectional study documents persistent racial disparities in food insecurity over 23 years, with smaller disparities among SNAP-participating households. The study highlights the need for targeted policies to address food insecurity and its intersectional effects.
A nationwide cohort study found a significantly elevated incidence of out-of-hospital cardiac arrests on post-holiday weekdays, particularly among vulnerable populations after consecutive rest days. The study supports enhanced emergency preparedness and targeted public health messaging during holiday periods.
A study found that only 9% of older adults with advanced cancer prioritize extending survival over maintaining quality of life. The lack of responsiveness of the current oncology care delivery system to patient preference may be a significant issue. This highlights the need for care system changes to prioritize patient needs.
A comparative effectiveness study found that lower music volume levels in group fitness classes did not significantly impact perceived exercise intensity. The research suggests implementing safer sound practices and increased awareness on hearing protection to minimize the risk of noise-induced hearing loss.
A decision-support system improved depressive and anxiety symptoms, increased medication adherence, and reduced symptoms over time for patients with major depressive disorder. The system used clinical and demographic predictors to tailor treatment, resulting in better outcomes for patients compared to usual care.
Semaglutide and tirzepatide prescriptions increased dramatically between 2018 and 2025, while MBS use rates declined substantially starting in 2023. Recent shifts in MBS use may be more pronounced in certain patient subgroups, such as those seeking sleeve gastrectomy or with lower BMIs.
Researchers analyzed data from over 62,000 participants, finding that loneliness partially mediated the link between anxiety and suicidal thoughts as well as depressive symptoms and suicidal ideation. Targeting loneliness may be a crucial strategy to prevent progression from these conditions.
Higher ultraprocessed food consumption in Canadian preschoolers was associated with increased emotional symptoms by age 5. Replacing UPF with minimally processed foods may support healthier behavioral development and long-term mental health.
A recent study found that standard therapy plus catheter ablation did not significantly reduce the risk of primary composite end point in patients with atrial fibrillation and a recent stroke history. The observed event rate was lower than anticipated, suggesting underpowered detection of clinically meaningful differences.
A recent study found that nearly 6 in 10 long COVID patients have recovered, but many adults over 35 continue to experience lasting symptoms. The study's authors suggest greater investment in understanding biological mechanisms may provide insights into pathways of persistence and potential targets for intervention.
A study found insufficient sleep among US adolescents, with trends suggesting environmental and structural factors are driving the issue, rather than specific behaviors. The findings highlight the need for population-level interventions to address widespread sleep loss.
A systematic review and meta-analysis found a small correlation between daily screen use and later sleep onset in youth. However, short-term fluctuations in screen time had limited effects on sleep duration, efficiency, or quality.
A recent study by JAMA Pediatrics reveals stark disparities in birth outcomes by poverty status, with low-income families facing increased risks of low birth weight. The findings underscore the importance of supporting vulnerable populations during pregnancy and birth through evidence-based antipoverty policies.
Researchers investigated low-dose lithium as a potential treatment for mild cognitive impairment in a pilot clinical trial. The study found that none of the primary outcomes met the significance threshold, but effect size estimates suggest potential benefits for future trials.
A systematic review and meta-analysis found GLP-1 RAs produce significant weight loss across various subpopulations, including women who show improved outcomes compared to men. These findings have implications for clinical decision-making.
A cross-sectional study of former American football players found prior participation to be associated with worse later-life cognitive and neuropsychiatric function. The findings support a dose-response association with years and level of play, providing context for clinicians and researchers assessing symptom risk among former players.
The article summarizes updated recommendations on fertility preservation in people with cancer, considering potential health risks to offspring and treatment side effects. Clinicians should inform patients about available options before treatment initiation.
Contemporary donation after circulatory death (DCD) donors are now at 44% of organ procurement organizations. DCD donations account for half of all deceased donors in the US, leading to increased reliance on these organs to maintain transplant access.
Pickleball professionals and amateurs showed low use of high-quality protective eyewear, with many relying on personal prescription glasses that may not provide adequate protection. This study underscores the importance of consistent use of well-fitting protective eyewear to prevent pickleball-related eye injuries.
