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Paul Scherrer Institute


Protein droplets likely don’t cause Parkinson’s

Researchers investigated the relationship between protein aggregation and liquid-liquid phase separation, finding that droplet formation may actually protect against aggregation. The study, led by Paul Scherrer Institute, used over 500 conditions to test the behavior of alpha-synuclein proteins.

SourcePaul Scherrer Institute·JournalAdvanced Science·TypeExperimental study·DateJul 15, 2024

Slipping a note to a neighbor: The cellular way

Researchers from PSI and ETH Zurich studied connexin-36 gap junction channels and found that antimalarial drug mefloquine binds to the channels, potentially explaining its severe side effects. The study provides new insights into how drugs interact with connexins and may lead to the development of therapies for neurological diseases.

SourcePaul Scherrer Institute·JournalCell Discovery·TypeExperimental study·DateJun 26, 2024

A bionanomachine for green chemistry

Scientists at the Paul Scherrer Institute have precisely characterized the styrene oxide isomerase enzyme, enabling the production of valuable chemicals and drug precursors in an environmentally friendly manner. The enzyme's unique mechanism and high specificity make it a promising tool for green chemistry.

SourcePaul Scherrer Institute·JournalNature Chemistry·TypeExperimental study·DateMay 14, 2024

How to clean up New Delhi’s smoggy air

A study led by the Paul Scherrer Institute reveals that incomplete combustion and biomass burning are major contributors to New Delhi's air pollution. The research found that particulate matter in the air causes oxidative stress, leading to illnesses such as asthma and hypertension.

SourcePaul Scherrer Institute·JournalNature Communications·TypeExperimental study·DateApr 26, 2024

Charge fractionalisation observed spectroscopically

Researchers discovered charge fractionalisation in an iron-based metallic ferromagnet using laser ARPES spectroscopy, revealing collective excitations and quasiparticles. The study challenges fundamental quantum mechanics by showing electrons can behave as independent entities with fractionally charged pockets.

SourcePaul Scherrer Institute·JournalNature·TypeExperimental study·DateMar 6, 2024

Glacier melting destroys important climate data archive

Researchers found that global warming made the Corbassière glacier unusable as a climate archive, destroying reliable information about past climate and air pollution. The glacier's ice core showed flattened concentration curves and lower amounts of trace substances, likely due to meltwater washing away the deposits.

SourcePaul Scherrer Institute·JournalNature Geoscience·TypeExperimental study·DateJan 26, 2024

New possibilities for a healing toxin

PSI researchers develop antibody-like proteins that accelerate Botox's effects on nerve signals, suggesting faster pain relief. The discovery opens new options for therapeutic use of botulinum toxin A1 in treating conditions like cramping muscles and faulty nerve signals.

SourcePaul Scherrer Institute·JournalNature Communications·TypeExperimental study·DateDec 18, 2023

Enabling early detection of cancer

Scientists at Paul Scherrer Institute achieve breakthrough in detecting developing tumors at an early stage and monitoring therapy success. They used artificial intelligence to analyze blood cell chromatin, distinguishing between healthy and sick cells with high accuracy, and identifying tumor types with over 85% precision.

SourcePaul Scherrer Institute·Journalnpj Precision Oncology·TypeExperimental study·DateDec 14, 2023

The secret life of an electromagnon

Scientists have discovered how atoms and spins move together in electromagnons, a hybrid excitation that can be controlled with light. The study used time-resolved X-ray diffraction to reveal the atomic motions and spin movements, showing that atoms move first and then the spins fractionally later.

SourcePaul Scherrer Institute·JournalNature Communications·TypeExperimental study·DateNov 28, 2023

Reprogramming tissue mechanically

Researchers at PSI and ETH Zurich successfully transplanted mechanically reprogrammed fibroblasts into a model of old, damaged skin tissue, revealing that the tissue can be rejuvenated and injuries heal faster. The technique uses spatially confined conditions to erase functional errors accumulated by aged cells during the aging process.

SourcePaul Scherrer Institute·JournalAging Cell·DateNov 27, 2023

3D insights into an innovative manufacturing process

Using a new technique, researchers created the first 3D tomograms of a ceramic object being printed using laser-based powder bed fusion, revealing detailed information about the manufacturing process. The findings will help improve this promising technology and provide valuable insights for future applications.

SourcePaul Scherrer Institute·JournalCommunications Materials·TypeExperimental study·DateSep 19, 2023

How trees influence cloud formation

Researchers at PSI have identified sesquiterpenes as a major factor in cloud formation, which could reduce uncertainties in climate models. The study's findings suggest these compounds form ten times more particles than other organic substances.

