A new study found that delayed-release, extended-release methylphenidate can be taken in the evening without affecting its efficacy for at least 10 hours. This formulation may provide a more flexible treatment option for adults with attention deficit hyperactivity disorder (ADHD).
Researchers have successfully targeted the tumor biomarker EpCAM with chimeric antigen receptor-modified T cells, significantly delaying tumor growth in mice. The study suggests that EpCAM could be a promising target for cancer immunotherapy in various tumor types.
The article discusses the rising trend of heroin abuse in the US, which has led to an increase in surgical complications such as skin and soft tissue infections, septic thrombophlebitis, and mycotic pseudoaneurysms. Rapid recognition and management of these complications are crucial to prevent life-threatening outcomes.
Researchers optimized a 20-nucleotide DNA aptamer to improve its binding properties to myelin, a promising lead molecule for multiple sclerosis therapy. The study provides the first evidence of cross-reactivity with human brain cells.
A new study reveals that pulsed electromagnetic fields (PEMFs) increase osteoblast precursor cell proliferation and induce osteogenic gene expression, but do not enhance calcium deposition. Careful selection of PEMF parameters is crucial for inducing a favorable effect.
Studies from the Epilepsy Connectome Project reveal a difference in memory-related connections between healthy individuals and those with epilepsy. The researchers identified an excitatory connection association with inhibition of formation of the left hippocampal region in patients with temporal lobe epilepsy.
A new review of 12 spaceflight experiments and simulated microgravity studies found that microgravity does not hinder stem cell-dependent tissue regeneration, but rather accelerates it. This valuable in vivo data has implications for human tissue repair and regeneration during spaceflight.
Researchers discovered a new mechanism by which influenza A viruses alter host immune systems, making them more susceptible to deadly bacterial infections. The PDZ-binding motif regulates cytokine production, controlling the severity of secondary bacterial infections.
The VA's 'whole health' model is a leading-edge effort to address social determinants of health and move from volume to value. The model features multimodal approaches in integrative health, including evidence-informed complementary and integrative approaches as part of a commitment to diminishing reliance on opioids.
A new study found that inhaled doses as little as 2 mg of the synthetic cannabinoid JWH-018 can significantly impair cognitive function. The study also revealed that mixtures of synthetic cannabinoids can lead to serious adverse effects.
A new study by CDC researchers found that US hospital breastfeeding policies improved slightly between 2009 and 2015, with over 70% of hospitals still offering free infant formula. The study analyzed data from the Maternity Practices in Infant Nutrition and Care survey, which showed increases in model policy adoption and early breastfe...
This special issue reviews whole systems research methods in healthcare and its patient-centered salutogenic focus. It highlights the convergence of conventional medicine and whole systems research to combat opioid reliance and promote integrative chronic pain models.
Researchers explore link between bacterial vaginosis and HIV transmission in women, highlighting importance of standardized diagnosis and testing. The study aims to standardize discussions around BV clinical and research findings, shedding light on the microbial make-up of the vagina and its impact on HIV acquisition.
Researchers have identified a novel transcription factor called Osteoblast Inducer-1 (ObI-1) that regulates the differentiation of mesenchymal stem cells into bone in mice. This discovery has significant implications for regenerative medicine, as MSCs offer a promising source of stem cells for therapeutic applications.
Researchers analyzed brain connectomes to understand healthy brain development and contribute to disorders like epilepsy. The study identified abnormalities in the salience network of subjects with autism, providing insights into the neural basis of autism.
Researchers used time-lapse imaging to show that mouse induced pluripotent stem cells differentiated into cardiomyocytes significantly faster at microgravity. The study, published in Stem Cells and Development, suggests a promising area of research for regenerative medicine and manned space travel.
The study focused on the design and results of the second field deployment of BASALT, identifying critical capabilities needed for science-driven EVAs. Researchers presented recommendations for future directions and subsequent research objectives.
A new study reveals that diabetes impairs the antibacterial activity of multipotent stromal cells (MSCs), leading to diminished capacity to fight off bacterial infections. This finding has significant implications for the use of MSCs as a therapeutic strategy in treating diabetes and other autoimmune disorders.
A new pilot study found that autistic adults showed real-life improvement after a virtual reality treatment combining graded exposure to fear and anxiety-producing experiences. The approach, which included cognitive behavioral therapy, aimed to minimize anxiety and promote functional improvement in individuals with autism.
A new CMP-fusion strategy called CRISPR-chrom enhances CRISPR-Cas9 genome editing efficiency, especially at previously difficult-to-target sites. The approach demonstrates a substantial increase in CRISPR-Cas9 activity with no notable increase in off-target effects.
A new study published in the Journal of Child and Adolescent Psychopharmacology found that saffron was as effective as methylphenidate in controlling ADHD symptoms in children and teens. The researchers also noted similar side effects, making saffron a promising herbal alternative for treating ADHD.
The CRISPR Journal announces publication of its February 2019 issue, featuring studies on strain tracking, single-step genome editing, and chromatin modulating motifs. Researchers discuss advancements in CRISPR technology and its applications.
A new special issue of JACM reports on recent naturopathy research advancements, exploring the effectiveness of whole-foods-based nutrition education and traditional knowledge in naturopathic education. The studies collectively demonstrate the potential benefits of multimodal, whole-person approaches for chronic conditions.
A 21-year longitudinal study found that family stress, maternal depression, and lack of active stimulation are significant risk factors for childhood obesity. The study, published in Childhood Obesity, identified four BMI trajectories through childhood, highlighting the importance of early intervention strategies.
