University at Buffalo researchers have made significant breakthroughs in genetic engineering of micro-organisms into cellular factories, enabling the production of high-value chemicals and pharmaceutical compounds. The team has successfully produced flavonoids with yields far above previous microbial synthesis efforts.
A new study by University at Buffalo's Research Institute on Addictions found a strong correlation between malt liquor consumption and marijuana use. Young adults who drink malt liquor are more likely to develop alcohol problems and use illicit drugs.
UB researchers discover that certain solvents can significantly impact acid-base interactions, strengthening chemical bonds between molecules. The study suggests a new tool for initiating these interactions in important biological enzymes.
Researchers at the University at Buffalo have found that copper absorption increases when iron levels decrease, suggesting a crucial role for copper in maintaining iron homeostasis. The study aims to understand the molecular mechanisms behind this relationship and its implications for human health.
A study by University at Buffalo endocrinologists found that flavonoids in orange juice suppress destructive oxygen free radicals, reducing oxidative stress and inflammation in healthy participants. The two types of flavonoids, hesperetin and naringenin, inhibited ROS generation by 52% and 77%, respectively.
A randomized clinical trial found that selenium supplementation increased the risk of developing type 2 diabetes by 55%, with higher levels associated with a greater risk. The study suggests that taking high doses of selenium may have detrimental effects in well-nourished populations.
Researchers at Hauptman-Woodward Institute have solved the structure of a novel protein in Pseudomonas, a bacterium that causes cystic fibrosis and tuberculosis. The discovery may lead to the development of new antibiotics to prevent infection in patients with CF and TB.
A 19-year study found that primate tourism practices can lead to adult aggression, disease transmission, and increased infant mortality. The study suggests that range restriction and provisioning for tourists contribute to the problem, making them an inappropriate management strategy.
Researchers at University at Buffalo developed a method to isolate functional smooth muscle cells from bone marrow, which can be used in regenerative medicine for cardiovascular applications. The engineered blood vessels function similarly to native tissue, demonstrating potential as an alternative to venous grafts.
Researchers at the University at Buffalo discovered that high levels of cystatin C can predict an increased risk of developing pre-diabetes. The study, based on the Western New York Health Study, found a three-fold association between cystatin C levels and progression to pre-diabetes.
A new study suggests that women who suffer from morning sickness during pregnancy may be less likely to develop breast cancer later in life. The study found a 30% lower risk of breast cancer among women with nausea and vomiting compared to those without, suggesting potential protective effects against cancer cells.
A four-year study investigates how dietary iron is used by cells, addressing endemic iron deficiency affecting 80% of the world's population. The researchers aim to understand cellular iron metabolism, a key process impacted in various human diseases.
Researchers at University at Buffalo discover how enzymes work, providing insight into catalysis complexity and potential for improving synthetic catalysts. The study reveals interactions between enzymes and substrates are critical for large catalytic rate accelerations.
A study of postmenopausal women has found that infection with four known gum-disease-causing bacteria is associated with more severe oral bone loss. The two most prevalent pathogens were P. gingivalis and T. forsythensis, found in 15.1% and 37.9% of the participants.
A content analysis of newspaper stories on organ and tissue donation found 57% positive and 14% negative articles. The most frequently referenced topics were kidneys, post-transplantation health, and the critical shortage of organs.
Women who drink in moderation have a significantly lower risk of heart attack compared to abstainers, with daily drinkers experiencing the most benefits. Moderate drinking reduces heart attack risk regardless of beverage preference or pattern.
Researchers at the University at Buffalo have discovered a significant association between chronic gum disease and the risk of tongue cancer. The study found that every millimeter of alveolar bone loss increases the risk five-fold, with no effect from other conditions.
Researchers identified DNA hypermethylation in E-cadherin, p16, and RAR-B2 genes as common in breast tumors. The study found that these alterations were more frequent in ER-negative and PR-negative tumors, but not associated with other clinicopathological features.
Researchers at the University at Buffalo are investigating endocannabinoid, the 'brain's own marijuana,' to regulate stress and anxiety. The study aims to develop a new pharmacotherapy strategy for stress-related mood disorders.
The University at Buffalo team conducts research on Baffin Island's fjords and sediments to reconstruct past climates and study the effects of climate change. They also educate the local Inuit community about global warming's impact on their traditional way of life.
Researchers at University at Buffalo developed a seismic design methodology for bridge towers that allow them to rock during earthquakes, reducing construction and retrofitting costs. The new approach uses devices to control the tower's uplift and absorption of earthquake energy.
A University at Buffalo study finds that IL-17, a primary cause of bone destruction in autoimmune diseases like rheumatoid arthritis, protects bones from infectious pathogens in the oral cavity. Researchers discovered that blocking IL-17's receptor increases susceptibility to periodontal disease.
Researchers at the University of Buffalo have developed a device that can rapidly detect infectious viruses in biological samples. The innovation uses nanoparticles to transport viral particles to specific locations, allowing for quick detection and paving the way for an 'on-the-spot' virus detector.
A recent study published in Law and Society Review reveals that pro bono work is influenced more by institutional factors than personal goodwill. The research found significant variations in attitudes towards pro bono work among lawyers in different practice settings, including small firms, large firms, solo practices, and in-house cou...
Third- and fourth-year dental students at the University at Buffalo are using tobacco counseling to encourage patients to quit. After eight hours of training, they adhere to a modified version of the '5 As' protocol, showing a 51% success rate in getting patients to quit immediately. Over six months, 32% of patients remain smoke-free.