SourcePaul Scherrer Institute·JournalScience Advances·TypeExperimental study·DateSep 8, 2023

Earlier detection of breast cancer

A team of researchers has developed a new method for detecting breast cancer using X-ray phase contrast imaging, which increases the resolution of images by up to 45% while reducing the radiation dose. This improvement enables earlier detection of small calcium deposits and improves the chances of survival for women with breast tumors.

SourcePaul Scherrer Institute·JournalOptica·DateJul 19, 2023

Mystery of microgels solved

Soft particles called microgels can shrink abruptly when their concentration in a solvent is increased above a certain threshold, even without physical contact. Researchers have provided experimental proof of this phenomenon using neutrons from the Paul Scherrer Institute's SINQ spallation source.

SourcePaul Scherrer Institute·JournalNature Communications·TypeExperimental study·DateJul 10, 2023

Climate-neutral air travel: Is it possible?

Air traffic cannot become climate-neutral solely by replacing fossil fuels with synthetic ones; reductions in air traffic are necessary. Non-CO2 effects, like particulate matter and nitrogen oxides, play a major role in aviation's overall climate impact.

SourcePaul Scherrer Institute·JournalNature Communications·TypeComputational simulation/modeling·DateJul 7, 2023

Hairy cells: How cilia’s motor works

Researchers used cryo-electron tomography to study the dynein motor protein, revealing new details about how it generates force and coordinates with other proteins. This knowledge may help develop treatments for diseases related to cilia dysfunction, such as fertility issues and lung disease.

SourcePaul Scherrer Institute·JournalThe EMBO Journal·TypeExperimental study·DateJun 19, 2023

An algorithm for sharper protein films

Researchers have developed an algorithm that can be used to evaluate measurements at X-ray free-electron lasers, improving the precision of protein film analysis. The new method, called low-pass spectral analysis (LPSA), mitigates errors in protein movement reconstruction, allowing for more detailed information to be extracted from data.

SourcePaul Scherrer Institute·JournalStructural Dynamics·TypeExperimental study·DateMay 30, 2023

Calcium sensor helps us to see the stars

Researchers from PSI deciphered the structure of an ion channel found in the eye while interacting with calmodulin, a protein that enables cell response to calcium fluctuations. This interaction is believed to be responsible for achieving remarkable sensitivity to dim light.

SourcePaul Scherrer Institute·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateApr 3, 2023

How vision begins

The study found that a microscopic change in a protein in the retina occurs within a fraction of a trillionth of a second, triggering the perception of light. This process involves the transformation of a molecule called retinal from its 11-cis form to its all-trans form, which takes just one picosecond.

SourcePaul Scherrer Institute·JournalNature·TypeExperimental study·DateMar 22, 2023

Using light to switch drugs on and off

Researchers at the Paul Scherrer Institute have developed a film that demonstrates the potential of photopharmacology in treating diseases such as cancer. The new approach uses light to switch on and off a molecular photoswitch, allowing for targeted and reversible drug action.

SourcePaul Scherrer Institute·JournalNature Communications·TypeExperimental study·DateFeb 20, 2023

Imaging biomarkers for Alzheimer’s disease

Scientists have developed an AI method to pinpoint cells indicative of Alzheimer's disease based on DNA packing in mouse brain images, offering a potential early detection tool. This approach combines multi-scale imaging with artificial intelligence to identify biomarkers for aging-related diseases.

SourcePaul Scherrer Institute·JournalNature Communications·TypeImaging analysis·DateDec 3, 2022

Making sense of the muon’s misdemeanours

Researchers studying exotic atom muonium aim to detect deviations from the Standard Model, which could reveal new physics. By measuring energy levels with unprecedented precision, they may uncover evidence for additional particles or forces that explain the muon's misbehavior.

SourcePaul Scherrer Institute·JournalNature Communications·TypeExperimental study·DateNov 25, 2022

Nanomaterial from the Middle Ages

Researchers at the Paul Scherrer Institute use advanced microscopy to visualize fine details in Zwischgold, a highly advanced medieval material. The technique reveals the structure and composition of the material, shedding light on its production methods.

SourcePaul Scherrer Institute·JournalNanoscale·TypeExperimental study·DateOct 11, 2022

Making it easier to differentiate mirror-image molecules

Researchers from PSI, EPFL, and the University of Geneva developed a new method to distinguish between mirror-image molecules using helical dichroism. This approach provides stronger signals compared to circular dichroism (CD), which is widely used but has weak signals suitable only for gas-phase samples.

