Researchers have made significant progress in developing computational models, human tissue-based assays, and other advanced systems to assess the toxicity of inhaled materials without using animals. These novel approaches aim to improve safety and regulatory compliance in industries such as pharmaceuticals and personal care.
Scientists have created a new hydrogel adhesive made from two naturally derived polymers that is 15 times stronger than traditional adhesives used for nerve reconstruction. The material supports cell survival, extension, and proliferation essential for nerve regeneration in vitro and in animal models.
Researchers compared six adeno-associated viral (AAV) vectors for efficiency of gene transfer to both retinal pigment epithelial and photoreceptor cells. Human pluripotent stem cell-derived organoids were used as an in vitro test system for AAV vector development.
Researchers used periodontal ligament-derived stem cells to create a cell sheet that promoted the formation of both cementum- and PDL-like tissue in dogs. This innovative work combines traditional dental implants with stem cell sheet technology, offering a promising solution for widespread dental health care issues.
A case study and literature review concludes that breastfeeding should continue normally in mothers and babies with red diaper syndrome caused by Serratia marcescens. Treatment of the bacteria is not recommended for healthy infants, and clinical judgement should guide physicians' decisions.
Dr. Michel Sadelain shares his role in advancing CAR T-cell therapy, a rapidly evolving field that targets cancer cells. He describes the FDA approval of the first CAR T-cell therapy and predicts next-generation technology advancements.
Two commentaries in JACM question whether colonial models devalue traditional and complementary practices. Researchers Heather Boon and Nadine Ijaz argue that biomedical dominance subordinates indigenous knowledge systems, while Editor-in-Chief John Weeks emphasizes the need for re-examining harmful limits of biomedicine's approach.
Researchers at Allina Health examined pain treatment outcomes of integrative medicine in hospitalized patients and found significant cost savings associated with pain reductions. The study, published in JACM, suggests that integrative interventions can lead to a decrease in hospital costs by up to $1,000 per admission.
A recent commentary examines the ethical fit of mindfulness practices in corporate America, highlighting potential conflicts between prioritizing shareholder return and mindfulness' philosophical commitment to non-harm and wholesome living. The authors argue that infiltrating corporate culture with mindfulness can raise the ethical bar...
A multidisciplinary panel of experts discussed the role of medicinal cannabis in alleviating chronic pain and easing the opioid crisis. Despite strict federal laws, state laws allowing medicinal cannabis have impacted communities most affected by opioid use.
A gene therapy case report published in Human Gene Therapy reveals a safe and effective treatment for lipoprotein lipase deficiency, with improved quality of life outcomes after discontinuing plasmapheresis. The treatment, ali-pogene tiparvovec, has been approved in Europe to treat the rare inherited disorder.
Researchers found that adults on the autism spectrum have increased use of primary care, mental health services, and laboratory services, but lower use of gynecology visits and cervical cancer screening. The study highlights the importance of considering autism throughout the lifespan and emphasizes the need for better access to afford...
A new study reveals significant differences in post-concussion symptom severity and length of recovery between male and female college athletes. Notably, female athletes who used hormonal contraceptives experienced different outcomes compared to non-users, suggesting a potential impact on concussion recovery.
The CRISPR Journal publishes new research on cell-free CRISPR systems, which enable the study of gene editing mechanisms in a defined manner. Additionally, a universal CRISPR activity model called TUSCAN has been developed to predict CRISPR-Cas9 activity and genome-wide screening tasks.
The FraudBuster approach uses proactive risk prediction at the underwriting stage to identify unprofitable drivers who are likely fraudulent risks. This novel method can help insurers reduce fraud in high-risk markets, such as the automobile insurance market.
Research found higher prevalence of frailty, pre-frailty, and comorbidities like depression & anxiety among adolescent & young adult cancer survivors. Lifestyle factors, including smoking & obesity, contributed to this risk, as did delay in care due to lack of health insurance.
Researchers engineered a donor cornea with genes that inhibit vascularization, reducing the risk of tissue rejection in high-risk patients. The study shows promising results for gene therapy in preventing corneal graft rejection.
A new study of 45 years reveals that Alaska Natives have a similar incidence of thyroid cancer as the U.S. white population, but their tumors tend to be larger and have spread beyond a localized area. The study suggests that differences in access to healthcare may contribute to these discrepancies.
A new bioinformatics tool, CRISPRdisco, has been developed to identify and classify CRISPR-Cas systems in genome assemblies. The software detects CRISPR repeats and accurately assigns class, type, and subtypes, enabling researchers to distinguish between complete and incomplete CRISPR systems.
The Childhood Obesity Declines Project (COBD) has successfully implemented community-based strategies to combat childhood obesity, documenting their development and implementation. The project's findings provide valuable insights into effective programs and policies that can help address the rising prevalence of childhood obesity.
New gene editing regulations could hinder the use of CRISPR technology in food animals, potentially limiting disease resistance and beneficial traits. The FDA's proposal would impose drug-like regulatory scrutiny, but experts suggest alternative routes to approval that could accelerate benefits from conventional breeding.
The CRISPR Journal has published new research on gene editing regulations, introducing potential global implications for food animal production. A bioinformatic pipeline, dubbed CRISPRdisco, has been developed to help researchers identify and characterize CRISPR repeats and genes encoding Cas nucleases.
A new study reveals that spaceflight triggers cellular adaptations in heart cells, paving the way for novel stem cell therapies. Researchers found altered calcium signaling pathways that could be harnessed to improve heart repair.
Researchers developed novel strategies to engineer more stable and active proteins, enhancing mRNA therapy potential. Sequence engineering improved protein expression, duration, and enzymatic activity in mice.
