A team from UNIGE and EPFL has demonstrated the Entropic Pulling mechanism of Hsp70 chaperones, a long-debated theory that explains their role in controlling protein quality. The study uses nanopore single-molecule technology to show that Hsp70s generate a strong force to manipulate protein structure, ruling out previous models.
Researchers at UNIGE and HUG have developed CAR-T cells capable of targeting malignant gliomas while sparing healthy tissue. The treatment uses a specific marker on tumour cells and appears to be effective in controlling tumour growth without signs of toxicity.
Researchers found that adult mice with only beta cells have better glycaemic balance and insulin sensitivity than standard animals. Non-beta cells are not essential for maintaining blood sugar levels, contradicting the prevailing conception.
Researchers identified genetic and metabolic characteristics of leukaemic stem cells, including a specific iron utilisation process that can be blocked to kill these cells without harming healthy ones. This breakthrough paves the way for new therapeutic strategies to combat leukemia.
Researchers at UNIGE have discovered how yeast cells respond to physical stress on their membranes. Cryo-electron microscopy revealed that specific lipid domains can stabilize and trigger cellular responses to mechanical stimuli. This study sheds light on the role of membrane compartmentalization in cell survival.
A UNIGE team studied a cohort of patients with a 22q11.2DS microdeletion and found unique «coupling» between structure and activity of their brain regions, leading to either over- or under-coupling. This specificity paves the way for identifying reliable risk markers.
A recent UNIGE study highlights the risks of high-protein diets, also known as Paleolithic diets, which can lead to severe neurological disorders. Excess protein increases ammonium production, overwhelming the liver and potentially causing coma in severe cases.
A UNIGE team has successfully determined the exact moment when the brain detects another person's gaze direction. The study enhances our understanding of autism spectrum disorders and offers therapeutic prospects for people affected by Alzheimer's disease.
Researchers found individuals with schizophrenia struggle to discriminate between reward levels, leading to apathy and motivation deficits. The study suggests potential treatments, including brain stimulation and targeted psychotherapy.
An international team has revealed that sub-Neptunes exist in two distinct populations: dense and less dense. The research suggests a physical link between resonance and density, with planets in resonant systems being less dense due to formation processes involving collisions and fusion.
Researchers from UNIGE have measured the increase in soil erosion caused by global warming, with a four-fold increase observed in sediments from the Paleocene-Eocene Thermal Maximum. This study suggests that current warming could lead to similar effects, increasing flood risks and threatening populated areas.
A study published in Nature Communications reveals that the hippocampus is activated differently depending on whether goals are near-term or distant, suggesting it plays a key role in prioritization. The findings have significant implications for understanding psychiatric disorders like depression.
A study published in Journal of Clinical Oncology found that socioeconomic status significantly impacts the quality of life of women diagnosed with breast cancer. Women from lower socioeconomic backgrounds experience more pronounced physical and psychological side effects, despite similar medical treatment.
Researchers at UNIGE have identified 2700 genetic enhancers that regulate genes responsible for bone growth, providing insights into adult height and potential causes of bone diseases. The study suggests that variations in these enhancers could explain differences in human size and potentially contribute to developmental pathologies.
A study published in the Journal of Archaeological Science: Reports reveals that all members of a Neolithic agropastoral society in Switzerland, including non-locals, had equal access to food resources. The analysis of bone isotopes suggests that this egalitarian society was one of the oldest known in the western part of Switzerland.
A new anticoagulant with on-demand reversible activity has been developed by a team from UNIGE and the University of Sydney. This breakthrough offers a more reliable and easier-to-use option for surgical procedures, reducing the risk of serious bleeding associated with current treatments.
An international team of researchers, including those from the University of Geneva, detected a giant magnetar eruption coming from a neutron star with an exceptionally strong magnetic field. The discovery was made using ESA's satellite INTEGRAL and confirms that magnetars are young neutron stars.
Researchers at UNIGE and ETH Zurich have created biofortified rice lines with enhanced vitamin B1 content, targeting the nourishing tissue of the grain. The modified lines multiplied vitamin B1 levels by 3-4 without compromising agronomic yield, providing a significant advance in combating deficiency.
Researchers at the University of Geneva have successfully visualized and reconstructed the assembly of the human centriole, a critical structure in the cell skeleton. By combining high-resolution microscopy and kinematic reconstruction techniques, they were able to model the first 4D assembly of the centriole, providing new insights in...
Astronomers have detected a 'glory', a luminous phenomenon like a rainbow, in the atmosphere of WASP-76b, an ultra-hot giant exoplanet. The phenomenon occurs when light is reflected by clouds made up of perfectly uniform droplets, which could be iron or water.
Despite therapy, cystic fibrosis patients still suffer from persistent respiratory infections due to unregulated cell signals. By studying lung cells, scientists found a disruption in TGF-β and Wnt pathways, leading to bacterial docking station formation.
A UNIGE team has identified the mechanism of action of PARP inhibitors, used to treat breast and ovarian cancer. By blocking one activity while preserving another, these inhibitors can maintain toxic effects on cancer cells while sparing healthy cells.
Researchers from UNIGE have developed an AI that can learn a task solely based on verbal instructions, then describe it to another AI, which reproduces the task. This breakthrough is promising for robotics and understanding human language.
A study found that maternal obesity increases the risk of developing liver disease and liver cancer in offspring, due to the transmission of an altered gut microbiota. The risk is significantly higher in mice fed a junk food diet, highlighting the importance of microbiome health.
Researchers found that mental representations, as seen in children's and adults' drawings, influence calculation strategies for solving simple arithmetic problems. The study reveals that certain drawing typologies are associated with effective calculation strategies, regardless of age or experience. This discovery opens up new perspect...
