A study by Keio University researchers has identified two blood proteins, beta-2-microglobulin and cystatin C, that are consistently associated with future disability in adults aged 85 years and older. These biomarkers have the potential to enable earlier interventions and preventive support.
Recent research found that D-serine accelerates gastric cancer growth by suppressing cytotoxic T-cell activity and promoting immunosuppressive macrophages. High serum D-serine concentrations were linked to ICI therapy resistance in patients, suggesting its potential as a biomarker for disease progression.
A new study explores an FMQA-based optimization framework for RNA design, revealing that encoding matters in achieving optimal results. The approach identifies high-quality RNA sequence candidates with relatively few evaluations, outperforming competing methods.
A new study by Keio University researchers explores the association between residential environments and subjective well-being, finding that better living conditions are linked to higher satisfaction with important life domains, which in turn is associated with greater overall well-being. The study suggests that housing design and poli...
Researchers discover recurrent COPA mutations driving intestinal tumorigenesis through an independent route. These mutations activate the Wnt pathway in a way that bypasses essential amplifiers, leading to cancer progression.
Scientists discover autoimmune vicious cycle in Sjögren's disease, where CD4+ T cells recognize Ro60 protein and sustain antibody production. This process forms a self-reinforcing loop, contributing to chronic disease, and could lead to targeted therapies with fewer side effects.
Researchers identify gut-derived cells as key initiators of autoimmune neuroinflammation in Multiple Sclerosis. The study reveals that intestinal epithelial cells upregulate antigen presentation pathways, leading to the expansion of pathogenic Th17 cells that migrate to the CNS.
Researchers developed an EEG-based system to decode pleasure from listener's brain activity and suggest personalized playlists. The system outperformed 'acoustics-only' methods, capturing neural markers of pleasure with high accuracy.
A team of researchers from Keio University has developed a novel system that uses Gaussian process regression to model and reproduce complex human motions. This enables robots to adapt to touch and interact with objects in dynamic environments, improving their dexterity and versatility.
Researchers from Keio University Global Research Institute successfully generated orbital currents using sound waves, establishing a foundation for integrating acoustic technology with orbitronics. The discovery paves the way for next-generation electronic devices.
Scientists develop molecular strategies for creating soft materials that can sense, move, and evolve in response to their environment. Three key principles of supramolecular robotics enable programmed motility, phase transitions, and prototissue formation.
Researchers developed a smartphone diary app, WEDiary, to promote positive reflections on daily work and improve work engagement. The app significantly improved employees' vigor and dedication after just 2 weeks of intervention and persisted for 3 weeks post-intervention.
Researchers found that recalling positive autobiographical memories before a performance enhances valence and arousal, leading to improved performance. This is attributed to increased sympathetic nervous system activity, which regulates involuntary bodily functions.
A new study found that vibrato is the most significant vocal attribute in determining an opera singer's score, while acoustic features like SPR and HNR have a greater impact than previously thought. The research provides objective insights into how judges evaluate performances and offers tools for vocal training.
Researchers discovered that GLP-2 analogs reshape the intestinal environment by expanding villi and crypts, increasing regulatory T cells, and improving nutrient absorption. This breakthrough offers new hope for patients with short bowel syndrome and potentially benefits immunocompromised individuals.
A study found that evaluators' musical experience influences the sight-over-sound effect, reducing its impact for those with auditory expertise. The study used Japanese high school brass band competitions and found no significant evidence of the effect in musicians, but a stronger presence in non-musicians.