Scientists at Johns Hopkins Medicine discovered an energy sensor mechanism that helps regulate cell energy storage. The study found that a protein called AMPK, which acts like an energy thermostat, is affected by acetyl groups added to it.
A new study led by Johns Hopkins researchers estimates nearly 23 million Americans age 50 and older have untreated hearing loss. The finding highlights the need for increased awareness and access to hearing aids, as well as rehabilitative training to learn how to integrate devices into daily lives.
Researchers developed a minimally invasive treatment to dissolve brain blood clots, increasing patients' independence by 10-15% six months post-procedure. The technique reduces the need for craniotomy surgery and is as safe as supportive therapy.
Cell biologists have identified key steps in how small molecules alter a cell's skeletal shape and drive cell movement. By manipulating the cell membrane, researchers created ruffles that helped pull cells across surfaces, a process previously difficult to recreate.
Despite virtual imaging advancements, traditional autopsies are still essential for determining cause of death. Current imaging technologies often miss common diagnoses when compared to autopsy findings.
A new study by Johns Hopkins researchers reveals that thousands of senior citizens with kidney disease are good candidates for transplants, but are often overlooked. The study estimates that between 9,000 and 40,000 adults over 65 would have been eligible for a transplant, but none were given the chance.
Researchers have identified a rare, inherited mutation linked to a significantly higher risk of developing prostate cancer. The mutation was found in 10-20 times more men who inherited it compared to the general population. Further studies may lead to genetic testing for inherited prostate cancer.
Researchers at Johns Hopkins Medicine tracked Google Flu Trends data and found a strong correlation between rising search queries for flu information and an increase in patients visiting the hospital with flu-like symptoms. The study suggests that using this tool could provide early warning systems for frontline healthcare workers.
Allergy tests are not magic bullets for diagnosis, according to new guidelines from Johns Hopkins Medicine. Blood and skin tests should be used to confirm suspicion and monitor established allergies, but not as standalone diagnostic strategies. This approach aims to prevent misdiagnosis and unnecessary restrictions on patients.
Scientists at Johns Hopkins have found that PARP inhibitors can block the ability of pre-leukemic cells to repair broken DNA, leading to their self-destruction. The treatment has shown promise in clinical trials for patients with aggressive myeloproliferative disorders.
New Johns Hopkins research suggests that presumed consent legislation is unlikely to increase organ donation rates in the US. The study found that countries with presumptive consent laws do not have dramatically different organ donation processes than those without such laws.
A Johns Hopkins study found that mobile clinics and home visits had minimal effects on improving disease outcomes among low-income, inner-city children with asthma. The programs showed some improvement in symptom-free days, but these benefits were short-lived and not sustained over time.
A recent study has found that nearly a third of children with sickle cell disease have suffered silent strokes, highlighting the need to identify early signs of anemia and high blood pressure. Researchers believe anemia is the key factor contributing to these risk silent strokes.
Researchers at Johns Hopkins have successfully manipulated yeast life span by removing and restoring a protein function related to aging. By restoring this function, the organism's life span is dramatically extended. The discovery reveals molecular components of an aging pathway that appears related to one regulating longevity in humans.
A new study by Johns Hopkins researchers found no correlation between non-alcoholic fatty liver disease (NAFLD) and increased mortality. NAFLD, prevalent among those with heart disease and obesity, does not appear to undermine health and longevity.
A study by Johns Hopkins researchers found that black senior citizens are 26% more likely to undergo riskier surgery and spend more time in the hospital recovering from intestinal surgery. Despite equal health insurance coverage, black patients experience higher mortality rates and greater healthcare costs.
A national study led by Johns Hopkins cardiologist Thomas Aversano found that nonemergency angioplasty can be performed safely at hospitals without cardiac surgery backup, with low rates of complications and death. The study compared over 18,500 patients who underwent heart artery-opening angioplasty or stenting at hospitals with or wi...
A new study by Johns Hopkins researchers found that nearly 30 million Americans have severe hearing loss, with prevalence doubling every decade. The finding suggests that many more people than previously thought are affected by this condition, which has significant consequences for cognitive decline and physical functioning.
A Johns Hopkins study reveals racial disparities in pediatric heart transplant patient outcomes, with white patients more likely to survive a decade after surgery. The analysis of 2,721 transplants found that children who received their hearts from younger donors and were transplanted later had better long-term survival rates.
A combination epigenetic therapy has shown positive effects in a small clinical trial of late-stage lung cancer patients. The treatment increased median survival by two months and showed complete or near-complete responses in some patients. Researchers believe the therapy may reprogram gene expression to prevent cancer growth.
Research at Johns Hopkins Medicine reveals that Bacteroides fragilis causes colon inflammation and increases activity of a gene called spermine oxidase (SMO), leading to DNA damage and tumor formation. A compound blocking SMO enzyme activity prevented DNA damage in cells.
A new technique developed by Johns Hopkins surgeons allows for the removal of skull base tumors without traditional incisions, resulting in faster recovery times and reduced complications. The procedure uses a natural opening above the jawbone and beneath the cheekbone to access the tumor site.
Researchers at Johns Hopkins Medicine have developed a new breast cancer therapy that delivers anticancer drugs directly into the breast ducts via the nipple. The treatment has shown no major side effects in human patients and has been effective in animal models, with some drugs even preventing tumors from forming.
Researchers from Johns Hopkins have quantified a cell's decision-making ability, finding it to be only two possible choices. Cells can overcome their individual limitations by forming multicellular organisms, which enables them to transfer information and make decisions together.
Researchers analyzed medical records of 717 children and 1,368 young adults diagnosed with melanoma. Children were found to have a higher risk of metastases in lymph nodes compared to adults. Survival rates did not differ significantly by age among those with metastatic melanoma.
