Researchers found a link between depression and the paraventricular thalamus, a previously untied region of the brain. The study used a mouse strain with mitochondrial dysfunction, which exhibited periodic depressive episodes resembling human cases.
Researchers at RIKEN Center for Emergent Matter Science have found a way to create and delete skyrmions using mechanical energy, which could lead to inexpensive and low-energy-consuming memory devices. The discovery uses a specially designed stress probe to apply mechanical stress to the surface of manganese-silicide material.
Researchers at RIKEN Brain Science Institute found that two forebrain regions determine whether males exhibit paternal or infanticidal behavior. Activity patterns in these regions were associated with paternal behavior and inhibited infanticide.
Ocean cells differentiate environmental contexts, which are then sent to the hippocampus for memory formation. The entorhinal cortex plays a crucial role in context-dependent learning, and understanding Ocean cells' contribution may help diagnose Alzheimer's disease.
Researchers at RIKEN Brain Science Institute developed a new optical clearing technique called Sca l eS, enabling the creation of transparent brain samples for detailed analysis. The technique has provided new insights into Alzheimer's disease pathology and revealed associations between amyloid beta plaques and microglial cells.
A study published in Nature Neuroscience reveals how the protein centrosomin controls the growth of microtubules within neurons, influencing dendritic branching. The researchers found that centrosomin acts as a 'glue' to fix microtubules, preventing excessive branching and promoting more complex arbors.
Researchers have discovered that epigenomic changes induced by pathogen infections, mediated by a transcription factor called ATF7, are the underlying mechanism of innate immunological memory. This finding could increase our understanding of the hygiene hypothesis and lead to the development of more efficient vaccines.
Researchers at RIKEN and Hiroshima University create technique to analyze metabolites, hormones, nutrients, and lipids in individual cells using nanospray tip and mass spectrometer. This breakthrough could speed up understanding of molecular distribution in time and space, transforming agricultural science.
Scientists at RIKEN Brain Science Institute discovered that glial cells release phospholipid LysoPtdGlc, which repels pain-sensing axons and directs position-sensitive neurons to specific regions in the spinal cord. This lipid-based signaling system has potential as a therapeutic target for spinal cord injury.
The RIKEN collaboration has confirmed proton-antiproton symmetry through a high-precision experiment testing CPT invariance. The results show that charge-to-mass ratios are identical within 69 parts per trillion, constraining violations of the standard model and informing future research on antimatter and dark matter.
A team of scientists from RIKEN has developed a new hydrogel that can stretch and contract in response to temperature changes without absorbing or excreting water. The material's unique property allows it to change shape rapidly and efficiently, making it suitable for practical applications such as artificial muscles.
Researchers have identified a gene associated with susceptibility to adolescent idiopathic scoliosis. The BNC2 gene is linked to increased expression of protein BNC2, which regulates YY1. Studies found that the gene variation leads to higher BNC2 production in genes with the variant, contributing to the development of scoliosis.
A RIKEN-led team has developed a large-scale map of primary cell-to-cell interactions, revealing common signaling routes between cells and new insights into receptor evolution. This data can contribute to the development of medical treatments by identifying potential targets for therapies in various diseases.
Researchers at RIKEN Center for Developmental Biology found that as egg cells mature in older women, paired chromosomes separate prematurely, leading to early division and incorrect segregation. This results in age-related chromosomal errors, such as Down syndrome and miscarriages.
Researchers have produced pairs of spin-entangled electrons, demonstrating their ability to remain entangled even when separated on a chip. This achievement could contribute to the development of futuristic quantum networks operating using quantum teleportation.
A study published in PNAS reveals that the neurotransmitter GABA plays a crucial role in encoding seasonal changes through changes in chloride levels. By blocking GABA activity, researchers were able to synchronize the brain's internal clock, suggesting a potential therapeutic strategy for individuals with disrupted seasonal rhythms.
Researchers at RIKEN discovered that photons exhibit a quantum spin Hall effect, leading to unusual properties and topological phenomena. This finding has implications for the development of optical devices and materials science.
Researchers have found that artificially reactivating positive memories can suppress the effects of stress-induced depression in mice. The study reveals how brain circuits interact with negative experiences and provides a potential target for therapeutic approaches.
Researchers from the RIKEN-MIT Center for Neural Circuit Genetics demonstrated that traces of old memories remain in the amnestic brain and can be reactivated, allowing lost memories to be found. The study suggests that past memories may not be erased but lost and inaccessible for recall.
Researchers at RIKEN achieved a power conversion efficiency of 10% in polymer solar cells, bringing them closer to commercial viability. The key to their success lies in the optimized molecular orientation of the materials, which improves electron transport and enhances overall efficiency.
A two-stage brain circuit is essential for tactile sensation, involving communication between the skin and brain. Mice were rendered unable to sense floor textures when their inner circuit was disabled, highlighting the critical role of this neural pathway in touch perception.
A new mechanism for regulating blood pressure has been uncovered, involving the stress-sensitive gatekeeper protein ERp44. When ERp44 is released from cells, it accelerates the removal of angiotensin II from circulation, leading to a dramatic drop in blood pressure.
The eardrum evolved independently in mammals and diapsids, depending on lower jaw formation in mammals and upper jaw development in diapsids. The study used developmental biology techniques to overcome the lack of fossil evidence for eardrum evolution.
Researchers at RIKEN have developed a novel method for preserving donor livers, significantly extending their viability and improving transplant outcomes. By cooling organs to 22°C and supplementing with red blood cells, the team achieved remarkable success rates, even with organs obtained after cardiac arrest.
The study found that two specific brain regions, the posterior cingulate cortex and rostral anterior cingulate cortex, are activated when making defensive or offensive strategies. This suggests that intuition plays a key role in rapid strategic decisions, rather than deliberate reasoning.
