A single infusion of wildtype hematopoietic stem and progenitor cells into a mouse model of Friedreich's ataxia restored normal cellular functions, halted cellular damage, and improved mitochondrial function. This breakthrough suggests a potential therapeutic approach for the currently incurable disease.
Researchers used machine learning technology to identify entities illegally selling prescription opioids online. The study found 1,778 tweets marketing controlled substances, with 90% including hyperlinks to purchase sites.
Human exposure to glyphosate has increased significantly since the introduction of genetically modified crops, with 70% of study participants having detectable levels by 2016. Glyphosate use has also increased 15-fold since 1994.
Researchers developed a 3D spatial visualization tool to understand the effects of chemicals on diseased organs in context of microbes. The tool helps advance targeted drug delivery for cystic fibrosis and other conditions where medications struggle to penetrate, revealing new insights into microbial anatomy.
Researchers at UC San Diego found mutant p53 amplifies inflammatory responses in cancer cells, increasing invasive behavior and tumor growth. Chronic inflammation plays a crucial role in predisposition and progression of human cancers like colon and breast cancers.
Research found that astrocytes from children with autism exhibit innate inflammation, contributing to neuronal dysfunction. However, when normal astrocytes were co-cultured with autistic neurons, the latter reverted to normal functioning.
Researchers have identified key pathways and mechanisms underlying viruses and infections, opening new avenues for treatment. The studies found that targeting the Hedgehog pathway may reduce severity of flu symptoms and could lead to effective treatments for anthrax infection.
Researchers developed a genome-scale model that predicts how E. coli cells respond to temperature changes and genetic mutations, highlighting the importance of chaperone networks in adaptive cell modeling for precision medicine.
Researchers at UC San Diego have developed a solution to control Asian hornets by luring males with synthesized sex pheromones, providing a simple and reliable way to monitor and potentially reduce populations. The study's findings demonstrate the key role of pheromones in long-distance attraction for these invasive insects.
The researchers have demonstrated the first laser cavity that can confine and propagate light in any shape imaginable, even pathways with sharp bends and angles. This new design could enable higher speed optical communication technologies.
Researchers teach Chinese children to identify black male faces, reducing implicit bias that lasts for at least two months. A second training session boosts effects and has a longer-lasting impact.
Developed by engineers at the University of California San Diego, the gripper combines capabilities to twist, sense, and build models of objects. Researchers tested it on an industrial robot, demonstrating its ability to manipulate a wide range of objects in low light conditions.
Researchers discovered that stomach acid suppression alters specific gut bacteria in a way that promotes liver injury and progression of three types of chronic liver disease. This association was found in both mouse models and human patients with chronic alcohol abuse, highlighting the potential risks of common acid reflux medications.
Researchers have developed a new diagnostic method for early detection of hepatocellular carcinoma, based on a simple blood sample containing circulating tumor DNA. The test has been shown to highly correlate with tumor burden, treatment response, and stage of cancer.
Researchers have identified a gene that may provide potential therapy for cerebral cavernous malformations (CCMs), a condition characterized by enlarged and irregular blood vessels in the central nervous system. The study suggests using angiogenesis inhibitors, such as TSP1, to treat or prevent CCMs.
At randomly selected high-angle general grain boundaries in a nickel-bismuth polycrystalline alloy, researchers found that interfacial reconstruction can form ordered superstructures. These segregation-induced superstructures enrich theories and fundamental understandings of grain boundary segregation and liquid metal embrittlement.
A study by University of California San Diego School of Medicine researchers reveals that a simple blood test can predict which patients will respond to checkpoint inhibitor-based immunotherapies, with 45% of patients showing significant response. The findings suggest that patients with high numbers of genomic alterations in their tumo...
Researchers developed a new mouse model lacking the Upf3b gene to study its underlying role in intellectual disabilities and neurodevelopmental disorders. The study found that Upf3b-deficient mice exhibited defects in neural stem cell specialization, dendrite formation, and sensory processing.
Researchers found that transcranial electrical stimulation significantly improved neural function in participants with mild traumatic brain injury, as shown by reduced abnormal slow-waves in MEG scans. The treatment also led to a significant reduction in post-concussion scores.
Researchers have engineered smart protein molecules called iSNAPS that can rewire macrophages to ignore a 'don't eat me' signal from cancer cells, allowing them to engulf and destroy cancer cells. This breakthrough could lead to a new method of re-engineering immune cells to fight cancer and infectious diseases.
A study published in Cancer Research found that inhibiting two metabolic enzymes, NADK and KHK, reduced the growth of KRAS-mutant colorectal cancer cells in mice by approximately 50%. The research also identified new genes that, when inactivated, increased tumor growth in KRAS-mutant cancers.
Researchers have discovered that planarian fission occurs in three stages: waist formation, pulsation, and rupture. This process is crucial for the regeneration of missing structures, allowing flatworms to reproduce asexually and potentially giving rise to diversity in populations.
Researchers from UC San Diego showcase self-folding robots, robotic endoscopes, and improved computer vision techniques to enhance human-robot collaboration. The conference focuses on developing friendly robots that can work effectively with humans in various domains.
Scientists at UC San Diego uncover a previously unknown link between non-coding DNA regions and the formation of immune cells. The discovery reveals a precise mechanism for the pairing of promoter and enhancer elements, which brings them into close proximity to initiate immune cell development.
Researchers at University of California San Diego School of Medicine found exosomes from inflamed adipose tissue macrophages cause metabolic derangements of diabetes. Exosomes carry microRNA that inhibits key proteins, leading to insulin resistance.