A UNIGE team found that impulsivity, not dopamine production, predicts cocaine abuse. The study suggests alternative mechanisms controlling dopamine release may drive individual vulnerability to drugs.
A study published in EuroSurveillance found that 40% of COVID-19 infected individuals were identified through contact tracing, with socio-economic factors influencing reporting rates. The effectiveness of contact tracing alone was relative, but its psychological impact on the population should not be overlooked.
Research reveals that autistic children develop their own unique visual preferences for social elements, unlike typically developing children who synchronize their attention on social interactions. Early intervention targeting social attention may help guide autistic children onto developmental courses more akin to their peers.
Researchers discovered that humans can differentiate between primate vocalizations based on acoustic similarity to human speech. The study suggests that the human brain processes primate calls more efficiently when they are closer in frequency to human language, not just phylogenetically close.
Scientists simulated the runaway greenhouse effect, transforming habitable climates into hostile environments, with significant changes in atmospheric structure and cloud coverage. The study provides key insights for the search of life elsewhere, as it demonstrates a critical water vapor threshold beyond which a planet cannot cool down.
Researchers from UNIGE and ISVV have successfully identified the chemical mark of red wines from seven major Bordeaux estates with 100% accuracy using artificial intelligence. The team analyzed gas chromatograms from 80 wines and applied dimensionality reduction techniques to develop a reliable model.
A study by UNIGE researchers found that six psychological interventions had a small and temporary impact in preventing the spread of climate misinformation. The interventions targeted factors such as trust in climate scientists, transparency, and accuracy, but only one group showed a slight advantage in resisting disinformation.
A UNIGE team has developed a super-model to simulate the spread of three green technologies in Swiss municipalities by 2050. The results show that Switzerland is unlikely to achieve zero net carbon emissions by 2050 without significant policy changes, highlighting the need for increased efforts and updated policies.
A large cross-sectional study of over 2,800 young men in Switzerland found an association between mobile phone use and lower sperm concentration. While no link was discovered to poor sperm motility or morphology, the results suggest that reduced semen quality may be linked to increased mobile phone usage.
Studies reveal subtle variations in time and geographical space between Sapiens and Neanderthals. The presence of about 2% of DNA of Neanderthal origin in present-day Eurasians varies slightly between regions.
A study comparing dreams from Western and non-Western populations found that non-Western groups produced more cathartic and socially-oriented dreams, while Western groups had more threatening but less emotionally resolving dreams. The results suggest a strong link between societal norms and the function of dreams.
A UNIGE team has developed an electrical device that can activate and accelerate chemical reactions using a simple electric field. The device, called an electrochemical microfluidic reactor, enables chemists to control chemical reactions with ease, reducing the need for complex strategies and resources.
A UNIGE team investigated the destruction of neurons at different times of the day using fruit fly models and found that cellular stress was more deleterious to neurons at night. This suggests that the circadian clock exerts a protective effect on dopaminergic neurons against oxidative stress.
An international team has decoded the TSPO protein to visualize neuroinflammation, revealing its relationship with microglial cells. The study's findings pave the way for optimizing observation of neuroinflammatory processes and re-reading previous studies.
Researchers at the Swiss Cancer Center Léman have discovered a way to prolong the functionality of CAR-T cells, which are used against blood cancers. By inhibiting a specific metabolic mechanism, they created CAR-T cells with enhanced immune memory, capable of fighting tumour cells for longer.
A team from Université de Genève and University of Teacher Education, State of Vaud conducted an innovative field study on pedagogical authority. They found that 'double addressing' strategies, combining direct and indirect communication, are particularly effective in exercising teaching authority. This approach allows teachers to prev...
A study of 50,000 COVID-19 cases found that immunity following infection provides better protection against transmission than vaccination, but only for a short period. Vaccination reduces contagiousness over a longer time, making it essential to consider simple public health measures like air filtration and mask-wearing.
A UNIGE team has identified a new mechanism governing microtubule growth, involving two proteins that form a liquid-liquid phase separation at the tip of the microtubule. This discovery opens up unprecedented prospects for developing new treatments that can act at the heart of cells.
A UNIGE team has developed a method to rapidly obtain valuable information about the structure of volcanoes. By analyzing three key parameters: height, rock thickness, and chemical composition of magma, scientists can identify the active volcanoes most likely to produce large-scale eruptions.
A new imaging technique, tau PET, has been shown to predict cognitive decline in Alzheimer's patients with greater accuracy than current methods. This breakthrough could lead to earlier diagnosis and treatment, improving patient outcomes.
A team of scientists from UNIGE, Northwestern University, and the University of Florida used POSYDON code to simulate binary-star populations, predicting the existence of massive 30 solar mass black hole binaries in Milky Way-like galaxies. This challenges previous theories and provides new insights into the astrophysical origins of me...
Researchers from UNIGE have developed a new method to test the validity of Einstein and Euler's theories on the accelerating Universe expansion and dark matter. The study uses time distortion as a never-before-used measure, allowing for differentiation between the two equations.
Researchers at UNIGE have identified a new type of molecular sensor that enables the malaria parasite to infect human cells or mosquitoes at just the right moment. By understanding how this sensor works, scientists can potentially scramble its signals to disorientate the parasite and block its multiplication and transmission.
A team from UNIGE created a book with tactile illustrations that associate sounds with objects, enabling visually impaired children to identify them more easily. The combination of gestures, shapes, and sounds helps bridge the gap between visual and tactile experiences.
A UNIGE team has identified how the influenza A virus manages to penetrate cells to infect them by hijacking the iron transport mechanism. By blocking this receptor, researchers were able to significantly reduce its ability to invade cells, highlighting a potential strategy for treating influenza virus infections.