Research at University at Buffalo School of Dental Medicine found that bacteria from dental plaque can cause ventilator-associated pneumonia. The study identified a strong relationship between oral and respiratory pathogens, suggesting that proper dental care may prevent lung disease.
Researchers at the University at Buffalo have discovered that estradiol helps maintain bone density by stopping the activation of caspase-3, an enzyme involved in osteoblast apoptosis. This finding suggests that estrogens may prevent both bone loss and fractures through anti-apoptotic effects on bone cells.
Researchers at the University at Buffalo have developed a novel drug delivery system using nanocrystals of hydrophobic drugs, which can target tumors with comparable efficacy to conventional surfactant-based systems. The system eliminates the need for separate carriers, reducing toxicity and improving drug penetration.
A study by researchers at the University at Buffalo's Research Institute on Addictions found that 18% of young women experienced sexual victimization over a two-year period. The majority (66%) of these cases involved intimate partners, highlighting the need for tailored prevention strategies to address both types of victimization.
A new clinical trial aims to investigate whether low-dose aspirin can improve pregnancy outcomes for women who have miscarried. The study will enroll 535 women and follow them for five years to assess the impact of aspirin on implantation, blood flow, and preeclampsia.
Researchers found that women with pre-diabetic markers are at higher risk of cardiovascular disease and may benefit from more intense screening. The study suggests that the 'diabetes clock' starts ticking sooner for women than men, contributing to sex differences in heart disease mortality.
Researchers found that individuals with high appearance-based rejection sensitivity experience low self-esteem, neuroticism, and disordered eating habits. Self-affirmation and close relationships can buffer these negative effects, reducing symptoms of anxiety and depression.
Researchers at University at Buffalo are testing a nasal spray anesthetic and ozone delivery device to eliminate drilling and injections in dental procedures. The studies aim to improve patient comfort and reduce pain associated with dental care.
Researchers have gathered quantitative temperature data from arctic lake sediments and glaciers, revealing temperatures five degrees warmer than today. This finding provides a climate analogue to inform future predictions, highlighting the exceptional magnitude and rate of warming in the Arctic.
Researchers found that resistance-breathing training and endurance respiratory muscle training improved swimming endurance by 33-38% and breathing capacity. The study also showed significant improvements in underwater scuba swimming time by 66%.
A monoclonal antibody JAA-F11 has been shown to extend the survival of mice with human breast-cancer tumors and inhibit their spread to the lungs, a result attributed to its ability to block adhesion and growth stages of cancer cells.
A longitudinal US study explores how individuals respond to national trauma and their long-term health outcomes. The research found that people's initial emotional response to a disaster, their approach to coping with the trauma, and their demographic background significantly impacted their health over time.
A study at the University at Buffalo found that synthetic cannabinoid AM-1346 can improve fertility in male smokers with poor semen quality, doubling fertilizing capacity. Researchers believe a communication imbalance between cannabinoid and cholinergic receptor systems may be responsible for nicotine-induced infertility.
A study found that only 14 of 15 hospitals provided inadequate discharge information, with most instruction sheets written at a high reading level. The researchers propose an evidence-based emergency department discharge form to improve patient safety and reduce the risk of brain hemorrhage or swelling.
Researchers developed a new method for treating post-concussion syndrome, known as regulated exercise, which involves individualized exercise programs to improve brain function and reduce symptoms. The treatment has shown promising results in reducing depressive symptoms and improving patient outcomes.
Researchers found five proteins overexpressed and three underexpressed in response to chronic alcohol exposure, affecting programmed cell death, cholesterol balance, and signal transduction. The study suggests a progressive increase in behavior disruption with prolonged exposure, highlighting the potential for new therapeutic targets.
Researchers found that Botox injections can minimize scarring by temporarily weakening surrounding muscles during the healing phase. The treatment showed significant improvement in wound-healing results, with median scores of 8.9 for botulinum toxin versus 7.1 for saline.
Researchers at University at Buffalo found that methamphetamine increases expression of DC-SIGN receptor, allowing more virus to invade the immune system and promote HIV infection. The study suggests that dopamine receptor blockers could be beneficial in reducing HIV infection in high-risk populations.
Researchers have developed a 'Fingertip Digitizer' that can transfer the meaning and intent of common hand gestures to virtual worlds, allowing for greater precision and control. The device can also sense physical characteristics of objects and detect health anomalies.
Researchers at the University at Buffalo are part of a global effort to prevent type 1 diabetes through a $172 million grant from the National Institutes of Health. The project aims to identify 100,000 individuals at risk and test interventions to halt the onset of the disease.
Researchers aim to determine if metabolic changes in 'hibernating' heart cells limit their ability to recover after revascularization. The grant builds on previous work using a novel pig model with hibernating myocardium.
Researchers found that occupants of the middle back seat are 59-86% safer than front-seat passengers and 25% safer than other back-seat passengers. The study analyzed data from fatal crashes in the US between 2000 and 2003, controlling for various factors to confirm the safety advantage of the middle back seat.
Researchers at UB aim to improve heart function in hibernating myocardium using bone marrow mesenchymal stem cells. The study will investigate the effects of aging on MSC potency and develop optimized therapeutics for managing chronic coronary artery disease.
A team of researchers led by UB microbiologist Steven R. Gill analyzed the DNA of microbes in the human distal gut using metagenomics. The study found significant differences between two microbial communities from healthy individuals, highlighting the importance of understanding the interactions between human and microbial genomes.
Researchers found that examiners can replicate tension-headache symptoms in 82% of subjects by testing the temporalis muscle, which is involved in TMJD. This study aims to establish valid and reliable diagnostic criteria for TMJD, which could improve treatment outcomes for those suffering from the disorder.