Researchers created a new iPS-cell model to study spinocerebellar ataxia type 6, finding that mature Purkinje cells with the SCA6 mutation become vulnerable when deprived of thyroid hormone. The team discovered compounds that can suppress this vulnerability and prevent cell death.
Researchers have uncovered the mechanism by which cryptochrome 2, a key photoreceptor, is switched on and off in plants. This desensitization mechanism allows plants to maintain homeostasis of their blue light responsiveness in fluctuating light environments.
Researchers identify two distinct genetic markers, Rspo2 and Ppp1r1b, corresponding to negative and positive neurons in the basolateral amygdala of mice. These neurons regulate behaviors tied to negative and positive stimuli, respectively.
A novel small-molecule Wnt inhibitor named NCB-0846 has been discovered with potential to eradicate colorectal cancer stem cells. The inhibitor targets the Traf2- and Nck-interacting kinase (TNIK) regulatory component of the Wnt signaling pathway, blocking its signal even in colorectal cancer cells with APC gene mutations.
Researchers used the K computer and advanced radar data to accurately predict torrential rains in localized areas. They achieved this by synchronizing data between large-scale simulations and observational data through 'big data assimilation', resulting in high-resolution maps of rain every 30 seconds.
Scientists create a film that curls up and straightens autonomously when exposed to tiny changes in humidity, using it to transform environmental fluctuations into mechanical energy. The film can jump high and repeatedly bend and straighten without deterioration.
Researchers from RIKEN successfully attach a biologically active molecule to a titanium surface, inspired by the adhesive properties of mussels. The hybrid protein showed strong binding capabilities to the metal, even when washed with water-based solutions.
Scientists have developed a new vaccine that stimulates both innate and adaptive immune responses, allowing the body to remember and attack cancer cells. The treatment, called aAVC, uses modified foreign cells that promote the maturation of dendritic cells, key coordinators of the immune response.
Researchers have successfully sequenced the genome of Hevea brasiliensis, the natural rubber tree, uncovering key genes responsible for its unique properties. The study identifies a cluster of genes related to rubber biosynthesis and disease resistance, which may contribute to the tree's high latex production.
Adding torrefied biomass to poor soil from Botswana increased water retention and promoted plant growth. The treated soil showed higher levels of potassium, phosphorus, and sulfur, as well as thicker stems, longer roots, and heavier plants.
A study published in Neuron reveals how smell preference is computed in the brain, suggesting that most glomeruli contribute to attraction or aversion. The model predicts that relative preferences can flip depending on other odors present.
A new study from RIKEN Center for Sustainable Resource Science reveals that amino acid sequences are key determinants of silk fiber material properties. The research sheds light on the unique properties of silkworm silks, including their mechanical and thermal behavior.
Researchers successfully used terahertz lasers to induce permanent changes in a polymer's conformation, increasing its crystallization pattern by 20%. The study demonstrates the potential of terahertz waves as a 'soft' method for modifying materials without inducing chemical changes.
Researchers at RIKEN discovered that acrolein can combine with polyamines to form substances that prevent the aggregation of amyloid-beta peptides, a process linked to Alzheimer's disease. The findings suggest that acrolein may have an anti-fibrillation effect, potentially influencing the progression of neurological disorders.
Researchers from RIKEN Quantitative Biology Center create a new type of electricity generator based on the electric organs of torpedoes, achieving peak voltages and currents comparable to conventional systems. The breakthrough could lead to a future high-efficiency power generator that uses ATP directly.
Researchers discovered that a molecule involved in fish reproduction, PGF2α, activates the brain via the nose, synchronizing reproductive behaviors between male and female zebrafish. The molecule binds to specific olfactory receptors, activating a dedicated neural pathway to areas of the brain responsible for courtship behavior.
Research from RIKEN Brain Science Institute in Japan identifies the brain clock that keeps memories organized across time. Without CA3 input, the neural orchestra loses its conductor, leading to errors in representing space and impairing accurate prediction of spatial location.
The study found that artificially applying synchronous slow wave brain activity during non-REM sleep can enhance memory consolidation, allowing mice to retain memories for up to 4 days. This discovery suggests a potential route to therapy using transcortical magnetic or direct-current stimulation to reactivate sleep-deprived neurons.
Current simulation models consistently underestimate black carbon aerosols in Arctic air, but fine-grained simulations using powerful supercomputers can mitigate this underestimation. The research found that more realistic modeling of weather and climate patterns is possible with finer grids and larger computational power.
A new study from RIKEN Brain Science Institute reveals that the brain processes ambiguous associations, like those between odors and food or sounds and predators. Researchers found that the amygdala stores both memories and uncertainty in neural circuits.
Researchers at RIKEN Brain Science Institute discovered myosin-Va's role in directing neuron growth. The protein complex acts as a calcium sensor that tells new axon pieces where to go.
Researchers at RIKEN Brain Science Institute have demonstrated that astrocytes regulate changes in synaptic strength, which is crucial for learning and memory. By examining cultured cells and brain slices, they found that astrocyte activity helps maintain normal variation of synaptic strengths.
Researchers at RIKEN and the University of Bristol have experimentally verified that light exerts a new type of optical force proportional to its circular polarization. The team used an extremely precise nano-cantilever to measure this force, which is much weaker than usual radiation pressure.
Researchers successfully grew skin tissue with hair follicles and sebaceous glands in the laboratory using reprogrammed iPS cells. The tissues formed normal connections with surrounding nerves and muscle fibers, paving the way for potential functional skin transplants.
A deep-brain structure called the habenula contains two neural circuits that influence whether a fight will be won or lost in zebrafish. The circuits regulate surrender or continuing aggression based on activity levels in different sub-regions, suggesting a dynamic mechanism for determining fight outcomes.
