Research from the UC San Diego School of Global Policy and Strategy warns of democratic backsliding globally. The US is not immune to such threats, with Americans worrying about election fraud. Scholars investigate how illiberal regimes use international organizations to erode democracy.
A pilot study found that AI tools can accurately process hospital quality measures, achieving 90% agreement with manual reporting. This can lead to more efficient and reliable approaches to healthcare reporting, especially for complex measures like severe sepsis and septic shock.
Researchers at UC San Diego have developed a faster and more affordable method to study chromatin organization, which influences gene activation and cell function. The droplet Hi-C technique has been successfully deployed to analyze chromatin organization in mouse brain cells and human tumors.
A new study has found that men and women utilize different biological systems to relieve pain. Women rely on non-opioid based pathways, which may explain why they respond poorly to opioid therapies and are more likely to become addicted. The research suggests tailoring pain treatment to an individual's sex may improve patient outcomes.
Researchers found that the oral medication palbociclib stabilized tumor growth and reduced blood tumor marker levels in patients with peritoneal mucinous carcinomatosis, a form of appendix cancer often resistant to standard chemotherapy. The study's findings introduce a first targeted therapy for this rare disease.
A study from the University of California - San Diego found that early communication from election officials can reduce voter distrust in delayed results. When voters are informed in advance that counting ballots takes time and security measures are in place, their trust remains steady despite delays. This proactive message can help ma...
Researchers at UC San Diego developed a fluorescent biosensor to observe PKC activity in real time and 3D space. The study revealed designated signaling territories where different types of PKC are active, shedding light on their critical role in human disease.
A new study found that increased public attention led to a 22% decrease in fires in the Brazilian Amazon, avoiding approximately 24.8 million tons of CO2 emissions. The heightened scrutiny prompted the government to deploy fire brigades and implement subsequent measures.
Researchers at UC San Diego developed nanopillars that breach the nucleus of a cell without damaging its outer membrane. This technology has potential applications in gene therapy and drug delivery. The researchers observed that only the nuclear membrane was punctured, leaving the rest of the cell intact.
Plant biologists have mapped two paths that plants implement during elevated heat conditions to minimize heat damage. Carbon dioxide sensors play a central role in the stomatal warming-cooling responses, while a second heat response pathway bypasses normal photosynthesis-driven responses, leading to increased water use efficiency.
Researchers found significant challenges in spider silk production, including scale-up issues and toxicity concerns. The study highlights potential host organisms for producing spider silk, such as microbes and bacteria, to address these challenges.
A recent study found that limiting food consumption within a 10-hour window per day improved key indicators of heart health in adults with metabolic syndrome. The study demonstrated significant reductions in blood sugar and cholesterol levels, as well as lower levels of hemoglobin A1c, a marker of long-term blood sugar management.
Researchers at UC San Diego School of Medicine identified ZNF750 as a key player in controlling inflammation, shedding light on susceptibility to inflammatory skin diseases. The study paves the way for more effective therapies and broader insights into molecular biology of skin cells.
Neurobiologists identify shared brain mechanism behind meth and PCP-induced cognitive deficits, finding a reversible switch in neurotransmitters. Reversing this switch restores memory function, offering potential for new treatments.
Researchers at University of California - San Diego have discovered that Crohn's disease consists of two distinct molecular subtypes, each exhibiting unique patterns of genetic mutation and cellular phenotypes. This finding could lead to more effective management strategies, with therapies tailored to specific subtypes.
A study from University of California San Diego reveals a direct association between inherited genetic variants in mitochondrial DNA and the severity of Gulf War illness. The findings support an emerging hypothesis that GWI is driven by mitochondrial dysfunction rather than inflammation.
A study by University of California San Diego researchers found that displaced Syrian refugees with higher self-compassion levels reported fewer poor mental health outcomes. The study surveyed 272 participants and explored the relationship between self-compassion and resilience in mitigating mental illness.
A team of researchers led by University of California San Diego's David Kleinfeld will study the coordination of multiple sensory inputs and head movements using laboratory mice and rats. They aim to understand how individual cells and complex neural circuits interact in time and space.
A UC San Diego study finds machine learning algorithms outperform humans in detecting deception, particularly when presented early in decision-making processes. This technology could help online platforms flag suspicious content more effectively, reducing the spread of misinformation.
Researchers developed guidelines to enhance accuracy of spike-in normalization, a widely-used molecular biology technique. The study highlights common pitfalls and provides recommendations for improving results.
A new study from the University of California Rady School of Management finds that most US states with food waste bans have seen little to no reduction in landfill waste, except for Massachusetts. Researchers highlight three key features of Massachusetts' law as effective in reducing waste.
A massive landslide triggered by climate change melted the glacier at its base, causing a 200-meter (650-foot) tall tsunami that rocked back and forth inside a narrow fjord for nine days. The resulting seiche generated seismic waves that reverberated through Earth's crust, baffling scientists worldwide.
A new study reveals that mindfulness meditation reduces pain intensity and unpleasantness ratings by directly modifying how we experience pain. Unlike the placebo cream, which only affects brain activity patterns associated with the placebo effect, mindfulness meditation employs a separate neural pathway to alleviate pain.
Researchers identified seasonal patterns in Valley fever cases influenced by California droughts. The study found that while most cases occur from September to November, drought periods temporarily dampen these peaks, but lead to bigger surges once rain returns.
The wearable device monitors vital chemical levels in fingertip sweat, fueling its own energy and powering a suite of sensors. It can track glucose, vitamins, lactate, and levodopa levels without requiring physical activity or stimuli, offering a reliable health monitoring solution.
