A new approach to treating tuberculosis could significantly reduce treatment time and improve patient outcomes. Researchers identified an effective four-drug regimen that kills TB bacteria in the lungs and cures mice up to four times faster than current treatments.
Researchers have found that women's mental sharpness starts to decline as early as their 50s, with an average decline of 5% over 10 years. Cognitive processing speed and verbal memory also show significant declines, highlighting the importance of menopause transition in understanding cognitive changes.
A new study from UCLA suggests modifying federal health guidelines to use a risk calculator that takes into account more factors, potentially increasing effectiveness of PrEP in preventing HIV transmission. The calculator uses real-world data and is expected to be useful for gay and bisexual men who have sex with men.
Researchers will create a detailed map of the heart's nerves to develop new therapies targeting neural structures and improve electrical stimulation therapies. More than 800,000 US deaths annually from cardiovascular diseases link to the autonomic nervous system.
Researchers found that temporarily blocking type I interferon can restore immune function and speed up viral suppression in HIV-infected mice. This approach may help eradicate HIV throughout the body when combined with antiretroviral therapy.
A UCLA study found high rates of moderate-to-high drug use in East Los Angeles (19.4%) and Tijuana (5.7%). Screening could steer people away from risky drug use with just a few minutes of counseling.
A recent study published in the New England Journal of Medicine found that Zika-linked abnormalities in human fetuses are more common and severe than initially thought. Out of 125 pregnancies among Zika-infected women, 46% resulted in birth defects or fetal death, with microcephaly being only one of several complications.
Researchers define how genetic factors affect blood-forming stem cells' regenerative properties, accelerating or hindering their ability to restore the immune system. The findings highlight two molecular mechanisms that could be manipulated to increase hematopoietic stem cell regeneration.
A special edition of the International Journal for Equity in Health examines Brazil's improved access to medical care and highlights areas where health inequalities persist. The study finds disparities in healthy life expectancy, chronic diseases, mental health care, and violence across different regions and socioeconomic groups.
A comprehensive model estimates the cost of providing a set of essential medicines to all people in low- and middle-income countries. The model suggests that it would cost $13 to $25 per capita annually to ensure access to these medicines, with total costs ranging from $77 billion to $152 billion.
Researchers found that surgical reconstruction of the phrenic nerve can lead to significant improvement in breathing and an increase in regular physical activities. Eighty-nine percent of patients reported overall improvement in breathing function.
A recent study published in Menopause found a gene variant associated with hot flashes in postmenopausal women. The study examined genetic variations across the human genome and discovered that specific variants on chromosome 4 linked to the tachykinin receptor 3 were more common among women experiencing hot flashes.
Researchers found that CTA tests led to higher adoption of preventive measures and healthier lifestyle practices compared to exercise electrocardiography and stress tests. After 60 days, more people who underwent CTA tests started taking aspirin, statins, and beta-blockers, and eating healthier, with lower rates of obesity.
A new study aims to evaluate treatment strategies for older adults with depression who have not responded to medications. The researchers will compare the effectiveness of switching people to a new medication or augmenting their current medication with a second drug.
A UCLA-Caltech study has pinpointed the individual neurons in the brain that support observational learning, a skill essential for human decision-making. The research team discovered that these neurons fire in response to schadenfreude, the pleasure of seeing someone else make a mistake.
A UCLA study finds that Latinos age more slowly at the molecular level, with an epigenetic clock measuring their age as 2.4 years younger than non-Latino women of the same age after menopause. This discovery may help scientists understand how to slow the aging process for everyone.
A new study by UCLA researchers found that Bisphenol S (BPS) damages a woman's eggs at lower doses than BPA. The study exposed roundworms to various concentrations of BPA and/or BPS, revealing decreased fertility in those exposed to either chemical.
The study found that despite progress toward universal coverage, citizens still reported gaps in primary care organization, financing, and delivery in six Latin American and Caribbean countries. People with better experiences at the primary care level were less likely to say their health system needed major reforms.
Researchers developed a noninvasive device that tricks premature infants' brains into thinking they're running, reducing apnea of prematurity incidents and low oxygen levels. The device uses vibrating disks on the skin to stimulate nerve fibers, promoting increased breathing.
Researchers found an association between low physical activity and a higher risk for dementia in older individuals, with regular exercise potentially leading to higher brain volumes and reduced dementia risk. The protective effect was strongest in people aged 75 and older.
UCLA studies find that menopause speeds up cellular aging by an average of 6 percent, making women biologically older than their chronological age. Insomnia also accelerates aging, with postmenopausal women experiencing nearly two years more biological aging due to five insomnia symptoms.
Researchers from UCLA have discovered a type of cell called chimeric antigen receptors that can be used to kill HIV-infected cells. CARs are artificially created immune T cells engineered to produce receptors designed to target and kill specific cells containing viruses or tumor proteins.
Researchers found that Grindr's ad campaign effectively reached untested high-risk populations, increasing the distribution of HIV self-testing kits. The study showed that 74% of test recipients had last been tested for HIV over a year ago, highlighting the need for targeted testing initiatives.
A UCLA-led study found that nearly half of California nursing home residents completed Physician Orders for Life-Sustaining Treatment forms in 2011. The study also identified areas where the use of these forms could be improved, including facilities with low completion rates and a lack of signatures on some forms.
The National Institutes of Health has awarded a five-year grant of $69.6 million to support the UCLA Clinical and Translational Science Institute's research partnership, building on previous funding totaling over $152.7 million. The consortium aims to accelerate the translation of laboratory discoveries into effective treatments for pa...