A new space-based system combines a super-wide field-of-view telescope with a high-efficiency laser to track and deorbit centimeter-sized space debris. The system, proposed by RIKEN scientists, could remove most of the debris within five years of operation.
Researchers at RIKEN have successfully demonstrated the integer quantum Hall effect in a new type of film, known as a 3D topological insulator. By quantizing surface Dirac states, they overcame limitations that had hindered previous efforts to harness these materials for low-power consumption electronics.
Researchers at RIKEN Brain Science Institute identified IRBIT as a key player in regulating dopamine levels in the brain. The absence of IRBIT leads to hyperactivity and abnormal social behavior in mice, highlighting its role in maintaining balance.
Researchers have elucidated the structure of two adiponectin receptors, revealing a completely new type unlike G protein-coupled receptors. The discovery may lead to new adiponectin receptor agonists for treating obesity-related diseases like type 2 diabetes.
Researchers at RIKEN Brain Science Institute engineered fluorescent protein that rapidly assembles into large crystals in living cells. Cells actively targeted the crystals for degradation, a process known as autophagy, suggesting potential evolutionary pressure to discourage crystal formation.
Researchers have identified a chemical compound that prevents plants from taking up cesium, reducing the harmful effects of radiation-contaminated soil. The compound, CsTolen A, selectively binds to cesium, preventing its entry into plant cells and promoting physiological processes.
The FANTOM5 project has discovered that the activation of enhancers triggers coordinated changes in gene expression, leading to dramatic cellular phenotypic changes. This understanding is crucial for understanding cell differentiation and human biology.
Researchers developed two cryogenically cooled optical lattice clocks that can synchronize to a one part in 2.0 x 10^-18, nearly 1,000 times more precise than current international timekeeping standard. This precision could enable clock-based geodesy and measure the strength of gravitational potential at different locations.
Researchers at RIKEN have identified a key mechanism in which brassinosteroids, expensive plant hormones, control plant height and growth. The study reveals that BIL1, a master switch regulating 3,000 genes, interacts with BSS1 to regulate brassinosteroid signaling.
The researchers demonstrated a chain-growth process to assemble supramolecular polymers at room temperature and pressure. They were able to create polymers with controlled chirality, length, and sequence, opening the way for precision engineering of macromolecules. The findings also suggest potential applications in electronics and sus...
Scientists from RIKEN have found that chronic hepatitis infection and inflammation can lead to similar genetic mutations in liver tumors, potentially paving the way for targeted therapies. The study identified changes in mutations associated with aggressive biliary-type liver cancers and discovered new targets for future treatments.
Scientists at RIKEN have successfully induced human embryonic stem cells to self-organize into a three-dimensional structure resembling the cerebellum. The resulting neurons demonstrated proper responses to currents and inhibition, indicating functional development. This breakthrough could lead to modeling of cerebellar diseases like s...
New research published in Psychological Science suggests that mothers may speak less clearly to their infants than they do to adults. The study found that mothers tend to use cutesy words and a sing-song voice when talking to babies, but still pronounce sounds slightly less distinctly than when addressing adults.
Research at RIKEN-Max Planck Joint Research Center reveals ENGase enzyme responsible for protein degradation in absence of NGLY1. Studies show that inhibition of ENGase activity may serve as therapeutic target for patients with NGLY1 mutation.
Researchers at RIKEN found that preventing abnormal sugar attachment to BACE1 enzyme reduces Alzheimer's plaques and improves cognitive performance in mice. This study reveals a novel mechanism for Alzheimer's disease development and potentially offers a new therapeutic target.
Researchers from RIKEN Brain Science Institute have made significant strides in understanding the mechanism of dynein's movement along microtubules. The study found that specific amino acid residues on the microtubule structure play a crucial role in activating the dynein motor, enabling directional movement and cargo transport.
Researchers from RIKEN and Okayama University identified PHT4;4 as the transport protein allowing vitamin C to enter chloroplasts. This discovery could lead to crop plants with higher tolerances to environmental stress, reducing damage to farmland in regions with strong light.
Researchers develop new hydrogel with electrostatic repulsion properties, inspired by articular cartilage and maglev trains. The material easily deforms under shear forces but resists compressive forces.
A study published in Nature Communications reveals that mutations can converge on similar physical changes in bacteria, leading to resistance to multiple antibiotics. The researchers found a common set of features responsible for the development of resistance, which could help combat this growing problem.
A new study identifies a neural mechanism for translating unpleasant experiences into fear memories by changing amygdala connections. The findings suggest that Hebbian plasticity is partially correct but requires concurrent activation of noradrenaline to form memories.
A neural pathway in the habenula enables animals to predict dangers and update their expectations based on actions and new outcomes. The study's findings have implications for understanding anxiety and panic disorders, suggesting a potential therapeutic target for improving behavioral learning.
Researchers from RIKEN found that a subtle change in the Lon enzyme allows bacteria to quickly adapt between low-oxygen gut environments and high-oxygen outside conditions. This discovery could lead to new therapeutic targets for enteric diseases.
Researchers at RIKEN developed a new technique to analyze protein structures by suspending crystals in a greasy substance, enabling the use of smaller samples and faster data collection. This breakthrough could lead to improved understanding of dangerous proteins, such as those containing mercury.
A single mutation in the beta-catenin gene can lead to abnormalities in sexual organ morphology, making natural reproduction impossible. The study found that this mutation affects specific tissues, causing malformations that prevent successful reproduction.
Researchers at RIKEN Quantitative Biology Center in Japan have developed a method to image tissues and whole organisms with high precision. They discovered that aminoalcohols included in the CUBIC reagent can elute heme from hemoglobin, making organs dramatically more transparent.