Researchers at University of California San Diego have identified a novel mechanism of cardiac inflammation that may prevent heart failure after a heart attack. The borderzone, surrounding the infarcted area, is found to be a key region for this inflammation, with heart muscle cells playing a dominant role in initiating it.
A new study published in PLOS ONE shows that dogs trained with soundboard buttons can comprehend specific words and respond appropriately. The study's findings suggest that dogs are not merely 'reading' their owners' body language but are indeed processing the words themselves.
A recent analysis found that cannabis use and cannabis use disorder are associated with increased workplace absenteeism. The study, published in the American Journal of Preventive Medicine, showed that even infrequent cannabis use can lead to more workdays missed due to illness or injury.
Researchers have developed two new methods to produce circular RNAs, which can silence genes and serve as templates for making therapeutic proteins. These circular RNAs display enhanced stability and biological activity in heart muscle cells and neurons.
Researchers at University of California - San Diego have discovered a link between environmentally induced autism and altered neurotransmitter expression in the brain. The study suggests that manipulating these neurotransmitters early in development can prevent autistic-like behaviors.
Researchers at UC San Diego School of Medicine used intracranial EEG to study co-rippling in the cortex, finding synchronized activity between neurons enables integration of information and conscious thought. This breakthrough has potential implications for understanding neurological and psychiatric disorders and human experience.
Researchers infer that Mars' crust has stores of liquid water, essential for a habitable planet. The study suggests that liquid water in the mid-crust is the most plausible explanation for the data collected by the InSight lander.
Researchers at UC San Diego's Scripps Institution of Oceanography have discovered the largest protein yet identified, PKZILLA-1, which builds toxic algal toxins. The finding could enhance monitoring efforts for prymnesin-producing golden algae blooms and unlock potential for new medicines.
A new 3D printing method developed by UC San Diego engineers uses a polymer ink and salt water solution to create solid structures with ease. The process is reversible, allowing the PNIPAM ink to be reused for further printing.
University of California San Diego researchers used cryo-electron microscopy to capture the first 3-D images of a key muscle receptor, shedding light on why newborn humans develop slowly while cows mature quickly. The study's findings may help develop future treatments for muscular disorders.
Scientists from UC San Diego detected geochemical signatures of magma pooling and melting beneath the surface during Iceland's recent volcanic episode. The study found that massive pooling of magma preceded the eruption, contrasting initial hypotheses for magma ascent straight from the mantle.
Using 3D models, researchers tracked the response of 1,832 coral colonies to two moderate-strength bleaching events off Maui. They found that some corals showed signs of acclimatization, surviving both bleaching events and potentially informing approaches to coral reef conservation.
A new AI protocol called DeepHRD enables accurate, instantaneous detection of cancer genomic biomarkers directly from tumor biopsy slides. This breakthrough technology saves weeks and thousands of dollars from clinical oncology treatment workflows, providing access and equity in cancer care for resource-constrained settings.
Researchers find significant association between illicit fentanyl use and HCV transmission, highlighting need for point-of-care testing and treatment access. The study suggests that fentanyl's short half-life may lead to increased risk of HCV transmission through frequent dosing and sharing.
UC San Diego researchers have developed a wearable, non-invasive device that can record activity in human cervical nerves, providing early warning signs for conditions like sepsis and PTSD. The device uses magnetoneurography to detect changes in nerve activity, offering an early diagnostic marker of pathogen infection or inflammation.
Researchers found that a cancer drug can restore phagocytosis, a process crucial for brain health, in individuals with Rett syndrome by targeting microglia. The study highlights the potential therapeutic target of microglia in neurological conditions and may lead to new treatments.
A species of freshwater flatworm has been found to produce sterile soldiers that defend its colonies without reproduction. The discovery is significant as it sheds light on the evolution of complex animal societies.
A significant increase in cannabis use among adults with diabetes has been found, with a 33.7% rise in prevalence between 2021 and 2022. Cannabis use may be driven by perceived therapeutic benefits and increased access to products after legalization.
Diatoms, single-celled plankton, build biomass by feeding on organic carbon, challenging the assumption that photosynthesis is their only strategy. The discovery has major implications for understanding the global carbon cycle and could alter estimates of carbon dioxide diatoms pull out of the air.
Studies in glassfish reveal that vision plays a crucial role in coordinated schooling behavior, with maturity also essential for developing this ability. Researchers discovered that older fish can distinguish between movement patterns of their social partners, allowing them to align their bodies and swim together effectively.
Researchers found that autologous bone marrow aspirate concentrate (BMAC) and adipose-derived stromal vascular fraction (ADSVF) have distinct cellular compositions and protein profiles. The study's findings challenge the marketing of these therapies as interchangeable and highlight the need for standardized cell therapies.
A humanoid robot has been trained to learn and perform various expressive movements, including simple dance routines and gestures. The enhanced expressiveness and agility of the robot pave the way for improving human-robot interactions in settings such as factory assembly lines, hospitals, and homes.
Researchers at University of California San Diego have found that genetically modified NK-cell therapy can effectively target and treat hepatocellular carcinoma, a highly treatment-resistant form of solid tumor. The therapy works by disabling the inhibitory protein TGF-β, allowing immune cells to kill cancer more efficiently.
Researchers discovered that phage viruses have weaponized mobile introns to sabotage competing viruses' reproduction. This finding has significant implications for understanding the evolution of genomes and developing effective phage therapy against antibiotic-resistant bacteria.
Scientists identify PI3K gamma as a key player in recruiting damaging myeloid cells to infected tissues, and show that inhibiting this enzyme with eganelisib can prevent excessive inflammation. The study provides a new approach to preventing irreversible organ damage in infectious diseases like COVID-19.