Researchers at UC San Diego School of Medicine have developed a drug combination that doubles down on immunotherapy's effectiveness in treating head and neck cancer. The combination of toll-like receptors agonists and other immunotherapies injected directly into tumors suppresses tumor growth throughout the body.
Researchers developed a new tool, San Diego Wisdom Scale (SD-WISE), to measure an individual's level of wisdom. The scale successfully measured five out of six targeted domains, including prosocial attitudes and emotional regulation, and showed correlation with psychological well-being.
A pilot study of 87 female breast cancer survivors found that increased physical activity more than doubled their post-treatment mental processing speed. The intervention program tailored to each person's interests and abilities improved cognitive processing speed and some improvements in perceived mental abilities.
A recent study found a 37% increase in the gap between the average lifespan of people with schizophrenia and the general population. Longitudinal studies suggest that this widening trend is due to factors such as inadequate healthcare, unhealthy lifestyles, and biological aging.
Researchers have created a new climate risk classification system to account for potential existential threats from rapid global warming. The categories include catastrophic and unknown risks, which could play out by century's end, posing dangers such as species extinctions and human health risks.
A recent study published in Psychological Science found that praising children for their intelligence can lead to dishonest behavior and cheating as early as age 3. The research suggests that this type of praise can create performance pressure, causing kids to feel compelled to cheat in order to meet expectations.
Researchers have identified a new strategy to target KRAS mutant cancer using a Galectin-3 inhibitor. The study found that binding of the protein to a specific cell surface receptor amplifies the advantages driven by mutant KRAS, creating a unique vulnerability that can be targeted with an existing drug.
Researchers have discovered a new type of glycan that survives in 4 million-year-old animal fossils from Kenya. This breakthrough could reveal human origins and diet, including the consumption of red meat. Gc-CS detection may classify ancient hominin fossils into two groups.
A team of researchers has created a model to analyze short tandem repeats in the human genome, which are implicated in about 30 harmful conditions. The model predicts the frequency and mutation rate of repeats, providing insights into constraints that may narrow down disease signals.
Researchers found that plants have adapted to rising CO2 levels by becoming more efficient at using water, which could help offset human-induced climate change. The study provides new insights into the impact of CO2 on plant behavior and photosynthesis.
A new dental imaging method using squid ink combines light and ultrasound for a comprehensive and accurate examination of gums without pain or discomfort. This non-invasive approach enables dentists to create detailed maps of gum pocket depths, surpassing the conventional method's limitations.
Researchers created algorithms that allow homes to use and share power from renewable energy sources during outages. The system improves grid reliability by prioritizing distribution of power based on forecasts and energy storage availability.
Researchers at the University of California San Diego have unlocked the mechanisms underlying animal kinship attachments and social attraction. The study found that neurotransmitters and microRNAs play a crucial role in regulating these behaviors, including the switching of neurotransmitters in response to olfactory cues.
Researchers found that human neural stem cells retained an intrinsic human rate of maturation despite being placed in a traumatic rodent environment. The study's findings suggest that clinical outcome measures for future trials need to focus on long time points after grafting, as success may take time.
Researchers have discovered a way to activate the proteasome in CD8+ T cells, generating more long-lived memory cells that can provide lifelong protection. This approach could be used as an adjuvant therapy to enhance vaccine and immunotherapy effectiveness.
Researchers at UC San Diego will study the combination of cirmtuzumab and ibrutinib in a phase Ib/IIa clinical trial to boost remission rates and long-term cancer control for B-cell cancers. The approach targets cancer stem cells, potentially improving complete and lasting remissions.
Engineers at UC San Diego developed stretchable fuel cells that extract energy from sweat to power electronics. The biofuel cells generate 10 times more power per surface area than existing wearable biofuel cells.
A new study from the University of California San Diego suggests that the moon's interior is likely very dry, contradicting recent findings of wetness. The researchers analyzed fragments of the 'Rusty Rock,' a lunar rock collected during the Apollo 16 mission in 1972.
Researchers have found a high frequency of GISTs with NF1 gene mutations in the duodenal-jejunal flexure. This discovery highlights the importance of genomic testing for patients with GIST and potentially affected family members.
Researchers developed micromotors that swim through stomachs to deliver antibiotics, reducing need for proton pump inhibitors. The treatment was more effective than traditional methods in mice with Helicobacter pylori infections.
Researchers identified genetically targetable alterations in 66% of patients with cancer of unknown primary (CUP), a rare disease. The study used circulating tumor DNA in blood samples to detect these alterations, which could be targeted using existing FDA-approved drugs or therapies currently under investigation.
Researchers found that compounds from the desert creosote bush exhibit powerful anti-parasitic effects, particularly against Giardia and Naegleria fowleri. The study offers a promising lead for developing new antimicrobial agents to combat deadly parasitic infections.
A new version of the CRISPR-Cas9 gene editing technique has been developed to correct molecular mistakes that lead to microsatellite repeat expansion diseases. The approach eliminated 95% or more of RNA foci linked to myotonic dystrophy and other diseases in laboratory models and patient-derived cells.
Researchers have developed a new way to map differences in brain cells by analyzing chemical modifications in their DNA. The study identified 16 subtypes of neurons in mice and 21 in humans, offering new insights into the diversity of brain cell types and potential for understanding brain development and dysfunction.
Researchers created a human stem cell-based model of Aicardi-Goutieres Syndrome to identify underlying genetic mechanisms and test existing drugs. Two FDA-approved HIV antiretroviral drugs showed promise in rescuing mutated cells, offering hope for future clinical trials.