Researchers found that gene therapy using adeno-associated viral vectors can only temporarily alleviate congenital adrenal hyperplasia (CAH) by replacing the defective gene. A long-term solution requires targeting genetic mutations in adrenocortical stem cells, according to a study published in Human Gene Therapy.
Elon Musk presents an updated design for the Big Falcon Rocket, a powerful rocket intended to propel a space vehicle to the International Space Station and beyond. The BFR's updated design includes a huge carbon fiber tank and new fueling system to lower costs and achieve rendezvous and docking.
Researchers at Harvard Medical School propose a coordinated effort to develop clear definitions of acupuncture points and evaluate their biological basis. The study aims to address the skepticism surrounding acupuncture's legitimacy in mainstream healthcare.
A study found racial disparities in HIV control exist even when patients have equal access to care, with differences attributed to adherence to combination antiretroviral therapy. Black veterans had higher viral loads than white counterparts, highlighting a critical issue in healthcare disparities.
A new study identifies alterations in functional connectivity across the whole brain in carriers of the Huntington's disease gene mutation, associated with motor and cognitive function. The study also shows significant associations between the extent of the degree of gene mutation and measures of brain connectivity.
A comprehensive review found that acupuncture reduced the frequency and severity of hot flashes in menopausal women. The treatment also showed significant improvements in health-related quality of life, presenting a promising approach for managing bothersome vasomotor symptoms.
A national sample of transgender individuals reported high levels of concern about violence and discrimination related to the 2016 US Presidential election. The majority had been directly exposed to hate speech and violence, with many expressing concerns that the election may have emboldened these acts.
The new peer-reviewed journal Systems Medicine captures leading research in medical systems biology, emphasizing molecular mechanistic biomarkers. This approach aims to drive innovations in new drug discovery and preventive therapies based on healthy aging research.
A new study using recombinant adeno-associated virus (rAAV) delivery vectors found that ZMapp antibodies administered to mice resulted in 100% protection against Ebola infection. The study also compared different doses and routes of administration, with the best results achieved using a single rAAV-delivered antibody.
A recent review article emphasizes the urgent need for more clinical research, data, and prognostic models on traumatic brain injury in older adults. The lack of geriatric-specific TBI guidelines presents barriers to optimal care, and the authors discuss issues related to neurocritical care, neurosurgical management, and rehabilitation.
Researchers have identified a range of synthetic antisense oligonucleotides that can activate the frataxin gene in FA patients. The discovery demonstrates flexible options for increasing frataxin protein expression and alleviating FA symptoms.
The Osher Collaborative for Integrative Medicine has launched a new quarterly column in JACM, discussing strategies to advance health justice through integrative medicine principles. The inaugural column highlights the need to address bias and discrimination in intrapersonal attitudes and behaviors.
Dr. Koplewicz highlights the urgent need to prioritize mental health in response to mass shootings like Parkland. He emphasizes that social isolation can exacerbate emotional problems and calls for better support systems in schools.
New research fails to support desvenlafaxine's effectiveness in treating major depressive disorder (MDD) in children and adolescents. A recent study found that neither a low nor high dose of the medication was significantly more effective than placebo.
Two novel ocular hypotensive agents, netarsudil and latanoprostene bunod, have been approved for use in humans, reducing intraocular pressure with lasting results. These breakthrough drugs also show promise for treating dry eye disease and delivering ophthalmic drugs via microneedles.
A special issue of Human Gene Therapy highlights Chinese research advancements in gene and cell therapy, including novel viral and nonviral vectors for gene delivery. The articles explore innovative applications of CRISPR technology in various disease areas.
The inaugural issue of The CRISPR Journal features a range of articles on CRISPR biology, technology, and genome editing. Research highlights include progress in treating genetic diseases, such as hereditary blindness and Batten disease, using CRISPR-Cas9 gene editing.
The CRISPR Journal debuts with original research papers on plant editing, gene drives, and therapeutic applications. Researchers make progress in targeting specific mutations for inherited diseases like retinitis pigmentosa.
A new systematic review of eleven clinical trials involving nearly 500 participants found that cupping therapy has a high risk of bias and inconsistent results. The authors concluded that no conclusive recommendations for or against the use of cupping in sports performance can be made until further trials are carried out.
The Eversense implanted continuous glucose monitoring system has been proven to be safe and highly accurate in patients with type 1 and 2 diabetes. The system achieved an average absolute relative difference of 4%, exceeding regulatory requirements for approval.
Researchers identified common bucket-list themes among patients with chronic and serious illnesses, including travel, personal goals, and quality time with friends and family. This knowledge can serve as a roadmap for clinicians to provide tailored care that respects patients' preferences and values.
A new study found that an intensive 6-day Ayurveda-based mind-body program increased self-awareness and related health benefits. The program was compared to a control group, showing significant increases in neti values at both immediate completion and the 1-month follow-up.
Researchers found liver and neuronal toxicity with high doses of gene therapy delivered using an adeno-associated virus (AAV9) vector. The study warns about the importance of prioritizing patient welfare in gene therapy research.
A new article highlights responsible strategies for managing end-of-life foams and plastics containing harmful flame retardants. Researchers emphasize the need for proper disposal and recycling methods to minimize health risks from environmental exposure.
A recent study has confirmed that the spleen acts as an HIV sanctuary, hiding the virus from detection even when antiretroviral therapy is effective. Researchers also explore natural products with therapeutic compounds and gather insights on people living with HIV's perceptions of cure-related research.
Researchers are exploring gene delivery strategies for osteoarthritis and rheumatoid arthritis, enabling sustained drug production at the site of disease. Clinical trials are underway in the U.S., with the first arthritis gene therapy recently approved in Korea.