A UCLA-led study estimates that nearly 28,500 deaths in the US could be prevented annually through use of a new FDA-approved class of cardiovascular medication. The therapy helps reduce mortality in patients diagnosed with heart failure and reduced ejection fraction by enhancing protective hormonal systems.
Researchers found that eliminating α-synuclein protein protects zebrafish from ziram-induced dopamine loss and provides potential treatment for pesticide-exposed Parkinson's patients. This study supports the approach of targeting α-synuclein to slow or stop disease progression in most people with Parkinson's.
Researchers at UCLA have found laser heat ablation to be a safe and effective treatment option for men with intermediate risk prostate cancer, with no serious adverse effects reported. The technique uses MRI guidance to target and destroy cancerous tissue, offering a middle ground between radical surgery and active surveillance.
Researchers identified a possible intervention for age-related memory problems by exploring how the brain links two memories and whether time affects their connection. Boosting neural excitability may reverse age-related inability to link memories.
Researchers found that surgeons differ in recommending surgery based on how they perceive risks and benefits, rather than just the patient's diagnosis. A surgical risk calculator can lead to more accurate predictions, but does not change a surgeon's likelihood of recommending an operation.
A new UCLA study finds no evidence to link the anti-nausea drug Zofran to an increased risk of birth defects. Women with extreme morning sickness who took Zofran reported fewer miscarriages and higher live birth rates compared to those without the medication.
A UCLA study found a significant decline in funding for the US government's HIV/AIDS initiative, PEPFAR, from $448.6 million in 2013 to $302.8 million in 2014. This drop is concerning as many countries rely on PEPFAR for vital health care services.
A new study by UCLA researchers reveals that children in households with less than three months of savings are at a higher risk of obesity and chronic illnesses. Having enough savings to cover basic expenses for three months is crucial in avoiding debt and maintaining good health, according to the study.
Researchers found significant increases in health insurance coverage, quality of coverage, and diagnoses for chronic health conditions among low-income adults in states that expanded Medicaid under the Affordable Care Act. The study's findings provide valuable insights for policymakers and residents in states with ACA Medicaid expansions.
A UCLA study found that anti-inflammatory gut bacteria can slow or stop the development of certain types of cancer. Researchers discovered that a specific bacterium, Lactobacillus johnsonii 456, reduced gene damage and inflammation in mice with cancer, leading to a lower risk of tumor formation.
A state-of-the-art molecular genetic test, exome sequencing, has been found to greatly improve the diagnosis of neurogenetic disorders in children and adults. The test can identify disorders that may have gone undiagnosed for years with greater speed and accuracy.
A new study by UCLA researchers proposes expanding the use of recycled water to reduce water and energy consumption, lower greenhouse gas emissions, and improve public health. The strategy has potential global applications, particularly in addressing water scarcity and related health issues.
Researchers found that IGF2BP3 regulates various RNA messages contributing to the development of MLL-rearranged leukemia. The protein binds to and stabilizes hundreds of leukemia-promoting messages, leading to cancer cell growth.
A study by UCLA researchers found associations between Zika infection and grave outcomes, including fetal death, placental insufficiency, and central nervous system damage. The study suggests that Zika can cause a range of abnormalities in pregnant women, even if the fetus is not directly affected.
Researchers found that charges are inflated by a factor of three to one, disproportionately affecting the underinsured and uninsured. The study suggests targeting office-based events and procedures rather than operating room interventions for improved value within surgical care.
A UCLA study reveals that cancer surgery significantly increases the risk of injuries and age-related health issues in older patients, leading to prolonged hospital stays, increased healthcare costs, and a higher risk of death. The study highlights the importance of discussing potential events with doctors before surgery.
Scientists at UCLA have developed a new approach using CRISPR/Cas9 to correct genetic mutations that cause Duchenne muscular dystrophy. The approach, which can be used in clinical trials within 10 years, has the potential to treat 60% of patients with the deadly disease.
A study published in the Journal of the American Medical Informatics Association found that follow-up emails from doctors are crucial to keeping patients informed about their care. Patients who continued receiving reminders tended to access their notes more frequently, leading to better health outcomes.
A recent study published in JAMA Internal Medicine found that remote telemonitoring did not significantly reduce all-cause 180-day hospital readmissions among heart failure patients. Despite this, the intervention group reported improved quality of life at 180-days compared to usual care patients.
Researchers identified two tiny clusters of neurons responsible for transforming normal breaths into sighs. Sighing is vital to lung function and helps preserve lung function, but frequent sighing can be debilitating.
New UCLA research demonstrates that BPS, a common replacement for BPA, speeds up embryonic development and disrupts the reproductive system. Exposure to low levels of BPA and BPS alters physiology in as quickly as 25 hours, leading to premature birth and disruption of reproductive endocrine brain cells.
A new UCLA study found that hospitals with shorter lengths of stay and higher readmission rates tend to use more post-acute care services. This can lead to patients being discharged prematurely, resulting in higher readmission rates.
Researchers review studies on PrEP and aspirin, finding similar low rates of serious side effects. PrEP works well to prevent HIV when taken daily, supporting efforts to make it available over-the-counter.
UCLA scientists have discovered a crucial role for the Rbfox1 gene in regulating genes that contribute to autism risk. The study highlights an untapped region in brain cells as a goldmine of drug targets for new treatments.
A new study from UCLA Health Sciences reveals that Mexico's homicide rate has taken a devastating toll on men's life expectancy, with life expectancy among men ages 15-50 falling by 0.6 percent between 2005 and 2010. The murder rate in Central America and Mexico more than doubled during the same period, leading to increased mortality r...