Researchers at UCLA discovered that vitamin A and a specific gene assist the immune system by reducing cholesterol levels in TB-infected cells, allowing lysosomes to kill bacteria effectively. This finding may lead to new treatment approaches for tuberculosis.
Researchers develop a method to predict future clinical events using genomic testing over multiple patient visits. The AlloMap test can assess the risk of dysfunction or rejection of a transplanted heart months before such an event may occur.
A study found that giving stroke patients intravenous magnesium within an hour of symptom onset does not improve stroke outcomes, while working with paramedics can increase the chances of administering potentially brain-saving drugs in time. The researchers plan to continue searching for new treatments and are grateful for the collabor...
A new study by UCLA researchers found that certain pesticides inhibit an enzyme called ALDH, which converts toxic aldehydes into less harmful agents, increasing the risk of Parkinson's disease. The study identified 11 pesticides that increase the risk, particularly in individuals with a common genetic variant of the ALDH2 gene.
Researchers found that the current US Preventive Services Task Force strategy identifies only 34% of women in this age group with osteoporosis. This could lead to missed opportunities for fracture risk reduction among high-risk women.
A UCLA team developed an easy-to-use risk calculator that predicts heart failure patients' chances of survival for up to five years. The calculator uses four key variables: B-type natriuretic peptide level, peak oxygen consumption, New York Heart Association classification, and heart failure medications.
A new UCLA study found that married men who waited until 25 or older to get married had stronger bones than those who got married earlier. In contrast, women with supportive partners had greater bone strength, regardless of their age at marriage. The study suggests that marriage quality plays a significant role in bone health.
A recent study by UCLA researchers found that minority patients and those of lower socioeconomic status are more likely to have advanced thyroid cancer at diagnosis. Black patients faced the worst outcomes, while Hispanic and Asian/Pacific Islander patients surprisingly survived longer despite having later-stage disease.
A new study found that acute otitis media, or ear infection, is associated with significant increases in direct costs incurred by consumers and the health care system. The research showed that pediatric AOM accounts for approximately $2.88 billion in added health care expenses annually.
Researchers found no evidence of an association between iron levels and the risk of atherosclerosis, contradicting a long-held hypothesis. The study's findings carry important implications for patients with chronic kidney disease or anemia related to inflammatory disorders.
A pilot program using telehealth technology found that pediatric patients were satisfied with their virtual appointments, considering them just as good as in-person visits. The program also showed positive outcomes in BMI scores and blood pressure normalization, making it a promising tool for overcoming barriers to care.
Researchers found that the risk of developing diverticulitis from diverticulosis is significantly lower than previously thought, with only 1% over seven years. Younger patients diagnosed with diverticulosis are more likely to progress to diverticulitis.
Scientists at UCLA have made a breakthrough in understanding the biology of autism by mapping groups of autism-risk genes by function. They found that gene variants are expressed in the developing brain during critical processes, disrupting neural circuits and leading to miswiring between brain regions.
Men with prostate cancer who followed a low-fat fish oil diet had lower levels of pro-inflammatory substances in their blood and a lower cell cycle progression score compared to those on a Western diet. The study suggests that altering the diet may favorably affect prostate cancer biology.
Researchers at UCLA found that engineered tomatoes can reduce the negative effects of unsaturated lysophosphatidic acids (LPAs) in mice, which are linked to high cholesterol and inflammation. The tomatoes produce a peptide that mimics HDL ('good') cholesterol, stopping increases in 'bad' cholesterol and inflammation.
Researchers found that modulating the hormonal environment makes endometrial cancers more sensitive to PARP inhibitors. In high estrogen environments, tumors did not respond to the therapy due to increased DNA repair capabilities.
Researchers will investigate links between substance abuse and HIV among Latino and African-American men who have sex with men. The MASCULINE study aims to determine how substance use affects HIV transmission and treatment outcomes.
A UCLA study has identified a biological clock embedded in the human genome that can accurately measure the age of diverse organs, tissues, and cell types. The clock found that some parts of the anatomy, like breast tissue, age faster than the rest of the body.
A new Pain and Interoception Imaging Network (PAIN) will feature hundreds of brain scans and clinical information to tease out similarities and differences between chronic-pain conditions. The database aims to improve research and treatment development for conditions like migraine, irritable bowel syndrome, and rheumatoid arthritis.
A study found that lawsuits related to procedures when non-physicians operate the laser are increasing, particularly outside traditional medical settings. Non-physician operators, including nurse practitioners and medical assistants, were involved in 75.5% of hair removal lawsuits from 2004 to 2012.
The Latin American Urology Association names its highest accolade after UCLA's Dr. Shlomo Raz in recognition of his efforts to educate and train urologists in the region. The inaugural Shlomo Raz Medal will be awarded annually to a deserving urologist who furthered Raz's mission.
A new UCLA study reveals that cocaine makes quiescent CD4 T cells susceptible to HIV infection. Chronic cocaine exposure can increase the pool of infected cells with a higher viral reservoir, posing significant implications for HIV-positive individuals who abuse stimulants.
A new UCLA-led study examines the effects of childhood abuse and lack of parental affection across the body's entire regulatory system. The research finds a strong biological link between negative early life experiences and physical health, with parental warmth offering protection against these effects.
Researchers found that patients diagnosed with early Alzheimer's disease who received brain imaging test results had better clinical outcomes, including superior executive function and memory abilities. The study suggests that earlier diagnosis can lead to significant benefits, potentially saving healthcare dollars.
A study found that 11% of ICU patients received treatments perceived by physicians as 'futile', with high costs and poor outcomes. The majority of patients received appropriate care, but many were given aggressive therapies without expected benefits.