SourcePaul Scherrer Institute·JournalNature Photonics·TypeExperimental study·DateJul 5, 2022

Reaction insights help make sustainable liquid fuels

Researchers from ETH Zürich and Paul Scherrer Institute gained unprecedented insight into the complex mechanism of converting CO2 to carbon neutral fuels. Using sophisticated analytical techniques, they identified two distinct reaction pathways, one driven by methyl radicals and another by oxygenated species, which shed light on how me...

SourcePaul Scherrer Institute·JournalNature Catalysis·TypeExperimental study·DateJun 27, 2022

How to find anti-cancer agents

The Paul Scherrer Institute and Italian Institute of Technology have developed a novel substance called Todalam that disables tubulin, a protein essential for cell division. In cell cultures, Todalam kills cells, making it a promising starting point for developing an anti-cancer drug.

SourcePaul Scherrer Institute·JournalAngewandte Chemie·TypeExperimental study·DateApr 12, 2022

A look into the magnetic future

Scientists at Paul Scherrer Institute have observed artificial spin ice structures aligning with temperature changes, revealing a complex phase transition. The discovery could lead to novel high-speed computers with low power consumption.

SourcePaul Scherrer Institute·JournalNature Physics·TypeExperimental study·DateApr 4, 2022

Mobile excitons as neutral information carriers

Researchers have created and detected dispersing excitons in a metal using angle-resolved photoemission spectroscopy, a breakthrough that could enable efficient data transmission. The discovery of mobile excitons in TaSe3 reveals their mobility and potential to revolutionize electronics.

SourcePaul Scherrer Institute·JournalNature Materials·TypeExperimental study·DateFeb 21, 2022

New insight into unconventional superconductivity

Researchers at PSI's Laboratory for Muon Spin Spectroscopy have discovered strong evidence of exotic charge order and orbital currents in a correlated kagome superconductor. The findings provide a new insight into unconventional superconductivity and its relationship with the quantum anomalous Hall effect.

SourcePaul Scherrer Institute·JournalNature·TypeExperimental study·DateFeb 9, 2022

How to get chloride ions into the cell

A study led by Przemyslaw Nogly at PSI has detailed insight into the mechanism of a light-driven chloride pump in bacteria, revealing how light energy converts to kinetic energy and transports chloride ions inside cells. The pump uses two molecular gates to ensure one-way transport, with the process taking around 100 milliseconds.

SourcePaul Scherrer Institute·JournalScience·TypeExperimental study·DateFeb 3, 2022

New, better coronavirus rapid test

The new test, developed at the Paul Scherrer Institute, uses a novel functional principle to provide reliable results on Covid-19 disease progression and its course. It can also detect other diseases and Covid variants, offering more predictive power than existing rapid antigen tests.

SourcePaul Scherrer Institute·JournalACS Applied Nano Materials·TypeExperimental study·DateJan 24, 2022

Towards compact quantum computers thanks to topology

Scientists have compared electron distribution in two semiconductors to develop stable topological quantum bits for quantum computing. Indium antimonide shows a low electron density below its oxide layer, which is advantageous for forming Majorana fermions and creating compact, efficient quantum computers.

SourcePaul Scherrer Institute·JournalAdvanced Quantum Technologies·TypeExperimental study·DateJan 20, 2022

More insight into how vision works

The study reveals the three-dimensional structure of the cyclic nucleotide-gated (CNG) ion channel, which helps detect light in the eye. The discovery may lead to new treatments for genetic disorders like retinitis pigmentosa, where photoreceptors die off and people go blind.

SourcePaul Scherrer Institute·JournalNature Structural & Molecular Biology·TypeExperimental study·DateJan 3, 2022

Semiconductors reach the quantum world

A composite material consisting of superconducting and semiconducting materials has been discovered, enabling the integration of quantum devices into semiconductor technology. This breakthrough could lead to significant improvements in data transmission bandwidth, energy efficiency, and information security.

SourcePaul Scherrer Institute·JournalScience Advances·TypeExperimental study·DateDec 22, 2021

Effective combination cancer treatment

Researchers at the Paul Scherrer Institute have discovered a combination of rapamycin and a radiopharmaceutical that can effectively inhibit tumour growth, improving treatment outcomes for medullary thyroid cancer. The new therapy uses mini-gastrin coupled with lutetium-177 to target cancer cells more efficiently.

SourcePaul Scherrer Institute·JournalPharmaceutics·TypeExperimental study·DateDec 15, 2021

Biased signalling for better drugs

Researchers at PSI have developed a platform to measure biased signalling in G protein-coupled receptors (GPCRs), enabling selective therapeutic effects and fewer side effects. By testing specially designed bivalent ligands, they can bias signalling towards desired pathways.

SourcePaul Scherrer Institute·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateDec 15, 2021