Researchers at Stanford University School of Medicine identified beta-1 integrin as a key molecule involved in tumor development and invasion. Inhibiting this molecule slowed the growth of tumors and improved tissue separation, offering new potential targets for cancer treatment.
A new Stanford University School of Medicine study found that administering a potent clot-busting medication can benefit patients up to 4.5 hours after they experience their first symptom, improving outcomes without negatively affecting mortality.
A Stanford University study found that disrupting the interferon pathway, a critical immune signaling mechanism, can lead to cancer progression and impaired immune response. This defect was detected in patients with breast, melanoma, and gastrointestinal cancers, suggesting a possible explanation for treatment failures.
A Stanford University School of Medicine survey finds that Asian Americans living in California are adopting unhealthy sun-exposure behaviors as they become more westernized. The study highlights the need for increased skin-health awareness among primary care physicians and people of Asian ancestry.
A new Stanford University study finds that early antiretroviral treatment can reduce the risk of death or complications in HIV-positive patients with serious AIDS-related conditions. The treatment was shown to improve immune system function and increase survival rates by 50 percent.
Researchers found skin cells can become muscle-like and vice versa by changing who they associate with, providing insight into genetic reprogramming. This discovery may lead to more efficient ways to create stem cells and treat diseases like diabetes.
Researchers confirm that narcolepsy is an autoimmune disease caused by a specific immune cell variation. A study found that nearly 90% of patients with narcolepsy carry a variant of the human leukocyte antigen gene, which is also associated with other autoimmune diseases like multiple sclerosis and juvenile diabetes.
A new study from Lucile Packard Children's Hospital and Stanford University School of Medicine reveals that infants with bowel disease may have two distinct disease processes with different origins. The research suggests that premature infants, heart defect patients, and others with NEC may be affected by reduced blood flow to the bowe...
Researchers found that precisely tuning oscillation frequencies of certain neurons can affect how the brain processes information and implements feelings of reward. The study suggests that parvalbumin neurons play a crucial role in generating gamma brain waves, which enhance information flow among different cell types.
Scientists found ion channels on middle and shortest rows of stereocilia, not as previously thought. The discovery could lead to new treatments for hearing loss and deafness by understanding the adaptation process.
A low-dose of naltrexone reduced symptoms of pain and fatigue by an average of 30% in women with fibromyalgia, according to a Stanford pilot study. The drug's use was found to be particularly promising due to its low cost and limited side effects.
A new imaging technology uses specially designed dye-containing nanoparticles to simultaneously monitor changes in two intracellular proteins in cancer cells. This could provide a better picture of what's happening in individual tumor cells and potentially improve diagnosis and treatment.
Researchers at Stanford University School of Medicine developed a machine that can analyze tiny blood samples for cancer-associated proteins, detecting subtle changes in protein modifications. The technique may provide a faster and less invasive way to track solid tumors and monitor treatment response.
A Stanford study found that the US AIDS Relief program reduced HIV/AIDS death tolls by over 10% in targeted African countries, saving an estimated 1 million lives. However, there was no significant impact on disease prevalence rates.
A Stanford study reveals that HLA molecules, crucial for immune function, also contribute to brain circuits involved in learning and memory. The absence of these molecules can enhance motor learning but may compromise other learning abilities.
A new study by Stanford researchers has developed a method to assess the quality of women's eggs, which could enhance IVF success rates. The non-invasive test uses metabolomic profiling to identify unique biomarkers in the eggs that predict embryo viability and pregnancy rates.
A new study published in The Lancet found that coronary artery bypass graft may be a better treatment choice than percutaneous coronary intervention (angioplasty) for patients with multi-vessel coronary artery disease who have diabetes and are older than 65. In contrast, PCI may be the best option for patients 55 years and younger.
A Stanford study found that stimulating neural wires rather than cells in the subthalamic nucleus can improve Parkinson's symptoms, offering new insights into the disease and possible treatments. The researchers used optogenetics to activate specific types of cells in rodents, revealing a key role for axons in transmitting signals.
Researchers discovered that neutrophils respond to conflicting signals from cystic fibrosis patients' lungs, leading to severe lung damage. The study's findings suggest that targeting the molecular pathway responsible for this response could lead to new disease therapies.
Researchers at Stanford University School of Medicine have compiled a list of 93 common HIV mutations associated with drug resistance to track the spread of the virus. The updated list is based on data from over 15,000 patients and will be used globally to gauge the effectiveness of HIV medication programs.
Researchers at Stanford University School of Medicine have developed a technique to generate solid organs using stem cells. By utilizing microcirculatory beds and a bioreactor, the team can keep tissue healthy enough for reimplantation into a second animal, overcoming the major hurdle of blood supply in tissue engineering. The techniqu...
A new study from Stanford University School of Medicine found that brain activity patterns differ in women with hypoactive sexual desire disorder compared to those without the condition. The research suggests that increased attention to one's own responses to erotic stimuli may play a role in sexual dysfunction.
Scientists at Stanford University School of Medicine have identified a protein complex that plays a pivotal role in controlling the ability of embryonic stem cells to become any cell type. The finding is an important advance in harnessing the unique abilities of embryonic stem cells to treat disease and generate replacement tissue.
A new immune-system 'atlas' will improve doctors' ability to monitor transplanted organs and shed light on the mechanisms of gradual, cumulative kidney malfunction after transplant. The atlas allows for inexpensive, noninvasive blood tests that show whether a donated kidney is infected or accruing chronic injuries.
Scientists developed a gene-based strategy for warfarin dosing using data from over 5,000 patients worldwide. The algorithm predicts ideal doses with high accuracy, reducing the need for trial-and-error approaches.