A UCLA study demonstrates that combining behavioral science with social media and online communities can lead to increased HIV testing and encouraged significant behavioral change among high-risk groups. The approach proved to be one of the best HIV-prevention methods on the Internet, with high retention rates and successful engagement.
Researchers at UCLA have identified a new form of irritable bowel syndrome (IBS) that occurs after an acute bout of diverticulitis. The study, published in Clinical Gastroenterology and Hepatology, found that patients who developed IBS-like symptoms after diverticulitis may also experience mood disorders such as depression and anxiety.
A team of UCLA researchers is working on a new approach to improve the quality of donor livers, aiming to reduce organ rejection and increase transplant survival rates. They plan to target specific immune activation pathways and enhance local mechanisms that promote liver regeneration.
A new UCLA-led study finds that substituting less expensive medications for brand-name counterparts can result in significant cost savings for Medicare beneficiaries. The study identified 50 common medications and found that 39% of patients receiving the low-income subsidy were eligible for generic or therapeutic substitutions, leading...
A culturally tailored HIV prevention program has been shown to significantly reduce unprotected sex among bisexual black men. The innovative approach, MAALES, takes a holistic approach to minimizing behaviors that could put men at risk for HIV.
A new study found that replacing soybean oil with fish oil in intravenous nutrition can reverse intestinal failure-associated liver disease in children. After 17 weeks, nearly 80% of patients experienced a reversal of their liver disease, while only 5% of those who received soybean oil saw a reversal.
Researchers at UCLA invented a tool called research maps, which helps neuroscientists quickly scan existing knowledge, plan their next study, and optimize investments. The maps classify information into categories and score the weight of evidence based on criteria such as reproducibility and convergence.
A UCLA-led research team found that religiosity in Hindus and Sikhs but not Muslims is associated with being overweight or obese. Despite differences in diet and physical activity, the link persists due to various factors including societal stigma and religious gatherings.
Researchers found that women with more severe past trauma improved the most in an HIV/trauma intervention, suggesting a tailored approach may be necessary. The study suggests focusing on the most severely traumatized individuals can lead to greater psychological improvement.
Dr. Gary Mathern, a pediatric neurosurgeon at UCLA, was honored with the Ambassador for Epilepsy Award for his significant work in improving clinical care for children with medically refractory epilepsy. His research has led to breakthrough discoveries on mechanisms of the disease process and how seizures develop in the brain.
A new UCLA-led study found that primary care physicians rarely discuss the risks and benefits of dietary supplements with their patients. The study analyzed audio recordings from over 1,400 office visits and discovered that only six out of 738 supplements were discussed in detail regarding all five major topics.
Researchers discovered that Alzheimer's drugs designed to target amyloid plaques are ineffective against small Aβ clumps called oligomers. Future studies aim to develop new drugs specifically targeting these oligomers to potentially treat the disease.
A recent UCLA-led study highlights the crucial role nurse practitioners play in treating chronic geriatric conditions. Nurse practitioners were found to improve the satisfaction of quality indicators for patients with falls, urinary incontinence, dementia, and depression when co-managed with primary care physicians.
A study by UCLA researchers found that older adults who used the Dakim BrainFitness program demonstrated significant improvements in both immediate and delayed memory skills, as well as language abilities. The findings suggest that computerized brain training can be an effective way to improve cognitive skills in this age group.
A new minimally invasive procedure called CELS allows doctors to remove large and hard-to-reach polyps while keeping the colon intact. The procedure has been shown to have lower complication rates and shorter hospital stays compared to standard surgery.
Hyundai Hope on Wheels has awarded a $75,000 Hyundai Scholar Grant to Dr. Vivian Chang at UCLA's Children's Discovery and Innovation Institute to support her research on DNA sequencing technology for identifying cancerous genes in children. The grant will enable oncologists to design personalized surveillance programs using advanced to...
A UCLA study found that women with hyperemesis gravidarum (HG) who take antihistamines are more likely to experience bad outcomes, including low birth weight babies and premature births. The study also showed that these medications are not effective in treating HG symptoms
A new study reveals that hormonal treatment for endometrial cancer works by binding to stromal tissue cells, rather than directly targeting cancerous cells. Researchers hope to develop a simple test to determine patient suitability for progesterone therapy.
Researchers at UCLA have isolated a new population of pluripotent stem cells, called Multi-lineage Stress-Enduring (Muse-AT) cells, from fat tissue that can differentiate into virtually every cell type in the human body. These cells are stress-resistant and may even be activated by severe stress, making them potentially superior source...
Researchers at UCLA have identified TR4 as a key driver of tumor growth in Cushing disease. By knocking down TR4 in lab mice, they reversed tumor growth and excess ACTH production, paving the way for potential drug therapy.
Researchers found that consuming beneficial bacteria probiotics through yogurt altered brain function in healthy women, both at rest and in response to emotional tasks. The discovery highlights the gut-brain connection and potential benefits of dietary changes for brain function.
UCLA will study the use of videoconferencing technology to deliver integrated behavioral and mental health services to children in community primary care settings. The project aims to provide effective, efficient, and family-centered care to children in low-income communities.
Despite improvements, one-third of advanced heart failure patients don't survive three years. The study found decreased mortality and sudden cardiac death rates, but patient mortality from progressive heart failure increased.
A 14-year study found older men with multiple health issues were at higher risk of dying from other causes, making watchful waiting a viable option for low- to intermediate-risk prostate cancer patients.
Researchers found that breathing motor vehicle emissions alters high-density lipoprotein (HDL) cholesterol, making it contribute to clogged arteries. The inhalation of emissions activates components of oxidation, leading to inflammation and hardening of the arteries.