Medical benefits of infant male circumcision are clear, with substantial protection against certain STIs. Experts counter misinformation on circumcision's effects on sexual satisfaction and performance. They defend parental rights to make informed decisions about their children's health.
Researchers at Johns Hopkins found that interactive video games safely enhance physical therapy for ICU patients, boosting their interest in therapy and motivation to do more. The study suggests that video game therapy activities can improve muscle weakness and balance in critically ill adults.
A survey of radiation oncologists and healthcare professionals reveals that fears of getting into trouble and embarrassment are the primary barriers to using online error-reporting systems. Despite this, most respondents recognize the value of reporting errors and near-misses for improving care and patient safety.
A protocol developed by Johns Hopkins cardiologists has enabled patients with implanted cardiac devices to safely undergo MRI scans. With appropriate precautions and careful patient monitoring, the risk of device malfunction is very low.
Researchers tested a combination of oral drug sorafenib and microbead chemotherapy directly into tumors in advanced liver cancer patients. The treatment showed promise with no increased side effects compared to existing therapies.
Researchers found evidence of large-scale dynamic DNA demethylation in non-dividing brain cells, challenging scientific dogma. This discovery has major implications for understanding learning, memory, and mood regulation, as well as potential new treatments for depression and neurodegenerative disorders.
A single high dose of psilocybin has been shown to induce significant and lasting changes in personality, particularly openness, in nearly 60% of participants. The study found that these changes were comparable in magnitude to those observed over decades of life experiences.
Scientists at Johns Hopkins Medicine have corrected the genetic alteration causing sickle cell disease by using a patient's own stem cells. The team found four working iPS cell lines containing correct copies of the hemoglobin gene and successfully converted them into immature red blood cells.
Researchers at Johns Hopkins Medicine found that oxaliplatin, a widely used chemotherapy drug for colorectal cancer, causes permanent nerve damage in some patients. A new study suggests using simple skin biopsies to track nerve cell degeneration and develop new treatments to prevent or slow the damage.
Researchers at Johns Hopkins have modified HIV to trigger an immune response, a major hurdle in vaccine development. The altered virus activates the adaptive immune system's response against HIV, negating its immunosuppressive properties.
Researchers at Johns Hopkins Medicine have found a way to halt life-threatening arrhythmia using lower amplitude, high-frequency alternating current. This approach may prove less painful for patients and could lead to a new device that replaces painful defibrillator shocks.
Researchers found that kibra protein is essential for regulating brain circuitry and learning, leading to impaired memory in mice lacking the protein. The study suggests that kibra plays a crucial role in shaping brain connections during learning and memory formation.
A Johns Hopkins team discovered that MRI's strong magnet pushes on fluid in the inner ear's balance organ, leading to vertigo. This finding may affect results of functional MRI studies and could lead to a non-invasive method for diagnosing balance disorders.
A study by Johns Hopkins researchers found a significant rise in serious prostate biopsy complications requiring hospitalization among Medicare beneficiaries. Hospital admission rates were two-fold higher among those who underwent a biopsy compared to controls, with infection-related complications on the rise since 2000.
A new genetic mutation has been discovered in the C9ORF72 gene, responsible for over a third of familial ALS cases. The repeated DNA sequence causes toxic RNA buildup, leading to motor neuron demise and disease progression.
Three Johns Hopkins researchers, including Andrew Feinberg, Gyanu Lamichhane, and Thomas Hartung, have received NIH Director's Awards for their groundbreaking work in epigenetics, tuberculosis, and toxicological testing. Their research aims to revolutionize cancer treatment, develop new antibiotics, and improve human health.
A study published in Neurology has shown that spinal digital subtraction angiography is safe and effective, ruling out misdiagnosis of inflammation and transverse myelitis. The procedure, considered the gold standard for vascular disorders near the spine, was found to have no reported cases of stroke or kidney damage in 302 patients.
Researchers engineered a computer-designed yeast chromosome with an inducible evolution system, allowing them to rapidly introduce genetic changes. This allows for the custom design of organisms that can grow better in adverse environments or produce more ethanol.
Researchers have discovered the fossil of a newborn nodosaur, the youngest known species, in Maryland. The discovery sheds light on the development of limbs and skulls early in a dinosaur's life, as well as dinosaur parenting and reproductive biology.
Researchers at Johns Hopkins Medicine found that a widely used pacemaker for heart failure works by raising regulator of G-protein-signaling proteins in the heart. This helps restore balance between two proteins, allowing the heart muscle to respond to hormones like adrenaline more effectively.
Researchers identified 29 DNA sequence variations linked to blood pressure, suggesting a complex genetic regulatory mechanism. The study pooled data from over 200,000 people worldwide and found common genetic variants in individuals of Asian and African ancestry.
A study by Johns Hopkins Medicine found that medical students' unconscious biases towards race and social class do not directly affect their treatment decisions. Despite this, the researchers argue that training and experience may be reinforcing negative stereotypes, highlighting the need for interventions to address racial bias in hea...
Researchers discovered a molecular mechanism allowing signals from target cells to support neuron survival. Activated protein Rac plays a crucial role in long-range signaling and retrograde transport of neuronal survival signals.
A Johns Hopkins Children's Center study of over 3,000 hospitalized children reveals that those colonized with MRSA but not sick are at significant risk for developing full-blown infections. The study found nearly six times more likelihood of invasive MRSA infections among carriers compared to noncarriers.
A new Johns Hopkins study reveals that uninsured trauma patients are 60% more likely to seek follow-up care in the emergency department (ED) for minor medical needs. This is despite having access to free follow-up appointments. Patients living in poor neighborhoods and those with Medicaid or Medicare are also more likely to use the ED.