Scientists at Stanford University School of Medicine have devised a new biological marker to monitor mitochondrial disorders, which cause organ failure, seizures, and premature death. The discovery enables researchers to hunt for treatments and helps physicians check patients' status before health crises erupt.
A Stanford study finds that dogs that bred with wolves thousands of years ago passed on a genetic mutation for dark coat color to their wild ancestors. This mutation is now found in nearly exclusive in North America's black wolf population, which has a selective advantage over lighter-colored wolves in forested areas.
A new study by Stanford researchers finds that combined estrogen plus progestin hormone therapy increases the annual risk of breast cancer in postmenopausal women, with a doubling of risk after five years. Stopping hormone therapy can quickly reduce this risk, as observed in a follow-up study.
Cancer stem cells are more resistant to radiation due to a protective pathway that shields normal stem cells from DNA damage. By blocking this pathway, cancer stem cells become more susceptible to killing by radiation.
Researchers at Stanford University School of Medicine identified a key protein involved in pancreatic cancer growth. Blocking its expression slowed or prevented tumor growth in mice and made cultured cancer cells vulnerable to low oxygen conditions.
Researchers at Stanford University School of Medicine have identified a protein called TCAB1, which is crucial for telomerase to repair the ends of chromosomes. This discovery may lead to new anti-cancer therapies by blocking the inappropriate expression of TCAB1 in human cancer cells.
A Stanford study establishes a method for projecting future kidney function, which could improve transplant outcomes for older kidneys. The research found that older kidneys perform only 70% as well as younger ones and contain fewer functioning glomeruli.
A new diagnostic tool can help doctors determine whether stenting is necessary for patients with coronary artery disease. The study found that using this tool resulted in a significant reduction in cardiac events, including death, heart attack, and repeat stenting or bypass surgery.
Stanford researchers have discovered a connection between two aging pathways, SIRT6 and NF-kB, which could lead to a new understanding of how cells age. The study found that SIRT6 regulates gene expression by modifying histones, making it harder for NF-kB to trigger the expression of genes associated with aging.
Scientists at Stanford University School of Medicine and UC-San Francisco have successfully isolated stem cells from human testes, which can differentiate into various types of tissues. The findings suggest that these cells are not as pluripotent as embryonic stem cells but have unique therapeutic applications.
Researchers at Stanford University School of Medicine have discovered that metastatic cancer cells use a protein called lysyl oxidase (LOX) to target specific organs. By blocking LOX expression, the cells' migration and invasion can be prevented, offering a potential new approach to treating human disease.
A leading researcher at Stanford University School of Medicine argues that the time has come to shift from mouse-centered approaches to a broader 'systems biology' approach to tackle human diseases. The current small-laboratory approach has limitations in translating results to humans.
Researchers at Stanford University School of Medicine found that a fruit fly's immune system responds to infections based on its daily cycle and circadian rhythms. The study suggests that understanding the relationship between sleep patterns and immunity could have significant implications for human health.
Researchers successfully recreate a functional stem-cell niche in adult mice, enabling further study of stem cell development and fate. The discovery has potential implications for leukemia treatment and bone healing.
Researchers found a retrovirus in the DNA of a gray mouse lemur, suggesting lentiviruses may have coevolved with primates for millions of years. This discovery could lead to new insights into why non-human primates don't get AIDS and potential treatments for humans.
Researchers at Stanford University School of Medicine have shown that distinct groups of proteins each control one of four simple activities involved in the cells' collective migration. The study overturns an assumption common in genomics and provides a powerful tool for developing new therapeutics.
A new study by Stanford University researchers found that nifedipine, a muscle relaxant, has no effect on prolonging pregnancy after preterm labor is halted. The study suggests that prolonged treatment with nifedipine does not appear to be an answer in preventing premature birth.
Researchers at Stanford University School of Medicine have devised a new way to track the location and survival of specially modified cancer-killing cells in living patients for months and years. The technique uses a reporter gene that is expressed throughout a cell's lifetime, providing repeated snapshots of the cells' status.
A new study from Stanford University School of Medicine found at least 5,600 separate species or strains of bacteria in the human colon, surpassing previous estimates. The research uses pyrosequencing technology to assess bacterial ecosystems and reveals the critical functions performed by intestinal microbes.
Researchers at Stanford University School of Medicine discovered that Wnt-responsive cells in embryoid bodies spontaneously form a primitive streak, which is a hallmark of gastrulation. The study suggests that understanding this process can help direct the differentiation of embryonic stem cells for therapy.
A Stanford study found that gene expression patterns in mice with type-1 diabetes were similar to those in humans before symptoms appeared. The researchers identified clusters of genes that participated in coordinated changes over time, which may provide an early warning for pre-diabetics.
A new study by Stanford researchers found that newer, more expensive diabetes medications do not automatically translate to improved patient outcomes. The study suggests that the higher cost of these medications may be due in part to increased use and diagnosis rates, rather than actual clinical benefits.
Researchers have uncovered an extensive network of regulatory interactions influencing protein production and placement in cells. A pervasive system of biological regulation, similar to transcription factors, guides the fates of most protein-coding RNA molecules by recognizing specific sequences.
Researchers at Stanford University School of Medicine have shown that the nervous system of the minuscule worm Caenorhabditis elegans induces a change in its susceptibility to bacterial pathogen Pseudomonas aeruginosa. By manipulating the secretion patterns of nerve cells, they identified a particular molecule that binds to receptors i...
Researchers at Stanford University School of Medicine have pinpointed the crucial role of Rb proteins in regulating blood stem cell division, finding that blocking their function leads to abnormal proliferation and immune system disruption.