Researchers have provided experimental evidence confirming Alan Turing's 1950s theory on how biological patterns such as tiger stripes are formed. The study identifies the specific morphogens involved in this process, including FGF and Shh, and demonstrates a mechanism that is widely relevant in vertebrate development.
A large-scale study found that young urban Sri Lankans have a high prevalence of risk factors for type 2 diabetes, including raised BMI and physical inactivity. The research highlights the need for early intervention and preventive strategies to address this growing public health concern.
Researchers found that a single 'Goldilocks' gene, LTA4H, regulates the immune response to TB. Variations in this gene lead to excessive or insufficient inflammation, which can affect treatment response. The study suggests personalized medicine could improve TB treatment outcomes.
A recent study published in Lancet Neurology has found that brain tsunamis, or 'killer waves,' contribute to poor outcomes in patients with major head injuries. Researchers have identified a phenomenon called cortical spreading depolarizations, which can cause further damage to the brain.
Researchers at King's College London have made a breakthrough in developing xeno-free human embryonic stem cell lines that are suitable for public benefit. The lines will be grown and processed by the UKSCB to provide stem cell stocks for clinical research and treatment.
Researchers at King's College London have discovered how paracetamol works by identifying the protein TRPA1 as a key molecule needed for its analgesic effect. This breakthrough could lead to the development of less toxic and effective pain relief medications.
The Chem-TCM database, developed by King's College London researchers, provides a comprehensive tool for the pharmaceutical and biotechnology industries to explore age-old remedies. The database features four major parts, including chemical identification and predicted activity against Western therapeutic targets.
Dr. Thomas Rid argues that cyber warfare has never taken place and is unlikely to occur in the future due to the lack of lethality in most attacks. He suggests that modern cyber attacks are more sophisticated versions of traditional sabotage, espionage, and subversion.
A twin study at King's College London found significant epigenetic differences between psychosis discordant twins, suggesting a role for epigenetic processes in neuropsychiatric disease. The study provides potential new avenues for treatment and may lead to the development of novel therapeutic drugs.
Researchers at King's College London have found a way to produce natural sunscreen compounds from coral, which could be used in humans and crops. The study aims to recreate these compounds synthetically for sun protection.
A large global study concludes that exclusive breastfeeding for four months or longer does not protect against childhood eczema. The study, involving 51,119 children in 21 countries, suggests that the current guidelines on breastfeeding and eczema prevention need to be reviewed.
A new study led by King's College London found that childhood maltreatment increases the risk of developing both multiple and long-lasting depressive episodes. Maltreated individuals are also more likely to respond poorly to treatment for depression, with antidepressant medication and psychological treatment being less effective.
Researchers have identified a molecular pathway affected in schizophrenia and successfully alleviated symptoms using a cancer drug. The study found that reducing p35 enzyme levels led to cognitive impairment, which was addressed by administering the cancer drug MS-275.
Researchers at King's College London have discovered a molecule called CXCL5 that controls sensitivity to UVB irradiation-induced pain, providing a potential new target for medicines. The findings also suggest the possibility of developing new analgesics for conditions like arthritis and cystitis.
Researchers at King's College London have identified a way to eliminate leukaemic stem cells, which could lead to new treatments enabling complete remission for leukemia patients. The study found that suppressing two proteins, Bmi1 and Hoxa9, can abolish the ability of MLL leukaemic stem cells to proliferate.
Researchers at King's College London have developed a new approach using immune cells to prevent organ rejection. The 'specific' Tregs can regulate only the activity of effector cells that would target a transplanted organ, leaving the remaining effector cells to function normally.
A study published in Nature Genetics reveals that the KLF14 gene acts as a master regulator controlling multiple genes found in fat tissue, influencing metabolic traits such as body-mass index, cholesterol, insulin, and glucose levels. This discovery has great therapeutic potential for treating conditions like obesity and diabetes.
Researchers at King's College London have identified the genetic cause of Adams-Oliver Syndrome, a rare condition that can lead to birth defects. The study found mutations in the ARHGAP31 gene, which regulates proteins involved in cell division and growth, potentially leading to disruptions in limb formation.
Researchers have uncovered 8 genes that control the main steroid produced by the adrenal gland, which is believed to play a role in aging and longevity. The study found that these genetic regions are also associated with common age-related diseases, providing the first genetic evidence for the ageing role of the steroid.
Scientists have discovered how anti-depressants make new brain cells by regulating the glucocorticoid receptor, a key protein involved in stress response. This finding holds promise for developing more effective anti-depressant treatments to combat depression.
Researchers have identified specific bone marrow cells that can transform into skin cells to repair damaged tissue. The discovery provides new insights into the mechanisms behind skin repair and has the potential to revolutionize approaches to wound treatment.
A Europe-wide survey of over 9,000 people across seven countries found that 71% prioritize improving quality of life in their final time, while 4% aim to prolong life and 25% value both equally. The study calls for a shift towards prioritizing patients' needs alongside potentially life-prolonging treatments.
Scientists have identified NOTCH2 as the causative gene for Hajdu-Cheney syndrome, a rare disorder characterized by progressive bone loss and osteoporosis. The study provides vital insight into possible causes of osteoporosis and highlights the gene as a potential target for treating the condition.
Researchers found that women who consume a diet high in allium vegetables like garlic have lower levels of hip osteoarthritis. The study also identified compounds in garlic that may limit cartilage-damaging enzymes, suggesting potential for future treatments and prevention.