A strategic trauma center placement was associated with reduced firearm mortality in Chicago's high-violence areas. The study highlights the importance of equitable access to trauma care, particularly in communities with limited resources.
The article discusses current evidence on risks of ambient heat to pregnant women, including hot weather and occupational exposures. Effective strategies for managing heat-related risks are also highlighted as critical for maintaining maternal health.
The study reveals marked variation in radiation dose to patients from diagnostic testing, particularly affecting low- and middle-income countries. Standardized protocols and updated equipment are urgently needed to reduce global radiation exposure and improve the quality of CAD diagnosis.
This study found that US thyroid cancer overdiagnosis persists even after accounting for possible true incidence rises, highlighting opportunities to reduce unnecessary referrals and diagnoses
Patients who are dual-eligible for Medicare and Medicaid, or enrolled in Medicare Advantage plans, are less likely to receive high-quality postacute care after a stroke. This disparity highlights the need for equitable access to specialized care to improve outcomes for high-need patients.
Exposure to alcohol-related social media content is associated with increased desire to drink among young adults, regardless of prior alcohol use. Social media influencers may contribute to normalization of alcohol consumption among this age group.
The study found that increased community disadvantage leads to fewer options for receiving hemodialysis and more likelihood of living without nearby dialysis facilities. Patients with end-stage kidney disease in these areas have limited access to essential care services.
A new study found that US newborn hepatitis B virus vaccination rates declined by over 10 percentage points in the last 2 years. This decline reverses 6 years of growth and is aligned with WHO and CDC coverage estimates through 2022.
A study published in JAMA Neurology found that adhering to healthy dietary patterns, such as the DASH diet, is associated with lower subjective cognitive decline and better cognitive function. The findings highlight the importance of a balanced diet for maintaining long-term brain health.
A cohort study found that adolescent cannabis use is associated with an increased risk of developing psychiatric disorders, particularly psychotic and bipolar conditions. The study's results inform the development of interventions and policies to prevent or delay adolescent cannabis use.
This cross-sectional study highlights critical gaps in accessible mental health services for adults with intellectual and developmental disabilities. The findings underscore the need for policy reforms to address systemic inequities and provide disability-informed care.
A nationwide study found that adolescents and young adults with prior cervical high-grade squamous intraepithelial lesion (HSIL) are at a higher risk of cardiovascular events and mortality. The study suggests that women with prior HSIL should be more closely monitored for cardiovascular disease and prevention strategies should be imple...
A cohort study of 3,230 kidney transplant recipients found that transplantation reverses declining employment income, enabling meaningful economic recovery. The findings highlight the socioeconomic value of transplantation and inform policies to support patients during pretransplant vulnerability.
Cohort study finds prenatal depression and gestational diabetes independently increase childhood obesity risk, while children exposed to both face the greatest risk, highlighting need for universal screening and targeted interventions.
A recent study predicts that nearly 1 in 10 Medicare Advantage beneficiaries will be forced to disenroll from their current plans in 2026. The drivers of these disenrollments include changes to plan payments and risk adjustment, as well as unanticipated increases in healthcare use among Medicare Advantage enrollees.
A meta-analysis of 55 studies found a significant protective association between spirituality and hazardous alcohol and drug use. The study suggests that spiritual practices may be effective in preventing or reducing the risks associated with these substances.
A cohort study of patients with chronic kidney disease found that more advanced stages of the condition are associated with a higher incidence of cognitive impairment. The study underscores CKD severity as a key risk factor for cognitive decline across the entire spectrum of CKD.
A study of six pooled cohorts found that moderate to vigorous physical activity after a cancer diagnosis is associated with reduced risk of cancer mortality. Higher levels of physical activity were linked to longer survival rates and overall health benefits for cancer survivors.
A population-based study reveals that rotator cuff abnormalities are common after age 40 and often represent normal age-related changes. The findings challenge the clinical value of routine imaging for atraumatic shoulder pain, questioning the need for regular scans in this demographic.
Nearly 2/3 of US adults reported using medication in the past 7 days, with similar prevalence of over-the-counter and prescription medications. This study emphasizes the reliance on these therapies and underscores the need for increased accessibility to address health disparities.