A UCLA study found that patients with bladder cancer who did not receive optimal biopsies had a significantly higher risk of death from the disease. In fact, about half of patients' biopsies lacked sufficient material to accurately stage their cancer, leading to incorrect tumor staging and increased mortality rates.
A new study found that US osteoporosis screening guidelines failed to identify the majority of younger post-menopausal women who experienced major fractures. The guidelines recommended testing and treatment for women aged 65+, but only predicted fractures in around 25% of those aged 50-64.
A new test using DNA sequencing identifies single mutations causing rare genetic disorders in children, improving diagnosis rates from 5% to 40%. The UCLA Clinical Genomics Center uses the test to provide concrete diagnoses and treatment plans for families seeking answers.
Researchers at UCLA have discovered that fibroblasts can transform into endothelial cells, which form blood vessels. This finding suggests a potential new strategy for improving heart repair after a heart attack.
The UCLA Center for Healthier Children, Families and Communities has established a national Health Care Transitions Research Network for individuals with autism spectrum disorder (ASD), focusing on research to improve physical, psychosocial, educational and vocational outcomes for adolescents and young adults with ASD.
Researchers used an epigenetic clock to measure the biological age of liver tissues in obese subjects, finding a significant acceleration of liver aging. The study suggests that obesity may contribute to the premature development of age-related diseases such as liver cancer and insulin resistance.
The University of California, Los Angeles (UCLA) will develop new strategies for mining and understanding complex biomedical data sets. The center's findings will help shape guidelines for future data integration and use.
The UCLA Children's Discovery and Innovation Institute has named three recipients of the inaugural Harry Winston Fellowships, supporting young pediatric physician-scientists conducting research to prevent, treat, and cure diseases in children. Dr. Kristina Adachi, Dr. Leslie Kimura, and Dr. Edward Talya will receive funding for their p...
Researchers found that combining resveratrol with benzoyl peroxide reduces bacteria counts more effectively than either compound alone. The combination treatment may lead to new, less irritating topical acne therapies.
Researchers found that medical students from underrepresented minority backgrounds are more likely to have attended a community college at some point. Additionally, community college students who were accepted to medical school were more likely to commit to working with underserved populations.
Researchers have discovered a link between genetic factors and the development of early-onset ulcerative colitis. The study's findings suggest that phosphatase and tensin homologue (PTEN) may play a role in helping the disease develop, and that altering the gut microbiome could be a key to prevention.
Researchers discovered a peptide mimicking high-density lipoprotein (HDL) protein helps reduce oxidized lipids in pulmonary hypertension, improving heart and lung function. The study also found elevated levels of oxidized proteins in rodents with the disease, which can be targeted for treatment development.
A UCLA study found that men with low prostate cancer knowledge experience increased decisional conflict and lower perceived effectiveness of treatment. Doctors can help by providing educational information before consultations to increase patients' comprehension and reduce regret.
A UCLA-led study discovered a protein called interleukin-32 that helps protect people with latent tuberculosis from developing the active form of the disease. The researchers found that vitamin D levels play a crucial role in this protection, and supplementing with vitamin D may help prevent TB.
A study by UCLA and RAND Health found that providing futile treatment in the ICU sets off a chain reaction, delaying critical care for other ill patients. The study shows that on 16% of days when ICUs were full, one patient received futile treatment, causing others to wait longer for admission.
A new vaccine, rBCG30, offers superior protection against tuberculosis in animal models and cross-protection against leprosy. Boosting rBCG30 with the Antigen 85B protein significantly enhances its effectiveness against leprosy.
A new UCLA-led research study has found that racial and ethnic minorities who receive implantable devices to treat heart failure derive the same substantial survival benefit as white patients. The study, involving over 15,000 patients, monitored two years of data from a registry to improve heart failure therapies in outpatient settings.
A new disposable biosensor may help physicians determine which patients can safely be fed following surgery by monitoring intestinal movements. The device, AbStats, uses sound waves to measure the rate of acoustic events in the intestines, allowing doctors to make evidence-based decisions about post-operative feeding.
A UCLA-led analysis found that changes in treatment over the past decade have associated with higher survival rates for all patient groups, regardless of age or risk factors. The study tracked 6.5 million patients treated for heart attacks between 2002 and 2011 and found improved outcomes with earlier cardiac catheterization
A new UCLA study reveals that California diabetics living in low-income neighborhoods are 10 times more likely to lose a toe, foot or leg than those in affluent areas. The research highlights the need for earlier medical care and expanded access to treatment to prevent amputations.
Researchers found that diverticulitis patients suffer from chronic symptoms such as anxiety, depression, bloating, and abdominal pain, which can significantly impact their quality of life. The study aims to develop a screening tool to better assess the long-term impact of diverticulitis.
A team of researchers from UCLA discovered that autophagy, a process that clears damaged proteins, is impaired in people with Type 2 diabetes, leading to the destruction of insulin-producing beta cells. This impairment contributes to the accumulation of toxic IAPP protein.
A new UCLA-led study reveals that high-performing public charter high schools in Los Angeles significantly reduced the likelihood of engaging in risky health behaviors, such as tobacco and alcohol use, among low-income minority adolescents. These students also scored better on standardized tests and exhibited improved cognitive skills.
A team of experts at UCLA will collaborate to create, implant, and test a memory prosthesis to help restore lost memory functions in brain-injured individuals. The project aims to stimulate the entorhinal area, a key region involved in learning, memory, and Alzheimer's disease.
A UCLA study found that depressed men with localized prostate cancer were more likely to be diagnosed with aggressive cancer, received less effective treatments, and had shorter survival times. The study identified demographic factors that contributed to the disparity in treatment and outcomes.