Scientists at King's College London have made a critical discovery about the role of beta-catenin in leukemia stem cells. By suppressing this protein, they were able to reverse leukaemic stem cells to a pre-leukaemic stage and 're-sensitize' resistant cells to treatment.
Researchers at King's College London are creating a mathematical model to measure personal exposure to traffic pollution, allowing individuals to adapt their journeys and reduce harmful emissions. The project will also study the effects of different particles on human health, leading to more focused traffic planning.
Research by King's Health Partners found that people with psychotic disorders are 12 times more likely to commit suicide than average. The risk of suicide persists long-term, remaining four times greater than the general population ten years after diagnosis.
Researchers at King's College London have discovered a new gene associated with Hypospadias, a congenital malformation of the male genitalia. The study found that changes in the DGKK gene are strongly linked to an increased risk of hypospadias.
Researchers have identified 30 new genes controlling the age of sexual maturation in women, which also affect body weight regulation. The study highlights specific genetic links between early puberty and body fat, shedding light on how biological processes control puberty timing.
The NEWMEDS collaboration has pooled resources to create the single largest database of clinical trial data ever amassed in psychiatric research. The database combines data from 23,401 anonymized patients from 67 trials on 11 compounds in over 25 countries.
Researchers at King's College London found a correlation between VGLUT1 protein levels and cognition scores in individuals with and without dementia. Preserving VGLUT1 artificially after a stroke may reduce the risk of developing vascular dementia.
The UK's NIHR Biomedical Research Centres have established a cutting-edge translational research infrastructure, driving progress in disease research and treatment. With strong focus on interdisciplinary working, public engagement, and industry partnerships, the centres aim to deliver rapid benefits for patients.
A genome-wide association study of 2,622 patients with psoriasis and 5,667 healthy individuals has identified six regions of the genome associated with the condition. The study found evidence for an interaction between two associated regions – HLA-C and ERAP1, providing new insights into psoriasis susceptibility.
The World Alzheimer Report 2010 estimates that dementia costs $604 billion globally, with the problem set to accelerate in coming years. The report urges governments worldwide to take immediate action to address the social and health consequences of dementia.
Scientists at King's College London have developed protein therapeutics and cell therapy techniques to extend organ transplant life. Protein Mirococept coating protects donor kidneys from damage during transit, while regulatory T cells may prevent immune system over-activation.
The Epitwin project will analyze methylation patterns of 20 million sites in DNA from 5,000 twins to identify differences that explain why identical twins don't develop the same diseases. This study has the potential to uncover key genes responsible for disease and accelerate research into human healthcare.
A randomized controlled trial of 301 patients with severe left ventricular dysfunction found no difference in major cardiovascular complications between those with and without planned balloon pump support. However, the study highlighted the importance of having a balloon pump on standby for high-risk cases.
Researchers at King's College London have developed a pioneering new method of diagnosing autism in adults using a quick brain scan that takes just 15 minutes. This technique can identify adults with autism with high accuracy and may lead to the screening for autism spectrum disorders in children.
Researchers at King's College London have discovered a new biochemical test that can accurately diagnose osteoarthritis earlier than existing methods. The test measures 163 chemical signals in a single blood sample and has been shown to be highly effective in identifying metabolite ratios associated with the condition.
Epigenetic signals vary across alleles in numerous genomic regions, influencing gene expression and regulation. The study reveals over 35,000 such sites across the genome, with implications for genetic studies of complex diseases, including psychiatric conditions.
A consortium of scientists, including top researchers from academic institutions and pharmaceutical companies, is developing new methods for drug discovery in depression and schizophrenia. The project aims to overcome bottlenecks such as lack of accurate animal models and symptom-based diagnostic categories.
Research from the Dunedin Multidisciplinary Health and Development Study found that childhood abuse, neglect, social isolation or economic hardship can affect nervous, immune and endocrine functioning in adulthood. Adults who experienced these traumas were more likely to exhibit depression, chronic inflammation and metabolic markers of...
Climate change is projected to exacerbate existing mental illness and increase overall burden of mental disorder worldwide. This is due to factors such as natural disasters, heat-related deaths, and mass migration, which disproportionately affect vulnerable populations.
A study found that depression increases mortality risk similar to smoking, but anxiety reduces it when combined with depression. Researchers suggest that help-seeking behavior may explain this pattern, and highlight the need for more attention on physical health in people with mental disorders.
The BRC's Case Register Interactive Search (CRIS) system, a groundbreaking research tool, will be expanded with the new funding. CRIS allows researchers to search and analyze electronic medical records in an anonymized format, facilitating personalized diagnosis and treatment for mental health patients.
Researchers at King's College London discovered abnormalities in white matter that trigger the onset of schizophrenia, particularly in posterior regions. The study suggests that faulty 'wiring' in key brain areas contributes to the development of full-blown symptoms.
A recent study in China found that people with higher levels of pesticide exposure are more likely to have suicidal thoughts. The study suggests a potential causal link between pesticide exposure and increased risk of suicidal ideation in rural areas.
Researchers aim to identify 'biomarkers' in tissue and blood samples to diagnose conditions like psoriasis, rheumatoid arthritis, and Crohn's disease. They will test these signatures using tissue and blood samples from patients with various inflammatory diseases.
Researchers aim to develop 'enhanced' cells that can fight diseases from within the body. They will extract specific cells from patients, activate or modify them in the laboratory and transfer them back into patients for treatment.
Researchers found significant alterations in brain function similar to posttraumatic stress disorders shortly after the Wenchuan earthquake. Hyperactivity in certain areas and decreased functional connectivity were observed, suggesting a need for early treatment and potential long-term psychological impact.