Researchers found that silencing microRNA-132 improved insulin secretion and reduced blood glucose in mice and human islet cells. The study suggests antagomir-132 as a potential treatment approach for type 2 diabetes.
Dasotraline shows significant improvement in efficacy in the treatment of ADHD compared to placebo, particularly at a dose of 4mg/day. The study also assesses safety and subgroup analysis, providing hope for new treatments with fewer side effects.
A new study found that smoked cannabis as an adjunctive therapy can be both effective and cost-effective in treating chronic peripheral neuropathy. The research simulated its use in one million patients and compared it to usual care, finding that cannabis was a viable alternative.
A first-in-human study demonstrated the ability of a new class of antisense oligonucleotide therapeutics to target the liver, resulting in improved potency and safety at therapeutic doses. The study showed that the conjugated drug was up to 30-fold more potent than the parent antisense oligonucleotide.
The interoperable Artificial Pancreas System smartphone app has shown improved time in the target glucose range and a statistically significant reduction in time below 70mg/dL. The study suggests that this system could provide personalized care for patients with diabetes, offering flexibility and convenience.
A new study found that only a minority of US adults with type 1 diabetes achieve target hemoglobin A1c levels, indicating poor blood glucose management. The study revealed increasing HbA1c levels in young adults and teens over the past 5 years.
This special issue of Viral Immunology delves into the intricacies of viral brain infection, focusing on immune responses such as IFNα/ß signaling and chemokine CXCL10. Research reveals the importance of astrocytes, brain-resident memory T-cells, and chemokines in protecting against encephalitic viruses.
Researchers found that patients with biochemical hypoglycemia are at increased risk of severe hypoglycemic events. The study analyzed the DCCT data set and used two levels of biochemical hypoglycemia to determine the relationship to severe hypoglycemic events.
Researchers suggest caffeine as a potential therapeutic tool for treating motivational symptoms of depression and cognitive impairments in attention-deficit/hyperactivity disorder. A new study also proposes targeting the adenosine A1R-D1R heteromer to improve spinal cord injury outcomes.
Researchers at MIT have developed a novel 3D printing method for creating transparent glass structures with improved speed, scale and reliability. The G3DP2 platform enables the fabrication of large-scale transparent objects with precise control over behavior and design specifications.
The CRISPR Journal publishes outstanding research on all aspects of CRISPR and gene editing. Two new articles explore the ethics of germline editing and the use of alternative PAM sequences for mouse genome editing.
Researchers are using big data and machine learning techniques to optimize sports performance, game-day decision making, and even predict the end of daily fantasy sports. The special issue explores various applications of big data in sports analytics, from pacing strategies in long-distance running to business-side insights.
Columbia University researchers used voxel printing to create digital wood, a complex material for 3D printing. The technique allows for the creation of objects with internal grains and external color textures. Digital wood has potential applications in various fields, including architecture and product design.
A new study reveals that testosterone use can significantly increase bone mineral density (BMD) in HIV-infected men. In particular, testosterone was associated with a higher BMD score at the lumbar spine in virologically suppressed individuals.
A recent study found that the prevalence of metabolic health among American adults is very low, even among those with normal weight. The researchers estimated that only about 12% of Americans meet the criteria for optimal metabolic health using more rigorous guidelines.
A study published in Human Gene Therapy found that urocortin 3 gene therapy significantly improved left ventricular function and ejection fractions in mice with induced heart failure. The therapy resulted in a 1.9-fold increase in left ventricular function and a 32% relative increase in ejection fractions.
Researchers developed a combinatorial gene therapy approach that inhibits inflammation and promotes pro-anabolic cartilage genes, preserving articular cartilage better than each approach alone. This strategy was shown to be effective in both moderate and severe post-traumatic osteoarthritis models.
A new study examines geographic disparities in death due to traumatic brain injury among US veterans, finding higher mortality rates for those living in the US territories. The researchers highlight concerns about potential differences in healthcare quality between the US mainland and US territories.
Researchers have developed a mouse model expressing human tau protein to study the effects of repetitive brain injury on cognitive function, motor dysfunction and white matter damage. The study found that repetitive concussive injuries resulted in chronic disruptions in white matter and associated neuroinflammation.
Researchers found significant reductions in PTSD symptoms and increases in self-compassion among veterans who participated in the Dogs2Vets program. The 12-month study showed veterans experienced lower levels of perceived stress, isolation, and self-judgment.
The new law allows investigational stem cell treatments for patients with certain severe chronic diseases or terminal illnesses, sparking debate over increased access vs. unproven treatments.
The American Psychiatric Association and the American Telemedicine Association have released new best practices for videoconferencing-based mental health services, covering topics such as emergency situations, technical considerations, and patient selection. These guidelines aim to enhance the delivery of effective and safe telemental ...
Researchers compared iSCs and BM-MSCs for CNS repair capacity. iSCs exhibit potential for neuronal differentiation, making them promising candidates as therapeutic agents.
A systematic review of 15 studies found that breastfeeding was associated with a reduced risk of high blood pressure in women, even after extended follow-up. The study suggests that lactation provides major health benefits for both mothers and infants.
A new study found that fasting hyperglucagonemia in type 2 diabetes is associated with higher waist-to-hip ratio, poor glycemic control, and increased insulin concentrations. Visceral fat deposition may play a role in the development of this condition.
A systematic review and meta-analysis of non-digital board games found promising results in improving health-related knowledge and behaviors. The study evaluated 21 studies and revealed that board games can be a widely disseminable method for delivering the benefits of games for health.