The UCLA Center for East–West Medicine has published a document to help students, educators, and practitioners evaluate and digest Chinese medical texts with greater sensitivity and comprehension. The 15-page document addresses translation-specific issues, technical terminology, and cultural perspective to promote accurate translations.
UCLA's David Geffen School of Medicine has received a $7.2 million NIH grant to tackle rare genetic disorders through comprehensive bedside-to-bench clinical research. The program aims to provide answers to patients living with undiagnosed diseases by analyzing patients' genomes and identifying environmental factors that lead to disease.
A working group recommends removing sexual orientation-related disorders from the ICD to improve healthcare access for LGBTQ individuals. The move could lead to improved treatment and reduced risk of mistreatment, such as conversion therapy.
A new study by Dr. Andrew Hudson and colleagues provides clues about the brain's processes used to navigate from unconsciousness back to consciousness after anesthesia. The researchers found that the brain activity occurred in discrete clumps, or clusters, and that certain patterns consistently occurred in anesthetized rodents.
Surgical residents who received anonymous peer feedback through a social networking site improved their robotic surgery skills more than those without feedback. The study found that residents in the intervention arm completed procedures faster and earned better scores.
Researchers developed a new design for preventive health care from birth to age 3 in low-income communities, focusing on family-centered, effective, and efficient care. The study suggests two working groups improved well-child visits by providing longer visit times, trained health educators, and online resources.
A new UCLA study found that depression, lower education levels, physical inactivity, and high blood pressure increase the likelihood of self-perceived memory complaints across all adult age groups. Memory issues rose with more risk factors, affecting 20% of those polled.
A UCLA research team has discovered a new hormone called erythroferrone, which regulates the iron supply needed for red blood-cell production. Erythroferrone suppresses hepcidin, allowing more iron to be made available for red blood-cell production and potentially treating iron disorders.
A new UCLA-led study found that depression is linked to a far greater chance for early death among adults 65 and older with diabetes, compared to those without depression. The researchers suggest that depressed individuals are less likely to adhere to their prescribed medications and lifestyle changes.
A new UCLA study reveals that conventional biopsies may fail to detect aggressive cancers in men with low-risk prostate cancer, highlighting the need for a targeted biopsy approach. The findings suggest that the criteria for active surveillance should be re-evaluated to account for the risk inflation seen with targeted prostate biopsy.
A new study suggests that physician partners can lighten the administrative load of primary care physicians, allowing them to spend more time with their patients. The study found that geriatricians who worked with a physician partner had shorter patient visits and higher patient satisfaction rates compared to those without a partner.
A study by UCLA researchers found that treating older men with early-stage prostate cancer who also have other serious underlying health problems with aggressive therapies does not help them live longer. In fact, it can be detrimental and result in additional health issues such as impotence, urinary incontinence, and bowel problems.
A UCLA research team has made significant progress in developing a computer-aided diagnostic system to accurately distinguish between epileptic and non-epileptic seizures. By analyzing clinical notes from patients with medication-resistant seizure disorder, the team achieved a diagnosis accuracy of 65% using machine learning methods.
Researchers used a genetic approach to find that cortical neurons play a key role in initiating the disease, while shutting down mutant huntingtin in both sets of cells corrected symptoms. The study suggests new targets for therapeutic drugs to slow the devastating disease.
A new UCLA-led study suggests that people taking statins in the 2009-10 year consumed more calories and fat than those who used statins 10 years earlier. Researchers found a significant increase in caloric intake among statin users, with no similar change among non-statin users.
Hospitals participating in UCLA's Target: Stroke program have increased tPA administration speed, leading to improved patient outcomes, including reduced mortality and increased independence. The average time-to-treatment fell from 74 minutes to 59 minutes.
A community-based HIV prevention effort boosted testing rates by 45% and reduced new infections by 14% in Africa and Thailand. The intervention also led to increased social acceptance of testing and lower rates of sexual partners among infected individuals.
The UCLA/RAND community research team won a prestigious award for their 10-year effort to improve depression care in low-income areas. The team's collaborative approach showed that community engagement can provide measurable added value, leading to improved mental and physical health outcomes.
A UCLA-led study found that higher education levels are associated with lower rates of bone fractures among non-white women. The study followed over 2,000 pre-menopausal women for nine years and found that those with at least some postgraduate education had an 87% lower non-traumatic fracture rate than those with less education.
Dr. Ira Kurtz's research aims to understand the molecular processes affecting kidney function, with a focus on designing specific drugs targeting disease-causing proteins. The goal is to reduce side effects and costs associated with current treatments, which affect millions of people worldwide.
A UCLA study found that increasing Kir4.1 levels in astrocytes improves walking and prolongs survival in a mouse model of Huntington's disease. The discovery could lead to new drug targets for treating the devastating disorder, which affects one in every 20,000 Americans.
A new study from the University of California - Los Angeles Health Sciences found that older Americans with more muscle mass are less likely to die prematurely. The research suggests that clinicians should focus on improving body composition rather than relying solely on body mass index (BMI) when counseling older adults.
Researchers from UCLA have updated guidelines for managing skin abscesses associated with community-acquired MRSA. The new guidelines focus on improving diagnostic accuracy and treatment options, including the use of ultrasound and preferred antibiotics like trimethoprim-sulfamethoxazole and doxycycline.
A UCLA-led team of researchers has found evidence that photosensitizing a virus's membrane covering can inhibit its ability to enter cells. This process could lead to the development of stronger, cheaper medications to fight a host of tough viruses.
Researchers used Twitter 'big data' to track HIV incidence and drug-related behaviors, mapping where tweets originated and linking them with geographic distribution of HIV cases. The study suggests that monitoring tweets can predict sexual risk and drug use behaviors, potentially preventing outbreaks.