Researchers found that transcranial direct current stimulation causes synchronized calcium surges from astrocytes, reducing depressive symptoms and increasing neural plasticity. This effect is absent when blocking astrocytic calcium surges, highlighting their importance in therapeutic outcomes.
Scientists discovered that Zscan4 is a repair mechanism triggered by telomere shortening, allowing cells to recover from cell division stress. The protein expression is linked to longer cell cycles, enabling the cells to lengthen their telomeres before speeding up the cycle again.
Researchers at RIKEN have discovered that calcium inside neurons regulates slow-wave sleep, with seven genes identified as critical for controlling sleep duration. The study's findings could lead to new treatments for sleep disorders and neurologic diseases associated with them.
Researchers used optogenetics to re-grow lost spines and restore memories in AD mice by stimulating engram cells. This method suggests that impaired retrieval of memories underlies early Alzheimer's disease symptoms and highlights the importance of targeted manipulation of neurons for future therapies.
A new process for making brain tissue transparent has been developed at RIKEN Center for Developmental Biology, allowing for the creation of super-resolution 3-D images of delicate structures deep in the brain. This breakthrough enables researchers to visualize synaptic changes and neural structures with unprecedented detail.
Researchers have discovered that complex brain divisions in vertebrates evolved before the emergence of jaws, contradicting previous assumptions. The study found similarities between jawless fish and jawed vertebrates in brain development patterns.
Researchers investigated magnetism's influence on atomic vibrations in iron-pnictide superconductors, finding magnetic fluctuations play a crucial role. The study provides insight into the interaction between magnetism and atomic vibrations, potentially leading to materials that superconduct close to room temperature.
Researchers identified two genetic variations in the ORA1 gene associated with increased risk of Kawasaki disease in East Asian populations. The study provides new insights into the disease's etiology and potential mechanisms behind its seasonal variation and higher prevalence in children of this ancestry.
Researchers have discovered a new mutation that rescues abnormal axonal growth in the developing mouse brain affected by CFEOM3. The mutation targets the kinesin-microtubule interface and suppresses abnormal axon guidance.
Researchers at RIKEN QBiC have developed a new method for monitoring mouse sleep cycles using the Snappy Sleep Stager, a non-invasive and automated system. The system has identified a new short-sleeper gene, Nr3a, which is associated with schizophrenia, Alzheimer's disease, and depression, all of which are linked to sleep disturbances.
A RIKEN group led by Kosuke Morita has discovered element 113, the first superheavy element found in Asia. The discovery was confirmed through a series of experiments that demonstrated the decay chain of the new element.
Researchers have successfully multiplied teeth in mice by splitting tooth germ cells and implanting them into the jaw. This discovery could lead to new treatments for people born with missing teeth or who lose teeth due to accidents or disease.
The study reveals that glutamate triggers calcium release to stabilize GABAA receptors, maintaining proper excitatory-inhibitory balance. This finding has implications for understanding disorders related to imbalance, such as epilepsy and autism.
Researchers discovered a bacterium that can use direct uptake of electrons from an electrode to fuel its metabolic pathway. This finding suggests the existence of electro-ecosystems, where microorganisms sustain life by electrical current, not relying on inorganic substances or light.
Researchers extend catalogue of material properties with first liquid measurements under extreme conditions. The study suggests that only about 1.2% of the core is carbon, with other light elements present.
A recent study published in Nature Immunology revealed that the body suppresses long-lived lymphoid cells to prevent excessive inflammation. Cytokine chemicals like interferon-beta, gamma and interleukin-27 can shut off these cells, allowing for a targeted immune response.
Researchers developed a new system to image individual neurons in the marmoset brain, overcoming limitations with two-photon microscopy. This allows for long-term study of neural activity related to cognitive and social behaviors.
Researchers have discovered a large number of genes that are upregulated in various types of cancer, which could be used to develop early detection tests and targeted therapies. The study, published in Cancer Research, utilized two different technologies to identify 128 markers that were consistently perturbed in both datasets.
Researchers at RIKEN Advanced Institute for Computational Science in Japan ran an enormous global weather simulation with 10,240 simulations of a model of the global atmosphere. They found that faraway observations can impact the eventual state of the weather forecast, which could lead to more accurate forecasts.
Research suggests that retroviral long-terminal-repeat promoters may contribute to the emergence of hepatocellular carcinoma. The study found that these elements are highly activated in liver cancer tumors and non-tumor tissue from patients with different etiologies, including viral hepatitis or alcohol use.
Scientists have identified the enzyme responsible for synthesizing tenuazonic acid (TeA), a well-known fungus-killing toxin that affects rice and other crops. The unique TeA synthetase 1 (TAS1) enzyme has an NRPS-PKS structure, previously thought to be exclusive to bacteria.
Researchers at RIKEN have discovered that wrinkles in graphene can form a junction-like structure, changing its electronic properties from zero-gap conductor to semiconductor and back. By manipulating the carbon structure using scanning tunneling microscopy, they have opened up new possibilities for graphene engineering.
Researchers at RIKEN have discovered a method to maintain immune cells in a stem cell-like state by inhibiting differentiation, allowing them to proliferate extensively. This breakthrough could lead to the development of new treatments for regenerative medicine and immune therapy.
Researchers identified a neural circuit in the brain that regulates REM sleep and show it controls NREM sleep physiology. The study also found that REM sleep interacts with NREM sleep in a hierarchy, affecting slow wave activity.
Researchers identified three genetic factors associated with peripheral artery disease, including variations on chromosome 13 that affect protein expression and blood vessel constriction. The study provides insight into the condition's causes and potential therapeutic targets.